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Introduction
Skills and Expertise
Publications
Publications (650)
Importance
Frontal fibrosing alopecia (FFA) is an inflammatory and scarring form of hair loss of increasing prevalence that most commonly affects women. An improved understanding of the genetic basis of FFA will support the identification of pathogenic mechanisms and therapeutic targets.
Objective
To identify novel genomic loci at which common gen...
The unique immunomodulatory properties of hydroxychloroquine (HCQ) have attracted considerable interest beyond its use for malaria and rheumatological diseases, including a variety of dermatological conditions. Over recent years, especially after the coronavirus disease 2019 (COVID-19) pandemic, the prescription of HCQ has also significantly expand...
Introduction: Onychomycosis is one of the most common nail diseases. Fingernail onychomycosis is significantly less frequent than toenail onychomycosis and it is often misdiagnosed due to its subtle clinical presentations. Objectives: We sought to analyze the clinical and onychoscopic features of culture-proven cases of fingernail onychomycosis in...
Objectives
Scabies infestation, caused by the Sarcoptes scabiei mite, has recently emerged as a public health concern in Western nations, with increased incidence worldwide. In Bologna, Italy, local health authorities report a rise in scabies diagnoses, although detailed data are limited. This study aimed to analyse the temporal trends of scabies c...
Syphilis has resurged globally, especially in urban areas of developed countries. This study analyses syphilis cases over a decade at an STD centre in Bologna, Italy, examining new diagnoses, reinfections, and impacts on high-risk subgroups, compared with national and European data. Data from 2009–2019 were retrospectively reviewed, including prima...
Introduction: Baricitinib, a approved for adults with severe alopecia areata (AA), demonstrated a high level of sustained efficacy (89.1%) at Week 152 among patients who achieved a Severity of Alopecia Tool (SALT) score ≤20 at Week 52 following one year of treatment with once-daily baricitinib 4 mg in phase 3 trials (BRAVE-AA1, BRAVE-AA2). In this...
Introduction: Previous data on baricitinib treatment in severe alopecia areata (AA) has shown that treatment response varies by baseline disease severity and by duration of current episode. In general, hair regrowth response varies, and clinicians lack data on how long to optimally treat patients to achieve response. In the literature, time to onse...
Research on standard forehead proportions is crucial for dermatologists assessing conditions like frontal fibrosing alopecia (FFA) [1-3]. To our best knowledge, this study is the first to compare the distance from the glabella to the frontal hairline between patients with FFA and a healthy population. Our goal is to determine if there's a correlati...
This retrospective case series compares vitiligo resulting from immune checkpoint inhibitor (ICI) therapy vs preexisting vitiligo among patients receiving ICI treatment for cancer.
Alopecia areata (AA) is a non-scarring autoimmune disease characterized by patchy hair loss. The aim of this study was to validate a novel trichoscopic scoring tool, the Severity TRichoscopy Index for Alopecia Areata (STRIAA), for rapid assessment of AA severity.
Anonymized images from 340 patients were scored by two independent raters who analyzed...
Introduction: Chronic ulcers significantly burden healthcare systems, requiring precise measurement and assessment for effective treatment. Traditional methods, such as manual segmentation, are time-consuming and error-prone. This review evaluates the potential of artificial intelligence AI-powered mobile apps for automated ulcer segmentation and t...
Importance
The results of small studies suggest that off-label use of low-dose oral minoxidil (LDOM) may be safe and effective for patients with hair loss, but larger trials and standardized guidelines are lacking.
Objective
To create an expert consensus statement for LDOM prescribing for patients with hair loss.
Evidence Review
The current liter...
Introduction. Elevations in total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) can occur with baricitinib treatment, consistent with a class effect of JAK inhibitors. In this analysis, we characterized changes in lipid levels and use of lipid-lowering medication among patients with sever...
