Berthold V Koletzko

Berthold V Koletzko
Ludwig-Maximilians-University of Munich | LMU · Children's Hospital and Children clinic at the Dr. von Hauner Children's Hospital

Dr med (MD) Dr med habil (PhD) Dr h c mult Professor of Paediatrics Prof h c

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1,021
Publications
253,610
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45,181
Citations
Citations since 2017
120 Research Items
17142 Citations
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201720182019202020212022202305001,0001,5002,0002,5003,000
201720182019202020212022202305001,0001,5002,0002,5003,000
201720182019202020212022202305001,0001,5002,0002,5003,000

Publications

Publications (1,021)
Article
Introduction Placental function can be modified by maternal obesity affecting the materno-fetal fatty acid transport process. We analyze for the first time the in vivo materno-fetal kinetic transfer of fatty acids (FA) labeled with stable isotopes in control and obese pregnant women. Materials and Methods Labelled FA with similar metabolism (stear...
Article
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Objective The aim of this study was to analyse the differences in the phospholipid composition of very low density (VLDL), low density (LDL) and high density lipoprotein (HDL) monolayers in pregnant lean and obese women. Methods LDL, HDL, and VLDL were isolated from plasma samples of 10 lean and 10 obese pregnant women, and their species compositi...
Article
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Pureed complementary feeding products packed in squeezable plastic pouches, usually with a spout and a screw cap, have been increasingly marketed. The Committee on Nutrition recommends that infants and young children should not suck pureed or liquid complementary foods from baby food pouches. Complementary foods should be offered with a spoon or sh...
Article
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Lifestyle behavioral habits such as excess screen time (ST), a lack of physical activity (PA), and high energy-dense food consumption are associated with an increased risk of children being overweight or obese. This study aimed to (1) track longitudinal adherence to PA and ST recommendations at baseline (T0) and follow-up (T1) and (2) assess the as...
Article
Today, awareness has been raised regarding high consumption of n-6 polyunsaturated fatty acids (PUFA) in western diets. A comprehensive analysis of total and individual postprandial fatty acids profiles would provide insights into metabolic turnover and related health effects. After an overnight fast, 9 healthy adults consumed a mixed meal comprisi...
Article
Zunehmend werden pürierte Beikostprodukte für Säuglinge und Kleinkinder mit Verpackung in quetschbaren Kunststoffbeuteln, üblicherweise mit einer Tülle und einem Schraubverschluss, angeboten. Säuglinge und Kleinkinder sollten pürierte oder flüssige Lebensmittel nicht aus einem Plastikbeutel saugen. Beikost soll mit dem Löffel oder durch die Hand de...
Article
Objectives: The aim of this study was to examine the reproducibility and relative validity of a semiquantitative food frequency questionnaire (FFQ) in assessing food group estimates. Methods: Food group estimates were assessed via a 37-item FFQ and a 3-d food record (FR). Pearson's correlation coefficients for log-transformed values were calcula...
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Childhood obesity prevalence is rising in countries worldwide. A variety of etiologic factors contribute to childhood obesity but little is known about underlying biochemical mechanisms. We performed an individual participant meta-analysis including 1,020 pre-pubertal children from three European studies and investigated the associations of 285 met...
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Objective: To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design: Individual participant data meta-analysis of 39 cohorts. Setting: Europe, North America, and Oceania. Population: 265 270 births...
Article
Aims Maternal obesity and gestational diabetes mellitus (GDM) were frequently reported to be risk factors for obesity and diabetes in offspring. Our goal was to study the impact of maternal prepregnancy BMI (pBMI) and GDM on both maternal and cord blood metabolic profiles. Methods We used LC–MS/MS to measure 201 metabolites comprising phospholipid...
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Background: A considerable body of evidence accumulated especially during the last decade, demonstrating that early nutrition and lifestyle have long-term effects on later health and disease ("developmental or metabolic programming"). Methods: Researchers involved in the European Union funded international EarlyNutrition research project consoli...
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Background Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the se...
