Berrak C Yeğen

Berrak C Yeğen
Marmara University · Department of Physiology

MD

About

340
Publications
46,490
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8,274
Citations
Citations since 2017
54 Research Items
2796 Citations
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20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
20172018201920202021202220230100200300400
Introduction
In 1977: graduated from Izmir American Collegiate Institute In 1983: graduated from Aegean University Medical Faculty, İzmir 1992 Professor of Physiology, Marmara University Medical Faculty MAJOR FIELDS OF INTEREST IN RESEARCH: -Gastrointestinal Motility -Neural and hormonal mechanisms that control gastric emptying and gastric acid secretion -Ulcer and colitis pathogenesis -Inflammatory processes and free radicals
Additional affiliations
January 1986 - present
Marmara University

Publications

Publications (340)
Article
Full-text available
Background/aims: Gastrointestinal motility changes contribute to development and maintenance of obesity. Nesfatin-1 (NES-1) is involved in central appetite control. The aim is to elucidate effects of NES-1 and high-fat diet (HFD) on gastrointestinal motility and to explore myenteric neuron expressions of tyrosine hydroxylase (TH), vasoactive intes...
Preprint
Full-text available
Sepsis leads to systemic hypotension, disturbed perfusion, inflammation and tissue toxicity in vital organs. Neuropeptide W (NPW) has modulatory effects in the control of blood pressure and inflammatory processes, implicating a potential beneficial effect against sepsis-induced oxidative damage. Under anesthesia, male Sprague Dawley rats underwent...
Article
Aims Acetaminophen-induced hepatorenal toxicity varies among sexes with controversial results among species. The aim was to compare the impact of sex and ovarian hormones on hepatorenal toxicity and to elucidate protective effects of estrogen and estrogen receptor (ER) agonists. Main methods Under anesthesia, female rats underwent ovariectomy (OVX...
Article
The protective effects of ACE inhibitor, Captopril, and angiotensin receptor blocker, Valsartan, were evaluated in the treatment of chronic renal failure (CRF) with and without the presence of N-acetylcysteine (NAC). The renal mass of Wistar albino rats was reduced at a rate of 5/6. Captopril, Valsartan and NAC were applied intra-peritoneal alone o...
Article
Background Although alterations in the plasma levels of leptin, GLP-1 and gastrin were linked with bariatric surgery outcomes, gastric production of these peptides was not elucidated before. The aim was to evaluate the impact of estrogen depletion and estrogen receptors (ER) on sleeve gastrectomy (SG)-induced alterations in gastric hormone producti...
Article
Full-text available
In order to investigate the role of the vagus nerve in the possible gastroprotective effect of obestatin on the indomethacin-induced acute oxidative gastric injury, Sprague-Dawley rats of both sexes were injected subcutaneously with indomethacin (25 mg/kg, 5% NaHCO3) followed by obestatin (10, 30 or 100 μg/kg). In other sets of rats, surgical vagot...
Article
Key points: A moderate level of exercise has beneficial effects on the prevention of gastric ulcer. Although regular aerobic exercise was shown to elevate serum oxytocin levels and exogenously administered oxytocin exerts an antiulcer activity, the role of endogenous oxytocin in the gastroprotective effects of exercise was not elucidated yet. We s...
Article
Full-text available
z Amaç: Bifosfonatlar menopoz sonrası osteoporozda kemik kütlesinin korunması amacıyla sıklıkla kullanılmaktadır. Melatonin kemik metabolizmasında da düzenleyici rolü olduğu düşünülen bir antioksidan hormondur. Ancak seks hormonları ve Vitamin D düzeylerine etkisi daha önce çalışılmamıştır. Gereç ve Yöntem: Anestezi altında, Sprague-Dawley sıçanlar...
Article
Background and Purpose Ongoing high mortality due to necrotizing enterocolitis (NEC) necessitates the investigation of novel treatments to improve the outcome of the affected newborns. The aim was to elucidate the potential therapeutic impact of the nesfatin-1, a peptide with anti-inflammatory and anti-apoptotic effects in several inflammatory proc...
Poster
Full-text available
INTRODUCTION Metabolic syndrome (MetS) defines a combination of risk factors, which raise the risk of developing cardiovascular disease, stroke, diabetes and chronic kidney disease. The present study was designed to evaluate the effects of exercise and CR on rats induced with MetS model. MATERIALS and METHODS In male Sprague-Dawley (12-week-old) ra...
Article
Full-text available
BACKGROUND: This study was designed to determine possible protective effect of betaine treatment against oxidative injury in pulmonary tissue induced with thermal trauma.
Article
Full-text available
Amaç: Menopoz sonrası dönemde ortaya çıkan metabolik bozukluklar kadınlarda yağlı karaciğer hastalığı gelişme riskini arttırmaktadır. Bu çalışmanın amacı, ghrelinin overektomize (OVT) sıçanlarda metabolik biyobelirteçler ve hepatik morfoloji üzerindeki etkilerini değerlendirmektir. Gereç Ve Yöntem: Ketamin-klorpromazin anestezisi altında (100 mg /...
Article