Pityriasis rubra pilaris (PRP) presents a diagnostic challenge due to its varied clinical manifestations and the scarce literature on scalp involvement. This article presents a case report of a 59-year-old female with PRP solely affecting the scalp, detailing its clinical, trichoscopic, and histopathological features. Trichoscopy revealed a novel f...
Human hair, particularly on the scalp, serves as a significant aspect of social identity and well-being. The exposome, encompassing both intrinsic and extrinsic factors, plays a fundamental role in hair weathering. Intrinsic factors include genetic predispositions and physiological changes within the body, while extrinsic factors comprise environme...
Introduction:
Dupilumab, a monoclonal antibody targeting IL-4 receptor subunit alpha, treats atopic dermatitis (AD) and may impact alopecia areata (AA). AA involves Th1-driven immune activity, and recent studies suggest a role for Th2 pathways. Dupilumab's effects on AA are mixed, with reports of both improvement and worsening.
Objectives:
This...
Objectives:
Alopecia areata incognita is a non-scarring autoimmune hair loss condition primarily affecting women aged 20 to 40. It is often misdiagnosed due to its resemblance to other conditions. Diagnosis relies on clinical suspicion, trichoscopic findings, and histological features. Reflectance confocal microscopy (RCM) shows promise as a non-i...
Introduction:
Dermatological conditions affecting the nails can manifest differently in individuals with distinct skin tones. This often leads to difficulty in the recognition of nail diseases, especially in people with skin of color (SoC), who are not well represented in the literature.
Objectives:
Our aim was to provide dermatologists with use...
Background
The ALLEGRO phase 2a and 2b/3 studies demonstrated that ritlecitinib is efficacious and well tolerated in adult and adolescent patients with alopecia areata (AA) up to 48 weeks.
Objective
The efficacy of ritlecitinib through Month 24 and safety through data cutoff were assessed in the ALLEGRO phase 2b/3 study and the ongoing long-term,...
Introduction: Chronic ulcers significantly burden healthcare systems, requiring precise measurement and assessment for effective treatment. Traditional methods, such as manual segmentation, are time-consuming and error-prone. This review evaluates the potential of artificial intelligence (AI)--powered mobile apps for automated ulcer segmentation an...
Pseudolipoblastic perineurioma is a very uncommon variant of extraneural perineurioma, with only a limited number of cases documented in the medical literature. The most remarkable histopathologic characteristic is the existence of vacuolated cells that closely resemble lipoblasts; besides the presence of small, spindle shaped, or epithelioid perin...
In their recent publication, George Kroumpouzos et al. provided a comprehensive update on the complications caused by filler procedures in the lips and perioral area. These injections have been associated with various arterial accidents and an incidence of vision loss mainly when such procedures are performed at the level of the central facial mass...
Background: Chlormethine gel is a promising treatment for early-stage mycosis fungoides (MF) with strong efficacy and manageable side effects. This study evaluates its effectiveness as a second-line treatment in patients unresponsive to prior skin-directed therapies (SDTs) or combined systemic treatments, hypothesising significant therapeutic benef...
The problem The management of chronic wounds in Western healthcare systems is burdened by significant costs due to the high intensity of care required. Various problems, such as those of an economic-organizational nature (personnel, material, adequate devices and settings, etc.), and the need for standardized measurement and treatment methods to cl...
Introduction & Objectives:
Chronic wounds pose a significant challenge in healthcare, leading to extensive treatment durations and
inconsistent care methodologies, which increase the economic burden on healthcare systems. The primary
objective of this paper is to propose the integration of artificial intelligence (AI) in wound care management and
t...
Introduction & Objectives:
While generally rare, tattoo-induced skin reactions can lead to significant dermatological issues, including allergic
reactions and pseudolymphomas. Pseudolymphoma is a benign condition characterised by lymphoid proliferation
that mimics lymphoma but does not have the same potential for malignancy. It can occur as a react...
