Betül Demirci

• Marmara University

Objective: The chemical composition and bioactive properties of essential oils, fatty oils and aqueous extracts of Prunus cerasifera, Malus sylvestris and Cornus mas were investigated. Material and Method: Antidiabetic, antimicrobial, anticholinesterase and antioxidant activities of P. cerasifera, M. sylvestris and C. mas were reported. The quantit...

Objective: This study aimed to analyze the chemical profile of volatile and non-volatile components of Narcissus tazetta subsp. tazetta (daffodil) is grown in Türkiye. The chemical profiles of fresh and dried flowers were analyzed using Headspace Solid-Phase Microextraction (HS-SPME) and Gas Chromatography-Mass Spectrometry (GC-MS) methods. The stu...

Anthemis pauciloba Boiss. var. pauciloba is one of four recognized varieties in Türkiye, locally known as “bol papatya.” Its flowers are traditionally used as a cold infusion to treat asthma. The aim of the research was to determine the chemical composition of essential oil (EO) of A. pauciloba var. pauciloba aerial parts obtained by hydrodistillat...

Salvia pachystachya is a medicinally promising plant species, yet its pharmacological properties remain underexplored. This study aimed to investigate its anatomical, phytochemical and bioactive characteristics to assess its therapeutic potential comprehensively. Microscopic analysis revealed distinctive anatomical features, including quadrangular...

Background/objectives: Fungal infections have significant health risks due to virulence factors like biofilms that lead to chronic and persistent infections. To decrease associated rates of morbidity and mortality, it is crucial to develop effective antifungal treatments. The present study aims to evaluate the bioactive potential of Ferulago spp....

Melaleuca alternifolia (tea tree) essential oil (TTO) is widely recognized for its anti-inflammatory and antimicrobial properties, attributed primarily to its major constituent, terpinen-4-ol. Kojic acid, a well-established compound used mainly in cosmetic formulations, exhibits potent antioxidant and broad-spectrum antimicrobial activities. In thi...

The genus Teucrium L., member of Lamiaceae, is represented by approximately 36 species in Türkiye. In this study, the essential oil composition of the aerial parts of Teucrium kotschyanum Poech collected from İzmir (Ödemiş) was investigated by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The major compounds were identif...

Cyclotrichium origanifolium, a plant widely used in Eastern and Southern Anatolia for culinary purposes, was subject of this study, which aimed to comprehensively evaluate its potential therapeutic applications. This research stands out due to its holistic approach, combining morpho-anatomical studies, chemical, and biological analyses to explore a...

Punica granatum L. (Pomegranate) grows naturally in a wide area from northwest Türkiye to western and northern Pakistan and is also cultivated throughout subtropical and tropical regions of the world. Pomegranate is in the form of a spiny shrub or a small tree. The barks, fruit peels, flowers, and seeds of the plant are used in traditional medicine...

Garlic (Alliaceae), an annual herb, is renowned not only for its distinctive flavor but also for its extensive therapeutic applications in managing various ailments and health conditions. In this study, garlic products identified as the best‐selling items in Turkish pharmacies for various purposes were compared with garlic grown under standard cond...

Essential oil content of and phenolic compounds flower-fruit, root, and aerial parts of Heracleum pastinacifolium subsp. incanum were analysed by GC/MS and LC/MS methods, respectively. Antidiabetic, anticholinesterase, and antioxidant activities of flower-fruit, root, aerial parts methanol extracts were evaluated. Apiole (35.0%), myristicine (72.2%...

In the present study, Cinnamomum verum J. Presl. bark essential oil and its main component cinnamaldehyde was evaluated in vitro for neuraminidase (NA), transmembrane serine protease (TMPRSS2), and angiotensin converting enzyme 2 (ACE2) inhibitory activities. The chemical composition of C. verum essential oil was confirmed by both gas chromatograph...

