Bhisma K Patel

• Ph.D
• Professor at Indian Institute of Technology Guwahati

An environmentally benign synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed starting from N-aroylhydrazones and N-acetylhydrazones at room or ambient temperature using a catalytic quantity of iodine in the presence of an aqueous hydrogen peroxide oxidant.

A unique copper‐catalyzed cross‐dehydrogenative coupling (CDC) of thiols and alkylbenzenes has been developed for the synthesis of thioesters without the assistance of any directing group. A thioester moiety is created via successive CS and CO bond formation at the expense of three sp ³ CH bonds of the alkylbenzene and one sp ³ SH bond of the t...

A metal free synthesis of 3-aroylindole involving two sp3 CH activation has been achieved starting from o-alkynyl-N,N-dialkylamines using catalyst TBAI and oxidant TBHP.

A variety of styrenes and phenylacetylenes serve as excellent arylcarboxy sources in bringing about substrate directed o-benzoxylation of 2-phenylpyridine derivatives catalyzed by Cu(II) in the presence of TBHP. This reaction proceeds via formation of phenylglyoxal followed by decarbonylation to benzoyl radical/benzaldehyde which acts as the arylca...

A room-temperature NaI-mediated oxidative sulfoximidation of aryl methyl ketones to synthesize α-keto-N-acyl sulfoximines has been disclosed. This metal- and base-free NH-sulfoximidation is facilitated by tert-butyl hydroperoxide (TBHP) as the oxidant,...

A cobalt(III)‐catalyzed dual C(sp²)−H/C(sp²)−H activation of 2‐arylimidazopyridines and its annulation with N‐substituted maleimides leads to polycyclic aromatic heterocycles. This sustainable oxidative annulation uses earth‐abundant, less toxic, and cost‐effective cobalt(III) catalyst that complement expensive 2nd and 3rd‐row metals. This oxidativ...

A Pd(II)‐catalyzed non‐template synthesis of furo[2,3‐b]pyrrolo[2,3‐d]pyridines from β‐ketodinitriles and buta‐1,3‐diynes has been accomplished via dual annulative cyclization. The participation of both the nitrile (−CN) groups led to the concurrent construction of three heterocycles viz. furan, pyrrole, and pyridine forming C−C, C=C, C−O, C−N, and...

Solvent plays an important role in many chemical reactions. The C−H activation has been one of the most powerful tools in organic synthesis. These reactions are often assisted by solvents which not only provide a medium for the chemical reactions but also facilitate reaching to the product stage. The solvent helps the reaction profile both chemical...

Developed here is a highly fluorescent organic N-O bidentate BF2 complex from isoxazole in the presence of Ru(II) catalyst. Herein, the complexation proceeds via a selective N-O cleavage of the...

An electrochemical N‐acylation of sulfoximine has been achieved via the coupling of α‐keto acids and NH‐sulfoximines. This process involves the sequential cleavage of C−C bond followed by C(sp²)−N bond formation, with the liberation of H2 and CO2 as the by‐products. A library of N‐aroylated sulfoximines is produced via the coupling of aroyl and sul...

Demonstrated here is an external photo‐sensitizer‐free (auto‐sensitized) singlet oxygen‐enabled solvent‐dependent tertiary hydroxylation and aryl‐alkyl spiro‐etherification of C3‐maleimidated quinoxalines. Such “reagent‐less” photo‐oxygenation at Csp³‐H and etherification involving Csp³‐H/Csp²‐H are unparalleled. Possibly, the highly π‐conjugated N...

Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the -NCS group serves both as electrophile and nucleophile in organic synthesis. ITCs share a rich legacy in organic, medicinal, and combinatorial chemistry. Compared to their oxygen equivalents, isocyanates, ITCs are easily a...

A visible-light-induced oxidative cross-coupling between methylarenes and NH-sulfoximines leading to N -acyl sulfoximines is presented.

Sulfur-containing heterocycles are ever-trending core molecules in pharmaceutical research. Derivatives of thiophene are a class of S-containing heterocycles that have been long known for their biological activities. They are important analogs for medicinal chemists because a large number of advanced compounds with a varied range of biological acti...

