Bhuchitra Singh

• Doctor of Medicine
• Johns Hopkins Medicine

Previous epidemiological studies have suggested that green tea catechins, including Epigallocatechin‐3‐gallate (EGCG), the most abundant polyphenol in green tea, may be associated with reduced serum folate levels. This is of particular interest as women of childbearing age may be consuming EGCG from tea, dietary supplements, or involved in active c...

Pomegranate (Punica granatum) is a widely cultivated fruit historically recognized for its health benefits and is regarded as a nutritional powerhouse. Pomegranate has a unique composition of bioactive compounds including hydrolysable tannins, anthocyanins, and other polyphenolic components. Of those, punicalagin and its subsequent metabolites are...

In 2010, the estimated annual cost of uterine fibroids in the United States ranged from 5.9 to 34.4 billion USD. In the past decade, more uterine-sparing and fertility preserving interventions have become available to treat symptomatic fibroids. This comparative cost-analysis aims to evaluate change in societal costs of uterine fibroids in the US b...

While endometriosis is a common gynecologic disease associated with infertility, the psychosocial impact of endometriosis has not been evaluated against various quality of life (QoL) instruments and compared with other chronic illnesses. We rigorously analyzed the psychosocial burden of endometriosis in adult women and compared standardized and val...

Introduction Uterine fibroids affect 30%–77% of reproductive-age women and are a significant cause of infertility. Surgical myomectomies can restore fertility, but they often have limited and temporary benefits, with postoperative complications such as adhesions negatively impacting fertility. Existing medical therapies, such as oral contraceptives...

Although significant improvements in assisted reproductive technology (ART) outcomes have been accomplished, a critical question remains: which embryo is most likely to result in a pregnancy? Embryo selection is currently based on morphological and genetic criteria; however, these criteria do not fully predict good-quality embryos and additional ob...

Conversion therapy is a set of practices that aim to alter an individual's sexual orientation or gender identity. This review aimed to explore the medico-socio-legal implications of conversion therapy in the context of the Indian subcontinent. Review of medical literature has shown that conversion therapy does not lead to changes in sexual orientat...

Uterine leiomyomas are the most common tumor of reproductive-age women worldwide. Although benign, uterine fibroids cause significant morbidity and adversely impact the quality of life for affected women. Somatic mutations in the exon 2 of the mediator complex subunit 12 (MED-12) gene represent the most common single gene mutation associated with u...

Autoimmune primary ovarian insufficiency (POI) is a devastating disease with limited clinical guidance. The objective of this systematic review was to identify treatments for autoimmune POI and analyze their efficacy. A comprehensive search of CINAHL, Cochrane, Embase, PubMed, Scopus, and Web of Science was performed from inception to April 2022. E...

While polycystic ovarian syndrome (PCOS) is one of the most common hormonal endocrine disorders among women of reproductive age, the psychosocial impact of PCOS has not been evaluated across different quality of life (QoL) indicators. We rigorously analyzed available evidence pertaining to the psychosocial burden of PCOS in women of reproductive ag...

Objective: Is prior beta blocker (BB) use associated with reduced odds of the clinical incidence of leiomyomas? What is known already: In-vitro and in-vivo evidence has supported the role of beta receptor blockade in reducing leiomyoma cell proliferation and growth. However, no population-based study to date has investigated this potential assoc...

Green tea is harvested from the tea plant Camellia sinensis and is one of the most widely consumed beverages worldwide. It is richer in antioxidants than other forms of tea and has a uniquely high content of polyphenolic compounds known as catechins. Epigallocatechin-3-gallate (EGCG), the major green tea catechin, has been studied for its potential...

A similar abstract of the interim analysis was previously published in Fertility and Sterility. EPIGALLOCATECHIN GALLATE (EGCG) FOR TREATMENT OF UNEXPLAINED INFERTILITY ASSOCIATED WITH UTERINE FIBROIDS (PRE-FRIEND TRIAL): EARLY SAFETY ASSESSMENT. Uterine fibroids are the most common cause of unexplained infertility in reproductive-aged women. Epiga...