Onychoscopy (nail dermatoscopy) plays a key role in the diagnosis and differential diagnosis of most diseases of the nail apparatus, including onychomycosis, being an easy-to-perform, quick and non-invasive procedure. Although the definitive diagnosis of onychomycosis relies on mycology or histopathology, in poor settings where laboratory testing i...
Vorasidenib, an oral dual inhibitor targeting mutant enzymes isocitrate dehydrogenase 1 and 2, is utilized in the management of diffuse low-grade gliomas. Despite limited documentation of its adverse events, we present the case of a 44-year-old male who exhibited trichomegaly and hypertrichosis of body hair, eyebrows, and eyelashes following one mo...
Background
Demographic changes impose a number of issues regarding the biological treatment of elderly patients with moderate-to-severe psoriasis.
Patients and methods
A retrospective, single-center study was conducted on patients aged 65 years or older with moderate-severe psoriasis who had been undergoing treatment with biologic drugs for at lea...
Objective
The prevalence of anxiety and depression in patients diagnosed with Alopecia Areata (AA) is very high and this significant burden of psychological symptoms threatens the Health-Related Quality of Life (HRQoL) of affected patients. Indeed, AA often does not produce significant physical symptoms, but it nonetheless disrupts many areas of me...
Importance
Baricitinib has demonstrated efficacy for treating severe alopecia areata in adults. There is currently limited information about the need for continuous therapy after achieving scalp hair regrowth.
Objective
To report results from the randomized withdrawal period of the BRAVE-AA1 trial.
Design, Setting, and Participants
BRAVE-AA1 was...
Introduction
Oral antifungals are the treatment choice for onychomycosis, and topical therapies are favored in cases of limited nail involvement. Recently, carbon dioxide (CO2) laser treatment has emerged as an option to enhance the effectiveness of topical therapies.
Objectives
Our objective was to compare the efficacy of fractional ablative and...
Scalp metastases (SMs) are particularly noteworthy, representing around 4–7% of cutaneous neoplasms in this region of the body, possibly due to its rich blood supply. Diagnosis of SMs involves a systematic approach encompassing oncologic history, clinical examination, dermoscopy, imaging, and histopathological assessment. Clinical presentations of...
Alopecia areata (AA) is a common, immune-mediated, nonscarring alopecia associated with increased risk of other autoimmune conditions such as thyroid disease. Risk of cardiovascular disease in AA is contentious, but is relevant in the era of Janus kinase (JAK) inhibitor therapy. Rarely, nutritional deficiency and infective disorders, such as syphil...
The prevalence of onychomycosis in adults varies considerably between countries. Ina recent survey conducted in Italy, the prevalence of onychomycosis in subjectsaged >65 years was found to be as high as 35%. The most prevalent clinicalvariant of onychomycosis is distal and lateral subungual onychomycosis (DLSO),which affects both finger and toenai...
Background
Alopecia areata (AA) is an auto‐immune disorder characterized by non‐scarring hair loss. With the emergence of effective therapies for severe AA, there is a need to better understand the prognosis of untreated AA, specifically the potential for spontaneous hair regrowth.
Objectives
To describe hair regrowth occurring on placebo during t...
b> Background: Frontal fibrosing alopecia (FFA) is a scarring hair loss condition primarily affecting the frontotemporal hairline and often leading to partial or complete loss of eyebrows in a significant number of cases. It is characterized by slow progression and typically shows poor response to available treatments. Diagnosis relies on clinical,...
Seborrheic Dermatitis of the scalp (SSD) is a chronic and relapsing inflammatory skin condition. Current SSD treatments mainly consist of topical applications of anti-fungals and anti-inflammatory agents. to review information about SSD and to provide dermatologists with practical recommendations for managing adult SSD. Material and methods: Betwee...
Frontal fibrosing alopecia (FFA) represents a distinctive form of primary lymphocytic scarring alopecia characterized by fronto-temporal hair recession and eyebrow hair loss. While predominantly affecting postmenopausal women, FFA also occurs in women of reproductive age and men, with variations observed across different ethnic groups. Genetic pred...
