Berthold Langguth

Berthold Langguth
Universität Regensburg | UR · Department of Psychiatry and Psychotherapy

Prof. Dr. med

About

714
Publications
230,358
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Introduction
Berthold Langguth currently works at the Department of Psychiatry and Psychotherapy, Universität Regensburg. Berthold does research in Psychiatry, Neurology, Psychosomatic Medicine and Neuroscience.
Additional affiliations
January 2012 - present
Universidad de Buenos Aires
January 2011 - present
January 2011 - present

Publications

Publications (714)
Article
Full-text available
This perspective article explores how process mining can extract clinical insights from mobile health data and complement data-driven techniques like machine learning. Despite technological advances, challenges such as selection bias and the complex dynamics of health data require advanced approaches. Process mining focuses on analyzing temporal pr...
Preprint
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Machine-learning (ML) classification may offer a promising approach for treatment response prediction in patients with major depressive disorder (MDD) undergoing non-invasive brain stimulation. This analysis aims to develop and validate such classification models based on easily attainable sociodemographic and clinical information across two random...
Article
Background Motor cortex excitability may represent the neuronal endpoint of motivational processes and was shown to be modulated by both sexual arousal and deceptive behavior. Aim This is the first study to investigate the influence of lying and sex in heterosexual women and men based on motor-evoked potentials (MEPs) measured while viewing sexual...
Article
Background and Hypothesis Abnormal psychomotor behavior is a core schizophrenia symptom. However, assessment of motor abnormalities with expert rating scales is challenging. The Positive and Negative Syndrome Scale (PANSS) includes 3 items broadly related to hypokinetic motor behavior. Here, we tested whether a sum score of the PANSS items manneris...
Article
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Tinnitus, the perception of sound without an external source, affects 15% of the population, with 2.4% experiencing significant distress. In this review, we summarize the current state of knowledge about tinnitus management with a particular focus on the translation into clinical practice. In the first section, we analyze shortcomings, knowledge ga...
Preprint
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In the era of burgeoning high-dimensional data, particularly in fields likemedicine, where data collection is increasing, the need for effective feature selectionin machine learning is paramount. Feature selection helps mitigate challengessuch as noise and irrelevant information, leading to a deeper understanding ofresults and improved predictive c...
Article
Securing an accurate autism‐spectrum‐condition diagnosis, particularly among women, remains challenging for autistic adults. Building upon previous research highlighting the short‐story task (SST) as a promising tool for detecting fiction‐based mentalizing difficulties in autistic adults, this study expands its scope. We investigated the SST's disc...
Article
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Background: Despite the high frequency of tinnitus and its impact on wellbeing, little is known about its economic burden and no data to our knowledge are available on out-of-pocket (OOP) expenses. Methods: In 2022 a survey was conducted on OOP costs of tinnitus. We enrolled 679 participants with slight, moderate and severe tinnitus in Italy, Unite...
Article
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Background Accurate assessments of current and future fertility-including overall trends and changing population age structures across countries and regions-are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to i...
Data
This appendix provides detailed information on the methods for the paper “Global fertility in 204 countries and territories, 1950–2021 with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021”
Article
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Background Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensiv...
Article
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Summary Background Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injur...
Preprint
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Tinnitus, characterized by the perception of sound without an external source, affects a significant portion of the population and can lead to considerable individual suffering, yet understanding of its suppression remains limited. Understanding neural traits of tinnitus suppression may be crucial for developing accurate predictive models in tinnit...
Article
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Background Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-base...
Article
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Background Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important follow...
Article
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Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique capable of inducing neuroplasticity as measured by changes in peripheral muscle electromyography (EMG) or electroencephalography (EEG) from pre-to-post stimulation. However, temporal courses of neuromodulation during ongoing rTMS are unclear. Monitorin...
Article
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Tinnitus, the perception of sound without a corresponding external sound source, and tinnitus disorder, which is tinnitus with associated suffering, present a multifaceted clinical challenge due to its heterogeneity and its incompletely understood pathophysiology and especially due to the limited therapeutic options. In this narrative review, we gi...