New findings: • What is the central question of this study? Could different hormonally active substances, including oestrogen receptor (ER) agonists, protect against oxidative brain damage and memory impairment induced by a single epileptic seizure in rats? If so, which signalling mechanisms are involved in their anti-inflammatory effects? • What...
Article
Objective: Traumatic brain injury (TBI) is one of the most common preventable causes of mortality and morbidity. Inflammation, apoptosis, oxidative stress, and ischemia are some of the important pathophysiological mechanisms underlying neuronal loss after TBI. Mildronate is demonstrated to be beneficial in various experimental models of ischemic d...
Article
Full-text available
High-fat diet (HFD) consumption leads to metabolic disorders, gastrointestinal dysfunction and intestinal dysbiosis. Antibiotics also disrupt the composition of intestinal microbiota. The aim of the study was to investigate the impact of a short-term feeding with HFD on oxidative status, enteric microbiota, intestinal motility and the effects of an...
Book
Full-text available
Diş hekimliğinde özel öneme sahip fizyolojik mekanizmaların büyük çoğunluğunun genel fizyoloji kitaplarının içeriğinde yer almaması bilimsel bir boşluk oluşturmaktadır. Bu boşluğu doldurmak amacıyla konularında uzman bilim insanlarının katkılarıyla "Oral Fizyoloji” kitabı kaleme alınmıştır. Dolayısıyla, eser, Türk literatüründe bir ilk olma özelliğ...
Conference Paper
Full-text available
Introduction: Osteoporosis is a postmenopausal disorder characterized by a higher risk of fractures, while the medications aimed to treat osteoporosis, such as bisphosphonates, are known to induce gastric inflammation. In the present study, we aimed to determine the impact of melatonin on the gastric side-effects of bisphosphonates in rats with sur...
Article
Aim:In order to maintain bone mass in post-menopausal osteoporosis, bisphosphonates (e.g. alendronate) are frequently used, while the antioxidant agent melatonin was also suggested to have a regulatory role in bone physiology. However, their impact on the serum levels of sex hormones and vitamin D was not studied before. Material and Methods:Under...
Article
Abstract The anti‐catabolic bisphosphonate alendronate is considered as the first‐line medical treatment in post‐menopausal osteoporosis; but several side effects, including gastric mucosal injury, are associated with its use. The aim was to elucidate whether combined treatment with melatonin plus alendronate would be more advantageous in the main...
Article
Aims The purpose of the present study was to investigate the potential antioxidant, anti-apoptotic and sperm function-preserving effects of estrogen, estrogen receptor (ER)α and ERβ agonists in a rat model of testis torsion-detorsion (T/D). Main methods Under anesthesia, 6–8-week-old male Sprague-Dawley rats underwent sham-operation or testicular...
Conference Paper
Full-text available
Serulein ile oluşturulan sıçan akut pankreatit modelinde antioksidan astaksantin ve koenzim Q10 tedavisinin olası sinerjistik iyileştirici etkisinin incelenmesi Dilek ÖZBEYLİ1*, Esra Bihter GÜRLER2, Hülya BUZCU3, Özlem Tuğçe ÇİLİNGİR-KAYA4, Muhammet Emin ÇAM5, Burcin ALEV6, Meral YÜKSEL7, Özgür Kasımay ÇAKIR3, Berrak Çağlayan YEĞEN3 1Marmara Üniver...
Conference Paper
Full-text available
Aim: We investigated astaxanthin (ATX)’s thereupatic effects and underlying antiinflammatory mechanisms in a cerulein-induced acute pancreatitis rat model. Methods: After ethical approval (76.2017mar), female Wistar rats (n=18) were injected twice with cerulein (50 μg/kg/hr intraperitonally), with an hour in between (Acute pancreatitis; AP); while...
Article
Testicular torsion causes ischemia-reperfusion injury and an increased risk of infertility. Nesfatin-1 is a novel peptide with antioxidant, anti-inflammatory and anti-apoptotic properties. In the present study, we aimed to investigate the putative beneficial effects of nesfatin-1 on oxidative injury and impaired testicular function induced by testi...
Article
The risk of developing peptic ulcer disease (PUD) was shown to be associated with genetic inheritance, life-style and social status of the patients. Unhealthy lifestyle habits and failure in coping with stress have been closely associated with the occurrence of PUD. In contrary, limiting the use of analgesic drugs and glucocorticoids, controlling e...
Article
Full-text available
ABSTRACT Background/Aims: Cholestasis, which results in hepatic cell death, fibrosis, cirrhosis, and eventually liver failure, is associated with oxidative stress. The aim of this study was to evaluate the effects of milk thistle (MT, Silybum marianum) and ursodeoxycholic acid (UDCA) or their combination on the activation of hepatic stem cells and...
Article
Full-text available
Background The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. Materials and methodsCorrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3r...
Article
Full-text available
In order to elucidate the contribution of cycloxygenase (COX) enzymes in the anti-oxidant and anti-inflammatory mechanisms of nesfatin-1, which improves the healing process of chronic gastric ulcers, either acetic acid (80%; ulcer groups; n = 40) or saline (control groups; n = 40) was applied to the serosal surface of male Sprague Dawley rats' stom...
Article
Full-text available