A visible-light-initiated electron-donor-acceptor (EDA) complex-driven regioselective vicinal and oxidative geminal thiosulfonylation of alkynes is presented. Organic thiosulfonates act as an acceptor, producing either sulfonyl (RSO2•) or thiyl (RS•) radical under...

Developed here is a robust electrochemical cross‐coupling reaction between aroyl hydrazine and NH‐sulfoximine via concomitant cleavage and formation of C(sp²)−N bonds with the evolution of H2 and N2 as innocuous by‐products. This sustainable protocol avoids the use of toxic reagents and occurs at room temperature. The reaction proceeds via the gene...

A visible light-driven di-functionalization of maleimide with disulfide and in situ-generated singlet oxygen offers selective 1,2-thiohydroxylation under additive-free conditions. Here the disulfide plays the dual role of photo catalyst and...

A Ru(II) catalyzed regioselective Heck-type C-H olefination of isoxazole with unactivated allyl phenyl sulfone is revealed. The solvent DCM offers dual sp2-sp2 C-H activation via an N-directed strategy, leading to ortho-olefinated isoxazoles with exclusive E-selectivity. On the other hand, in DCE solvent, isoxazole serves as the nitrile synthon and...

The upsurge in interest in the development of methodologies for the synthesis of sulfur‐containing compounds via the use of visible‐light has been established as a sustainable tool in organic chemistry. Particularly, visible‐light mediated C−S bond formation has gained popularity due to its operational simplicity, minimized by‐products, easy handli...

Elegant synthetic strategies for chromenopyrroles (azacoumestans) have been devised via cycloaddition of 2-hydroxychalcone/cyclic enones and alkyl isocyanoacetate, followed by lactonization. Herein, ethyl isocyanoacetate acts as a C-NH-C-C═O synthon contrary to its hitherto applications as a C-NH-C synthon. Subsequently, pentacyclic-fused pyrroles...

A visible/solar-light-induced electron-donor-acceptor (EDA) aggregated/mediated radical cyclization between (E)-2-(1,3-diarylallylidene)malononitriles and thiophenols lead to poly-functionalized pyridines. The two reacting partners form an EDA complex that absorbs light and triggers the single-electron...

A Mn(I)-catalyzed site-selective nondirected C3-maleimidation of quinoxaline is established. Herein, the electrophilic C3-metalation precedes over the o-directed strategy to access diversely substituted quinoxaline-appended succinimides. The products undergo PIFA-promoted C(sp2)-C(sp3) spirocyclization via π-electrons drifting from aryls and Select...

N-Iodosuccinimide catalyzed, visible-light-induced oxidative decarboxylative cross-coupling between cinnamic acids and NH-sulfoximines is presented. This strategy results in the formation of α-keto-N-acyl sulfoximines via the construction of two new CO bonds and one C-N bond. The in situ-generated N-iodosulfoximine serves as the light-absorbing sp...

A Cu(OTf)2 mediated regioselective de-aromatized aryl-hydroxylation across C(sp2)N bond of 2-aryl quinoxalines and bis-N-arylation of (benz)imidazoles is developed using aryl boronic acids. For dearomative aryl-hydroxylation, the C-center should be electrophilic...

A light-triggered synthesis of thio-functionalized pyridines is demonstrated using γ-ketodinitriles, thiols, and eosin Y as the photocatalyst. The reaction proceeds via the selective attack at one of the cyano groups...

A solvent (2,2,2-trifluoroethanol (TFE) vs ethyl alcohol (EtOH)) switched synthesis of quinolines and pyridines is illustrated from (E)-2-(1,3-diphenylallylidene)malononitriles via a Pd(II)-catalyzed photochemical process. The active catalyst [L2Pd(0)] generated serves as an exogenous photosensitizer. The process offers predominantly Z-alkenylated...

In recent years, dual metallo-photocatalysis has grown rapidly, to emerge as one of the most powerful tools in functionalizing organic molecules. In contrast to conventional catalysis, photocatalysis exploits the formation of reactive intermediates by photo-induced atom, electron, or energy transfer processes. An interesting synergy evolved when ph...

Aldehydes have been widely utilized as an acyl source for the construction of C(sp2)—C(sp2) bonds via cross-dehydrogenative coupling (CDC) in an efficient and sustainable strategy. The aldehyde-based acylation is an important methodology for the synthesis of diaryl ketones, a significant motif in the field of agrochemicals, pharmaceuticals, and dye...