Article
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Objective: There is a high variability in the physiological effects of transcranial magnetic brain stimulation, resulting in limited generalizability of measurements. The cause of the variability is assumed to be primarily based on differences in brain function and structure of the stimulated individuals, while the variability of the physical prope...
Article
Full-text available
Background Accurate assessments of current and future fertility-including overall trends and changing population age structures across countries and regions-are essential to help plan for the profound social, economic, environmental, and geopolitical challenges that these changes will bring. Estimates and projections of fertility are necessary to i...
Article
Background: The evidence for repetitive transcranial magnetic stimulation (rTMS) to treat negative symptoms in schizophrenia (SCZ) is increasing, although variable response rates remain a challenge. Subject´s sex critically influences rTMS´ treatment outcomes. Females with major depressive disorder are more likely to respond to rTMS, while SCZ dat...
Article
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Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditio...
Article
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Background Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of D...
Chapter
Tinnitus is a common symptom for which, in most cases, there is no proved and reliable causal treatment. Thus, it is still a clinically unmet need. The proposed interventions for the management of tinnitus are diverse and most patients would welcome a compound that finally abolishes their phantom sound. The observation that tinnitus can be transien...
Chapter
Tinnitus is a phantom perception, analogous to hallucinations, visual snow, or some forms of chronic pain. These phantom perceptions can be associated with affective, cognitive, and behavioural symptoms, which are largely defining the related distress and the functional disability. Accordingly, it has recently been proposed that tinnitus without an...
Chapter
Tinnitus is a highly heterogeneous condition with respect to its perceptual characteristics, its etiology, its comorbidities, and its burden. Different forms of tinnitus also differ in their pathophysiology and presumably in their response to specific treatments. Thus, tinnitus heterogeneity is a major challenge in the identification of efficient t...
Chapter
1. Tinnitus can be a symptom of a wide range of different underlying pathologies and be accompanied by many different comorbidities, indicating the need for comprehensive multidisciplinary diagnostic assessment. 2. Exact diagnosis is required in each patient in order to provide the best management of tinnitus. 3. It is especially important to ident...
Chapter
1. A detailed case history is required in all tinnitus patients in order to obtain the necessary information for differential diagnosis and therapeutic management. 2. Qualitative data are best being obtained through case history questionnaires or a structured interview. 3. A case history should contain information about the history and descriptive...
Chapter
In this chapter, we give an outlook about future research strategies for the tinnitus field. The core question of every scientist, researcher, research team, or research organization is: what do you need to be successful? A literature research reveals characteristics such as multidisciplinarity, open-mindedness, spatial proximity, distributed respo...
Chapter
Sound stimulation combined with electrical vagus or trigeminal nerve stimulation has shown to modulate tinnitus-related brain plasticity. Sound stimulation paired with electrical nerve stimulation, also referred to as bimodal stimulation, has become an exciting new avenue for the treatment of tinnitus. This chapter discusses preclinical and clinica...
Chapter
We conducted an umbrella review of the scientific literature followed by a systematic review to comprehensively collect existing evidence on global prevalence from national or regional representative samples of tinnitus. The present chapter shows selected results from a comprehensive recently published systematic review and meta-analysis (Jarach et...
Chapter
It is a hallmark of modern medicine that it claims to be evidence based. This means that clinical decisions are based on research findings. Standardized algorithms have been developed to translate research findings into clinical recommendation. These involve a systematic review of the literature together with meta-analytic aggregation of research f...
Chapter
Quantitative assessment of the different aspects of tinnitus is important for clinical management of tinnitus patients and essential for research applications. Tinnitus is a subjective phenomenon, and there exist no established biomarkers. Assessment should include various aspects of tinnitus such as loudness, annoyance, distress, disability, and h...
Article
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Introduction Treating major depressive disorder (MDD) with transcranial direct current stimulation (tDCS) devices at home has various logistic advantages compared to tDCS treatment in the clinic. However, preliminary (controlled) studies showed side effects such as skin lesions and difficulties in the implementation of home-based tDCS. Thus, more d...
Article
Tinnitus subtypes are proposed to lie on a continuum of different symptom dimensions rather than be categorical. However, there is no comprehensive empirical data showing this complex relationship between different tinnitus symptoms. The objective of this study is to provide empirical evidence for the dimensional nature of tinnitus and how differen...
