Bhupinder Kapoor

Bhupinder Kapoor
Lovely Professional University | LPU · Discipline of Pharmaceutical Sciences

Doctor of Philosophy

About

55
Publications
16,637
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531
Citations
Additional affiliations
November 2021 - November 2021
Lovely Professional University
Position
  • Professor

Publications

Publications (55)
Article
In recent years, unique physicochemical properties of amphiphilic block copolymers have been utilized to design the polymeric micelles for brain-specific delivery of drugs, proteins, peptides, and genes. Their unique properties such as nano-size, charge-switching ability, stimuli-responsive cargo release, flexible structure, and self-assembly enabl...
Chapter
Cold injuries are very common amongst the service members who participate in the combat and military training missions in extremely cold areas. Many a times they are responsible for the loss of fingers and toes. Even civilian population like mountaineers and persons involved in winter sports are also found to suffer from cold injuries. The health e...
Article
Full-text available
Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology. Several conventional treatments for UC such as corticosteroids, immunosuppressive agents, tumor necrosis factor antagonist, integrin blockers, and interleukin antagonist, and salicylates are available but are associated with the various limitations and side-effects...
Article
Introduction: : Coronavirus disease 2019 (COVID-19), which emerged as a major public health threat, has affected >400 million people at a global level leading to >5 million mortalities to date. Treatments of COVID-19 are still to be developed as the available therapeutic approaches are not able to combat the virus causing the disease (severe acute...
Article
Metabiotics have emerged as the safer alternatives to probiotics in last one decade. Unlike probiotics that are live microbes, metabiotics are the low molecular weight bioactive metabolites produced by the gut microbiota. While offering a similar profile of health benefits as that of probiotics, metabiotics are free from the risks and uncertain res...
Article
Full-text available
Background Vanillic acid is a phenolic compound, found in various dietary sources and medicinal plants. Apart from its extraction from these biological sources, it is also synthesized chemically. It is used as flavouring agent in various food products. It possesses anticancer, antiobesity, antidiabetic, antibacterial, anti-inflammatory, and antioxi...
Article
Mucormycosis is a rare fungal infection mainly affecting immunocompromised patients. Recently, an alarming rise in cases of mucormycosis was observed in patients undergoing COVID-19 treatment. Commonly, this fungal infection is caused by Rhizopus spp., Mucor spp., and Lichtheimia spp., although the genera of other Mucorales such as Saksenaea, Rhizo...
Article
Today, antibacterial drug resistance has turned into a significant public health issue. Repeated intake, suboptimal and/or unnecessary use of antibiotics, and, additionally, the transfer of resistance genes are the critical elements that make microorganisms resistant to conventional antibiotics. A substantial number of antibacterials that were succ...
Article
Introduction Non-aqueous nano-emulsions (NANEs) are colloidal lipid-based dispersions with nano-sized droplets formed by mixing two immiscible phases, none of which happens to be an aqueous phase. Their ability to incorporate water and oxygen sensitive drugs without any susceptibility to degradation makes them the optimum dosage form for such candi...
Article
Background Inflammation, an important event of cellular defensive system, can be triggered by a variety of factors such as pathogens, allergens, damaged cells and toxic compounds. Inflammation indicates tissue remodeling and repair, and is characterized by redness, heat, swelling, pain and loss of function. Purpose Conventional treatment approache...
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Full-text available
Microfluidic chip technology is an emerging tool in the field of biomedical application. Microfluidic chip includes a set of groves or microchannels that are engraved on different materials (glass, silicon, or polymers such as polydimethylsiloxane or PDMS, polymethylmethacrylate or PMMA). The microchannels forming the microfluidic chip are intercon...
Article
The role of mushroom polysaccharides and probiotics as pharmaceutical excipients for development of nanocarriers has never been explored. In the present study an attempt has been made to explore Ganoderma lucidum extract powder (GLEP) containing polysaccharides and probiotics to convert liquid self nanoemulsifying drug delivery system (SNEDDS) into...
Article
