Beyhan Cengiz

Beyhan Cengiz
Gazi University · Department of Medical Genetics

PhD

About

193
Publications
11,340
Reads
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1,691
Citations
Additional affiliations
May 2014 - present
Gazi University
Position
  • Professor (Associate)
December 2008 - May 2014
Gaziantep University
Position
  • Professor (Associate)
December 2008 - May 2014
Gaziantep University
Position
  • Professor (Associate)

Publications

Publications (193)
Article
We previously showed two members of the ING family, ING1 and ING3 as a tumor suppressor gene in head and neck cancer. Progress in human genome sequencing provided additional information of the new members of the ING family genes. ING4 is localized to chromosome 12p13.31 region and harbors the PHD domain highly homologous among ING family proteins....
Article
We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were d...
Article
C-kit is a trans-membrane receptor tyrosine kinase (RTK) encoded by the proto-oncogene KIT located at 4q11-12. Gain-of-function mutations arising to c-kit activation independent of its ligand were observed in various tumors related to germ cells, mast cells, and interstitial cells of Cajal. C-kit also participates in melanocyte development; hence,...
Article
The epidermal growth factor receptor (EGFR)-RAS-RAF-mitogen-activated protein kinase signaling cascade is an important pathway in cancer development and recent reports show that EGFR and its downstream signaling molecules are mutated in a number of cancers. We have analyzed 91 Japanese head and neck squamous cell carcinomas (HNSCC) and 12 HNSCC cel...
Article
Our previous study showed high frequency of allelic loss at chromosome 2q37 region in oral cancer. This location contains several candidate tumor suppressor genes such as PPP1R7, ILKAP, DTYMK and ING5. We previously showed 3 members of inhibitor of growth (ING) family, ING1, ING3 and ING4 as tumor suppressor gene in head and neck cancer. As ING5 sh...
Article
Background Rhinitis medicamentosa, also known as ‘rebound congestion,’ is inflammation of the nasal mucosa caused by the overuse of topical nasal decongestants. Although local decongestants resolve the initial nasal obstruction, the overuse causes rebound obstruction. However, how the overuse of the decongestant causes rhinitis medicamentosa is not...
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Full-text available
Objective Migraine, a highly prevelant headache disorder, is regarded as a polygenic multifactorial disease. Serotonin (5-HT) and their respective receptors have been implicated in the patogenesis. Methods We investigated the 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor gene polymorphisms and their association with migraine in Turkish patients. The...
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Acute Myeloid Leukemia (AML) is a hematopoietic stem cell disorder. Many of the tumor development steps are processes regulated by Ca2+ dependent signaling pathways found in tumor growth. Calcium channels, which can be blocked by pharmacological agents such as verapamil, are important in the regulation of intracellular Ca2+ homeostasis. The failure...
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Background/aim: The objective of this experimental study was to examine the effects of epinephrine, dexmedetomidine, and clonidine added as adjuvants to bupivacaine on block onset and effect times, as well as the effects on the Na+ and Ca+2 channel gene expressions, which may indicate cell damage in the sciatic nerve cell membrane. Materials and...
Article
Migraine, a highly prevalent headache disorder, is regarded as a polygenic multifactorial disease. Single-nucleotide polymorphisms (SNPs) in the genes that involved in sex hormone metabolism may comprise risk for migraine, but the results of previous genetic association studies are conflicting. The aim of this study was to evaluate genetic variants...
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Objectives: Ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. Many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. Lung damage induced by ischemia/reperfus...
Article
Background: The inhibitor of growth (lNG) tumour suppressor gene family has been discovered over the past decade and five different genes have been idenüfied from lNG1 to lNG5. They have functions like cell transcripüon regulation, cell cycle control, DNA repair and apoptosis. Because of the fact that lNG3 gene expression has not been studied in br...
Conference Paper
Full-text available
Obesity is a multifactorial disease which is a risk factor for many diseases with increasing prevalence all over the world in recent years. Genetic predisposition plays an important role in the development of obesity. Identification of genetic factors that cause the disease and to reveal the relationship with the population will increase the succes...
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Objectives: This study aims to determine monocyte expression levels of interleukin 1 beta (IL-1β), IL-6, IL-8, and tumor necrosis factor alpha in fibromyalgia syndrome (FMS) patients and healthy females. Patients and methods: A total of 80 female FMS patients and 50 healthy females were evaluated. Twelve of the FMS patients who did not meet the 199...