In this research, essential oil was obtained from the aerial parts of Prangos platychlaena Boiss. by hydrodistillation using a Clevenger-type apparatus, separated into fractions having different polarities by column chromatography. Both essential oil and the fractions were analyzed by GC-FID and GC/MS simultaneously. Nona-3,5-diyne-2-yl acetate (46...

Aim: Arum rupicola Boiss. var. rupicola with a vernacular name of Dağ Sorsalı, are used etnobotanically for hemorroid, eczema, rheumatism, and cancer. Essential oil combination of A. rupicola var. rupicola, under the lower risk (lc) threatened category because of the excess gathering was investigated. Methods: The above ground samples of Arum rupic...

The genus Achillea (Asteraceae) is distributed in Europe and the Middle East and has approximately 140 endemic species. There are 40 Achillea sp. in the Turkish flora and 20 of them are endemic. This genus has a widespread area all over the world. Also, it has many different uses in traditionally, such as diarrhea, abdominal pain, hemorrhoids and w...

In current study antioxidant, antidiabetic, antimicrobial, anticholinesterase, and human carbonic anhydrase I, and II (hCA I and II) isoenzymes inhibition activities of Astrodaucus orientalis different parts were investigated. Achetylcholinesterse (AChE) and butyrylcholinesterse (BChE) inhibitory activities of octyl acetate were determined via mole...

Objective: Lavandula angustifolia L. (Lavender) is one of the most plants essential oils used in the cosmetic, food and biological activities. Kojic acid has been used in cosmetics for its whitening effect and pharmaceutical activity. The aim of this study to determine the composition of the Pharmacopoeia quality L. angustifolia essential oil (EO)....

The main aim of the study was the biotransformation evaluation of hesperidin for functionalization by 25 different nonhuman pathogenic microorganisms. As a result, four metabolites were identified and characterized. The structure of pinocembrin and naringenin from the microbial transformation of hesperidin was determined initially with LC/MS–MS. Th...

In this study, the composition of the volatile oils obtained from the fruits of 8 Ferulago species (Ferulago cassia Boiss., F. isaurica Peşmen, F. humilis Boiss., F. macrosciadia Boiss. & Balansa, F. setifolia K.Koch, F. silaifolia (Boiss.) Boiss., F. syriaca Boiss., F. trojana Akalın & Pimenov) growing naturally in Turkey were examined by means of...

The present work aims to evaluate Rosa x damascena Herrm. and Pelargonium graveolens L’Hér. essential oils, and the major constituent geraniol for their in vitro and in silico inhibitory activities against 5-lipoxygenase (5-LOX), cyclooxygenase (COX), acetyl cholinesterase (AChE), butyryl cholinesterase (BuChE), and angiotensin converting enzyme (A...

The essential oil (EO) of Origanum minutiflorum O. Schwarz et P. H. Davis was obtained by the hydrodistillation method. The analysis of the EO was conducted using Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS). The yield of the EO was determined to be 3.9%. Fifty-six compounds were identified, constituting 97.8% of the EO....

The essential oil of Pelargonium graveolens L. is valuable for its therapeutic benefits, so this study aimed to determine the synergistic effect of the combination of the essential oil of this plant with antibiotics instead of the extracts prepared with various solvents. In addition, the second goal of this study was to determine whether the essent...

The aim of this paper was to evaluate the antidiabetic and antioxidant activities of methanolic extracts, n ‐hexane, dichloromethane, ethyl acetate, butanol, aqueous subextracts and essential oils of flowers, roots, leaves and aerial parts of Thymbra spicata subsp. spicata , which has been utilized in the public medicine systems of Turkey, Greece,...

Ferula tingitana L. is a high perennial plant and its leaf is an alternate arrangement and yellow, and its flowers are unisexual like other Apiaceae. It has been used as a spice and for various medicinal purposes in the Mediterranean region. The paper reports antidiabetic, antimicrobial, anticholinesterase, antioxidant, and genotoxic activities of...