Objective To assess the current literature evaluating the role of vitamin D in endometriosis in humans. Evidence Review A systematic review was conducted in accordance with the PRISMA guidelines within PubMed, Embase, Cochrane Library, Web of Science and Scopus. A comprehensive search strategy was developed by a data informationist. Observational...

Objective: To assess the utilization and cost of intraoperative cell salvage (ICS) in minimally invasive myomectomy. Study design: Retrospective cohort study of patients who underwent minimally invasive myomectomy at a quaternary care academic hospital. Patients were classified into: ICS setup vs no ICS setup, ICS setup with reinfusion vs ICS se...

The objective of this study was to evaluate the utility and impact of the Painful Periods Screening Tool (PPST) to improve healthcare delivery for people with symptoms of pelvic pain. The design of this study was a survey study. After IRB approval, patients aged 18-55 years with self-reported pelvic, abdominal, or lower back pain before, during, or...

Improvement in symptom severity and quality of life (QoL) are critical concerns for women with fibroids as they evaluate treatment options. This systematic review analyzed available evidence regarding minimally invasive approaches to fibroid treatment and compared validated QoL and fibroid-associated symptom scores before and after treatment. A com...

Uterine fibroids are the most common tumor of reproductive-age women worldwide and cause significant morbidity in affected women. Vitamin D has emerged as a potential therapy for uterine fibroids based on experimental and epidemiologic evidence. The objective of this systematic review was to evaluate the role of vitamin D in the pathophysiology of...

Objective Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases and play a critical role in morphogenesis, wound healing, and tissue repair. Uterine fibroids are benign, fibrous smooth muscle tumors with excessive deposition of extracellular matrix rich in interstitial collagen. This systematic review aims to rigorously assess current...

Objective To determine if morphologically suboptimal embryo quality is associated with adverse perinatal outcomes. Design A retrospective cohort. Setting SART CORS database. Patient(s) Singletons conceived from autologous in vitro fertilization fresh cycles. Intervention(s) None. Main Outcome Measure(s) Birth weight (gram), birth weight z-scor...

Aims Uterine leiomyomas, or fibroids, are estrogen dependent benign tumor in women, however, they have limited treatment options. Simvastatin, a drug commonly used to treat high cholesterol. Recently we demonstrated that simvastatin alters estrogen signaling by reducing the expression and trafficking of the estrogen receptor-α (ER-α) in human uteri...

Background Randomized trials of assisted reproductive technology (ART) have been designed for outcomes of clinical pregnancy or live birth and have not been powered for obstetric outcomes such as preeclampsia, critical for maternal and fetal health. ART increasingly involves frozen embryo transfer (FET). Although there are advantages of FET, multip...

Newer minimally invasive techniques provide treatment options for symptomatic uterine fibroids while allowing uterus preservation. The objective of this review was to analyze the efficacy of uterine-preserving, minimally invasive treatment modalities in reducing fibroid-related bleeding. A comprehensive search was conducted of PubMed, Embase, PsycI...

Background Uterine fibroids are highly prevalent, collagen-rich, mechanically stiff, fibrotic tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) stiffness activates mechanical signaling and Hippo/YAP promoting fibroid growth, but no prior studies have tested either as a therapeutic target. We tested the hypoth...

Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, endometriosis and adenomyosis. Cu...

Uterine fibroids feature excessive deposition of types I and III collagen. Previous ex vivo studies showed an FDA-approved collagenase (EN3835)-digested types I and III collagen fibers in fibroid tissues; however, collagenase had not been evaluated in vivo for effects on uterine fibroids. The objective was to assess the safety and tolerability of c...

Objective The aim of this systematic review was to survey and assess modern methodologies used to test oocyte quality that have prognostic value in predicting assisted reproductive technology (ART) outcomes. Evidence Review Following PRISMA guidelines, we surveyed the English-language literature between January 1st, 2010 and December 31st, 2019 us...

Objectives To investigate the personal, ethical, and financial perspectives of individuals with Mayer−Rokitansky−Küster−Hauser syndrome (MRKH), a congenital uterine factor infertility condition, regarding uterine transplantation (UTx). Design Cross-sectional, quantitative survey. Setting A 60-item anonymous electronic questionnaire was disseminat...