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Children with phenylketonuria (PKU) follow a protein restricted diet with negligible amounts of docosahexaenoic acid (DHA). Low DHA intakes might explain subtle neurological deficits in PKU. We studied whether a DHA supply modified plasma DHA and neurological and intellectual functioning in PKU. In a double-blind multicentric trial, 109 PKU patient...
Article
: media-1vid110.1542/5849572910001PEDS-VA_2018-0994Video Abstract OBJECTIVES: Physical activity (PA) is presumed to decline during childhood and adolescence, but only few long-term studies about PA development during this period of life exist. We assessed PA and sedentary behavior (SB) over a 5-year period to gain a better understanding of the exte...
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Background Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to cons...
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Background/Objectives The aim of this study was to examine the effect of physical activity (PA) and sedentary behaviour (SB) on body mass index (BMI) and fat mass index (FMI) in children over the course of five years and identify potential bi-directional associations. Subjects/Methods Data were drawn from the EU Childhood Obesity Project (CHOP). P...
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Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in newborns and children related to childhood asthma. Methods: Within the Pregnancy And Childhood...
Article
Background and aims: Long chain polyunsaturated n-3 fatty acids (LC-PUFA) are of functional and structural importance for brain development. Observational studies have shown positive relations between fatty fish consumption and cognitive performance in children, but Results from intervention studies using supplementary n-3 LC-PUFA are conflicting....
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Background: Adequate availability of long-chain polyunsaturated fatty acids (LC-PUFAs) is important for human health from pregnancy to adulthood. Previous studies on fatty acid desaturase (FADS) gene single-nucleotide polymorphisms (SNPs) have been performed predominantly in Western populations and showed that FADS SNPs had a marked impact on LC-P...
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Objective The present study aimed to explore the mediating role of family-related determinants on the effects of the ToyBox-intervention on pre-school children’s consumption of healthy and unhealthy snacks. Design The ToyBox-intervention was a kindergarten-based, family-involved intervention with a cluster-randomized design, aiming to promote heal...
Conference Paper
Full-text available
BREASTFEEDING RATES AND NATIONAL PROGRAMS IN EUROPE: SURVEY OF 11 NATIONAL BREASTFEEDING COMMITTEE REPRESENTATIVES Presenting Author: Melissa Theurich, Dr. von Hauner Children’s Hospital, LMU-Ludwig-Maximilians-Universita¨t Munich, Germany Co-Authors: Riccardo Davanzo (IRCCS Burlo Garofolo, Trieste, Italy); Marianne Busck-Rasmussen (Danish Comm. He...
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Purpose In this cross-sectional study, we examined the association of selected basic motor abilities with biological (sex, age, and BMI), sociodemographic [socio-economic status (SES), migration status], and behavioural factors (membership of sport club) in children aged 3–6 years. Methods We performed two motor tests, jumping from side to side (J...
Article
Objectives: Fetal and early life represent a period of developmental plasticity during which metabolic pathways are modified by environmental and nutritional cues. Little is known on the pathways underlying this multifactorial complex. We explored whether 6 months old breastfed infants could be clustered into metabolically similar groups and that...
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Diet and exercise before and during pregnancy affect the course of the pregnancy, the childʼs development and the short- and long-term health of mother and child. The Healthy Start – Young Family Network has updated the recommendations on nutrition in pregnancy that first appeared in 2012 and supplemented them with recommendations on a preconceptio...
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Objectives: Available published advice on use of incentives is limited and generally refers to short term studies without longer follow-up, predominantly conducted in developed countries. We aim to summarise published information related to the use of incentives in long-term nutrition studies involving infants, children and adolescents and the vie...
Conference Paper
Rationale: Increased risk for obesity and altered glucose metabolism in offspring born to mothers with obesity and/or gestational diabetes mellitus (GDM) has been frequently reported. This study aims to identify the impact of maternal prepregnancy BMI (pBMI) and GDM on the metabolic profiles in both maternal and cord blood. We assume that the mater...
