Bhakti Bhusan Barik

• M. Pharm, Ph. D., FIC
• Professor (Full) at College of Pharmacy, Jazan University, Kingdom of Saudi Arabia.

Antibiotic treatment for bacterial infection is becoming a big challenge due to the expression of a resistant factor which is a major hurdle in curing the infectious diseases, especially nosocomial infections. Globally, multiple drug resistance has emerged as a major public health problem. Nanotechnology is the most unique technology that can effic...

A simple, specific and accurate isocratic RP-HPLC-DAD method was developed for the simultaneous determination of phenylephrine, paracetamol, caffeine and chlorpheniramine in bulk and tablet dosage form. The four contents are present in variable concentrations and have variable chromatographic behavior making the process of analysis very difficult....

Background: In the present scientific era, use of nanoparticles for antibiotic delivery is increasing due to increased prevalence of antibiotic resistant bacterial strains. The aim of this study was to formulate and characterize chitosan nanoparticles of penicillin G delivery to improve the bioavailability and prevent drug resistance. Method: In th...

The present work attempts to formulate and evaluate hollow microcapsules of an antihypertensive drug--ramipril, which will remain in vicinity of absorption site. The emulsion diffusion solvent evaporation method was employed for preparation of microspheres using Eudragit E100. Glycerol monostearate and sodium lauryl sulfate were used as surfactants...

Nanoparticles mediated vaccine delivery is an emerging technology and considered as better adjuvant for delivering vaccines when compared to conventional delivery system. The purpose of this delivery system is to provide simple stable formulation that elicits lifelong immunity preferably with single shot. In line to develop the biodegradable polyme...

The objective of the research work was to develop and characterize rifampicin (RIF) loaded Poly-ε-caprolactone nanoparticle (PCL NP). PCL NP containing RIF were prepared using single emulsion solvent evaporation method. The formulations were characterized through transmission electron microscopy (TEM), size and size distribution analysis, polydispe...

The purpose of the research was to design and development of gastro retentive floating tablets of cefixime trihydrate by statistical optimization technique and to investigate the effect of formulation variables on drug release characteristics. Guar gum (viscoelastic agents), sodium alginate (gelling agent) and sodium CMC (channeling agent) were use...

Poly-ε-caprolactone (PCL) is a biodegradable, biocompatible and semicrystalline polymer having a very low glass transition temperature. Due to its slow degradation, PCL is ideally suitable for extended drug delivery system over a period time. Coupled with relatively inexpensive production cost and Food and Drug Administration (FDA) approval, this p...

The objective of this study was to formulate and evaluate the drug-polymer interaction of Didanosine using two polymers with different characteristics as Ethyl cellulose or Cellulose acetate phthalate. Microspheres were prepared by the emulsion solvent evaporation. The effect of drug-polymer interaction was studied for each of microspheres. Importa...

The present study was aimed at enhancing the entrapment efficiency of highly water soluble Isoniazid (INH) nanoparticles using the biodegradable polymers, Poly-ε-caprolactone (PCL) by varying the different formulation parameters such as polymer ratio, amount of drug loading (w/w), solvent selection, electrolyte addition and pH in the formulation. T...

The present study involves preparation and characterization of floating microcapsules with simvastatin as model drug for prolongation of gastric residence time. The main objective is to improve solubility of simvastatin beta-CD complex (1:2) by co-precipitation method and then to deliver the same in sustained release dosage form. Sustained-release...

of Saudi Arabia 2 , Pioneer Pharmacy Degree college-vadodara 3 Department of Pharmacology, Dadhichi College of pharmacy-Cuttack 4 . ABSTRACT The present study was aimed at developing a sustained release formulation of Isoniazid (INH) nanoparticles using the biodegradable polymers, poly-e-caprolactone (PCL) as carrier. The PCL nanoparticles (NP) of...

The aim of this work was to study the formulation and in vitro characterization of hydro dynamically balanced floating matrix tablets using Cefuroxime axetil (CA) as model drug. Different excipients such as hydroxy propyl methyl cellulose (HPMC) K15M, E5LV (gelling agent), sodium bicarbonate (gas generating agent) and sodium lauryl sulfate (SLS) (s...