Riportiamo il caso di una paziente di 73 anni presentatasi alla nostra attenzione per la comparsa da circa due anni di lesioni violacee del versante antero-laterale delle gambe bilateralmente, associate ad invalidante sintomatologia pruriginosa. In anamnesi riportava ipertensione, ipercolesterolemia, insufficienza venosa cronica, artrosi delle mani...
This narrative review aims to summarise the classification of vascular anomalies, their clinical presentation, and their radiological features to propose a diagnostic algorithm to approach patients with suspected soft tissue vascular anomalies of the extremities. The management of vascular anomalies necessitates a multidisciplinary approach. Clinic...
Herpes zoster (HZ) is a condition caused by the reactivation of varicella-zoster virus (VZV), the virus responsible for chickepox, which is the clinical manifestation of the primary infection. Congenital or acquired immune system deficiencies, as well as the physiological decline in immune response occurring in the elderly, known as immune senescen...
Background
‘Men having sex with men’ (MSM) represent a key population with a significant prevalence of pharyngeal Neisseria gonorrhoeae (NG) infections and a high rate of antimicrobial resistance genes in the pharyngeal microbiome. As NG can acquire antibiotic resistance genes from other commensal oropharyngeal bacteria, monitoring the prevalence o...
Background:
Onychoscopy is a noninvasive method helpful in diagnosing nail disorders. The aim of the study was to review literature on the usability of onychoscopy in nail psoriasis, nail lichen planus, and nail lichen striatus.
Summary:
Onychoscopic features of nail psoriasis are pitting, onycholysis with erythematous border, salmon patches, sp...
Background:
Alopecia areata (AA) is an organ-specific autoimmune disease that affects the hair follicles of the scalp and the rest of the body causing hair loss. Due to the unpredictable course of AA and the different degrees of severity of hair loss, only a few well-designed clinical studies with a low number of patients are available. Also, ther...
Introduction:
Oral finasteride and topical minoxidil are long-standing androgenetic alopecia (AGA) treatments; topical finasteride is a more recent medicine. Few studies have compared their therapeutic effects in postmenopausal women. We compared the therapeutic impact of topical finasteride (1-4 sprays of 0.25% topical finasteride solution daily...
The CCR4 receptor is a pivotal target in cutaneous T-cell lymphoma (CTCL) therapy due to its role in impairing immune responses against malignant T-cells and expression profiles. Monoclonal antibodies like mogamulizumab effectively bind to CCR4, reducing tumour burden and enhancing patient outcomes by inhibiting the receptor’s interaction with liga...
Alopecia areata (AA) affects approximately 2% of the general population and is associated with significant psychosocial morbidity and poor health-related quality of life. Despite the high incidence of the disease the available clinical practice guidelines to help clinicians and improve patients’ care are very poor and of a low methodological qualit...
Introduction:
Pilomatricoma is a benign adnexal dermal or subcutaneous tumor derived from immature hair matrix cells.
Objectives:
The aim of our study is to evaluate clinical and dermoscopic features of pilomatricomas, with a specific focus on pediatric lesions, and to provide a concise review of the existing literature.
Methods:
A single-cent...
Alopecia areata (AA) is an autoimmune condition that causes non-scarring hair loss and can impose a high psychosocial burden on patients. The presence of comorbid conditions may impact the management of AA in clinical practice. This analysis aims to describe disease characteristics and management of AA in patients with concomitant atopic, autoimmun...
Introduction: Ritlecitinib demonstrated efficacy and safety to Week 48 in patients aged ≥12 years with alopecia areata (AA) in ALLEGRO-2b/3 (NCT03732807). ALLEGRO-LT (NCT04006457) is an ongoing, phase 3, open-label study investigating the long-term safety and efficacy of ritlecitinib in AA. We report updated interim efficacy results of ritlecitinib...