Beste Atasoy

Marmara University · Department of Radiation Oncology

Accelerated repopulation is a main reason for locoregional failure after fractionated radiotherapy for head and neck squamous cell carcinoma (HNSCC). Epidermal growth factor receptor (EGFR) is a key controller of cellular proliferation in HNSCC, which stimulated the current study to look for a direct link between EGFR status and a possible clinical...

The aim of this study was to investigate the effects of a specific diet, containing beta-hydroxy-beta-methylbutyrate, L-glutamine and L-arginine (HMB/Glu/Arg), on chemoradiation-induced injuries of the rat gastrointestinal mucosa. Wistar albino rats were divided into 4 groups: control (n = 5); radiation (n = 14); 5-fluorouracil treatment (5-FU; n =...

The classical knowledge of “the local only” effects of ionizing radiation has been started to change based on the recent results of preclinical and some clinical studies. The immune response that is observed after and may be triggered by radiotherapy in the human body may elicit a systemic immune response against tumor cells. It is called abscopal...

Aim: To analyze the dosimetric factors affecting long-term renal function in patients with gastric cancer following postoperative radiotherapy with concomitant chemotherapy to the upper abdomen. Methods: Between January 2005 and July 2010, 13 patients treated with three-dimensional conformal radiotherapy and concurrent fluorouracil-based chemothera...

Aim To investigate the potential radioprotective effects of Myrtus communis on brain tissue. Methods Thirty female rats were divided into four groups. The control group (C) was applied with oral saline solution (SF) for four days. Myrtus communis (MC) groups started to receive MC (100 mg/kg, oral) either four days before (R + preMC) or immediately...

Purpose The purpose of this multicenter retrospective study was to analyze the clinical and radiological effects of bevacizumab (BV) on radionecrosis (RN) that developed after stereotactic radiotherapy (SRT) for brain metastasis. Methods Forty patients with SRT related symptomatic brain RN treated in 10 radiation oncology centers were analyzed. Th...

Objective: Glioblastoma (GB) is a highly lethal form of brain tumor. Although standard therapy appears to be effective, the survival time is quite short, and the recurrence rate is high. Bortezomib (BTZ), is a proteasome inhibitor, used in GB therapies and resulted in serious off-target effects. Carfilzomib (CFZ), is an alternative for BTZ, has kno...

Purpose Children under 3 years old represent a notable portion, about 25 to 30%, of all central nervous system tumor (CNS) cases. Their clinical course, prognosis, and treatment significantly differ from older children. This single-center retrospective study aims to comprehensively analyze survival factors in children under three diagnosed with CNS...

Purpose This study aims to investigate the efficacy of lower dose pilocarpine in alleviating late dry mouth symptoms in head and neck cancer patients received radiotherapy. Methods Eighteen head and neck cancer patients experiencing persistent dry mouth were enrolled in this study. All participants started pilocarpine treatment a median of 6 month...

This cross-sectional study aimed to investigate the role of bioelectrical impedance analysis (BIA) and phase angle measurement in assessing malnutrition in head and neck (n = 37) and brain (n = 63) tumor patients received radiotherapy. Common nutritional screening and assessment tests were used to identify malnutrition in the patients. Each patient...

Hypoxia is a condition arising from an imbalance between oxygen production and consumption in cells, commonly observed in solid tumors. Hypoxic cells, indicative of increased angiogenesis, invasion, metastasis, metabolic changes, and genomic instability, also serve as markers for treatment resistance and poor prognosis. Pharmacological intervention...

Objectives: Widespread use of stereotactic radiotherapy (SRT) in the treatment of brain metastases has led to an increased incidence of radionecrosis (RN). Based on its pathophysiology, BV (BV), a VEGF antagonist, has been used in the treatment of RN in prospective and retrospective studies with a limited number of patients. In this multicenter ret...

Background: We aimed to evaluate patients with nasopharyngeal carcinoma (NPC) in a nonendemic population. Methods: In a national, retrospective, multicenteric study, 563 patients treated with intensity modulated radiotherapy at 22 centers between 2015 and 2020 were analyzed. Results: Median age was 48 (9-83), age distribution was bimodal, 74.1...

Purpose: To investigate development of radiation pneumonitis (RP) in relation to pulmonary function, dosimetric factors, and transforming growth factor beta-1 (TGFβ1) expression in irradiated breast cancer patients. Methods: A total of 49 breast cancer patients who received post-operative radiotherapy (RT) were evaluated in terms of pulmonary fu...

Purpose: The aim was to determine the validity and the reliability of the Turkish version of the screening test named NUTRISCORE in cancer patients. Methods: The language validity of the Turkish form of the study scale was provided by the translationback-translation method. NUTRISCORE and nutritional risk screening (NRS)-2002, malnutrition scree...