Within this work, it was aimed to investigate the in vitro antibacterial properties of the Pharma grade coriander (Coriandrum sativum L.) essential oil, and its combinations. The chemical composition of the essential oil was confirmed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analyses, simultaneously. Furthermore,...

Spearmint, Mentha spicata L., and the German chamomile, Matricaria chamomilla L., preparations are used against inflammatory conditions traditionally and in modern medicinal applications. This present study aimed to evaluate pharma-grade essential oils for their in vitro anti-inflammatory and anticancer effects using COX-1, COX-2, and 5-LOX enzyme...

Amaç: Tilia L. türlerinin çiçek durumlarından elde edilen uçucu yağın diüretik, sedatif, kas gevşetici, terletici, soğuk algınlığına karşı etkili olduğu bilinmektedir. Çalışmamızda benzer nedenlerle halk ilacı olarak kullanımı bulunun T. rubra subsp. caucasica (Rupr.) V.Engl. türünün uçucu yağının bileşiminin araştırılması ve bir yıl arayla toplana...

Ferulago glareosa Kandemir & Hedge. is an endemic species of the family Apiaceae for Turkey and has interesting morphological characteristics compared to the other members of the genus Ferulago Koch. In this study we investigated the essential oil compositions of the roots and aerial parts of F. glareosa for the first time and compared them with es...

The medicinal plant Satureja cuneifolia Ten. was widely utilized as spice, tea and traditional medicine. The objective of the current study was to examine the chemical composition and in vitro biological activities (LOX, MMP-1, and MMP-12 enzyme inhibition activity and cytotoxicity on A549 cell line) of Satureja cuneifolia extracts and essential oi...

This study aimed to increase the bioactivity of essential oils by fractionation, combination, and emulsification. In this regard, pharmaceutical quality Rosmarinus officinalis L. (rosemary), Salvia sclarea L. (clary sage), Lavandula latifolia Medik. (spike lavender), and Matricaria chamomilla L. (chamomile) essential oils were fractionated by vacuu...

The genus Tilia (Tiliaceae) represents 45 species, of which six species are European. Tilia sp. are simple, cordate or deciduous trees with long, silicate shaped, 5-valve fruits and fragrant flowers. It is used as a medicinal tea in traditional medicine for colds, coughs, and hypertension and as an antioxidant. Within the scope of this research, Ti...

Glaucosciadium cordifolium (Boiss.) Burtt. & Davis, which is a monotypic species naturally grown in Turkey belonging to the Apiaceae (Umbelliferae) family. In this study, the essential oil obtained from G. cordifolium was analyzed and evaluated for its antimicrobial effects. In chemical studies, the analyzes of essential oil compounds obtained from...

The paper aims to compare the chemical compositions of essential oils and anatomical properties of secretory structures differences between R. damascena which is cultivated in Iğdır and Isparta (EOI1, EOI2, and EOIg). GC/ MS and GC-FID were utilized for essential oils analysis. Nonadecane (31.0%), heneicosane (21.1%), citronellol (16.8%), and 1-non...

Objective: Microbial transformations are green biotechnological processes where different microorganisms, or their enzymes are used to produce new metabolites from defined substrates. Hesperidin, quercetin, and their derivatives have been proven in scientific research to have a variety of biological activities such as antioxidant, antimicrobial, an...

The genera Nigella and Garidella are two members of the Nigelleae tribe. Among all the taxa of the tribe, black cumin (Nigella sativa L.) is one of the most important plants concerning economic and medicinal uses. In this study, volatiles were analyzed in detail to elucidate the phytochemical profiles and to understand the taxonomic patterns of sec...

Origanum onites L. of Lamiaceae, is used as a culinary spice and herbal tea; also for its antioxidant, antimicrobial effects among other activities and effects. This research aims to examine the in vitro antimicrobial and antioxidant activities of the infusions and the essential oils (EOs) obtained using different conditions from the aerial parts o...