In the arena of functional group‐oriented organic synthesis, nitrile or cyano functionality is of immense importance. The presence of nucleophilic N‐atom, π‐coordinating ability of the triple bond, and electrophilic C‐center imparts unique and interesting reactivities. Owing to the ability of the nitrile to transform into various other functional g...

The isocyanate group in aryl isocyanates serves as a transformable transient directing group in a Ru(II)-catalyzed ortho olefination leading to o-alkenylanilines. In alcoholic solvents, aryl isocyanates are transformed into carbamates, which initiate the insertion of acrylates via o-C-H activation. In particular, tAmOH serves the dual role of solve...

An electrochemical amidation of benzoyl hydrazine/carbazate and primary/secondary amine as coupling partners via concomitant cleavage and formation of C(sp2)-N bonds has been achieved. This methodology proceeds under metal-free and exogenous oxidant-free conditions producing N2 and H2 as byproducts. Mechanistic studies reveal the in situ generation...

Petrochemicals are the primary source of energy due to their high energy density and accessibility of their established energy conversion technologies. Nevertheless, the sources of fossil fuels and oil reserves are getting exhausted due to their extensive exploration and usage. To reduce the reliance on hydrocarbon-based fossil fuels, the search fo...

A regioselective cross-dehydrogenative coupling between electron-deficient N-heterocycles (isoquinoline, qui-nolines, and quinoxalines) and methylbenzenes leading to regiospecific C−aroylation has been accomplished using AlCl 3 as the catalyst in the presence of oxidant TBHP. This protocol is a practical alternative to the classical Minisci reactio...

Thermally activated delayed fluorescent (TADF) molecules undergo efficient intersystem crossing (ISC) and reverse intersystem crossing (RISC) processes, making them as third-generation emitters in organic light-emitting diodes (OLEDs), photodynamic therapy (PDT) and time-resolved luminescence imaging. Apart from these applications, recently, TADF m...

The combination of organocatalysis with transition metal catalysis is an emerging research area for the scientific community. Various unprecedented transformations that are otherwise inaccessible by individual catalytic systems can be achieved with good efficiency and stereocontrolled manner by this dual‐catalytic strategy. This Review presents a d...

A Pd(II)-catalyzed synthesis of furopyridines has been developed from β-ketodinitriles and alkynes via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C═C, C-O, C-N, and C═N bonds are the important features. The synthetic applicabilit...

The nitrile or cyano (-CN) group is one of the most appreciated and effective functional groups in organic synthesis, having a polar unsaturated C-N triple bond. Despite sufficient stability and being intrinsically inert, the nitrile group can be easily transformed into many other functional groups, such as amines, carboxylic acids, ketones, etc. w...

Since their inception, heterocyclic compounds are the pillar of medicinal chemistry research. Out of all the heterocyclic moiety pyridines, dihydropyridines, and piperidines possess outstanding therapeutic effects and play eminent roles in medicinal, synthetic, and bio-organic chemistry. Derivatives of pyridine, dihydropyridine, and piperidine are...

In recent years, benzimidates and benzamidines have received tremendous importance as starting materials owing to their electronic properties and high reactivity. Their application as directing groups for constructing biologically active molecules has been a hot topic of discussion. Because of the presence of nucleophilic nitrogen in both these moi...

Hypervalent iodine (HVI) chemistry is a rapidly growing subdomain of contemporary organic chemistry because of its enormous synthetic applications. The high nucleofugality of the phenyliodonio group (-I⁺Ph) and its radical nature, serving as a single-electron oxidant makes HVI compounds highly valuable in organic synthesis. Due to the feasibility a...

A visible‐light‐mediated intermolecular radical insertion of isocyanides to electron‐deficient o‐alkenylanilines leading to isoindolinone is reported. Deuterium (D2O) and H2O¹⁸ labelling experiments suggest H and O incorporation in the product. The formation of an N‐centered radical (NCR) via stepwise PT/ET process was confirmed by radical trapping...

Hypervalent iodine (HVI) chemistry is a rapidly growing subdomain of contemporary organic chemistry because of its enormous synthetic applications. The high nucleofugality of the phenyliodonio group (I+Ph) and their radical...