Preprint
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Background: Tinnitus is associated with a variety of etiologies, phenotypes, and underlying pathophysiological mechanisms, and available treatments have limited efficacy. A combination of treatments, addressing various aspects of tinnitus, might provide a viable and superior treatment strategy. Methods: In this multicenter, parallel-arm, randomized...
Article
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Background Hypersomnia poses major challenges to treatment providers given the limitations of available treatment options. In this context, the application of non-invasive brain stimulation techniques such as transcranial electrical stimulation (tES) may open up new avenues to effective treatment. Preliminary evidence suggests both acute and longer...
Article
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Objective: Tinnitus assessment and outcome measurement are complex, as tinnitus is a purely subjective phenomenon. Instruments used for the outcome measurement of tinnitus in the context of clinical trials include self-report questionnaires, visual analogue or numeric rating scales and psychoacoustic measurements of tinnitus loudness. For the evalu...
Article
Objectives. The study aimed to assess the relationship of tinnitus with hyperacusis with cognitive impairment as indicated by the Montreal Cognitive Assessment (MoCA) tool.Methods. This multicenter cross-sectional study included individuals with chronic tinnitus from the “Unification of Treatments and Interventions for Tinnitus Patients” (UNITI) da...
Article
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Introduction Obsessive-compulsive disorder (OCD) affects 2–3% of the global population, causing distress in many functioning levels. Standard treatments only lead to a partial recovery, and about 10% of the patients remain treatment-resistant. Deep brain stimulation offers a treatment option for severe, therapy-refractory OCD, with a reported respo...
Article
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Objective: The aim of this study was to investigate the reliability of low-frequency and high-frequency repetitive transcranial magnetic stimulation (rTMS) on healthy individuals over the motor cortex. A secondary outcome was the assessment if low-frequency rTMS results in inhibition and high-frequency rTMS results in facilitation. Methods: In t...
Article
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Background Quick symptomatic remission after the onset of psychotic symptoms is critical in schizophrenia treatment, determining the subsequent disease course and recovery. In this context, only every second patient with acute schizophrenia achieves symptomatic remission within three months of initiating antipsychotic treatment. The potential indic...
Article
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Background Tinnitus is a leading cause of disease burden globally. Several therapeutic strategies are recommended in guidelines for the reduction of tinnitus distress; however, little is known about the potentially increased effectiveness of a combination of treatments and personalized treatments for each tinnitus patient. Methods Within the Unifi...
Article
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Introduction: Depression in the elderly is an understudied condition. Psychopharmacological and psychotherapeutic approaches suffer from specific difficulties with this patient group. Brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) offer a therapeutic alternative. rTMS remains understudied in this age group...
Article
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Background: Transcranial direct current stimulation (tDCS) has been proposed as a feasible treatment for major depressive disorder (MDD). However, meta-analytic evidence is heterogenous and data from multicentre trials are scarce. We aimed to assess the efficacy of tDCS versus sham stimulation as an additional treatment to a stable dose of selecti...
Article
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Background: The mild behavioral impairment (MBI) syndrome is defined by the emergence in later life of persistent neuropsychiatric symptoms. The MBI checklist (MBI-C) can be used for systematic detection and documentation of such symptoms. Objective: Development of a German version of the MBI‑C and assessment of its application in a clinical set...
Article
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Mobile applications have gained popularity in healthcare in recent years. These applications are an increasingly important pillar of public health care, as they open up new possibilities for data collection and can lead to new insights into various diseases and disorders thanks to modern data analysis approaches. In this context, Ecological Momenta...
Article
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Introduction: This study aimed to explore whether body mass index (BMI), systolic blood pressure (RR syst), diastolic blood pressure (RR diast) or heart rate (HR) are associated with tinnitus status and/or severity. Methods: To that end, we evaluated the influence of tinnitus status and Tinnitus Handicap Inventory (THI) score on BMI, RR syst, RR...
Article
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Evidence-based medicine (EBM) is generally accepted as the gold standard for high-quality medicine and, thus, for managing patients with tinnitus. EBM integrates the best available scientific information with clinical experience and patient values to guide decision-making about clinical management. To help health care providers and clinicians, the...
