Betul Aydin

Betul Aydin
Gazi University · Department of Biology

Doctor of Education

About

29
Publications
2,860
Reads
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224
Citations
Additional affiliations
March 2009 - present
Gazi University
Position
  • Research Assistant
Education
February 2012 - March 2018
Gazi University
Field of study
  • molecular biology
September 2008 - August 2011
Gazi University
Field of study
  • probiotic biotechnology

Publications

Publications (29)
Article
Full-text available
Substitution reaction of hexachlorocyclotriphosphazatriene (trimer; N3P3Cl6; HCCP) with N,N'-bis(4-fluorobenzyl)ethane-1,2-diamine (1) gave the starting compound tetrachlorobis(4-fluorobenzyl)monospiro(N/N)cyclotriphosphazene (2). Tetraaminobis(4-fluorobenzyl)spiro(N/N) cyclotriphosphazenes (2a-2c) were synthesized from the substitution reactions o...
Article
Full-text available
Mono-/dispirocyclotriphosphazenes with pendant arm(s) are robust, but they are less investigated inorganic ring systems. In this study, a series of mono (3 and 4)- and dispirocyclotriphosphazenes with 4-chloro-benzyl pendant arm(s) (13–16) was obtained from the Cl exchange reactions of hexachlorocyclotriphosphazene with sodium (N-benzyl)aminopropan...
Article
Full-text available
Pharmacological and biological activities of seaweeds are significant in terms of human health, functional food and cosmetic applications. One of the most striking properties of seaweeds is their an-tioxidant activity that protects cells from oxidative damage caused by free radicals that cause many diseases such as cancer, type 2 diabetes, obesity,...
Article
Full-text available
In the present study, the seaweeds belong to Phaeophyaceae (Cystoseira elegans Sauvageau 1912, Cystoseira amentacea (C.Agardh) Bory 1832, Padina crassa Yamada 1931) and Florideophyceae (Corallina elongata J.Ellis & Solander 1786) collected from nearby Iskenderun-Turkey of Mediterranean Sea were detected for their antimicrobial activities against se...
Article
Full-text available
The N3P3 ring of hexachlorocyclotriphosphazene, N3P3Cl6 (1) (HCCP; trimer), was used significantly as a scaffold for the syntheses of inorganic–organic-based hybrid cyclotriphosphazenes, as it is a highly robust skeleton among inorganic phosphorus–nitrogen ring systems. However, hybrid cyclotriphosphazenes with pendant arm(s) have been quite less e...
Article
Full-text available
The antibacterial activity of graphene nanostructures (GrNs) on glass (G) and nickel (Ni) substrates against Escherichia coli ATCC 35218 (Gram-negative) and Staphylococcus aureus ATCC 25923 (Gram-positive) has been researched in this study. GrNs have been synthesized via two different methods, namely, chemical vapor deposition (CVD) and plasma enha...
Article
Full-text available
Antibacterial activities of the methanolic extracts of Stypopodium schimperi (Kützing) Verlaque and Boudouresque, Halopteris filicina (Grateloup) Kützing, Dictyota dichotoma (Hudson) J.V.Lamouroux, Gracilaria bursa-pastoris (S.G.Gmelin) P.C.Silva, Ulva intestinalis Linnaeus species from the Iskenderun Bay, Turkey against Escherichia coli, Bacillus...
Chapter
Full-text available
Since human beings were created, they have interacted with other living organisms as part of nature. Some microorganisms like bacteria, viruses and yeasts that use people as hosts to continue their lives cause many infections. Some of these infections can be treated easily, while others spread rapidly among humans, resulting in epidemics and pandem...
Article
The N/N donor-type bromobenzyldiamines (1–3) were successively prepared by reduction of Schiff bases formed as a result of condensation reactions of 4-bromobenzaldehyde with aliphatic diamines. The Cl exchange reactions of hexachlorocyclotriphosphazene (HCCP; trimer; N3P3Cl6; 4) with the bidentate ligands (1–3) produced the new monospiro- (5–7) and...
Chapter
Full-text available
Gene therapy applications by using plasmid DNA (pDNA) drugs has been developed in the past two decades. After the improvement of in vitro transcription (IvT) methods, IvT mRNA based gene therapy has become a more useful alternative to pDNA for production of desired protein in the cells. One of the advantages of the IvT mRNA usage in gene therapy is...
Article
The Cl exchange reactions of hexachlorocyclotriphosphazene, N 3 P 3 Cl 6 , with two equimolar amounts of N-alkyl-N′-mono(4-fluorobenzyl)diamines (1–3), FC 6 H 4 CH 2 NH(CH 2 ) n NHR 1 (n = 2 and 3, R 1 = CH 3 or C 2 H 5 ), and N-alkyl-N′-mono(4-nitrobenzyl)diamines (4 and 5), NO 2 C 6 H 4 CH 2 NH(CH 2 ) n NHR 1 (n = 2, R 1 = CH 3 or C 2 H 5 ), led...
Article
Trans-[Pt(AMBi) 2 Cl 2 (1) in which AMBi is 2-acetoxymethylbenzimidazole, was synthesized and characterized by spectroscopic methods. Novel complex 1 was evaluated for its potential antiproliferative effect against three human cancer cell lines, including HeLa (human cervix cancer), MCF-7 (human breast cancer) and A549 (human non-small-cell lung ca...
Article
