Bilal Muhammad Khan

Bilal Muhammad Khan
PMAS - Arid Agriculture University | PMAS-AAUR · 1. University Institute of Biochemistry and Biotechnology. 2. National Center of Industrial Biotechnology

PhD; Postdoc (Biotechnology & Genetic Engineering)
Interested in characterization and associated bioactivities of natural products, particularly polysaccharides.

About

26
Publications
11,674
Reads
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351
Citations
Introduction
Teaching allows me to fulfill what I believe to be a fundamental responsibility of scientists: to communicate information to the public so they can make informed decisions. Hailing from an underdeveloped area, Malakand, I was no stranger to the use of indigenous weeds in the traditional medicinal preparations. Though, at that time I always wondered how an otherwise unwanted plant can cure an ill person; that too prescribed by an illiterate person. I was lucky enough to be a part of the team headed by Prof. Dr. Jehan Bakht of the Institute of Biotechnology & Genetic Engineering, The University of Agriculture, Peshawar, who encouraged me to find answers to my childhood queries which, in fact, resulted in new queries and efforts to find answers to these.
Additional affiliations
November 2019 - present
PMAS - Arid Agriculture University
Position
  • Professor (Assistant)
Description
  •  Teaching undergraduate and graduate level courses in Biochemistry, Biotechnology and Microbiology.  Research supervisor for Biotechnology research scholars.
March 2018 - September 2019
Shantou University
Position
  • PostDoc Position
Description
  •  Worked on the project titled “Selected Marine Red Algal Polysaccharides: Extraction, Purification and Activities.”  Secured a research bonus of CNY. 9000/- (the highest amount granted to an individual among researchers from College of Science) from Shantou University in appreciation for publishing high quality research articles during Spring 2018.  Published Thirteen (13) research articles in reputed international journals carrying JCR IF with this affiliation.
January 2016 - January 2017
Abdul Wali Khan University Mardan
Position
  • Professor (Assistant)
Description
  •  The following courses were taught in Spring/Fall 2016. 1. Biotech-651 "Pharmaceutical Biotechnology" (3+0) Spring 2016 2. Biotech-551 "Analytical Chemistry & Instrumentation" (3+0) Spring 2016 3. Biotech-301 "Introduction to Biotechnology" (2+1) Fall 2016 4. Biotech-503 "Genetic Resources and Conservation" (2+1) Fall 2016  Secured a research grant of PKR. 0.5 Million for the project titled “Evaluation of Different Solvent Extracted Samples from Indigenous Medicinal Plants for their Antimicrob
Education
September 2011 - December 2015
Khyber Pakhtunkhwa Agricultural University, Peshawar
Field of study
  • Biotechnology & Genetic Engineering
February 2007 - March 2009
Khyber Pakhtunkhwa Agricultural University, Peshawar
Field of study
  • Biotechnology & Genetic Engineering
October 2001 - November 2005
University of Malakand
Field of study
  • Biotechnology