Parotid gland tumors are the most common salivary gland tumors. They consist of 1-3% of all head and neck tumors. Heterogeneous features of tumor histopathology make it difficult to decide on adjuvant therapy. Although there are no randomized controlled trials, adjuvant therapy can be recommended based on retrospective studies. Therefore, loco-regi...

Objectives To investigate the possible protective effects of resveratrol against oxidative testicular damage due to scattered radiation during pelvic ionizing radiation exposure in rats. Methods Rats were divided into 5 groups; control, radiation, and radiation + resveratrol therapy in early and late periods. Under anesthesia, 20 Gy ionizing radia...

Introduction: Anaplastic thyroid carcinoma (ATC) is a highly aggressive, undifferentiated rare tumor. Median overall survival is usually between 8 and10 months, with a 1-year survival rate of 20%. Conventional anthracycline based chemotherapy regimens demonstrate low response rates with short duration. Novel therapeutic agents including BRAF and ME...

AimIn this study, we aimed to evaluate the neuromusculoskeletal late side effects and their impact on the quality of life of patients with nasopharyngeal carcinoma treated with radiochemotherapy.Patients and methodsTwenty-seven patients were included. The mean follow-up was 61 months (range, 18–111 months). The median external radiotherapy dose app...

Objectives Malignant high-grade gliomas are the most common and aggressive type of primary brain tumor. We aimed to evaluate the prognostic value of modified Glasgow Prognostic Score (mGPS), which is combination of C-reactive protein (CRP) and albumin, in recurrent high-grade glioma patients treated with systemic treatment. Patients and Methods Da...

Purpose: Malignant high-grade gliomas are the most common and aggressive type of primary brain tumor, and the prognosis is generally extremely poor. In this retrospective study, we analyzed the outcome of systemic treatment in recurrent high-grade glioma patients and the impact of prognostic factors on survivals. Methods: Data from 114 patients wit...

Background: Primary brain tumors are relatively rare malignancy, with high-grade gliomas (glioblastoma multiforme and anaplastic gliomas) are the most common types . We aimed to evaluate the prognostic value of Prognostic Nutritional Index (PNI), which is calculated by lymphocyte count and albumin, in recurrent high-grade glioma patients treated wi...

OBJECTIVE To maintain the barrier function against mucositis-induced pain and to improve the nutritional status and quality of life in head and neck cancer patients during radiotherapy. METHODS All patients (n=30) used oral gel to reduce mucositis-induced pain. Patients were examined weekly for the severity of mucositis, pain and nutritional status...

Glioblastoma is the most common high-grade brain tumor in adults, which has a rapidly developing radiotherapy/chemotherapy resistance and high recurrence rate. The aim of our study is to determine the effects of bortezomib that is a quite important proteasome inhibitor on glioblastoma tumors in the 3D environment. In this study, we have performed b...

Radyobiyolojik Modeller ve Prensipler Işığında Brakiterapi

Purpose/Objective(s) Rectal Squamous Cell Carcinoma (R-SCC) is a rare disease. The therapeutic approach is not well established. We report the clinical results of a large, multicentric study promoted by the Rare Cancer Network. Materials/Methods This study included 77 adult non-metastatic R-SCC patients treated in 13 American and European Instituti...

Glioblastoma (GBM) is the most common brain tumor in adults with its poor prognosis. Recently, programmed death ligand-1 (PD-L1) has become an important target for GBM (1) and PD-L1 binds to programmed death-1 receptor, which is expressed in CD8+ cytotoxic T lymphocytes (2). Studies showed a better treatment response in patients with high PD-L1 exp...

The aim of this study was to compare three screening tools for malnutrition in patients with head and neck cancers or central nervous system tumors (CNS) who are undergoing radiochemotherapy. The study evaluated 124 adult cancer patients. The Subjective Global Assessment (SGA), Mini-Nutritional Assessment (MNA), and Nutritional Risk Screening 2002...

Objective: The aim of this study was to evaluate the early histopathological changes of gastroesophageal reflux and irradiation on laryngeal mucosa in rats. Study design: Animal study. Setting: Experimental animal laboratory, tertiary referral center. Subject and method: Twenty-four adult female Wistar Albino rats were grouped as: control (n...

Radiotherapy (RT) for prostate cancer (PC) can cause erectile dysfunction (ED) by damaging neurovascular structures with oxidative stress. In this study, we evaluated the effects of resveratrol, an antioxidant, on post-RT ED. Fifty rats in five groups were evaluated; control (C), prostate-confined radiotherapy with short- and long-term vehicle or r...