Article
Recently, the use of mobile technologies in ecological momentary assessments (EMAs) and interventions has made it easier to collect data suitable for intraindividual variability studies in the medical field. Nevertheless, especially when self-reports are used during the data collection process, there are difficulties in balancing data quality and t...
Article
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At the beginning of the COVID-19 pandemic, with a lack of knowledge about the novel virus and a lack of widely available tests, getting first feedback about being infected was not easy. To support all citizens in this respect, we developed the mobile health app Corona Check. Based on a self-reported questionnaire about symptoms and contact history,...
Article
Borderline personality disorder (BPD) is characterised by impairments in emotional regulation, impulse control and interpersonal interaction. Comorbid depression is common. The orbitofrontal cortex (OFC) plays a crucial role in the biological substrate of BPD. We investigated the effects of 1 Hz repetitive transcranial magnetic stimulation (rTMS) t...
Article
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Cognitive behavioral therapy (CBT) was shown to be effective in reducing tinnitus-related distress in numerous controlled trials. Real-world data from tinnitus treatment centers are an important addition to controlled trials for demonstrating the ecological validity of the results from the randomized controlled trials. Thus, we provided the real-wo...
Article
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The risk for suicide in patients with cancer is higher compared to the general population. However, little is known about patients with lung cancer specifically. We therefore implemented a systematic review and random-effects meta-analysis of retrospective cohort studies on suicide in patients with lung cancer. We searched a high number of common d...
Article
There is preliminary evidence that high-frequency repetitive transcranial magnetic stimulation targeting the right dorsolateral prefrontal cortex (DLPFC) could reduce cue-induced sexual arousal. Here, we aimed to replicate this finding by using transcranial direct current stimulation (tDCS). In a randomized, double-blind, sham-controlled crossover...
Preprint
Full-text available
The neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) are often described as inhibiting for low frequency and facilitating for high frequency protocols, leading to the lofi-hife heuristic. However, the data basis for this is inconsistent and reliability of rTMS is barely evaluated. The present study examines the validit...
Article
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Tinnitus affects a considerable part of the population and develops into a severe disorder in some sufferers. App-based interventions are able to provide low-threshold, cost-effective, and location-independent care for tinnitus patients. Therefore, we developed a smartphone app combining structured counseling with sound therapy and conducted a pilo...
Article
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Background Low frequency repetitive transcranial magnetic stimulation (rTMS) is commonly used to inhibit pathological hyperactivity of the auditory cortex in tinnitus. Novel and supposedly superior and faster inhibitory protocols such as continuous theta burst stimulation (cTBS) were examined as well, but so far there is not sufficient evidence for...
Chapter
The advent of chatbots (also called conversational agents) has been recognized to support various treatment procedures in the medical and psychological fields. Chatbots may be particularly useful before and after medical procedures when patients are at home. For example, while being in the preparation phase of a colonoscopy, a chatbot might answer...
Chapter
Tinnitus is a condition associated with a continuous noise in the ears or head and can arise from many different medical disorders. The perception of tinnitus can vary within and between days. In the recent years, Ecological Momentary Assessments of tinnitus have been used to investigate these tinnitus variations during the daily life of the patien...
Article
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Optimization of dietary intake is an essential component in the multidimensional effort to prevent and manage chronic disease. Recently, demand has increased for nutrition-focused management strategies for chronic tinnitus. The primary aim of this study was to evaluate 10 dietary items for their association with changes in subjective tinnitus sever...
Article
This study aimed to validate the short-story-task (SST) based on Dodell-Feder et al. as an instrument to quantify the ability of mentalizing and to differentiate between non-autistic adults and autistic adults, who may have acquired rules to interpret the actions of non-autistic individuals. Autistic (N = 32) and non-autistic (N = 32) adult partici...
Article
Introduction So far studies on the efficacy of repetitive transcranial magnetic stimulation (rTMS) as treatment for tinnitus are inconclusive. Two large scale placebo-controlled randomized clinical trials (RCT) examined the efficacy of low frequency temporal cortex rTMS and report different findings. As the used TMS devices differ in their used pri...