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Unlabelled: Colorectal cancer (CRC) is the most common cancer of the gastrointestinal tract. Different factors are responsible for the development of CRC. Transient Receptor Potential (TRP) which is an important component of calcium channel is associated with several pathological conditions like cancer, neurodegenerative and cardiovascular disease...
Article
It is known that high-dose radiation has an effect on tissue healing, but tissue healing does not occur when low dose radiation is applied. To clarify this issue, we compare the treatment success of low dose radiation with programmed cell death mechanisms on wounded tissue. In this study, we aimed to investigate the interactions of low and high-dos...
Article
Full-text available
The aim of the present study was to compare the effectiveness of four different laser wavelengths used for low-level laser therapy(LLLT) on healing of mucositis in an animal model of wound healing, by investigating expression of transient receptor potential melastatin(TRPM) ion channels. Forty-five rats were intraperitoneally injected with 100 mg/k...
Article
Full-text available
It is known that high-dose radiation has an effect on tissue healing, but tissue healing does not occur when low dose radiation is applied. To clarify this issue, we compare the treatment success of low dose radiation with programmed cell death mechanisms on wounded tissue. In this study, we aimed to investigate the interactions of low and high-dos...
Article
Full-text available
Uridine 5'-diphospho-glucuronosyltransferases (UGT) are the key players in the biotransformation of drugs, xenobiotics, and endogenous compounds. Particularly, UDP-glucuronosyltransferase 1A (UGT1A) participates in a wide range of biological and pharmacological processes and plays a critical role in the conjugation of endogenous and exogenous compo...
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In loss of heterozygosity (LOH) studies at the chromosome 4q22-35 region, it was shown that the amount of deletion was high in basal cell carcinoma (BCC). It has been proposed that genes located in this chromosomal region could be tumor suppressor genes in BCC. It has been thought that deletions in the ING2 gene located in the same region can play...
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Full-text available
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which catalyzes the formation of reactive oxygen species (ROS) in phagocytic cells, has five subunits: p67phox ("phox"refers to "phagocyte oxidase"), p47phox, p40phox, p22phox, and gp91phox (catalytic subunit). Oxidative stress resulting from the accumulation of ROS and/or defective remov...
Conference Paper
AMAÇ Lokal dekonjestanların kısa süreli kullanımı nazal tıkanıklığı açarken, uzun süreli kullanımı daha şiddetli tıkanıklıkla kendini gösteren rinitis medikamentoza(RM) tablosuna neden olmaktadır. Lokal vazokonstriktörlerin aşırı kullanımında toksisiteye sebep olduğu gösterilmiş olup patofizyolojisini aydınlatan bir çalışma bulunmamaktadır. Biz bu...
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Cancer is a consequence of accumulation of genetic and epigenetic alterations in the cell which can lead to activation of oncogenes or inactivation of tumor suppressor genes (TSG). Since members of ING family were discovered as TSGs in different cancer types, it was aimed to analyze the chromosome 13q33-34 region, ING1 and p53 genes in bladder canc...
Article
Background: Breast cancer is the most common cancer type among woman. Ion channels are important for different physiologic functions as muscle contraction and hormone secretion. Recently the effect of Transient Receptor Potential (TRP) channels on calcium balance, cell proliferation, cell differantiation, tumor invasion, oncogen regulation and resi...
Conference Paper
Full-text available
Research for Mutation and Polymorphism of MC4R (Exon) and FTO (1. intron) Genes in Obese Patients Obezite son yıllarda tüm Dünya’da artan prevalansı ile birlikte birçok hastalık için risk faktörü olan multifaktöriyel bir hastalıktır. Obezite gelişiminde genetik yatkınlık önemli rol oynamaktadır. Hastalığa neden olan genetik faktörlerin belirlenmes...
Conference Paper
Amaç: İskemi, organ ve dokunun yetersiz perfüzyonu sonucu, oksijenden yoksun kalması şeklinde tanımlanmaktadır. İskemik dokunun reperfüzyonu, dokuda paradoksal olarak iskemi ile oluşan hasara göre, çok daha ciddi bir hasara yol açar. İskemi/Reperfüzyon (İ/R) ile indüklenen akciğer hasarı, akciğer tranplantasyonunda sık karşılaşılan bir durumdur. B...
Conference Paper
Amaç: Dünyadaki en önemli sağlık problemleri olan kardiyovasküler hastalıkların başında miyokardiyal iskemi (MI) ilk sırayı oluşturmaktadır. MI, mekanizma olarak kalbi besleyen koroner arterlerin tıkanması sonucunda oluşan patolojidir. Yapılan çalışmalarda iskemi sonrası reperfüzyon hasarının iskemiden daha çok olduğu bulunmuştur. Bu hasarla ilgili...
Conference Paper
Amaç: Böbrekteki iskemi-reperfüzyon hasarı (İ/R), moleküler basamakları tam olarak aydınlatılamamış, bir patofizyolojik süreçtir. İskemik hasarın derecesi, hipoksinin derinliğine bağlı olmakla birlikte hücre ölümüne kadar uzanan moleküler basamakları tetikler. Çalışmamızda iskemi gibi stres durumunda böbrek hücrelerinde Ca++ kanal blokeri verapamil...
