Bhupendra Raj Giri

Bhupendra Raj Giri
University of Texas at Austin | UT · College of Pharmacy

Ph.D student

About

13
Publications
2,338
Reads
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207
Citations
Citations since 2017
13 Research Items
207 Citations
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Introduction
I am a second-year graduate student at the Division of Molecular Pharmaceutics and Drug Delivery (MPDD, Dr. Mo's lab), College of Pharmacy, The University of Texas at Austin. My research focuses on (i) the development of pharmaceutical modified-release oral dosage forms using powder-based 3D printing techniques like SLS and (ii) hot-melt extruded or spray-dried amorphous solid dispersions (ASDs) and co-crystals as strategies to improve the biopharmaceutical performance of BCS II and IV drugs.
Additional affiliations
August 2018 - August 2020
Kyungpook National University
Position
  • MS in Pharmaceutics and Drug Design
Education
August 2012 - September 2016
Kathmandu University
Field of study
  • Pharmaceutical Science

Publications

Publications (13)
Article
Full-text available
Diabetes mellitus (DM) is a chronic metabolic disorder leading toward elevation of the blood glucose level due to insulin insufficiency (Type I) or insulin resistance of responsible tissues (Type II). Aside from allopathic medicine, herbal therapy using crude and extracted forms is drawing the interest of many researchers for its hypoglycemic effec...
Article
A multi-disciplinary approach involving continuous manufacturing (CM) of thermally stable food supplements containing vitamin D3 (VitD3) and iron (Fe++) via a single-step twin-screw granulation (TSG) process was tested in this work. Two selected excipients, namely Neusilin® US2 and corn starch, were used in the work. The particle size distribution...
Article
Three-dimensional (3D)-printed tablets prepared using powder-based printing techniques like selective laser sintering (SLS) typically disintegrate/dissolve and release the drug within a few minutes because of their inherent porous nature and loose structure. The goal of this study was to demonstrate the suitability of SLS 3DP technology for fabrica...
Article
Full-text available
The poor aqueous solubility and/or permeability and thereby limited bioavailability largely restricts the pharmaco-therapeutic implications of potent anticancer drugs such as methotrexate (MTX). Furthermore, MTX’s inherently unstable nature makes it difficult to develop a viable oral formulation. In this study we developed the spray-dried amorphous...
Article
Full-text available
3D printed drug delivery systems have gained tremendous attention in pharmaceutical research due to their inherent benefits over conventional systems, such as provisions for customized design and personalized dosing. The present study demonstrates a novel approach of drop-on-demand (DoD) droplet deposition to dispense drug solutions precisely on bi...
Article
Despite the development in novel drug delivery techniques and synthesis of multifunctional excipients, oral delivery of hydrophobic drug like docetaxel (DTX) is still challenging. The present work investigates the inclusion complexation of DTX, and dimethyl-β-cyclodextrin (DM-β-CD) to improve the solubility, dissolution and permeability of the drug...
Article
Full-text available
Telmisartan (TEL, an antihypertensive drug) belongs to Class II of the Biopharmaceutical Classification System (BCS) because of its poor aqueous solubility. In this study, we enhanced the solubility, bioavailability, and stability of TEL through the fabrication of TEL-loaded pH-modulated solid dispersion (TEL pHM-SD) using hot-melt extrusion (HME)...
Article
Full-text available
Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and photo-unstable drug. Several MTX-loaded SASD formul...
Article
Full-text available
COVID-19 has emerged as a devastating pandemic of the century that the current generations have ever experienced. The COVID-19 pandemic has infected more than 12 million people around the globe and 0.5 million people have succumbed to death. Due to the lack of effective vaccines against the COVID-19, several nations throughout the globe has imposed...
Article
Background Three-dimensional printing (3DP) has emerged as an advanced manufacturing technology capable of producing complex yet precise medicines intended for patient-centric drug therapy. However, printable materials currently available for 3DP are far too limited.Area coveredThe current article covers various cellulose-based polymers as well as...
Article
Full-text available
This work presents a novel approach for producing gastro-retentive floating tablets (GRFT) by coupling hot-melt extrusion (HME) and fused deposition three-dimensional printing (3DP). Filaments containing theophylline (THEO) within a hydroxypropyl cellulose (HPC) matrix were prepared using HME. 3DP tablets with different infill percentages and shell...
Article
Full-text available
Over the past few decades, the amorphous solid dispersions (ASDs) technique has emerged as a promising strategy to enhance the in vitro/in vivo characteristic of hydrophobic drugs. The low aqueous solubility and poor bioavailability of atorvastatin calcium (ATO), a lipid-lowering drug, present challenges for effective drug delivery. The objective o...
Article
Full-text available
Purpose: The objective of this study was to exploit a novel methotrexate (MTX)-loaded solid self-microemulsifying drug delivery system (SMEDDS) with enhanced bioavailability and photostability. Materials and methods: The optimized liquid SMEDDS was composed of castor oil, Tween® 80, and Plurol® diisostearique at a voluminous ratio of 27:63:10. The...

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