This study was carried out to determine the content of the essential oils of Salvia absconditiflora Greuter & Burdet populations which are naturally found in Mediterranean, Iran-Turan and Euro-Sibirya phytogeographical regions. S. absconditiflora plant samples were collected from eight different provinces (Aksaray, Kahramanmaraş, Karaman, Kayseri,...

Objective: This study aimed to determine and compare the volatile compositions of A. orientalis collected from Antalya, Balıkesir, Erzurum, and Samsun in Turkey. Material and Method: Microdistilled volatile samples of A. orientalis were determined by GC-FID and GC-MS systems simultaneously. Result and Discussion: o-Cresol is also present in the vol...

Objective:The purpose of this present study was to make a chemical analysis of the composition of essential oil obtained from sweetgum balsam and to examine its antimicrobial, anticholinesterase, α-glucosidase inhibition, and antioxidant activities.Methods:The essential oil obtained by the hydrodistillation method was analyzed by gas chromatography...

Microbial resistance is an important problem in modern healthcare systems. In addition to drug resistance, the side effects of current antibiotic applications are also known issues. In this present study, binary combinations of amoxicillin with European Pharmacopoeia quality lavender (Lavandula angustifolia) and fennel (Foeniculum vulgare) essentia...

Eucalyptus essential oils are well-known and used especially in upper respiratory tract pathologies or diseases as herbal drug preparations. In the present study, the in vitro angiotensin-converting enzyme 2 (ACE2) and lipoxygenase (LOX) enzyme inhibitory potentials of commercial Eucalyptus globulus Labill. and Eucalyptus citriodora Hook. essential...

Objective:This present study was conducted to determine the interspecific chemical variability and evaluate the biological effects of the essential oils of Daucus L. species growing naturally in Turkey. The species were D. carota, D. broteri, D. guttatus, D. littoralis, D. involucratus and D. conchitae (endemic).Methods:The essential oils were obta...

A phytochemical investigation of hexane extract of Rheum ribes L., Polygonaceae, shoots was analyzed by gas chromatography with flame ionization dection and mass specrometry and revealed seven components including methyl hexadecanoate (methyl palmitate) (2.4%), (Z)-9-methyl octadecenoate (methyl oleate) (2.9%), (Z,Z,Z)-9,12,15-methyl octadecatrieno...

In this present study, Rosmarinus officinalis essential oil and its new microemulsions (MEs) were evaluated both for the in vitro antibacterial and antifungal activity. The essential oil composition was verified initially both by GC-FID and GC/MS, where camphor (19.5%), 1,8-cineol (12%), and verbenone (11.1%) were characterized as the main constitu...

In this present study, commertially available Salvia triloba L., S.officinalis L., and S. sclarea L. essential oils were evaluated for their in vitro angiotensin converting enzyme 2 (ACE2) inhibitory activity. The Salvia essential oils compositions were confirmed both by GC-FID and GC/MS. Main components of the S. triloba essential oil was characte...

Propolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavono...

Clinopodium nepeta subsp. glandulosum (Req.) Govaerts is a natural perennial grass belonging to the Lamiaceae family, growing spontaneously on the Mediterranean coast. It is locally known as “kedi fesleğeni” in Turkey. This aromatic plant is used as a mint-like spice in food preparations and in the composition of some recipes during religious feast...

Propolis is a natural product with many biological activities, and it has been used in many industrial areas, such as pharmaceuticals, food and cosmetics. Thus, in this study, we aim to evaluate the chemical content, antioxidant, antiviral activities, cytotoxicity and the iNOS of propolis samples collected from 39 different regions in Turkey. Pheno...

In this present study, Rosmarinus officinalis L. essential oil, and its major component 1,8-cineole was evaluated in vitro for angiotensin converting enzyme 2 (ACE2), as well as for 5-lipoxygenase (5-LOX) enzyme inhibitory activity. The essential oil composition was confirmed both by GC-FID and GC/MS, where 1,8-cineole (62.7%), α-pinene (12.6 %), a...