Objective To determine whether in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy (PGT-A) is cost effective to achieve a live birth compared to IVF alone in fresh donor oocyte cycles. Design Theoretical cost-effectiveness study Setting Not applicable Patients/Animals None Intervention(s) Comparison between the cost...

Context: In-vitro and in-vivo evidence has supported the role of angiotensin II blockade in reducing leiomyoma cell proliferation and growth. However, no population-based study to date has investigated this potential association. Objective: To determine if prior Angiotensin-Converting Enzyme inhibitor (ACEi) use is associated with reduced odds o...

SARS-CoV-2 infection and pregnancy has been the topic of hundreds of publications over the last several months, however, few studies have focused on the implications of infection in early pregnancy and reproductive tissues. Here we analyzed available evidence pertaining to SARS-CoV-2 infection, early pregnancy, and reproductive tissues. We searched...

Currently-placed protocols for extended culture for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are not uniformly standardized in determining the optimal stage of oocyte maturation for maximizing clinical outcomes. The objective of this systematic review is to elucidate the relationship between extended cumulus-oocyte c...

For couples with sickle cell trait (SCT) who are at risk for having a child with sickle cell disease (SCD), cost is a barrier to using in vitro fertilization (IVF) with preimplantation genetic testing for monogenic diseases (PGT‐M) and insurance coverage is not universal. The objective of this study was to evaluate the cost‐effectiveness of IVF+PGT...

Objective To provide an update on single gene mutations identified as causative for pathologic diminished ovarian reserve (DOR) in order to inform clinical screening recommendations. Evidence Review A systematic review of the literature was performed in accordance with PRISMA guidelines using PubMed and EMBASE databases. Only full text articles in...

INTRODUCTION Period poverty refers to the lack of access to menstrual products. The “luxury tax” collected on menstrual products in the majority of the United States is a major contributor to period poverty and a barrier to reproductive health for the estimated 16.9 million women living in poverty in the U.S. In this study, we sought to determine t...

INTRODUCTION Uterine leiomyomas are the most common benign pelvic tumor in women. Angiotensin-converting-enzyme inhibitors (ACEi) are a drug-class used for the treatment of hypertension and work by inhibiting the production of angiotensin, an enzyme that promotes blood vessel constriction and tumorigenesis. Angiotensin receptors are expressed in hu...

Objective Despite the high prevalence of uterine fibroids, the psychosocial impact of fibroids has not been evaluated across different quality of life indicators and compared to other chronic conditions. Here we rigorously analyzed available evidence pertaining to the psychosocial burden of uterine fibroids in premenopausal women and compare valida...

The use of frozen-thawed embryo transfer (FET) has increased over the past decade with improvements in technology and increasing live birth rates. FET facilitates elective single-embryo transfer, reduces ovarian hyperstimulation syndrome, optimizes endometrial receptivity, allows time for preimplantation genetics testing, and facilitates fertility...

The use of opioid analgesics for pain management has increased dramatically over the past decade, with corresponding increases in negative sequelae including overdose and death. Physicians, policymakers, and researchers are focused on finding ways to decrease opioid use and overdose. This crisis calls for a coordinated response that includes the en...

Endometriosis is a common gynecological disorder characterized by pelvic pain, heavy menstruation, and infertility. The clinical diagnosis of endometriosis is often delayed 8–10 years after the onset of symptoms due to the lack of an effective and reliable noninvasive diagnostic method. In recent years, a number of research studies have reported us...

Study Objective The role of cell salvage use in gynecologic procedures, such as myomectomy, is not well established. We assessed the utilization and cost of cell salvage use in patients undergoing minimally invasive myomectomy from 2015 to 2018. Design Retrospective cohort study. Setting Academic medical center. Patients or Participants Patients...

Currently-placed protocols for extended culture for in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are not uniformly standardized in determining the optimal stage of oocyte maturation for maximizing clinical outcomes. The objective of this systematic review is to elucidate the relationship between extended cumulus-oocyte c...

Autism and Sensory Sensitivity in JOHNS HOPKINS