Bharath Guru

Bharath Guru
Manipal Academy of Higher Education | MAHE · Department of Biotechnology

Doctor of Philosophy

About

25
Publications
4,559
Reads
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710
Citations
Citations since 2016
13 Research Items
475 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
Additional affiliations
August 2003 - January 2009
Wayne State University
Position
  • Graduate Student (Ph.D. Student) and research assistant

Publications

Publications (25)
Article
In drug discovery, the hybridization of bioactive pharmacophores is a powerful tool for targeting enzymes involved in cancer and microbial cell growth. A combination of 1,3,4‐oxadiazole and isobenzofuran may improve the antitumor and antimicrobial properties of the hybrid molecules. A series of 1,3,4‐oxadiazole‐isobenzofuran hybrids are synthesized...
Article
Full-text available
Background: Glucocorticoids are employed for their anti-inflammatory effects in treatingglioma, whose cells are known to overexpress the folate receptors. Some glucocorticoids haveshown inhibitory effects, but the efficacy of prednisolone when delivered via folate receptormediateduptake, has not been attempted. The study aimed to assess the efficac...
Article
Full-text available
Background: Mesenchymal stromal cell conditioned medium (MSC-CM) contains a cocktail of bioactive factors that act synergistically to induce therapeutic effects. This has been clearly demonstrated by in vivo applications of MSC-CM, but the establishment of controlled delivery systems is an unmet requirement for clinical translation. Methods: We...
Research
Mesenchymal stromal cell conditioned medium (MSC-CM) contains a cocktail of bioactive factors that act synergistically to induce therapeutic effects. This has been clearly demonstrated by in vivo applications of MSCCM, but the establishment of controlled delivery systems is an unmet requirement for clinical translation. We developed a nanocomposite...
Article
Isoniazid (INH) is well-known as a crucial drug in all multiple drug treatment for tuberculosis (TB) as approved by the WHO. It is a small molecule and highly hydrophilic, has low cellular penetration. By modifying highly hydrophilic drugs into hydrophobic will help in enhancing the cellular penetration of the drug and this, in turn, improves the t...
Article
Full-text available
Fluocinolone acetonide (FA), a glucocorticoid is used to treat inflammation in the posterior segment of the eye. Due to short half-life and body clearance, it will not be able to give therapeutic effect for long time with a single injection. Formulating FA nanoparticles (NPs) or PEG conjugates can be an effective way to overcome these disadvantages...
Article
Full-text available
Introduction Tuberculosis (TB) is the single largest infectious disease which requires a prolonged treatment regime with multiple drugs. The present treatment for TB includes frequent administration of a combination of four drugs for a duration of 6 months. This leads to patient’s noncompliance, in addition to developing drug-resistant strains whic...
Article
Full-text available
Objective: The objective of the study was to develop and validate a simple and reproducible reverse phase high pressure liquid chromatography (RPHPLC) method for hydrophilic drug isoniazid (INH) to apply for the analysis of the INH in nanoparticle drug formulations. Furthermore, to estimate simultaneously rifampicin (RIF) and INH in combined form.M...
Article
Tuberculosis (TB), has been a serious global health problem, resulting in millions of deaths annually. In India itself, 40% of the population are having Latent TB infection and approximately 10% of infected individuals have higher risk of developing active disease, especially those who are immune compromised like HIV infected and patients on immune...
Chapter
Steroids like glucocorticoids, assist in reducing internal inflammation due to their anti-inflammatory properties. A sustained release of these steroids will help reduce the severe side effects. In this present study, nanoparticles (NPs) of poly (d,l-lactide-co-glycolide) (PLGA)—50:50 were prepared by emulsification method, with Polyvinyl alcohol (...
Article
Hyaluronic acid has a wide range of biomedical applications and its commercial value is highly dependent on its purity and molecular weight. This study highlights the utility of aqueous two phase separation as a primary recovery step for hyaluronic acid and for removal of major protein impurities from fermentation broths. Metabolically engineered c...
Article
Several promising anti-cancer drug candidates have been sidelined owing to their poor physicochemical properties or unfavorable pharmacokinetics, resulting in high overall cost of drug discovery and development. Using alternative formulation strategies that alleviate these issues can help advance new molecules to the clinic at a significantly lower...
Article
The oral absorption of drugs that have poor bioavailability can be enhanced by encapsulation in polymeric nanoparticles. Transcellular transport of nanoparticle-encapsulated drug, possibly through transcytosis, is likely the major mechanism through which nanoparticles improve drug absorption. We hypothesized that the cellular uptake and transport o...
Article
Retinal neuroinflammation, mediated by activated microglia, plays a key role in the pathogenesis of photoreceptor and retinal pigment epithelial cell loss in age-related macular degeneration and retinitis pigmentosa. Targeted drug therapy for attenuation of neuroinflammation in the retina was explored using hydroxyl-terminated polyamidoamine (PAMAM...
Conference Paper
Nanoparticles of highly insoluble drugs can be created by flash nanoprecipitation, FNP. Turbulent mixing combined with a polymer stabilizer produces particles in the 100 nm size range, ideal for passive targeting of tumors and advantageous to increase solubility. We have used FNP to create nanoparticles containing a series of labile silicate prodru...
Article
Chlamydia trachomatis and Chlamydia pneumoniae are intracellular bacterial pathogens that have been shown to cause, or are strongly associated with, diverse chronic diseases. Persistent infections by both organisms are refractory to antibiotic therapy. The lack of therapeutic efficacy results from the attenuated metabolic rate of persistently infec...
Article
Full-text available
Understanding the interactions between nanomaterials and disease processes is crucial for designing effective therapeutic approaches. This article explores the unusual neuroinflammation targeting of dendrimers (with no targeting ligands) in the brain, with significant consequences for nanoscale materials in medicine. The in vivo biodistribution of...
Article
Dendrimers are an emerging class of nanoscale intracellular drug delivery vehicles. Methylprednisolone (MP) is an important corticosteroid used in the treatment (through inhalation) of lung inflammation associated with asthma. The ability of MP-polyamidoamine (PAMAM) dendrimer conjugate to improve the airway delivery was evaluated in a pulmonary in...
Article
Nanoparticles formulated using poly(d,l-lactide-co-glycolide) (PLGA) copolymer have emerged as promising carriers for targeted delivery of a wide variety of payloads. However, an important drawback with PLGA nanoparticles is the limited types of functional groups available on the surface for conjugation to targeting ligands. In the current report,...
Conference Paper
Neurodegenerative diseases such as retinitis pigmentosa and age related macular degeneration are due to degeneration of photoreceptor cells of retina. Though some of the neuroprotective drugs like fluocinolone acetonide (FA) are available for treatment, it is difficult to deliver therapeutic amount of drug to the outer retina for a sustained period...
Conference Paper
Neurodegenerative diseases such as retinitis pigmentosa and age related macular degeneration are due to degeneration of photoreceptor cells of retina. Though some of the neuroprotective drugs like fluocinolone acetonide (FA) are available for treatment, it is difficult to deliver therapeutic amount of drug to the diseased site for a sustained perio...
Article
Nine-million Americans suffer progressive vision loss due to retinal neurodegenerative diseases such as age-related macular degeneration (AMD), diabetic retinopathy, glaucoma and retinitis pigmentosa. Number will grow by an estimated 200,000 new cases per year as the aged population in the society increases. An emerging body of literature has ident...

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Projects

Project (1)
Project
To combine surgery and post operative care in cataract patients