Bijoya BasuCase Western Reserve University School of Medicine · Department of Genetics and Genome Sciences
Bachelor of Science
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Citations since 2017
4 Research Items
Hormones have traditionally been classified by their mode of biosynthetic origin. We postulate a mode of hormone biosynthesis that leads to a new subclass of protein hormones. Members of this class are derived from a cleavage event that also generates a much larger, functionally unrelated, nonhormonal protein. Here, we examine four representative m...
Transcriptional regulatory changes in the developing and adult brain are prominent features of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly understood. We integrated brain-specific DNase footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network (TRN) model for the human...
Genetic and genomic studies suggest an important role for transcriptional regulatory changes in brain diseases, but roles for specific transcription factors (TFs) remain poorly understood. We integrated human brain-specific DNase I footprinting and TF-gene co-expression to reconstruct a transcriptional regulatory network (TRN) model for the human b...
Non-coding genetic variants with predicted regulatory functions contribute strongly to risk for psychiatric disorders, and psychiatric disorders are associated with changes in the expression of hundreds of genes in the brain. Understanding brain gene regulation may therefore provide insights into the mechanisms of psychiatric disorders, yet mechani...