Multidisipliner Baş Boyun Kanserleri Kongresi, 8-11 Mart 2018, Antalya, Bazal Hücreli Kanserde Radyoterapi Radiotherapy in Basal Cell Cancer

PRESENTATION IN NATIONAL RADIATION ONCOLOGY CONGRESS 2018-ANTALYA

INFORMED CONSENT

Florodeoksiglukoz ile işaretlenmiş pozitron emisyon tomografi yöntemi, onkolojide ayırıcı tanıda, evrelemede ve tedavi yanıtını değerlendirmede kullanılan önemli bir incelemedir. Onkolojik tedaviler sonrası tedavi yanıtı söz konusu olduğunda morfolojik değerlendirmenin yanında metabolik değerlendirmenin önemine vurgu yapan yayınlar giderek artmakta...

Table of contents A1 Hope and despair in the current treatment of nasopharyngeal cancer IB Tan I1 NPC international incidence and risk factors Ellen T Chang I2 Familial nasopharyngeal carcinoma and the use of biomarkers Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien I3 Genetic susceptibility risk factors for sporadic and familial NPC: recent findings A...

There is growing recognition for the consequences of rectal cancer treatment to maintain an adequate functional sphincter in the long-term rather than preserving the anal sphincter itself. This study aims to evaluate long-term effects of neoadjuvant chemoradiotherapy (nCRT) followed by sphincter-preserving resection on anal sphincter function in re...

To determine the effects of two different radiation doses on sperm parameters and the role of testosterone treatment on rat spermatogenesis. The experimental animal study was conducted at Marmara University, Istanbul, Turkey, from September 2012 to January 2013. Male Sprague Dawley 4-6 months old rats weighing 300-350g were randomely divided into 5...

Purpose: The present study was conducted to characterize the possible therapeutic effects of glucagon-like peptide (GLP)-1 and GLP-2 against oxidative damage in the ileum and colon of irradiated rats. Methods and materials: Sprague-Dawley rats of both sexes received either a single dose of GLP-1 (0.1 nmol/kg, intraperitoneally, ip; n = 6) 10 min be...

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82 adyoterapi karaciğer, safra kesesi ve safra yolu tümörlerinin tedavisinde uzun yıllardır bilinen bir tedavi seçeneğidir. Ancak üst batın bölgesi organ-larının küratif dozlara karşı radyosensitif davranışı nedeniyle zaman içinde kullanımı azalmıştır. Günümüzde radyoterapi, yüksek doğrulukta ve normal do-kuyu koruyarak ışınlamaya imkân veren yeni...

Mastoid region recurrence is a rare entity at the time of recurrence. This paper presents a patient with an isolated mastoid recurrence following definitive treatment and discusses the therapeutic approach which may help in the treatment of such cases.

Introduction The purpose of this study is to evaluate the possible predictors of thyroid disorders after neck radiotherapy, with a focus on radiation dose-volume factors. Methods Thyroid function was measured in 100 patients who had received radiotherapy to the neck, including the thyroid. All radiation-induced thyroid dysfunctions were determined...

To assess the outcomes, symptom palliation and survival rates in patients who received repeat whole brain radiotherapy (WBRT). Twenty-eight patients who had progression of brain metastasis received a second course of WBRT. Univariate log-rank testing and multivariate Cox regression analysis were used to determine the factors for death among several...

e14660 Background: Mucinous adenocarcinoma colorectal cancer (CRC) is defined as presence of more than 50% mucinous component and its prognostic significance is debatable. We analyzed the prognostic importance of positivity of any mucinous component in early stage adenocarcinoma patients who were operated and received adjuvant treatments in a singl...

Purpose We aimed to determine the efficacy and the toxicity of low dose weekly gemcitabine with radiation therapy in medically unfit muscle-invasive bladder cancer patients. Methods Twenty-six patients were included into the retrospective analysis. Weekly gemcitabine was administered 75 mg/m2 with a median dose of 63 Gy radiation therapy. Clinical...

Purpose: To identify a high risk group of non-small cell lung cancer (NSCLC) patients who may benefit from preventive strategies in order to reduce the rate of brain metastasis. Methods: Two-hundred stage IIIA (47.5%) and IIIB (52.5%) NSCLC patients were analysed (median age 61 years, range 29-82). Pathological diagnosis consisted of 27% adenoca...

Breast cancer metastases are rarely seen in paranasal sinuses or orbit with a poor prognosis, and these cases were published as case reports. Moreover, metachronous tumors following breast cancer diagnosis are somewhat common, but uterine cervix is infrequent in them. In the present case, we report a 61-year-old female patient who had a biopsy-prov...

Aim: Although preoperative chemoradiatherapy (CRT) has proven its benefits in terms of decreased toxicity, there is still a considerable amount of cases that do not receive postoperative CRT. Oncologists at different geographic locations still need to know the long-term effects of this treatment in order to manage patients successfully. The curren...