In the field of oil-water separation, carbon nanotubes (CNTs) have been proved as an efficient tool. The development of carbon-based nanotubes has shed bright light on gloomy disasters caused by oil spillage and industrial oily wastewater drainage. CNT is bestowed with many distinctive physicochemical properties such as superhydrophobicity, superol...

Manufacturing processes, clashes of different levels, military activities, open burning/open detonation (OB/OD), discarding of ammunitions, etc., have led to genesis of huge amounts of explosive substances. Dumping and detonation of these explosive chemicals pose hazard to natural resources and living creatures by contaminating soil and groundwater...

An inimitable illustration of blue-light-induced synthesis of β-keto sulfones has been disclosed using commercially available phenylacetylenes or ketones as precursors and sodium sulfinates as the sulfonyl source. Here, the synthesized heterogeneous graphitic carbon nitride (g-C3N4) was employed as a recyclable photocatalyst. The mechanistic invest...

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition–cyclization reaction followed by an Ullmann-type C–N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32–84% yields. The compounds show excellent photol...

An intermolecular radical based distal selectivity in appended alkyl chains has been developed. The selectivity is maximum when the distal carbon is γ to the appended group and decreases by moving from γ → δ → ε positions. In -COO- linked alkyl chains, the same distal γ-selectivity is observed irrespective of its origin, either from the alkyl carbo...

An intermolecular radical based distal selectivity in appended alkyl chains has been developed. The selectivity is maximum when the distal carbon is  to the appended group and decreases by moving from      positions. In-COO-linked alkyl chains, the same distal selectivity is observed irrespective of its origin, either from the alkyl carboxy...

In the last few years, the photo-redox process via single-electron transfer (SET) has received substantial attention for the synthesis of targeted organic compounds due to its environmental friendliness and sustainability. Of late visible-light-mediated difunctionalization of alkenes has gained much attention because of its step economy, which allo...

A Pd(ii)/Cu(ii) catalysed domino synthesis of tricyanovinylindoles has been achieved using DMSO as a one-carbon synthon. The reaction proceeds via the construction of 2-aryl-3-formyl indole followed by sequential addition of malononitrile and a CN resulting in two C-C, one C[double bond, length as m-dash]C and one C-N bonds in the final product. Fu...

This personal account is mainly focused on the author's involvement in the field of transition metal‐catalyzed peroxide based radical reactions. Over the past decades, radical chemistry has flourished and become crucial in contemporary synthetic organic chemistry. Owing to the presence of a single electron in one orbital, radicals are very unstable...

In last few decades, the transition metal-catalyzed C-H bond activation and alkyne annulation reactions have turned out to be effective methods for the construction of highly important heterocycles. In particular, the Ru(II) catalysts have been used for the oxidative coupling between an internal alkynes and readily available nitrogen directed compo...

Organic dyes are nonbiodegradable chemicals that are imperative to our everyday life as they are found in a number of products such as leather accessories, textiles, furniture, etc. The drawback of their extensive usage is the fact that during dyeing process 12% of these dyes are wasted and nearly up to 20% of it ends up in the water supply and pos...

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2-arylethyl)malononitrile, respectively under mild reaction conditions followed by intramolecular cyclization of...

Herein we have described crystal structures of Ni(II), Cu(II), Zn(II) and Cd(II) compounds of four racemic 1,2-dihydroquinazolinone based chelating ligands (L1-L4). The substituents on the ligands were varied by imidazolyl, pyrazinyl, 4-phenylpyridyl and quinolinyl to witness the effect of steric hindrance, hydrogen bonding and π···π stacking inter...

In an oxygen atmosphere tert‐butyl nitrite (TBN) reacts with unsymmetrical internal benzylic alkenes giving nitro‐nitratosation product exclusively. The γ‐diaryl‐substituted styrenes provided better yields compared to γ‐alkyl‐aryl‐substituted styrenes. The higher yields for the former type of substrates is possibly dictated by the additional stabil...

A visible-light-induced synthesis of N-hydroxybenzimidoyl cyanides from aromatic terminal alkenes is achieved by using Eosin Y as an organic photoredox catalyst. The process goes via a radical pathway with successive incorporation of two nitrogen atoms, one each from tert-butyl nitrite and ammonium acetate. The final product is achieved by the conc...

