Bertrand Colson

Bertrand Colson
Independent Researcher

Diplom-Mathematiker

About

32
Publications
4,928
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
231
Citations
Introduction
Bertrand Colson currently works at the Data Science department, QuoData – Quality & Statistics. As an experienced statistician specializing in Biochemistry, Analytical Chemistry and Applied Mathematics, his research has focused on solving real-life day-to-day problems. One of his recent publication is 'Diagnostic Performance of Risk of Ovarian Malignancy Algorithm Against CA125 and HE4 in Connection With Ovarian Cancer: A Meta-analysis'.

Publications

Publications (32)
Preprint
The emergence of Laboratory 4.0 and digital twin technologies necessitates reconsideration of how reference materials (RMs) can support modern analytical workflows. Digital reference materials (dRMs), existing as validated digital twins of physical standards, represent the convergence of traditional metrology and modern information technology, enab...
Preprint
Full-text available
Non-targeted methods (NTM) require robust methods for comparing spectral data for reliable classification and identification. Traditional approaches using match factors reduce complex spectral relationships to single values, limiting their utility in quality assurance. This study presents an evaluation of spectral comparison methodologies, contrast...
Preprint
Full-text available
A novel approach for designing acceptance sampling plans is presented. It is based on the Bayesian conformity assessment framework from JCGM 106. In particular, the concept of conformance probability plays a central role in the new approach. The new approach takes into account both the producer's and the consumer's perspective by allowing each to h...
Article
Background: The question whether a given set of test items can be considered “identical” is often addressed in terms of the homogeneity of the test material from which said items were taken. However, for some types of matrices – in particular, for matrices consisting of minute separate particles, only some of which carry the analyte under considera...
Article
Background: Matrix mismatch arises when the matrix of the test sample differs from the calibration or standard matrix. Matrix mismatch often accounts for a large part of between-laboratory variation. Notwithstanding, it is seldom characterized in method validation studies. Methods: Matrix-mismatch manifests itself as the variation of bias across ma...
Article
Full-text available
Background: Measurement uncertainty is typically expressed in terms of a symmetric interval y±U , where y denotes the measurement result and U the expanded uncertainty. However, in the case of heteroscedasticity, symmetric uncertainty intervals can be misleading. In this paper, a different approach for the calculation of uncertainty intervals is in...
Article
Full-text available
Background: Throughout the COVID-19 pandemic, veterinary diagnostic laboratories have tested diagnostic samples for SARS-CoV-2 both in animals and over 6 million human samples. An evaluation of the performance of those laboratories is needed using blinded test samples to ensure that laboratories report reliable data to the public. This interlabora...
Article
Full-text available
Food fraud, even when not in the news, is ubiquitous and demands the development of innovative strategies to combat it. A new non-targeted method (NTM) for distinguishing spelt and wheat is described, which aids in food fraud detection and authenticity testing. A highly resolved fingerprint in the form of spectra is obtained for several cultivars o...
Preprint
The question whether a given set of test items can be considered “identical” is often addressed in terms of the homogeneity of the test material from which said items were taken. However, for some types of matrices – in particular, for matrices consisting of minute separate particles, only some of which carry the analyte under consideration – even...
Preprint
Full-text available
Background: Since the beginning of the COVID-19 pandemic veterinary diagnostic laboratories have tested diagnostic samples for SARS-CoV-2 not only in animals, but in over five million human samples. An evaluation of the performance of those laboratories is needed using blinded test samples to ensure that laboratories report reliable data to the pub...
Article
Full-text available
The COVID-19 pandemic presents a continued public health challenge. Veterinary diagnostic laboratories in the United States use RT-rtPCR for animal testing, and many laboratories are certified for testing human samples; hence, ensuring that laboratories have sensitive and specific SARS-CoV2 testing methods is a critical component of the pandemic re...
Preprint
Measurement uncertainty is typically expressed in terms of a symmetric interval , where denotes the measurement result and the expanded uncertainty. However, in the case of heteroscedasticity, symmetric uncertainty intervals can be misleading. In this paper, a different approach for the calculation of uncertainty intervals is introduced. This appro...
Preprint
The ISO 2859 and ISO 3951 series provide acceptance sampling procedures for lot inspection, allowing both sample size and acceptance rule to be determined, starting from a specific value either for the consumer or producer risk. However, insufficient resources often make it difficult to implement “ISO sampling plans.” In cases where the sample size...