Polycystic ovarian syndrome (PCOS) is a combination of various symptoms like anovulation, hirsutism, chronic amenorrhea, infertility, obesity and polycystic ovaries. It affects over 7 million women worldwide. The current strategy to treat this disorder is based on the use of drugs that provide symptomatic relief. Most of these, however, exhibit num...
Article
Polycystic ovarian syndrome (PCOS) is the primary cause of female infertility affecting several women worldwide. Changes in hormonal functions such as hyperandrogenism are considered a significant factor in developing PCOS in women. In addition, many molecular pathways are involved in the pathogenesis of PCOS in women. To have better insights about...
Article
Capsiate is a non-pungent analogue of capsaicin. It belongs to the family of capsinoids which are esters of vanillyl alcohol with fatty acids while capsaicin belongs to the family of capsaicinoids that are amides of vanillylamine with a variety of branched-chain fatty acids. While capsaicin is extensively reported for plethora of pharmacological ac...
Article
Background Peptic ulcer (PU) is a collective term used for a group of chronic manifestations that affect mucosal integrity of stomach and/or duodenal lining. It is characterized by pain, perforations, bloating, nausea, blood in stool or vomit, loss of appetite and weight loss. Purpose Although a number of conventional treatment approaches such as...
Article
Ganoderma lucidium extract powder (GLEP) contains various polysaccharides which are well known for their antioxidant and anti-inflammatory actions. Probiotics (PB) are well-established for providing a plethora of health benefits. Hence, use of mushroom polysaccharides and probiotics as carriers to solidify liquisolid formulation is anticipated to f...
Article
Chronic wound infections are significant medical burden as the patients have to go through severe discomfort and distress. Invasion of various pathogenic microorganisms at the injured site further leads to damage of tissue which may results in resection of the organ. Appropriate wound healing is necessary to regain the functional and anatomical sta...
Article
Ethnopharmacological relevance: Elaeagnus conferta Roxb. (Elaeagnaceae) is a subtropical shrub mainly native to India, Vietnam, Malaysia and South China, whose various parts are used for treatment of diabetes, gastric ulcers, pain, oxidative stress and pulmonary disorders. Though the other parts of the plant have been reported for their ethnic use...
Article
Amphiphilic block copolymers are widely utilized in the design of formulations owing to their unique physicochemical properties, flexible structures and functional chemistry. Amphiphilic polymeric micelles (APMs) formed from such copolymers have gained attention of the drug delivery scientists in past few decades for enhancing the bioavailability o...
Article
Background Capsiate is a non-pungent analogue of capsaicin. Consumed worldwide, capsiate hitherto remains unexplored despite its proven track record as a food ingredient and recent use for its therapeutic profile. Though possessing a much better safety profile and an equivalent therapeutic potential, the molecule has not been extensively explored i...
Article
Full-text available
Introduction: Diabetic neuropathy (DN) is one of the major complications arising from hyperglycaemia in diabetic patients. In recent years polyphenols present in plants have gained attention to treat DN. The main advantages associated with them are their action via different molecular pathways to manage DN and their safety. However, they failed to...
Article
Huntington’s disease (HD) is an autosomal fatal genetic disease in which degeneration of neuronal cells occurs in central nervous system (CNS). Commonly used therapeutics in cludemonoamine depletors, antipsychotics, antidepressants, and tranquilizers. However, these drugs cannot prevent the psychotic, cognitive and behavioral dysfunctions associate...
Article
Flavonoids are polyphenolic compounds that are mainly derived from fruits and vegetables and constitute an essential part of plant-derived beverages such as green tea, wine and cocoa-based products. They have been shown to possess anticancer effect via different mechanisms such as carcinogen inactivation, antiproliferation, cell cycle arrest, induc...
Article
An infectious disease of colon, recurrent Clostridium difficile infection (RCDI) is hitherto considered insurmountable leading to significant morbidity and mortality. Gut dysbiosis, generally resulting from frequent use of antibiotics is considered to be responsible for the etiopathogenesis of rCDI. Ironically, the conventional treatment strategies...
Article
Simvastatin (SIM) and glimepiride (GLM) were co-formulated into nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) to improve their dissolution rate and oral bioavailability. Nanosuspension was prepared by liquid anti-solvent precipitation method, involving supersaturation of a solution by mixing the drug solution in an antisol...
Article