Terminal and internal alkenes react contrarily with tert‐butyl hydroperoxide (TBHP) giving various products. A Cu(I) catalyzed decarbonylative C–C bond formation followed by a carbonylation–peroxidation of vinyl arenes has been achieved using tert‐butyl hydroperoxide (TBHP) as the oxidant in acetonitrile. Whereas, α‐methyl styrenes yielded aryl met...

A Bu4NI-catalyzed regioselective N2-methylation, N2-alkylation and N2-arylation of tetrazoles have been achieved using tert-butyl hydroperoxide (TBHP) as the methyl, alkyl diacyl peroxides as the primary alkyl, alkyl peresters as the secondary and tertiary alkyls and aryl diacyl peroxides as the arylating sources. These reactions proceed without pr...

Managing chirality at supramolecular level is an important aspect in crystal packing of chiral organic and organometallic molecules. Herein molecular structure of Ni(II), Cu(II) and Cd(II) complexes of a racemic 1,2-dihydroquinazolin-4(1H)-one ligand is described. The Cd(II) complexes exhibit intriguing structural features viz. capped octahedral ge...

In the presence of [Ir(dtbbpy)(ppy)2]PF6 photocatalyst and white LEDs, one‐third of N‐alkylated indoles undergo oxidative dearomatization and serves twice as the C2‐electrophilic partner. The remaining two‐third act as the C3‐nucleophile, prompting two sequential electrophilic substitutions with the in situ generated C2‐electrophile that leads to C...

The upsurge interest in the development of efficient methodologies for the construction of nitrogen‐containing frameworks via the use of expedient reagents have been creating a renaissance in contemporary organic chemistry. In this perspective, tertbutyl nitrite (TBN) is an emerging building block. Due to its unique structural features, it shows di...

The synthesis of heterocyclic molecules has always been a central theme in organic chemistry since centuries. Numerous methodologies have been developed towards the construction of complex heterocyclic molecules. The traditional approaches generally involve the use of preactivated substrates as the essential requirement, thus making the overall met...

One of the cyano group of γ‐keto malononitrile gets hydrolyzed selectively to an amide in the presence of copper(II) acetate monohydrate. The in situ generated amide undergo an intramolecular dehydrative cyclization to a 1,2‐dihydropyridone intermediate. Further annulation of the 1,2‐dihydropyridone with an internal alkyne in the same pot produce a...

tert-Butyl nitrite (TBN) mediated synthesis of 3-aryl-1,2,4-oxadiazol-5(4 H)-ones has been accomplished using terminal aryl alkenes via a biradical reaction intermediate. Three consecutive sp2 C-H bond functionalizations of styrenes afforded 3-phenyl-1,2,4-oxadiazol-5(4 H)-ones via the formation of new C═N, C═O, C-O, and two C-N bonds. Both of the...

A visible-light-mediated concomitant C3 oxidation and C2 amination of indoles has been achieved at room temperature using an Ir (III) photocatalyst. This reaction proceeds without an isatin intermediate via the attack of a singlet oxygen at the C3 position followed by C2 amination leading to difunctionalization of indoles.

Multifaceted application potential of AEEgens in bioimaging, theranostics, chemo/biosensors, mechanochromics, solar cells, and organic photoelectronics opens up a new research paradigm to develop and design more such compounds. Herein, quinoxaline N-directed Ru(II)-catalyzed oxidative annulation of 2-arylquinoxalines with internal alkynes leads to...

A regiospecific C−H/S−H annulation of quinoline‐4(1H)‐thiones with alkynes have been demonstrated using a ruthenium(II) catalyst. This C−H/S−H annulation is directed via the C=S group, where preferential annulation takes place at the sterically hindered position even in the presence of three other competing sites viz. two C−H/N−H and one C−H/O−H. T...

A CuII catalyzed one‐pot sequential synthesis of N‐[2‐(phenylthio)phenyl]acetamides from benzo[d]thiazol‐2‐amines, iodoarenes and carboxylic acids (RCOOH) has been accomplished via ring opening rearrangement functionalization (RORF). Here, the ring opening is associated with the loss of carbon and nitrogen atoms with concurrent S‐arylation and N‐ac...