The present study involves preparation and characterization of floating multiparticulate microcapsules with Simvastatin as model drug for prolongation of gastric residence time. The main objective is to improve solubility of simvastatin beta-CD complex (1:2) by co-precipitation method and then to deliver the same in sustained release dosage form. S...

The present work is aimed at investigations of the effects of various stabilizers and process parameters on the properties of budesonide (glucocorticoid steroid) loaded PLGA (Poly-dl-lactide-co-glycolide) nanoparticles. Budesonide loaded PLGA nanoparticles were prepared following high pressure emulsification-solvent evaporation technique. The effec...

Purpose: To formulate theophylline microspheres with cellulose acetate using solvent evaporation method and evaluate the effect of various processing factors on their characteristics.Methods: Microspheres containing theophylline were prepared with a hydrophilic, biocompatible polymer - cellulose acetate - by an emulsion solvent evaporation techniqu...

Budenoside (glucocorticoid steroid) loaded Poly (lactide-co-glycolide) nanoparticles were prepared by high-pressure emulsification-solvent evaporation technique. Effect of three different stabilizers, polyvinylalcohol (PVA), carbomer (Carbopol 980) and poloxamer (Lutrol F-68) is used during emulsification along with different homogenization paramet...

Indinavir sulfate with ethyl cellulose microspheres was successfully prepared by an oil-in-oil emulsion solvent evaporation technique using acetonitrile: dichloromethane (1:1) and light liquid paraffin as primary and secondary oil phases respectively with span 80 as a droplet stabilizer. In present study the effect of formulation variable e.g., pol...

The present work is aimed at investigations of the effects of various stabilizers and process parameters on the properties of budesonide (glucocorticoid steroid) loaded PLGA (Poly-dl-lactide-co-glycolide) nanoparticles. Budesonide loaded PLGA nanoparticles were prepared following high pressure emulsification-solvent evaporation technique. The effec...

A simple, specific and isocratic reversed phase-high performance liquid chromatography (RP-HPLC) method with UV detection at 294 nm was developed and validated for analysis of Moxifloxacin Hydrochloride (MOXI) in presence of its degradation products. Retention time of the MOXI was found to be 7.8 min. A mobile phase consisting of 10mM sodium phosph...

Budenoside (glucocorticoid steroid) loaded Poly (lactide-co-glycolide) nanoparticles were prepared by high-pressure emulsification-solvent evaporation technique. Effect of three different stabilizers, polyvinylalcohol (PVA), carbomer (Carbopol 980) and poloxamer (Lutrol F-68) is used during emulsification along with different homogenization paramet...

The present work reports the study of different Lamivudine (LAM): excipient formulations, in order to determine the effect of the polymer substitution and type of diluents on the drug-release mechanism. Seven formulations were prepared using either HPMC K15M alone or in combination with Ethyl Cellulose (EC). Release kinetics was evaluated by using...

A reverse phase high performance liquid chromatographic (HPLC) method was developed for the assay of Cefditoren pivoxil in bulk forms and tablet dosage formulations. Isocratic separation was achieved on Nucleosil 100-5 C18 column (250mm×4.6mm i.d.,5mm particle size) using a mobile phase of water: methanol in the in ratio (20:80), pH 6.0 adjusted wi...

In the present research work mouth dissolving tablets of domperidone were developed with superdisintegrants like crospovidone, croscarmellose sodium and sodium starch glycollate in various concentrations like 3%, 4% and 6% w/w by direct compression method. All formulations were evaluated for physical characteristics of compressed tablets such as we...

A stability-indicating high performance liquid chromatographic (HPLC) method was developed for the assay of Prulifloxacin in bulk and tablet dosage formulations. Isocratic separation was achieved on Nucleosil 100-5 C18 column (250mm×4.6mm i.d.,5mm particle size) using a mobile phase of water: acetonitrile in the in ratio (20:80), pH 3.3 adjusted wi...

A reverse phase high performance liquid chromatographic (HPLC) method was developed for the assay of Cefditoren pivoxil in bulk forms and tablet dosage formulations. Isocratic separation was achieved on Nucleosil 100-5 C18 column (250mm×4.6mm i.d.,5mm particle size) using a mobile phase of water: methanol in the in ratio (20:80), pH 6.0 adjusted wi...

