Bianca K Itariu

Bianca K Itariu
Medical University of Vienna | MedUni Vienna

About

45
Publications
3,258
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1,010
Citations
Citations since 2017
9 Research Items
683 Citations
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120
2017201820192020202120222023020406080100120

Publications

Publications (45)
Article
Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment concepts need to be identified. Myostatin, a myokine known for restraining skeletal muscle growth, has been associated with the development of insulin resistance and type 2 diabetes mellitus. Yet, little is known about the regulation of myostatin in human obes...
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Full-text available
Elevated circulating fatty acids (FAs) contribute to obesity-associated metabolic complications, but the mechanisms by which insulin suppresses lipolysis are poorly understood. We show that α/β-hydrolase domain-containing 15 (ABHD15) is required for the anti-lipolytic action of insulin in white adipose tissue (WAT). Neither insulin nor glucose trea...
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Full-text available
Background Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients significantly improve their metabolic status upon losing weight. We aimed to investigate whether changes in subcutaneous adipose tissue gene expression reflect a restoration of a healthy lean phenotype...
Article
Background: Infiltration of white adipose tissue (WAT) by inflammatory cells in obesity is considered to be a key event in development of insulin resistance. Recently, mast cells (MCs) have been identified as new players in pathogenesis of obesity. We aimed to investigate the relationship between MCs and various inflammatory markers in serum and W...
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Full-text available
Obesity is strongly associated with metabolic syndrome, a combination of risk factors that predispose to the development of the cardiometabolic diseases: atherosclerotic cardiovascular disease and type 2 diabetes mellitus. Prevention of metabolic syndrome requires novel interventions to address this health challenge. The objective of this study was...
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Full-text available
Background and aim: Obesity is a major risk factor for liver fibrosis and tightly associated with low levels of adiponectin. Adiponectin has antifibrogenic activity protecting from liver fibrosis, which is mainly driven by activated hepatic stellate cells (HSC). Aquaporins are trans-membrane proteins which allow the movement of water and, in case...
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Breast and endometrial cancer are often estrogen dependent, and their incidence and mortality are increased by obesity in postmenopausal women. Osteopontin (OPN) is a cytokine strongly upregulated in adipose tissue (AT) in obesity. OPN function is potentiated by cleavage by matrix metalloproteinases (MMP). OPN and MMPs play a role in cancer develop...
Article
Osteopontin (OPN) is upregulated in adipose tissue (AT) in obesity and contributes to subclinical inflammation, adipocyte dysfunction, and insulin resistance. OPN effects can be increased by cleavage by matrix metalloproteinases (MMP). This study aimed at investigating the presence of OPN cleavage products in human AT in obesity and their impact on...
Article
Aims The current study aims to investigate practicability and effects of a combined dietary intervention with increased relative protein content supplemented with omega-3 polyunsaturated fatty acids (PUFA) on metabolic control and inflammatory parameters in a real life situation in type 2 diabetes patients. Methods In this observational study we a...
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Full-text available
Postprandial hypoglycemia is a complication following gastric bypass surgery, which frequently remains undetected. Severe hypoglycemic episodes, however, put patients at risk, e.g., for syncope. A major cause of hypoglycemia following gastric bypass is hyperinsulinemic nesidioblastosis. Since pancreatic islets in nesidioblastosis overexpress insuli...
Article
The newly identified liver- and fat-derived hormone, betatrophin, has recently been linked to insulin resistance and pancreatic beta cell growth in mice. These preclinical findings have suggested betatrophin as a potential candidate for novel glucose-lowering treatment concepts involving beta cell regeneration. However, the role of betatrophin in h...
Article
Autoimmunity is a well-known pathogenic component in type 1 diabetes (T1DM). The assumption that the pathogenesis of type 2 diabetes (T2DM) also encompasses autoimmune aspects is recognized increasingly, based on the presence of circulating autoantibodies against β cells, self-reactive T cells, but also on the glucose-lowering efficacy of some immu...
Article
OriginalarbeitHinnouho G-H, Czernichow S, Dugravot A et al (2013) Metabolically healthy obesity and risk of mortality: does the definition of metabolic health matter? Diabetes Care 36:2294–2300 HintergrundAdipositas geht mit einem erheblichen Risiko des frühzeitigen Todes einher [1], das wesentlich auf adipositasassoziierten kardiometabolischen Kom...
Article
Chronic systemic low-grade inflammation is a hallmark of obesity and insulin resistance associated with aging. Mechanisms that underlie inflammation and link it to insulin resistance in obesity are of crucial importance for understanding age-associated complications and for the identification of potential novel therapeutic targets. Adipose tissue p...
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OriginalpublikationHawa MI, Kolb H, Schloot N et al (2013) Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: action LADA 7. Diabetes Care 36:908–913 HintergrundSeit dem Nachweis von Autoimmunität gegen β-Zellen bei erwachsenen Patienten mit neu diagnostiziertem Diabetes mellitus begann die Grenze zwischen Typ-1...
Article
OriginalpublikationIsaac R, Boura-Halfon S, Gurevitch D et al (2013) Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. J Biol Chem 288:5682–5693 HintergrundAntidepressiva aus der Klasse der selektiven Serotonin-Wiederaufnahmehemmer („selective serotonin reuptake inhibitor“, SSRI) werden zur...
Article
OriginalpublikationHörtenhuber T, Rami-Mehar B, Satler M et al (2013) Endothelial progenitor cells are related to glycemic control in children with type 1 diabetes mellitus over time. Diabetes Care. DOI 10.2337/dc12-1206 HintergrundProgrediente und frühzeitige Atherosklerose ist eine Hauptursache des vorzeitigen Todes bei Typ-1-Diabetes. Zirkuliere...
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OriginalpublikationVen KC van de, Graaf M van der, Tack CJ et al (2012) Steady-state brain glucose concentrations during hypoglycemia in healthy humans and patients with type 1 diabetes. Diabetes 61:1974–1977 HintergrundDie Hirnglukosekonzentration kann unter normo- und hyperglykämischen Bedingungen anhand des etablierten mathematischen Modells ein...
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Full-text available
Obesity affects the vitamin D status in humans. Vitamin D and long-chain n-3 polyunsaturated fatty acids (PUFA) provide benefit for the prevention of fractures and cardiovascular events, respectively, and both are involved in controlling inflammatory and immune responses. However, published epidemiological data suggest a potential interference of n...
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Full-text available
Obesity-induced chronic low-grade inflammation originates from adipose tissue and is crucial for obesity-driven metabolic deterioration including insulin resistance and type 2 diabetes.Chronic inflammation may be a consequence of a failure to actively resolve inflammation,and could result from a lack of local specialized pro-resolving lipid mediato...
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Full-text available
Chronic adipose tissue inflammation is a hallmark of obesity, triggering the development of associated pathologies, particularly type 2 diabetes. Long-chain n-3 PUFAs reduce cardiovascular events and exert well-established antiinflammatory effects, but their effects on human adipose tissue inflammation are unknown. We investigated whether n-3 PUFAs...
Article
Objective: Obesity is associated with chronic inflammation of the adipose tissue, which contributes to obesity-associated complications such as insulin resistance and type 2 diabetes. Interleukin (IL)-33 acts via its receptor ST2 and is involved in the pathogenesis of inflammatory disorders including atherosclerosis and heart disease. IL-33 has be...

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