Aim of the present study was to give a second life to the long-abandoned drug, sulfapyridine (SP) for its anti-arthritic potential by design of nano-vesicular delivery system. For this, intra-articular delivery of its liposomal formulation was tried. As the prepared formulation exhibited rapid drug leakage, an arthritis responsive prodrug of SP sho...
Article
The objective of study was to develop modified apple polysaccharide (MAP) based silver nanoparticles (AgNPs) loaded with mesalamine (MES) for effective treatment of ulcerative colitis in acetic acid induced rat model. AgNPs were prepared by reducing silver nitrate using MAP solution. The size and zeta potential of AgNPs was 89 ± 3 nm and -16.3± 1.5...
Article
Solid self-nanoemulsifying drug delivery system (S-SENDDS) containing Curcumin (CRM) were prepared using combination of Ganoderma lucidium extract powder (GLEP) and probiotics (PB) as carriers. Liquid SNEDDS containing CRM were prepared by mixing Capmul MCM, Labrafil M1944CS, Tween 80 and Transcutol P. These were further spray dried and finally con...
Article
Fisetin (FS) was reported to have various pharmacological activities. But due to its lower aqueous solubility and oral bioavailability, it is not in much use. As solubility and bioavailability plays and important role in the pharmacological activity, in this research work we tried to improve the oral bioavailability of fisetin. In this research wor...
Article
Outbreak of Coronavirus disease 2019 (COVID-19) started in mid of December 2019 and spread very rapidly across the globe within a month of its outbreak. Researchers all across the globe started working to find out its possible treatments. However, most of initiatives taken were based on various hypotheses and till date no successful treatments have...
Article
Fisetin (FS) is a polyphenolic phytoconstituent reported to have various pharmacological activities such as antioxidant, antiparkinsonian, and antidepressant. An analytical method was developed and validated for the estimation of FS by ultrafast liquid chromatography using C-18 reverse phase column. Acetonitrile and orthophosphoric acid (0.2% v/v)...
Article
The objective of the current investigation was to develop a simple, rapid, and stability-indicating high-performance liquid chromatography method and to study the degradation behavior of sulfapyridine (SP) under different International Conference on Harmonization (ICH)-recommended conditions. The chromatographic method was developed using C18 (250...
Article
Full-text available
In recent years, gold nanoparticles have emerged as unique non-invasive drug carriers for targeting drugs to their site of action. Their site specificity has helped in increasing drugs' efficacy at lower dose as well as reduction in their side effects. Moreover, their excellent optical properties and small size offer their utilization as diagnostic...
Article
Fisetin is a plant derived flavonoid that possesses anti-cancer, anti-oxidant and anti-Parkinson's activities. However, due to its lipophilicity it suffers from dissolution rate limited oral bioavailability that reduces its therapeutic efficacy. In order to overcome this issue self-nanoemulsifying drug delivery system (SNEDDS) of fisetin were formu...
Article
The growing disease burden of diabetes mellitus is an important public health concern, affecting over 400 million people globally. This epidemic, if not controlled in time, leads to life threatening complications, compromise in quality of life, and eventually mortality. Over time, many attempts have been made for the effective treatment of diabetes...
Article
The aim of present study was to introduce the role of quality by design to produce curcumin crystals with enhanced dissolution rate and bioavailability. The liquid antisolvent method was used to produce crystals. The crystal growth was controlled using the Box-Behnken design. The variables used in the crystallization process included the ratio of p...
Article
Though vesicular delivery systems have been widely explored and reviewed, no comprehensive review exists that covers their development from the inception of the concept to its culmination in the form of regulated marketed formulations. With the advancement of scientific research in the field of nanomedicine, certain category of vesicular delivery s...
Chapter
Lipid-based nanovesicles such as liposomes, niosomes, and ethosomes are now well recognized as potential candidates for drug delivery and theranostic applications. Some of them have already stepped forward from laboratory to market. The property to entrap lipophilic drugs in their bilayers and hydrophilic drugs in the aqueous milieu makes them a un...
Article
The aim of present study was to co-administer curcumin (CRM) liquisolid pellets and coated duloxetine hydrochloride (DXH) pellets in rats to treat neuropathic pain (NP) associated with chronic constriction injury (CCI). To formulate liquisolid pellets of CRM, it was first dissolved in Tween-80 and then adsorbed on the porous surface of MCC PH102 an...