A catalyst and solvent free synthesis of S-allyl benzoylcarbamothioates has been achieved from the in situ generated benzoylcarbonimidothioates obtained by reacting MBH alcohols with aroyl isothiocyanates. An intramolecular thia-Michael addition...

A copper(I) catalyzed regioselective arylthio-arylamination of quinoline and isoquinoline N-oxides have been achieved at the expense of a cyano (-CN) group from N-(2-(arylthio)aryl)cyanamides. This reductive amination proceeds in one pot at 80 degrees C in the absence of any additives. This is a unique illustration of aryl cyanamides serving as ary...

A catalyst-free regioselective synthesis of 2-iminothiazolidines have been achieved by reacting un-activated aziridines with aroyl isothiocyanates at ambient temperature in 100% atom economy via a domino ring opening cyclization. The present protocol operates under a solvent free condition as well as in the absence of any catalyst making it a green...

A palladium‐catalyzed isocyanides insertion into 2‐halophenoxy acrylates leading to an unparalleled synthesis of dihydrobenzofurans (DHBs) having two exocyclic double bonds have been achieved. While the iodo substrates gave products having an exocyclic imine bond, its bromo analogue yielded reduced secondary amines as the product. An acid hydrolysi...

A tert-butyl peroxybenzoate (TBPB) mediated cycloalkylation and formamidation took place effectively in chlorobenzene or in respective formamides at 120 oC, while the former process requires the presence of acetic acid, the later goes in its absence. This radical mediated process gives moderate to good yields of the product having broad substrate s...

tert-Butyl nitrite serves the dual role of an oxidant as well as a N1 synthon in a multi-component reaction involving quinolines/isoquinolines and styrenes. Herein two sp2 C-H’s functionalization of styrenes and one of quinolines/isoquinolines leads to the formation of fused quinolines/isoquinolines via three sequential C-N bond formation.

The molecular structures of two isomeric 2-(chlorophenyl)-3-[(chlorobenzylidene)-amino] substituted 2,3-dihydroquinazolin-4(1H)-ones have been determined via single crystal XRD. Both isomers contain chloro substitutions on each of the phenyl rings and as a result a broad spectrum of halogen mediated weak interactions are viable in their crystal str...

Two bis-bromo substituted imidazo-[1,5-a]-pyridine derivatives IMPY1 and IMPY2 were synthesized from a 2:1:2 mixture of ortho/meta-bromobenzaldehyde, 2-cyanopyridine and ammonium acetate. The compounds IMPY1 and IMPY2 exhibit blue fluorescence in both THF and methanol solution and their highly fluorescent nature is revealed by the quantum yields ΦF...

A sequential construction of C-C, C-O, C=N and C=O bonds from alkenes leading to the direct synthesis of isoxazolines in the presence of tert-butyl nitrite, quinoline and Sc(OTf)3 catalyst in DCE at 80 oC has been accomplished. An unprecedented consecutive three CH functionalisations of two styrenes are involved during this isoxazoline synthesis....

The reaction of two 3-pyridyl-5-aryl substituted 1,2,4-triazole ligands (trz-1 and trz-2) with M(NO3)2 and MCl2 (M = ZnII/CdII) afforded the metal complexes [Zn(trz-1)Cl2], [Cd(trz-1)2(NO3)2] and [MII(trz-2)2](NO3)2·H2O (M = Zn, Cd). The reaction of Cd(NO3)2, trz-2 and NaNCS in a 1:1:1 molar ratio resulted in the formation of the complex [Cd(trz-2)...

The disparity in the electronic nature of organic (C-X) and inorganic (M-X) halogens in a supramolecular context has been demonstrated herein. Metal complexes [Zn(hyd-X)Cl-2] center dot nDMF of three o-halophenyl substituted hydrazide based ligands hyd-X (hyd = hydrazide, X = F, Cl and Br) have been synthesized and characterized by single crystal X...

The in situ generated o-alkynyl thioureas obtain by reacting 2-(phenylethynyl)anilines and aryl isothiocynates undergo efficient cascade cyclization in the presence of Ag2CO3 forming indoloquinolines under microwave heating. The present tandem process allows the generation of a variety of indolo[2,3-b]quinolines derivatives in good to moderate yiel...