Abstract The genus Artedia L. (Apiaceae) is represented in Turkey by 485 species and altogether 511 taxa. The rate of species endemism in Turkey is 37.7%. The plant material was collected from the province of Kahramanmaraş, Turkey. The essential oils from fruits and aerial parts were obtained by hydrodistillation using a Clevenger type apparatus. C...

Bisabolol is one of the bioactive constituents of chamomile. It was aimed to biotransform (–)-α-bisabolol by different fungi for the production of new bioactive metabolites, which was converted to α-bisabolol oxide A and B by Thamnidium elegans. Additionally, the biotransformation by Penicillium neocrassum yielded a new metabolite, which was charac...

Marrubium cuneatum Banks & Sol. is a perennial plant belonging to the Iran-Turan phytogeographical region, which is distributed in a limited region in the Middle East (Lebanon, Syria, Palestine, Turkey, Iraq and Iran). The chemical composition of the essential oil of Marrubium cuneatum Banks & Sol. (Lamiaceae) from Turkey was characterized. Hydro-d...

The current study reports the essential oil compositions of the aerial parts of Chaerophyllum crinitum Boiss. and Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A. Mey. ex Hohen. collected from Bitlis and Hakkari in Turkey, respectively. The essential oils, which were obtained with water distillation were analyzed by GC and GC-MS, simult...

The fruits, aerial parts and roots of Neomuretia pisidica (Kit Tan) Kljuykov, Degtjareva & Zakharova were extracted with n-hexane. Total of 18 compounds were characterised by GC analyses of the n-hexane extracts. Main volatile components of the n-hexane extract of aerial parts were characterized as 1,8-cineole (23.4%), camphor (21.4%), 2-ethyl hexa...

In this study we investigated antimicrobial activity against Klebsiella pneumoniae and the phagocytic functions of human leukocyte cells as revealed in an in vitro experimental model combining cefepime and gentamicin with Pelargonium endlicherianum Fenzl. essential oil treatments. The bactericidal effects of this essential oil and antibiotic combin...

Combination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the in vitro potential synergistic antibacterial effect of Lavandula latifolia (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; Staphylococcu...

Citrus fruits are cultivated and used as fresh fruits or for the production of juices Worldwide. These fruits are of great interest as raw materials for pharmaceutical, cosmetics and food industries due to their aromatic properties. Residues of the production of citrus juice, such as peels, membranes and seeds, possess a large variety of phytochemi...

Ethnopharmacological relevance: The preparations of Phlomis aerial parts are used traditionally in Anatolia for wound healing and in inflammatory disorders. Methods: For the identification of the active fraction, the air dried aerial parts of Phlomis rigida Labill. were extracted by methanol and fractionated successively by n-hexane, dichloromet...

In vitro cholinesterase inhibition, antioxidant and anticancer potentials of the essential oils and extracts of flowers and aerial parts of Salvia verticillata subsp. amasiaca have been studied. The GC-MS and GC-FID analyses found that major components of the essential oils were caryophyllene oxide, caryophylladienol II, spathulenol, hexahydrofarne...

The chemical compositions of the essential oils obtained by hydrodistillation from aerial parts of five subspecies of Scutellaria orientalis L. (subsp. carica, subsp. haussknechtii, subsp. macrostegia, subsp. orientalis and subsp. santolinoides) were analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS), simultane...

This investigation displays antioxidant potential of Cymbocarpum erythraeum essential oils and their biological effects like cytotoxic and anticholinesterase. The antioxidant capacities of the essential oils were estimated by DPPH, TBA, TOS assays. The anticholinesterase activity of essential oils was estimated utilizing Ellman method. The human U-...

The air-dried aerial parts of Phlomis russeliana (Sims) Lag. Ex Benth. was extracted by methanol and fractionated by n-hexane, dichloromethane, and ethyl acetate, respectively. The wound healing properties of P. russeliana extract gel was evaluated using the in vivo excisional wound model using Balb-c mice. Initially, the P. russeliana methanol ext...