Article
Full-text available
Objectives: The present study describes a disposable static diffusion cell for in vitro diffusion studies to achieve better results as compared to well existing Franz diffusion cell (FDC) in terms of the absence of bubbles, variable receptor compartment, ease of handling, and faster results. Materials and Methods: The cell consists of a cup-shaped...
Article
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic joint inflammation which ultimately leads to severe disability and premature mortality. It has a global prevalence of around 1% with the incidence among women being 2-3 times more than in men. The pathogenesis of the disease involves preclinical RA, genetic factors,...
Article
With the advent from the laboratory bench to patient bedside in last five decades, vesicular systems have now come to be widely accepted as pragmatic means for controlled delivery of drugs. Their success stories include those of liposomes, niosomes and even the lately developed ethosomes and transferosomes. Pharmacosomes, which, as delivery systems...
Article
Full-text available
Objective: The objective of this review is to collect and document information on the Indian medicinal plants with anti-gout potential.Methods: Bibliographic investigation was carried out by consulting worldwide scientific databases, analyzing Ayurvedic text books and research journals. The search terms were “gout,” “uric acid,” “hyperuricemia,” “x...
Article
Full-text available
Objective: The increased microbial resistance against commercially available drugs initiated the development of novel and safe antimicrobial agents in last few decades. In this view, a series of amino acid/dipeptide derivatives of quinazolin-3(4H)-one was synthesized and was evaluated for their antimicrobial potential.Method: Synthesis of amino aci...
Article
Full-text available
Objective: The synthesis of novel benzimidazole-hydrazone derivatives has been carried out based on the previous findings that both these pharmacophores possess potent antimicrobial activities. The antibacterial properties of synthesized derivatives were screened against both Gram-positive and Gram-negative bacteria.Methods: O-phenylenediamine on c...
Article
Conventionally, the juice and extract of Alangium salvifolium leaves have been used for the treatment of diabetes, wound healing, dog bite, and as a poultice in rheumatism. To carry out the sub-chronic toxicity and thereafter safety evaluation of A. salvifolium leaves. The aqueous extract of A. salvifolium leaves was administered orally at the dose...
Article
Rheumatoid arthritis (RA) is a chronic, progressive, sustained inflammatory autoimmune disease associated with articular, extraarticular, and systemic effects. It is characterized by synovial inflammation, hyperplasia, leading to destruction of articular cartilage, bone erosion, and ultimately permanent deformities. Conventional treatments for RA i...
Chapter
Poor bioavailability is one of the major limitations in absorption of certain nutraceuticals after their oral intake. This is especially applicable to vitamins, phytoconstituents, enzymes, and certain antioxidants. A number of formulation strategies are being developed for overcoming the problems related to oral absorption and bioavailability of th...
Article
Full-text available
The most common treatments for rheumatoid arthritis include nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease modifying antirheumatic drugs (DMARDs), and some biological agents. However, none of the treatments available is able to achieve the ultimate goal of treatment, that is, drug-free remission. This limitation has shifted...
Article
Full-text available
Clerodendrum phlomidis Linn. has been traditionally used for treatment of gynecological disturbances and for agricultural uses. It has been used in many Ayurvedic polyherbal formulations as an immunomodulatory agent. Irrespective of its widespread use, no data on subchronic toxicity has been described. The present study was designed to access sub-c...

Questions

Questions (3)
Question
We are working on the development of topical formulation for the treatment of stretch marks. We have found only in vitro models for evaluation of the cream. Please suggest appropriate animal models for the evaluation of formulation.
Question
Can we analyse the morphology of liposomes by Scanning Electron Microscopy (SEM)?
Question
We have to carry out in vitro hydrolysis of lipophilic prodrug (log P 3.39) to drug in the presence of enzymes. As the drug is having very poor solubility in aqueous phase (phosphate buffer pH 7.4), we have to dissolve the prodrug in organic solvents (chloroform and methanol).
a) Is the activity of enzymes will be affected by organic solvents or not?
b) Even if we spike 100-200 uL of prodrug solution to aqueous phase, there is immediate precipitation of prodrug.
Kindly resolve our issue.