Purpose/Objectives: Currently the standard treatment of glioblastoma (GBM) is radiotherapy (RT)+concomitant and adjuvant temozolomide (TMZ). In this retrospective analysis, we aimed to assess the value of addition of TMZ in GBM patients treated in a single center consecutively. Material/Methods: Between 1997 and 2010 there were 183 (116M: 67F) GBM...

The aim of this study was to investigate the effect of pre-treatment with the free radical scavenging molecules, magnesium and vitamin E, on lipid peroxidation to limit radiation-induced heart and lung injury. Female Sprague-Dawley rats were divided into 4 groups by a simple randomization method as saline-treated control (n=4), saline-treated irrad...

e16015 Background: Concomitant chemoradiatiotherapy (CRT) is the standard treatment in locally advanced nasopharyngeal cancer (LANPC). We studied the activity and tolerability of docetaxel, cisplatin and 5-fluorouracil-based induction chemotherapy (IC) followed by concurrent CRT with cisplatin in LANPC. Methods: Between 2004 and 2010 a total of 33...

t The communication between medical students and cancer caregivers, and the problems they have experienced as well as the outcomes for their professional development before starting clinical practice was assessed in the context of a student research project. Data were collected by questionnaires or by 20 to 40-min long interviews with cancer caregi...

zet Amaç: Bu çalışmada kemoradyoterapi (KRT) sırasında diyetisyen ve eğitim hemşiresiyle birlikte uygulanan yakın ve sürekli beslenme takibinin hastanın beslenme durumuna etkisi araştırıldı. Hastalar ve Yöntem: Prospektif planlanan çalışmaya küratif KRT endikasyonu konan, primer tümör bölgesi baş boyun (n=10), gastrointestinal sistem (n=3) ve akciğ...

Amaç: Bu çalışmada lokal ileri evre özefagus kanseri tanısıyla neoadjuvan/ definitif kemoradyoterapi (KRT) uygulanan hastaların sonuçlarının bildirilmesi amaçlanmıştır. Hastalar ve Yöntem: Histolojik tanısı skuamöz hücreli 10, adenokarsinom 4, adenoskuamöz karsinom 1 olan, T3N0M0 5 veya T3N1M0/T4N0M0 10, toplam 15 hasta geriye dönük olarak incelen...

Objective: This study aimed to retrospectively evaluate malignant glioma (MG) patients and compare the prognostic factors with different indices. Material and Methods: A total of 204 patients diagnosed as malignant glioma and received primary and/or postoperative radiotherapy (RT) were retrospectively evaluated. Median follow up was nine months (1-...

Hemangiopericytoma is an unusual tumor that arises from vascular smooth muscle cells. It is mainly experienced in 4th to 5th decades of life and soft-tissue masses are frequently located in lower extremity, pelvis, and retroperitoneum. A 29-year-old man presented with a mass lesion in the right nasal cavity associated with shortness of breath as a...

To investigate the impact of early insertion of percutaneous endoscopic gastrostomy-tube on nutritional status and completeness of concurrent chemotherapy in locally advanced head and neck cancer patients treated with chemoradiotherapy. Twenty-three patients were enrolled into this prospective study. Gastrostomy-tube was inserted in patients before...

This study aimed to demonstrate the efficacy and tolerability of low-dose weekly gemcitabine as a radiosensitizer in unresectable pancreatic cancer patients treated with chemoradiotherapy. Twenty-four histologically confirmed pancreatic carcinoma patients (female/male: 10/14, median age: 60) were evaluated. Seven (29%) patients received gemcitabine...

Multiple primary neoplasms (MPNs) comprise synchronous or metachronous tumors. They arise after diagnosis of the first primary tumor, and are commonly reported with an incidence of 0.7% to 11.7% of all cancer patients. By appropriate statistical methods, these tumors are shown to occur more frequently than expected, and therefore, may provide a mod...

this study analyzed prognostic factors and treatment outcomes of primary thyroid lymphoma. data were retrospectively collected for 87 patients (53 stage I and 34 stage II) with median age 65 years. Fifty-two patients were treated with single modality (31 with chemotherapy alone and 21 with radiotherapy alone) and 35 with combined modality treatment...

To investigate the protective effect of immune-enhanced diet (IED) on chemoradiation-induced injury of the gastrointestinal mucosa. Forty-eight Sprague-Dawley rats were divided into control (C, n=6), irradiation (IR, n=14), fluoropyrimidine (5-FU, n=14)-treated, IR + 5-FU (n=14)-treated groups. Half of each irradiated and/or 5-FU-treated groups wer...

The current standard therapy for newly diagnosed glioblastoma is multimodal, comprising surgical resection plus radiotherapy and concurrent temozolomide, then adjuvant temozolomide for 6 months. This has been shown to provide survival benefits; however, the prognosis for these patients remains poor, and most relapse. The objective of this prospecti...