The oxidant, cholinesterase, and carbonic anhydrase inhibitions of essential oils and their major compounds of Leiotulus dasyanthus and molecular docking studies of α-pinene and ™-3-carene were evaluated in this study. Phenolic constituents and antioxidant activity of samples were determined by Folin-Ciocalteu’s, DPPH, and TBA processes. Cholineste...

In the present study, the volatile compounds and antioxidant activities of A. sylvestris var. sylvestris belongs to the Apiaceae family were evaluated. The essential oils from roots, leaves, flowers and fruits obtained by hydrodistillation were analyzed by Gas Chromatography (GC) and Gas Chromatography-Mass Spectroscopy (GC-MS), simultaneously. The...

The aerial part, root and fruits of Ferulago longistylis, an endemic species, were subjected for the evaluation of essential oil compositions and antimicrobial activity. The essential oils were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The main components of the aerial part were identified as α-pinene (18...

The genus Bunium (Apiaceae) comprises about 50 species spreading in Asia, Europe and North Africa. It is encountered in almost every region of Turkey, especially in the Mediterranean, Southeastern Anatolia and Eastern Anatolia regions. It has various therapeutic effects on digestive and urinary tract disorders. In traditional medicine, it has been...

The genus Nepeta (Lamiaceae) is represented by 39 species, in total 50 taxa, 19 of which are endemic, in Turkey. Nepeta species are known as “kedinanesi” in Turkish and has many traditional usages such as antispasmodic, diuretic, antiseptic, antitussive, and antiasthmatic activities. The aerial parts of N. cadmea were hydrodistillated for 3 hours b...

Non-polar and polar compounds were isolated from the leaves and chemical composition of the essential oil from aerial parts of Sideritis cypria endemic in Northern Cyprus was also determined. The structures of all the isolated compounds were elucidated by means of spectroscopic (UV, NMR: 1D and 2D-NMR: 1H, 13C, COSY, HSQC, HMBC) methods and compari...

The genus Nigella L. s.l. (Ranunculaceae) is one of the most important plants in respect of economic and medicinal usage. Fatty acid compounds have been researched in detail for the taxa of Nigella s.l., naturally growing in Turkey. Among them, 19 Nigella taxa were researched in respect of 18 fatty acid compounds. These were acquired by the way of...

Amaç: Tilia tomentosa Moench. (Malvaceae) bitkisinin çiçeklerinden elde edilen n-hekzan ekstresinin uçucu bileşenleri, toplam fenolik madde miktarı, in vitro antioksidan, antimikrobiyal ve hücre canlılığı aktivitelerinin araştırılması amaçlanmıştır. Yöntem: Kurutulan bitki materyali toz edildikten sonra, n-hekzan kullanılarak maserasyon yöntemi ile...

Rosmarinus officinalis L. (rosemary) is a common culinary spice and herbal drug, which is used for centuries all over the world. In this present study, apolar to polar fractions of R. officinalis flowers were evaluated for their in vitro antioxidant, antibacterial, cytotoxic, anti-inflammatory and analgesic activities, respectively. Phytochemical c...

Bupleurum L. cinsi (Apiaceae) yaklaşık 200 tür içermektedir. Bu türler, Kuzey yarımküre, Avrasya ve Kuzey Afrika’da yaygın olarak yetişmektedir. Türkiye florasında yer alan 47 taksonun 21’i endemiktir. Bupleurum türleri halk arasında çoğunlukla antienflamatuvar ve antiseptik aktivitelerinden dolayı kullanılmaktadır. Bununla birlikte bazı Bupleurum...

Stachys tmolea subsp. tmolea Boiss. is endemic to Turkey and is a species of the genus Stachys L. which is one of the largest genera of the family Lamiaceae with about 300 species. The aims of this study were to examine the chemical composition of the essential oil and n-hexane extract of S. tmolea subsp. tmolea as natural sources of insecticidal a...