Bibhash C. Mohanta

Central University of South Bihar · Department of Pharmacy

Bioinformatics refers to the interdisciplinary approach that involves the application of computational tools to collect, store, analyze, and interpret biochemical and biological information. It combines biology, computer science, mathematics, and statistics to provide a forum for new drug discovery processes. Several studies on genomics and proteom...

Emulgel is considered an advanced leading form of topical drug delivery system. It possesses the quality of a dual control drug mechanism for drug release as it holds the properties of both gel as well as emulsion. Emulgel is capable of overcoming the problems of the conventional route of topical drug delivery, like low spreadability and stickiness...

The pharmacokinetic (PK) and toxicokinetic profile of a drug from its preclinical evaluation helps the researcher determine whether the drug should be tested in humans based on its safety and toxicity.Preclinical studies require time and resources and are prone to error. Moreover, according to the United States Food and Drug Administration Modernis...

During pharmaceutical or biopharmaceutical drug product development, one of the most important steps to be followed is characterization and reverse engineering of the drug product. Out of so many characterization tools and orthogonal reverse engineering techniques, thermoanalytical methods are the most useful techniques. Different thermoanalytical...

Objectives: Olmesartan medoxomil (OLM) is a low bioavailability antihypertensive drug. This study aimed to prepare and optimize an OLM niosomal gel and investigate drug permeation via a chicken buccal pouch. Materials and methods: OLM-loaded niosome were prepared using a film hydration technique. The vesicle size, zeta potential, entrapment effici...

The aim of the study was to green synthesis and evaluate the antiepileptic activity of herbal nanoparticles of Mimusops elengi (ME) on electrochemical convulsion models in mice. ME herbal nanoparticles (MEHNPs) were synthesized and characterized. The particles size and zeta potential of MEHNPs were found to be 24 nm and 29.5 mV respectively. FTIR s...

Background Green syntheses of silver nanoparticles using plant extracts have proven to have potential anti-cancer, antimicrobial, and antioxidant properties, among other aspects. The aim of the present study was to synthesize silver nanoparticles (AgNPs) using Vernonia cinerea plant extract. Methods The AgNPs were successfully prepared and were ch...

The present investigation was aimed to prepare isoniazid (INH) encapsulated Solid Lipid Nanoparticles (SLNs) and to evaluate its potency against drug resistant strain of Mycobacterium tuberculosis in an in vitro antitubercular model. The SLNs were prepared by high pressure homogenization followed by ultrasonication technique. The prepared SLNs were...

Background Health is a lively state of the body which adjusts and adopt with the response to various environmental changes. There are several features that can influence the health status of human beings. Therefore, the continuous research study is highly essential to maintain a proper health care system in the community. Objective The diverse are...

Introduction: Rifampicin (RIF), a first-line anti-tuberculosis drug having an inimitable potential of rapidly killing mycobacterium. Unfortunately, it has poor bioavailability, short half-life period (t 1/2), and intense toxicity. To solve the problem, solid lipid nanoparticles (SLN) of RIF were developed by high-pressure homogenization followed by...

Recently, targeted drug delivery systems have gained much more interest for delivering varieties of drugs as well as imaging agents specifically to the targeted disease cells or tissues. These are well known for their increased precision and accuracy in mode of drug delivery along with reduced side effects. Though numerous carriers are being employ...

Tuberculosis is one of the most devastating diseases present in the world which possesses a global health threat of escalating proportions. The concerned disease is the leading infectious cause of mortality today behind only HIV/AIDS. The impetus for the development of newer structural classes of antitubercular drugs is imminent from the fact that...

Controlled releasing drug delivery systems (CRDDS) are proved to be superior over the conventional immediate releasing dosage systems in numerous aspects such as lower incidences of dose dumping risks and side-effect problems, reduced frequency of dosing, enhanced bioavailability, and better patient compliances. Polyelectrolyte complexes (PECs) are...

Since last few decades, alginate has been continuously gaining much attention for its contribution as a natural polymer in drug delivery and tissue engineering applications. The reasons behind its popularity are cost-effective extraction procedure, excellent biocompatibility, as well as biodegradability. It is extracted from different varieties of...

Brain tumor diagnosis and therapy is an extremely challenging task. The absence of early stage symptoms and consequently delays in diagnosis matter a lot in tumor therapy. The chemotherapeutic approach is the most common therapeutic approach in brain tumor cases, still, it is linked with several precincts. The greatest challenge in chemotherapeutic...

The present study was aimed to develop and optimize isoniazid (INZ) loaded solid lipid nanoparticles (SLNs) for exploring in vitro anti-tubercular and cytotoxic activity. The INZ-SLNs were successfully prepared by high pressure homogenization followed by ultrasonication technique and optimized using 2 3 full factorial designs. INZ-SLNs were charact...

Microwave (MW) synthesis is considered as an efficient approach towards "Green and sustainable chemistry" because it is environmental-friendly in nature. This synthetic process is less time consuming because it uses MW as an alternative energy source. The benefits of MW synthesis include rapid heating, absence of inertia, ease of use, better homoge...

Tuberculosis (TB) is an airborne infectious disease spreading very fast from person to person, which affect the health as well as socioeconomic conditions harshly. Though varieties of antitubercular drugs (ATDs) are available for its treatment, associated stern side effects restrict the patients to receive complete therapeutic benefits. Moreover, e...

Lornoxicam is a non- steroidal anti-inflammatory drug (NSAID) of the oxicam class having analgesic, anti–inflammatory and antipyretic properties. A rapid, specific and economic UV spectrophotometric method has been developed using a solvent composed of methanol in phosphate buffer PH 7.4. In the proposed study, the lornoxicam content in bulk and ph...

Bhut Jolokia (Capsicum chinense), popularly known as the “ghost chilli,” renowned for its extreme heat and distinctive flavour is a hybrid derived from a cross between C. chinense and Capsicum frutescens. This review aims to provide a comprehensive overview of the applications of C. chinense in pharmacy and its potential benefits in managing differ...

The aim of this study was to formulate and evaluation of gliclazide loaded controlled release microspheres. The microspheres were prepared by quasi emulsion solvent diffusion technique using Eudragit RLPO, Eudragit RSPO alone and with combinations. The effect of drug-polymer ratio and polymer-polymer ratio on percent yield, mean particle size, enca...

The aim of this study is to prepare and characterize the microspheres of chlorpheniram ine maleate (CPM) with the combination of cellulose derivatives: ethyl cellulose and cellulose acetate. Microspheres were prepared with the combination of ethyl cellulose and cellulose acetate using oil-in-oil emulsion solvent evaporation method. Microspheres wer...