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In westlichen Ländern werden bei einer sorgfältig zusammengestellten vegetarischen Ernährung im Vergleich zur üblichen omnivoren Kost weniger Energie, gesättigte Fettsäuren und tierisches Protein, aber mehr Ballaststoffe und sekundäre Pflanzenstoffe aufgenommen. Inwieweit die dadurch bedingten positiven gesundheitlichen Effekte bei Vegetariern das...
Article
The influence of an early (within 24?h) vs. a late (from day 8) start of parenteral nutrition (PN) was investigated in 1440 pediatric intensive care patients in a prospective, randomized, controlled, multicenter investigation (PEPaNIC trial). The indications for PN were estimated on the basis of a nutrition screening score. The authors of the PEPaN...
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The relationships between nutrition, metabolic response, early growth and later body weight have been investigated in human studies. The aim of this follow-up study was to assess the long-term effect of infant feeding on growth and to study whether the infant metabolome at the age of 4 months might predict anthropometry at 4 years of age. The Belgr...
Data
Baseline characteristics (intention-to-treat population) of follow-up infants. (DOCX)
Data
Anthropometry and body composition at 4 years of age (per-protocol population). (DOCX)
Data
Amino acid, fatty acid and micronutrient composition of study formulae. (DOCX)
Article
Background & aims: At the 38th annual ESPEN congress in The Hague, the Netherlands, the Special Interest Group (SIG) in Paediatrics presented data about current research activities in the field of paediatric nutrition which are performed worldwide and translated this to future research perspectives. Methods: Extensive search of all registered ob...
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Background: Uncertainty remains about the effect of vitamin D therapy on biomarkers of health status in obesity. The molecular basis underlying this controversy is largely unknown. Objective: To address the existing gap, our study sought to compare changes in metabolomic profiles of obesity phenotypes (metabolically healthy obese (MHO) and metab...
Article
Background: Current recommendations for protein levels in infant formula are intended to ensure that growth matches or exceeds growth of breastfed infants, but may provide a surplus of amino acids (AAs). Recent infant studies with AA-based formulas support specific adjustment of the essential amino acid (EAA) composition allowing for potential low...
Article
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Background & aims: Breastfeeding is beneficial for mothers and infants. Underlying mechanisms and biochemical mediators thus need to be investigated to develop and support improved infant nutrition practices promoting the child health. We analysed the relation between maternal breast milk composition and infant metabolism. Methods: 196 pairs of...
Article
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Background: Previous guidelines on Paediatric Parenteral Nutrition (PN) were published in 2010, by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR) were published. The aim of...
Article
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Background: Previous guidelines on Paediatric Parenteral Nutrition (PN) were published in 2010, by the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), supported by the European Society of Paediatric Research (ESPR) were published. The aim of...
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Methods Literature search timeframe: Publications published after the previous guidelines [1] (i.e., from 2004–December 2014), were considered. Some studies published in 2015 or 2016 during the revision process have also been considered. References cited in the previous guidelines are not repeated here, except for some relevant publications; the pr...
Data
STROBE checklist of the used maternal breast milk and infant serum samples of the PreventCD Trial and the accomplished data analysis in the presented manuscript. (PDF)
Data
Associations/Correlations between breast milk macronutrient classes (fat and protein) to infant serum metabolites at 4 months of age. Breast milk components were measured at month 1 or month 4. Spearman correlation (S) was performed to assess correlation. Correlations coefficients (R), P-values (P) and number of observation (N) are presented for S....
Data
Associations/Correlations between breast milk fatty acid percentage to infant serum metabolites at 4 months of age. Breast milk components were measured at month 1 (a) or month 4 (b). Spearman correlation (“Spearman” sheets) was performed to assess correlation. Correlations coefficients (R) and P-values (are presented for S. Associations were calcu...
Data
Protocol of the PreventCD trial as outlined in the 6th framework programme, contract FP6-2005-FOOD-4B-36383–PREVENTCD. (PDF)
Data
Associations between breast milk macronutrient classes and hormones to infant serum metabolites at 4 months of age in the subgroup of exclusively breastfed infants. Breast milk components were measured at month 1 (a) or month 4 (b). Negative log-transformed P-values are plotted for each metabolite arranged by metabolite group and species. Higher va...