The cis- (5 and 6) and trans-dispiroferrocenylphosphazenes (7 and 8) containing ferrocenyl pendant arms were synthesized from the reactions of hexachlorocyclotriphosphazene, N3P3Cl6, with two equimolar amounts of the sodium salts of the ligands; [2-(N-ferrocenylmethylamino)-1-ethanoxide (1) and 3-(N-ferrocenylmethylamino)-1-propanoxide (2)]. The mo...
Article
Forms of discrimination such as racism, homophobia, and sexism have been negatively affecting the individuals that are being exposed to these both in daily life and in public aspect. In this study, the relationship between discriminatory attitudes, attachment styles, self-construal and sociodemographic variables were examined. Differences in discri...
Article
The aim of this study was to synthesize and evaluate plasmid DNA interaction of new platinum(II) complexes with some 2-substituted benzimidazole derivatives as carrier ligands which may have potent anticancer activity and low toxicity. Twelve benzimidazole derivatives carrying indole, 2-/or 3-/or 4-methoxyphenyl, 4-methylphenyl, 3,4-dimethoxyphenyl...
Article
Full-text available
The usage of Epilobium angustifolium L. in folk medicine against prostate and skin diseases encouraged us to investigate pBR322 DNA-binding ability, biological activities and chemical composition of wild growing Epilobium angustifolium L.’s methanolic, ethanolic and aqueous extracts from Canakkale, Turkey. DNA-binding activity was studied by agaros...
Article
The condensation reactions of hexachlorocyclotriphosphazene (N3P3Cl6, trimer) with the symmetric N2N2 or N2O2 donor type tetradentate bulky ligands (1-4) gave partly substituted spiro-bino-spiro (sbs) (5-8) trimeric phosphazenes. Compounds 5-8 reacted with pyrrolidine, morpholine and 1,4-dioxa-8-azaspiro[4,5]decane (DASD) to give octapyrrolidino- (...
Article
Full-text available
The reactions of octachlorocyclotetraphosphazene, N4P4Cl8, with N-alkyl-N-mono-ferrocenyldiamines, FcCH2NH(CH2)nNHR1 [n = 2, Fc = ferrocene, R1 = Me (1); n = 2, R1 = Et (2) and n = 3, R1 = Me (3)], led to the formation of monoferrocenyl-spirocyclotetraphosphazenes (4-6). When the reactions were carried out with excess pyrrolidine, morpholine and 1,...
Article
Full-text available
The condensation reactions of hexachlorocyclotriphosphazene, N3P3Cl6, with N-alkyl-N′-mono(4-nitrobenzyl)diamines (1–3), NO2PhCH2NH(CH2)n NHR1 (R1 = CH3 or C2H5), led to the formation of the mono(4-nitrobenzyl)spirocyclotriphosphazenes (4–6). The tetra-pyrrolidino (4a–6a), piperidino (4b–6b), and 1,4-dioxa-8-azaspiro[4,5]decaphosphazenes (4c–6c) we...
Article
A series of novel positional oximes (2a-2d), O-methyl oxime ethers (3a-3d), and O-benzyl oxime ethers (4a-4d) were synthesized in high yields starting from their corresponding methyl 3-, 4-, 6-, and 13-keto tetradecanoates. The synthesized compounds were characterized by ¹H NMR, ¹³C NMR, FT-IR, mass, and elemental analyses for their structures and...
Article
Full-text available
The salicylic acid salts of fully substituted mono(4-fluorobenzyl)spirocyclotriphosphazenes (10–15) were prepared. The structures of these phosphazenium salts (10a–15a) were determined by elemental analyses, FTIR and 1H, 13C{1H}, 31P{1H} NMR techniques. The crystal structure of 14a was verified by X-ray diffraction analysis. The thermal properties...
Article
Abstract Hexachlorocyclotriphosphazene, N3P3Cl6, and octachlorocyclotetraphosphazene, N4P4Cl8, were reacted with K2N2O2 salt of symmetric tetradentate ligand to obtain spiro-bino-spiro [(sbs) (2)] and 2,6-spiro-ansa-spiro [(2,6-sas) (3)] phosphazenes, respectively. The sbs was obtained in a very poor yield, whereas, 2,6-sas was obtained in a modera...
Article
Full-text available
The replacement reactions of the Cl-atoms in partly substituted spiro-ansa-spiro-cyclotriphosphazenes (7 and 8) with excess pyrrolidine, 4-(2-aminoethyl)morpholine, and 1,4-dioxa-8-azaspiro[4,5]decane in dry THF led to the formation of heterocyclic amine substituted cyclotriphosphazenes (9a-c and 10a-c). All cyclotriphosphazene derivatives were cha...
Conference Paper
Full-text available
Sideritis trojana Comparison of Biological Activity of Sideritis trojana and Sideritis athoa (Lamiaceae) Abstract The genus Sideritis belongs to the Lamiaceae family and comprises more than 150 species. Sideritis species are widely distributed in Turkey with 46 species, 36 subspecies and two varieties mainly in Marmara and Aegean regions. 36 specie...
Conference Paper
There are several biological activity studies about Salvia L. genus which is the largest genus of the family Lamiaceae. Several species of this genus were used for folk medicine. Ther is no study about Salvia siirtica Kahraman, Celep & Doğan which was described by Kahraman et al. in 2001 from Siirt Çatılı province. In this study antimicrobial activ...
Conference Paper
Phosphazenes (N=PX2)n are the compounds containing double bonds between phosphorus and nitrogen atoms which they may have the open chain (linear), cyclic or polymeric structures. Cyclophosphazenes are an important class of inorganic ring systems, and exhibit very different physical and chemical properties depending on the types and properties of th...

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