Publications

Publications (26)
Article
Full-text available
In the western mountainous region of Khyber Pakhtunkhwa Pakistan at the Shangla district, we found Physalis ixocarpa for the first time, not yet reported from Pakistan. Physalis ixocarpa was unidentified and has no ethnobotanical record in the flora of Pakistan. It is a member of family Solanaceae and having a close relation with Solanum tuberosum...
Chapter
Marine algae have attracted a great deal of interest as excellent sources of nutrients. Polysaccharides are the main constituents of marine algae, with much attention being focused on their isolation and purification, as they may have numerous beneficial effects on human health. In order to promote the utilization and application of marine algae po...
Article
Full-text available
MicroRNAs (miRNAs) are small non-coding RNA molecules that control the post-transcriptional gene expression. They play a pivotal role in the regulation of important physiological processes. Variations in miRNA genes coding for mature miRNA sequences have been implicated in several diseases. However, the association of variants in miRNAs genes with...
Article
Full-text available
Marine rhodophyte polysaccharides have a wide range of described biological properties with nontoxic characteristics, and show great potential in prebiotics and the functional foods industries. However, there is a virtual lack of Gracilaria blodgettii polysaccharides (GBP) profiling and their bioactivities. This study was designed while keeping in...
Article
Full-text available
Polysaccharides, with an extensive distribution in natural products, represent a group of natural bioactive substances having widespread applications in health-care food products and as bioma-terials. Devising an efficient system for the separation and purification of polysaccharides from natural sources, hence, is of utmost importance in the wides...
Article
Full-text available
To address the structure–activity relationship of Chlamys farreri polysaccharides on their immunostimulatory efficacy, two polysaccharides (CFP-1 and CFP-2) were extracted from Chlamys farreri by hot water extraction, and separated through column chromatography. The isolated CFPs were chemically analyzed to clarify their physicochemical characteris...
Article
This study was designed to fully characterize Porphyra haitanensis polysaccharides, and to evaluate their antioxidant activity. The polysaccharides primarily contained galactose and 3,6-anhydrogalactose in a molar ratio of 1.2:1.0, respectively and sulfate content about 3.8%. The molecular weight of polysaccharides is 2.5× 105 Da. Scanning electron...
Article
Full-text available
Every individual needs food for its nutritional value and flavor while the economic growth of a nation depends on a thriving profit-generating industry. The food industry caters to both needs in an efficient manner. Proteins can rightly be considered as the driving force behind the overwhelming success of this industry. However, purification of pro...
Article
Full-text available
A complete absence of the physicochemical characterization of Gracilaria chouae polysaccharides (GCP) and its corresponding bioactivities urged the need for this study. It was found that GCP is a heteropolysaccharide which exists in linear random coil conformation. It contained a sulfate content of 7.9% in addition to 52.63% total sugar content and...
Article
Full-text available
Restricted applications of chemical nematicides has directed to the development of ecofriendly alternatives. Culture filtrates in different concentrations (20, 40, 60, 80 and 100%) of the six isolates of Pochonia chlamydosporia were evaluated for their nematicidal activity. Significant variations were observed in the inhibitory activity of culture...
Article
This study aims at developing an effective, safe and economic hydrogel, with wound healing ability, by making use of polysaccharides. Bletilla striata polysaccharide (Bsp) and the bioactive natural polymers, carboxymethyl chitosan (CMC), were physically blended with Carbomer 940 (CBM940) in order to promote gel-forming and improve water retention....
Article
Full-text available
To support the crop improvement of Physalis ixopcarpa Brot., 16 accessions provided by National Plant Germ Plasm System USDA (USA) and one recently reported accession from Pakistan were characterized for morphometric and genetic diversity. These accessions were evaluated for morphometric and physiological traits. Among these traits, plant height, r...
Article
Full-text available
This study evaluates the antifungal, anti-yeast and antioxidant potency of various extracts from the commercially available rhizome of Acorus calamus. Sun-drying, due to its cost-effectiveness and associated simplicity, is the most usual form of drying for herbal practitioners. This choice of drying regime, however, does not guarantee retention of...
Article
Full-text available
High speed counter current chromatography (HSCCC) utilizes a liquid stationary-phase and, hence, does not suffer from irretrievable adsorption associated with conventional chromatography procedures. It is a good alternative for such techniques because of its speedier and economically viable separation, ease of scaling-up, ability for coupling with...
Article
Full-text available
Because of their potential use as functional ingredients in human nutrition, oligosaccharides derived from natural sources are receiving paramount consideration. Red seaweed, a proven rich source of agar and carrageenan, is one of the most abundantly present sources of such oligosaccharides. Agaro-oligosaccharides (AOS) and carrageenan-oligosacchar...
Article
Full-text available
The potential of Gallic acid as a broad-spectrum antibiotic was established by evaluating five solvent extracted samples (crude extract and its four fractions) from the shade-dried (S-D) rhizomes of Calamus aromaticus through disc diffusion assay wherein 0.05 mg Ciprofloxacin was used as control. The results of the study indicated that Staphylococc...
Article
Full-text available
Background: The large scale growing and harvesting of Calamus aromaticus, a medicinally important weed, is rampant in Asia due to its well-known medicinal importance. The gigantic antimi-crobial potential of C. aromaticus, however, is not reflected in the absolute sense by the efforts devoted to this purpose so far. Methods: The role of Gallic acid...
Article
Full-text available
The different parts of Physalis philadelphica were evaluated for the antifungal, anti-oxidant and HPLC assay. The methanol extract of leaf showed inhibitory activity against Pencillium digitatum (58% ZI), Aspergillus flavus (95% ZI) and Rhizopus oryzae (96% ZI) at a concentration of 400 ppm. Strong anti-oxidant activities were found in different pa...
Article
Full-text available
The current research investigates the anti-microbial activities of different solvent extracted samples from the leaves of Calamus aromaticus against Gram positive, Gram negative bacteria and fungi using 500, 1000 and 2000 µg disc-1 concentrations. Escherichia coli, Citorbacter freundii and Candida albicans showed resistivity to crude methanolic ext...
Article
Full-text available
Different extracts from the rhizomes of Acorus odoratus were assessed for the presence of antifungal, anti-yeast and anti-oxidant potential. Mild antifungal and robust anti-yeast potential were revealed by the tested samples. A gigantic anti-oxidant activity, however, was noted for all extracts at each concentration used. The data further revealed...
Article
Full-text available
p>The antifungal, anti-yeast and anti-oxidant effects of Calamus aromaticus leaves were studied. The extract showed mild activity against two fungal strains and strong activity against the yeast. The results also indicated the presence of extremely high DPPH radical scavenging potential in all tested samples at each of the seven concentrations used...
Article
Full-text available
A novel, cost-effective and indigenous micro-propagation protocol for the endangered A. calamus was successfully developed. Tang II (Natural Growth Substances) in a concentration of 20 ml L-1 was found as the best growth regulator for both shooting and rooting of the explants. It required 3.38 days to bud-break, showed 86.66% bud-break, 1.26 shoots...
Article
Full-text available
Wheat breeders in Pakistan relied upon phenotypic traits as indices of genetic variation among different wheat varieties which may genotypically be closely related or vice versa. The main objective of the current study was to determine the genetic diversity among different popular wheat cultivars grown in the Khyber Pukhtunkhwa (KPK) region of Paki...

Questions

Question (1)
Question
Respected all!
I am working on quantification of algal anhydrous galactose but I am not sure if there is a way to achieve this end without the need for derivatization. In fact, I have found a Korean patent referring to the use of FTIR and HPLC, but since its translation is machine-generated, I am unable to fully grasp the idea. The original patent (in Korean) and the translation are attached herewith. Your help in this regard will be highly appreciated.

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Projects

Projects (2)
Project
The project is designed to extract and characterize polysaccharides from different marine algae, and to evaluate their bioactivities.