Bhumika Kumar

• Ph.D in Pharmaceutical Sciences
• Assistant Professor at Sharda University

This study aspires to contribute significantly to the existing literature by offering a nuanced understanding of hypertension dynamics in urban and rural settings. The findings aim to inform policymakers, healthcare practitioners, and researchers, guiding the development of targeted interventions tailored to the specific needs of each population. I...

With an increase in the efficiency of the drug discovery process, the identification of potential drug moieties has increased rapidly. For developing an effective, competent, drug delivery system a drug with high permeability and solubility is preferred. The evolution of novel nanotechnology-based drug delivery systems has made drug delivery simple...

Dengue fever is a disease caused by a family of viruses transmitted by mosquitoes. Dengue virus (DENV), a member of the Flaviviridae family, causes the most widespread mosquito-borne viral infection in humans around the world. Dengue can affect anyone but tends to be more severe in people with compromised immune systems. Dengue hemorrhagic fever is...

Background: Moringa oleifera, often revered as a botanical miracle, holds significant traditional

Methotrexate is a folic acid inhibitor that works by inhibiting the enzyme dihydrofolate reductase and naringenin is an active phytochemical compound found in citrus fruits as a glycoside conjugate and has a number of therapeutic attributes, including inhibitory and anti-inflammatory effect on chemokine production, which is linked to the pathophysi...

Polysaccharide-based nanoparticles have garnered significant attention in recent years due to their unique properties and diverse applications in the biomedical field. These nanoparticles are fabricated from natural polysaccharides, such as chitosan, alginate, cellulose, starch, and hyaluronic acid, which offer inherent biocompatibility, biodegrada...

A complication of incision drainage or abscess ulceration around the anus and rectum is anal fistula which manifests as the creation of irregular channels linking the rectum and anal canal with the skin circumambient to the anus. It mostly affects the male population having a yearly frequency of two cases per ten thousand individuals. Histologicall...

Cancer is a lethal disease and is one of the leading causes of morbidity worldwide. Chemotherapy is successful to combat cancer but medical applicability of many chemotherapeutic agents is limited by the non-specific targeting of malignant cells, leading to unwanted side effects. Nanoparticles (NPs) are well-established nano-carriers that can prote...

Studies recognize amyotrophic lateral sclerosis (ALS) as a neurodegenerative illness attributed to motor neuron loss. The mechanics of neurodegenerative disorders are multifactorial and complex. Evidence suggests some commonly shared pathways, like mitochondrial dysfunctioning, intracellular Ca2+ overload, inflammation, and oxidation stress. Often...

Psoriasis is a recurrent, life-threatening anti-inflammatory condition that affects nearly 1–3% of the global population. It is an autoimmune illness distinguished by hyperplasia of skin cells or fast skin cell development, resulting in abnormally irritating scales and skin patches. Curcumin, as a selective phosphorylase kinase inhibitor, actively...

Background Curcumin is a bright colored polyphenolic moiety which is derived from the rhizomes of Curcuma longa of family Zingiberaceae . Its simple molecular structure, high efficacy, variable therapeutic effects and multidimensional use make it ideal for various treatment regimens. Main body It has been used for centuries for its antioxidant, an...

Abstract Background: Transdermal drug delivery is one of the most widely used drug administration routes, which ofer sev‑ eral advantages over other routes of drug delivery. The apical layer of the skin called the stratum corneum is the most dominant obstacle in the transdermal drug delivery, which restricts the passage of drugs across the skin. C...

Ethosomes are novel ethanolic phospholipid vesicles which are significantly used for the transdermal drug delivery. Ethanol is an efficient permeation enhancer which is used in ethosomes about 20-45%. These are non-invasive in nature and have emerged as an area of active research interest because they significantly lead to enhanced skin penetration...

Curcumin is a complex molecule with substantial activity against a number of diseases but its limited water solubility and low skin penetration offer significant challenges to its transdermal distribution and performance thus for enhancing its transdermal application curcumin-loaded invasomes were prepared using mechanical dispersion process. Invas...

Objective(s): Invasomes are nano-sized vesicular systems made of ethanol, soybean phosphatidylcholine and terpenes that promote skin penetration by disrupting the lipoidal structure of stratum corneum, interacting with the matrix proteins and augmenting the partitioning of the drug moiety in the skin layer. Curcumin is a well-known bright yellow co...

Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-...