Purpose: To examine the pharmacokinetics of a formulated aceclofenac sustained release tablet formulation and determine if it is bioequivalent to a commercial brand of aceclofenac immediate release tablet (Zerodol ® 100 mg). Methods: Each of two groups of twelve fasting volunteers received either the reference standard (Zerodol 100 mg tablets) or t...

Purpose: The objective of the study was to develop matrix tablets for oral controlled release of aceclofenac using ethyl cellulose, guar gum and various grades of cellulose polymers. Methods: Possible drug-excipient interaction was evaluated by high performance liquid chromatography (HPLC) and Fourier infrared spectroscopy (FTIR). The tablets prepa...

The aim and objective of the present investigation is to study the effect of chitosan on the various characteristics of Eudragit RS 100 and ethyl cellulose microspheres which were formulated by o/o emulsion, solvent evaporation method using methanol, acetone, light liquid paraffin system. Effect of chitosan was evaluated on several aspects such as...

The petroleum ether, chloroform, acetone, methanol and aqueous extracts of the aerial parts of Leptadenia reticulata Wight and Arn. (Asclepiadaceae) were studied for in vitro antifungal activity against Aspergillus flavus, Aspergillus ruantti, Candida tropicalis, Candida albicans, Trichodermata viride and Trichodermata koningii respectively. The me...

The purpose of the present study is to develop and optimize controlled release matrix tablets containing zidovudine (AZT) as model drug by optimization technique. A 23 factorial design was employed in formulating the matrix tablets with taking concentration of hydroxy propyl methyl cellulose (HPMC) K4M (X1), ethyl cellulose (X2) and types of filler...

The present investigation highlighted the formulation and optimization of losartan potassium tablets. To achieve this goal, various formulation of losartan potassium tablets were prepared and evaluated with respect to the various quality parameters both in process parameters for granules (loss on drying, bulk density, tapped density, compressibilit...

The methanolic extract of stem bark of Polyalthia longifolia var. Pendula was evaluated for its antidiabetic activity in alloxan induced diabetic rats as well as euglycaemic rats. The extract showed significant antihyperglycaemic activity after a single dose of 100 mg/kg in alloxan induced diabetic rats (p<0.05). The antihyperglycaemic activity was...

The objective of the study was to develop matrix tablets for oral controlled release of aceclofenac. Matrix tablets of aceclofenac, using various viscosity of hydrophilic polymer HPMC in two different proportions, hydrophobic polymer ethyl cellulose and Guar gum were prepared by wet granulation method and subjected to in vitro drug release studies....

Effect of petroleum ether extract of peel of Benincasa hispida (Thumb.) Cogn. (Family-Cucurbitaceae) was studied for hypoglycemic properties in alloxan induced diabetic rats. Petroleum ether, benzene, chloroform, methanol and aqueous extract of B. hispida peels were assessed by blood glucose, serum urea, serum cholesterol and serum triglyceride lev...

The present study was carried out in order to mask the bitter taste of the Etoricoxib by complexation with cation-exchange resin, Indion 204. The drug resin complexes (DRC) were prepared by batch process and efficient drug loading was obtained by using inactivated form of resin in the drug-resin ratio 1:3.3 with 30 min swelling time of resin in 25...

Glibenclamide (GL)-loaded microcapsules (MC) and transdermal patches (TDP) were formulated and in vitro and in vivo parameters compared to find out the best route of drug administration. The formulation TDP1 having a drug-polymer ratio 1:1 showed comparatively higher GL release and better permeation across mice skin (p < 0.05). From the comparative...

The investigation was concerned with design and characterization of oral controlled release matrix tablets of Zidovudine (AZT) in order to improve efficacy and better patient compliance. Tablets were prepared by direct compression method using various proportion of hydrophilic polymer viz; Eudragit RS100 and RL100 along or in combination with hydro...

Hydrophilic matrix tablets of Isosorbide - 5 - mononitrate (ISMN) were formulated using three viscosity grades of Hydroxy Propyl Methyl Cellulose viz. K4M, K15M, K100M (4000, 15000, 100000 cps at 2% aqueous solution) with 5 different ratio of drug:polymer (1:1, 1:1.5, 1:2, 1:2.5, and 1:3) of individual polymer taking other excipients as same for al...