Article
Full-text available
The EU commission established Regulation (2017/1495) in 2017 to reduce Campylobacter on chicken skin and to decrease the number of human cases of campylobacteriosis attributable to the consumption of poultry meat. A Process Hygiene Criterion based on colony-forming unit data was set to a maximum of 1000 CFU Campylobacter spp. per gram chicken neck...
Preprint
Full-text available
The coronavirus disease 2019 (COVID-19) pandemic presents a continued public health challenge across the world. Veterinary diagnostic laboratories in the U.S. use real-time reverse transcriptase PCR (RT-PCR) for animal testing, and many are certified for testing human samples, so ensuring laboratories have sensitive and specific SARS-CoV-2 testing...
Preprint
For the in-house validation of a droplet digital PCR method, a factorial experimental design was implemented. This design serves different purposes. On the one hand, it is an efficient design in relation to the workload involved in achieving a desirable level of reliability of variance estimates. On the other hand, it allows a partitioning of total...
Article
Full-text available
The continued search for intermediate hosts and potential reservoirs for SARS-CoV2 makes it clear that animal surveillance is critical in outbreak response and prevention. Real-time RT-PCR assays for SARS-CoV2 detection can easily be adapted to different host species. U.S. veterinary diagnostic laboratories have used the CDC assays or other nationa...
Article
Full-text available
This paper presents the results of a study which was conducted by 32 participating forensic laboratories, mainly from Europe. In this EU-funded study the prevalence of the most common types of Gunshot Residue (GSR) particles was investigated in various subpopulations. Specimens were collected from the hands of more than 1300 persons using carbon st...
Preprint
Detection of food fraud and geographical traceability of ingredients is a continually sought goal for government institutions, producers, and consumers. Herein we explore the use of non-target high-resolution mass spectrometry approaches and demonstrate its utility through a particularly challenging case study - to distinguish wheat and spelt culti...
Article
Full-text available
In the light of recent food fraud cases, the issue of food authenticity is receiving increasing attention. New analytical methods and evaluation approaches are currently being proposed. In this framework, the evaluation of mass spectral profiles constitutes a promising avenue, e.g. for the determination of food origin. Relevant evaluation approache...
Article
Leaching processes are responsible for the release of biocides from treated materials into the environment. Adequate modeling of emission processes is required in order to predict emission values in the framework of the risk assessment of biocidal products intended for long-term service life. Regression approaches have been applied to data obtained...
Article
Full-text available
According to ISO/IEC 17025:2017, testing and calibration laboratories should apply procedures for estimating measurement uncertainty. It would thus make sense to include these uncertainty estimates in the evaluation of laboratory performance in proficiency testing. According to ISO 13528:2015, submitted laboratory-specific uncertainties can be take...
Article
Data collected from FDA proficiency tests (PT) during 2012-2018 was used to evaluate the performance of most probable number (MPN) and polymerase chain reaction (PCR) methods used to enumerate Vibrio parahaemolyticus in oyster samples. The primary aim was to establish whether the MPN and PCR methods can be considered equivalent. The following crite...
Technical Report
The test methods UN Test L.2 / EN ISO 9038:2013 DIN EN 15188:2007 are applied to characterize the sustained combustibility of liquids i.e. the behaviour of a material under specified test conditions, whereby its vapour can be ignited by an ignition source and sufficient flammable vapour is produced to continue burning for at least 15 s after the so...
Article
Full-text available
Objectives: The aim of this study was to determine whether the Risk of Ovarian Malignancy Algorithm (ROMA) is more accurate than the human epididymis 4 (HE4) or carbohydrate antigen 125 (CA125) biomarkers with respect to the differential diagnosis of women with a pelvic mass. The secondary objective is to assess the performance of ROMA in early-st...
Article
Full-text available
Numerical values called L-scores, with properties similar to those of z-scores, can be calculated for proficiency tests involving qualitative test methods. These scores do not require the use of replicates and are defined in such a way as to reflect both the Level of Competence of the Laboratory (LCL) and the Level of Difficulty of the Task (LDT)....
Article
A new model for the probability of detection (POD curve) for qualitative PCR methods examined in a method validation collaborative study is presented. The model allows the calculation of the POD curve and the limit of detection (LOD 95%), i.e. the number of copies of the target DNA sequence required to ensure 95 % probability of detection. The betw...

Network

Cited By