Osteoporosis is a chronic, progressive bone condition which is mostly prevalent in post-menopausal women and the elderly population. An imbalance in the natural bone remodeling process which is involved in the formation of bone and resorption is responsible for osteoporosis leading to bone fragility. It shows no clinical manifestation until a fract...

Annona Squamosa commonly called as Sugar apple, is one of the best medicinal plant which belongs to family Annonaceae. It shows diverse pharmacological activities like analgesic, anti-inflammatory, anti-arthritic, anti-helminthic, anti-microbial, anti-ulcer, antitumor, hepatoprotective, anti-malarial, anti-diabetic etc. Its leaves are highly effici...

Aim:: Due to the various drawbacks associated with current treatment therapy of ony-chomycosis, the main aim was to develop thermosensitive hydrogels and thermosensitive polypseu-dorotaxanes hydrogels-based nail lacquer for transungual delivery of Efinaconazole for the management of onychomycosis. The objective is to enhance the permeation and rete...

Background Curcumin is a curcuminoid which is an active constituent of turmeric and is obtained from the rhizomes of Curcuma longa, family Zingiberaceae. Curcumin modulates the activity of various transcription factors and regulates the expression of inflammatory enzymes, cell survival proteins, adhesion molecules and cytokines by binding to a vari...

Dementia is a diverse category of a chronic and progressive disorder, which is commonly associated with loss of memory, difficulty in judgment, impaired language, cognitive impairment, and various other symptoms that affects a person’s daily routine life and social life. Dementia affects about 50 million people around the globe. Dementia exists in...

Background Breast cancer is the most frequent cancer and one of the most common causes of death in women, impacting almost 2 million women each year. Tenacity or perseverance of breast cancer in women is very high these days with an extensive increasing rate of 3 to 5% every year. Along with hurdles faced during treatment of breast tumor, one of th...

Parkinson’s disease (PD) is one of the most prevalent and severe neurodegenerative disease affecting more than 6.1 million people globally. It is characterized by age-related progressive deterioration of neurological functions caused by neuronal damage or neuronal death. During PD the dopamine producing-cells in the substantia nigra region of the b...

Background: Alzheimer's disease is an irreversible, progressive brain disorder manifested with symptoms like loss of memory (known as dementia), personality changes, loss of cognition, impaired movement, confusion, deteriorated planning and thought process. Neurodegeneration in Alzheimer's disease is the result of deposition of protein beta-amyloi...

Psoriasis is one of the most stern and persistent autoimmune disease which affects about 1-3% population around the globe. It influences an individual’s life quality by hindering them physically, socially and emotionally. The hyperproliferation of keratinocytes leads to excessive growth of skin cell which causes scaling and formation of plaques. Ps...

Onychomycosis is one of the most prevalent and severe nail fungal infection, which is affecting a wide population across the globe. It leads to variations like nail thickening, disintegration and hardening. Oral and topical drug delivery systems are the most desirable in treating onychomycosis, but the efficacy of the results is low, resulting in a...

Parkinson’s disease is one of the most severe progressive neurodegenerative diseases which have a mortifying effect on the health of almost hundreds of millions of people around the globe. The neural cells producing dopamine in the substantia nigra of the brain die out which leads to symptoms like hypokinesia, rigidity, bradykinesia and rest tremor...

In the past few years gene delivery system has gained a huge attention owing to its proved efficacy in several diseases especially in those caused by genetic and/or oncological malfunctioning. The effective gene delivery mainly depends on the carrier molecules that can ensure the safe and specific delivery of the nucleic acid molecules. Viral vecto...

New discoveries, ideas and thoughts emerging in clinical and research field need to be effectively communicated to different health professionals, patients and regulatory departments. All the scientific data should be written in appropriate manner in the field of medical research. A medical writer compiles all the data and then writes it down in a...

Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drugs and hence its bioavailability. The water soluble carriers used in preparation of solid dispersion enhance the dissolution rate of the poorly water soluble drug. The review article focuses on the methods of preparation, advantages, disadvantages and...

Psoriasis is an abnormal autoimmune inflammatory skin condition. Triggering factor of psoriasis includes injury to skin, emotional stress, various systemic infections, certain medications and intestinal upsets. Different psoriasis have been reported like plaque psoriasis, nail psoriasis etc which can be diagnosed using various clinical findings lik...

Safety and efficacy of a drug product for use in humans is essential before the drug product can be approved for import or manufacturing a new drug. For this every country has its regulatory authority that bears the responsibility of evaluating whether the research data of new drug/product supports the safety and efficacy to serve public health. Re...