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Background Urotensin II is a vasoactive polypeptide. It is known that some vasoactive polypeptides are produced and secreted by tumor cells, and act as a paracrine growth stimulant. The aim of this study was to examine the relationship between urotensin II and its receptor’s messenger RNA expression in breast cancer. Material/Methods Fifty-nine wo...
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A subset of renal cell carcinoma (RCC) patients has been shown to respond to anti-EGFR therapy. As KRAS and BRAF mutations are associated with poor response to anti-EGFR therapy in some cancers, it has been suggested that screening for KRAS and BRAF mutations in RCC may be a promising strategy to identify patients who might respond to EGFR-targeted...
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The purpose of this study was to investigate the possible association between childhood epilepsy and KCNJ10 gene polymorphisms (rs61822012 and rs2486253). A total of 200 epileptic cases and 200 healthy controls enrolled to this study. Genomic DNAs from the patients and control cases were analyzed by polymerase chain reaction (PCR) and restriction f...
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The tubers of Bongardia chrysogonum, which are used in the folk medicine in the form of 2-3% decoction in the province of Gaziantep, are supposed to treat urinary track, prost-hate disorders, and hemorrhoid. The objective of this study was to assess the effect of these tubers on some serum parameters and spleen, liver, and kidney tissues in rats. O...
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Rho/Rho-kinase pathway plays a critical role in the regulation of cellular functions such as proliferation and migration. One of the possible theories of the development of ventricular septal defects is cell migration disorder. The aim of this study was to analyze the genotype distributions and allele frequencies for the ROCK2 gene Thr431Asn polymo...
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Background: Migraine has a complex etiology determined by genetic and environmental factors, but the molecular mechanisms and genetics of this disease have not yet been fully clarified. Aim: This case/control study was designed to analyze the genotype distributions and allele frequencies for the Rho-kinase 2 (ROCK2) gene Thr431Asn polymorphism a...
Article
Background To determine effects on calcium and sodium channels of Ca2+ and Na+ channel blockers in the present study, expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, TRPM8, and NaV1.9 genes were evaluated in kidney tissues after induced ischemia-reperfusion. Material and methods Forty albino Wistar male rats were equally divi...
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Full-text available
In the present study, the expression levels of TRPM1, TRPM2, TRPM3, TRPM4, TRPM5, TRPM6, TRPM7, and TRPM8 genes were evaluated in heart tissues after ischemia/reperfusion (IR). For this study, 30 albino male Wistar rats were equally divided into three groups as follows: Group 1: control group (n:10), Group II: ischemia group (ischemia for 60 min) (...
Article
513 Background: Different factors are effective in the development of colorectal cancer (CC). With the discovery of that TRP (transient receptor potential) genes family is an important component of calcium channel, about 30 members of the family of TRP ion channel in mammals have been determined up to the present. TRP channels are associated with m...
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Full-text available
To determine the roles of hepcidin and its related genes in a renal ischemia/reperfusion model. A total of 20 Wistar albino rats were equally divided into 2 groups: Group I was the control group and Group II was the ischemia and reperfusion (I/R) group (60 min of ischemia + 48 h of reperfusion). I/R was performed on the left kidneys of these rats a...
Conference Paper
Full-text available
Amaç: Hepsidin, demir metabolizmasında ana kontrol merkezi konumunda olmasının yanında demir metabolizması ile inflamasyon ve immün sistem arasındaki bağı sağlayan moleküldür. İ/R’ye sebep olan hastalıkların hepsidin üretimine ve metabolizmasına olan etkisinin fizyolojik ve genetik mekanizmasını belirlemek amacıyla renal i/R yapılarak serumdaki hep...
Article
Full-text available
The aim of the present study was to compare the effectiveness of four different laser wavelengths (660, 810, 980, and 1,064 nm) used for low-level laser therapy (LLLT) on the healing of mucositis in an animal model of wound healing by investigating the expression of platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), and...
Article
Behcet's Disease (BD) is multisytemic vasculitis or chronic inflammation that may lead to various autoimmune and autoinflammatory syndromes. Exact etiopathogenesis of BD has not been clarified yet. Urotensin II (UTS-II) is predominantly a vasoactive peptide and Thr21Met polymorphism in UTS-II gene was proved to increasing in some autoimmune disease...
Article
Full-text available
Background: MicroRNAs (miRNAs) are small RNAs that regulate gene expression by suppressing protein translation and may influence RNA expression. MicroRNAs are detected in extracellular locations such as plasma; however, the extent of miRNA expression in plasma its relation to cardiovascular disease is not clear and many clinical studies have utiliz...