Present investigation highlights the formulations and statistical optimization of Cefuroxime Axetil (CA) floating matrixtablets. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroximehaving poor absorption. Unabsorbed drug causes high concentration of antibiotics entering colon and...

In the present study aceclofenac-gelatin micropellets were prepared by the cross linking technique using gluteraldehyde as cross linking agent and characterized by X-ray diffractometry, differential scanning calorimetry and scanning electron microscopy. The effect of drug: polymer ratio, temperature of oil phase, amount of gluteraldehyde and stirri...

A sustained release system for ciprofloxacin hydrochloride designed to increase its residence time in the stomach was achieved through the preparation of floating microparticles by the solvent diffusion technique, using Eudragit S 100 and Eudragit RL 100 polymers. Eight different ratios of Eudragit mixture were used for the formulation, all of whic...

Inspite of therapeutic discoveries and molecular understanding, diabetes mellitus still possesses a major threat globally where India has highest number of diabetic patients. A strategy must define the time-work horizons for the deliverables interms life-style and health education to prevent or mitigate diabesity, prevent insulin resistance. New de...

Purpose: The purpose of the present investigation was to formulate and evaluate microencapsulated glipizide produced by the emulsion – solvent evaporation method, Method: Microspheres were prepared using polymethacrylate polymers (Eudragit® RS 100 and RL 100) by solvent evaporation method and characterized for their micromeritic properties and drug...

Sustained drug delivery systems can improve patient compliance and provide extended periods of effective blood levels. In an approach, polymers and their blend are used in various formulations to achieve sustained drug release. The authors investigated various natural, semisynthetic and synthetic polymeric materials. Most thoroughly investigated an...

Alginate beads of aceclofenac were formulated by ionotropic gelation technique using sodium alginate. Prepared beads were evaluated for micromeritic, scanning electron microscopy and drug-polymer compatibility, X-ray powder diffractometry, drug entrapment efficiency and in vitro dissolution studies etc. The prepared beads were white and free flowin...

Eudragit RS PO microspheres containing stavudine as a model drug were prepared by the solvent evaporation method using acetone liquid paraffin system. The influence of processing temperature: 10, 30 and 40 degrees C on various parameters like particle shape, size distribution, drug loading, drug polymer interaction and release kinetic were studied....

Purpose: The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water-soluble drug, stavudine, using Copolymers synthesized from acrylic and methacrylic acid esters (Eudragit RS 100 and RL 100) as the retardant material. . Methods: Microspheres were prepared by solvent evaporation method us...

The aqueous extract of the leaves of Vitex pinnata at the doses of 200 and 400 mg/kg was tested for antipyretic activity. Brewer's yeast was used to induce pyrexia in albino rats of wistar strain. The extract showed significant dose dependent antipyretic activity. The wound healing efficacy of the aqueous extract (10% ointment in simple ointment ba...

The aim of this study was to formulate and evaluate microspheres of stavudine by water-in-oil-in-oil (w/o/o) double emulsion solvent diffusion method using ethyl cellulose and ethyl cellulose in combination with polyvinyl pyrrolidone. A mixed solvent system consisting of acetonitrile and dichloromethane in an 1: 1 ratio and light liquid paraffin wa...

A new simple, sensitive spectrophotometric method in UV region has been developed for the estimation of ondansetron in bulk and solid dosage form. It shows maximum absorbance at 310 nm with water. Beer′s law obeys in the concentration range of 5-15 µg/ml. Results of the analysis were validated statistically and by recovery studies.

A comparison was made between the hypolipidemic activities of five different marketed herbal formulations along with a prepared formulation in triton induced hyperlipidemic rats. Various parameters such as serum Cholesterol and Triglycerides were determined before 24 hours of triton administration and in two different phases (synthesis and excretor...

Microcapsules of isoniazid were prepared by phase separation coacervation process induced by non-solvent addition and using ethylcellulose (EC) as coating polymer. When polyisobutylene (PIB)--a protective colloid was present at sufficient concentration, film coated drug particles were formed. At 0-6% PIB concentration, the microcapsules were aggreg...

Purpose: The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water-soluble drug, stavudine, using Copolymers synthesized from acrylic and methacrylic acid esters (Eudragit RS 100 and RL 100) as the retardant material. . Methods: Microspheres were prepared by solvent evaporation method us...