Data
Associations/Correlations between breast milk hormones (adiponectin, IGF-II, insulin and leptin) to infant serum metabolites at 4 months of age. Breast milk components were measured at month 1 or month 4. Spearman correlation (S) was performed to assess correlation. Correlations coefficients (R), P-values (P) and number of observation (N) are prese...
Article
Background: Excess protein intake in early life has been linked to obesity and metabolic syndrome in later life. Yet protein, and in particular the essential amino acids (EAAs), need to be present in adequate quantity to support growth. Objective: With the use of a piglet model restricted in dietary amino acids (AAs), we compared the efficacy an...
Article
Overweight and obesity dominate the discussions about dietary problems in children and adolescents in Germany. In contrast, the challenges of disease-related underweight and malnutrition are often underestimated; however, the consequences of inadequate nutrition are severe, particularly in infants and young children. A working group comprised of ex...
Article
Objectives: Health inequalities are observed among different regions and socioeconomic groups. The present study aimed to record the prevalence of overweight and obesity among preschoolers across six European countries in relation to sociodemographic and family factors. Methods: A total of 7554 preschool-aged children and their parents participa...
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Background: Dietary habits established in infancy may persist into adulthood and determine long-term health. Objectives: The aims of this work were to describe dietary patterns, predictors of adherence to them, and their tracking from ages 1 to 8 y in European children. Methods: Three-day food diaries were prospectively collected at ages 1, 2, 3,...
Article
Background Low serum concentrations of vitamin D have been associated with rickets and also with other disorders in observational studies. Since vitamin D serum concentrations in German children and adolescents are frequently below reference values, it is debated whether vitamin D should be broadly supplemented also after infancy. Methods The effe...
Article
Since the conception of an idea of a few paediatric gastroenterologists in Europe to create a society for Paediatric Gastroenterology in 1967, and its foundation in 1968, half a century has passed. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) now celebrates its 50th anniversary and its utmost success in c...
Article
The European Society for Paediatric Gastroenterology, Hepatology and Nutrition has experienced an amazing development in the 50 years of its existence. It grew from a small group of 36 friends who held an informal meeting with some 20 oral presentations to share and discuss their clinical and research work, to a large, multiprofessional society tha...
Article
The first Committee on Nutrition (CoN) was founded in 1974. Two years later nutrition (N) was added to the society's name, which then became ESPGAN. The Committee systematised compositional and quality criteria for breast milk substitutes and food for special medical purposes, the first of many examples on how recommendations and comments published...
Article
Maternal obesity is associated with adverse outcomes. Placental lipid droplets (LD) have been implicated in maternal-fetal lipid transfer but it is not known whether placental LD fat composition is modifiable. We evaluated the effects of a diet and physical activity intervention in obese pregnant women compared to routine antenatal care (UPBEAT stu...
Conference Paper
Background/aim Maternal diet before and during pregnancy can contribute to an offspring’s mental and physical health. Moreover, maternal food intake can modulate overweight or obesity issues and the development of adverse metabolic related outcomes/diseases later in life. Thus, this study aims to evaluate the association of maternal diet during pre...
Article
Full-text available
This study is part of the ToyBox-study, which is conducted in six European countries (Belgium, Bulgaria, Germany, Greece, Poland and Spain), aiming to develop a cost-effective kindergarten-based, family-involved intervention to prevent overweight and obesity in four- to six-year-old preschool children. In the current study, we aimed to examine and...
Chapter
Growth characteristics during periods of early developmental plasticity are linked with later health outcomes and with disease risks. Infant growth is modulated by genetic and exogenous factors including nutrition. We try to explore their underlying mechanisms using targeted metabolomic profiling of small molecules in biological samples using high-...
Chapter
The complementary feeding period is a short transitional period from breastfeeding and formula feeding to family foods. Timing, quantity, and quality are implied to impact growth and obesity risk. We summarized the literature and analyzed data of monthly 3-day food diaries of >1,000 children from 5 European countries in the first 2 years of life, w...