The aim of the study is to assess the professional competencies and to examine the relations of those skills with emotional intelligence dimensions during the post-graduate medical education of the residents. The study was conducted on residents studying at medical and surgical departments of a university hospital. The data were gathered with multi...
Article
Full-text available
Background The present study aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) and prosthesis placement on gastric emptying rate in conjunction with serum ghrelin-obestatin-leptin responses in non-obese rats with intact or denervated afferent innervation. Methods Under anesthesia, male Sprague-Dawley rats underwent either sham ope...
Article
Full-text available
Neonatal unconjugated hyperbilirubinemia might cause severe bilirubin neurotoxicity in especially hemolytic conditions. The study aimed to elucidate the potential neuroprotective effects of erythropoietin (EPO) in hemolysis-induced hyperbilirubinemia. In newborn rats, hyperbilirubinemia secondary to hemolysis was induced by injecting with phenylhyd...
Article
Background & aim: Alpha lipoic acid (LA) was shown to exert neuroprotection in trauma-induced spinal cord injury (SCI), which is frequently associated with urinary bladder complaints in patients with SCI. Accordingly, the protective effects of LA on biochemical and histological changes in bladder as well as functional studies were assessed. Metho...
Article
Obestatin was shown to alleviate renal, gastrointestinal and haemorrhage-induced brain injury in rats. In order to investigate the neuroprotective effects of obestatin on seizure-induced oxidative brain injury, an epileptic seizure was induced with a single intraperitoneal (i.p.) dose of pentylenetetrazole (PTZ, 45mg/kg) in male Wistar rats. Thirty...
Article
Low-calorie sweeteners are considered to be beneficial in calorie control, but the impact of these sweeteners on gastric emptying is not well described. The purpose of this study was to compare the gastric emptying rate of agave nectar with those of glucose and fructose, and to evaluate the interaction of cholecystokinin (CCK)-1, CCK-2 and glucagon...
Article
Full-text available
Objectives: To investigate the impact of exercise on ulcerogenesis. Materials and Methods: Gastric ulcer was induced in Wistar albino rats that were either kept sedentary or had swimming exercise for 6 weeks. Under anesthesia, ulcer was induced by applying acetic acid on the stomach serosa, while control rats had sham-operation. On 3rd or 10th day...
Conference Paper
Full-text available
AIM: First line therapy for osteoporosis based on pharmaceuticals which maintains bone mass such as bisphosphonate alendronate (ALN). There are evidences that melatonin reduces inflammation and has a regulator role on bone physiology. The aim was to evaluate the possible anti-osteoporotic effect of melatonin. METHODS: Under anaesthesia, Sprague-Daw...
Article
Full-text available
Background: This study was designed to determine possible protective effect of betaine treatment against oxidative injury in pulmonary tissue induced with thermal trauma. Methods: Under ether anesthesia, shaved dorsum of Wistar albino rats was exposed to a 90°C water bath for 10 seconds to induce burn injury. Betaine was administered orally (250...
Article
Introduction: Despite its adverse health consequences, tobacco smoking is associated with lower incidence of several neurodegenerative and inflammatory diseases. The present study is aimed to show the effects of nicotine, major tobacco constituent, on five organs targeted by sepsis. Methods: Male Wistar albino rats received tap water with (5 mg/kg)...
Article
Background: There are contradictory results about stress response in hypothyroidism and in exercising ones with variant intensities. We aimed to investigate the potential anxiolytic and protective effects of different intensities of exercise on acute psychological stress in hypothyroidism. Methods: Rats (n= 48) were divided as sedentary, moderat...
Article
Although endogenous estrogen is known to offer cardiac and vascular protection, the involvement of estrogen receptors in mediating the protective effect of estrogen on hypertension-induced cardiovascular and renal injury is not fully explained. We aimed to investigate the effects of estrogen receptor (ER) agonists on oxidative injury, cardiovascula...
Article
Full-text available
The aim of this study was to evaluate the possible protective effects of halofuginone on burn-induced oxidative injury of the liver and kidney. For the induction of burn, backs of Wistar albino rats were shaved and exposed for 10 seconds to water bath at 90°C, whereas rats in the control group were exposed for 10 seconds at 25°C. Rats were then adm...
Article
To investigate the putative protective effects of oxytocin or oestrogen receptor agonists against postmenopausal myocardial injury of sedentary or exercised rats, female Sprague-Dawley rats assigned to sham-operated control and ovariectomy (OVX) groups were kept sedentary or had swimming exercise for 4 weeks and were treated with saline, ERβ (DPN)...
Article
The importance of physical activity in the management of renovascular diseases is well-known, but lacks evidence of underlying mechanisms. The purpose of the study was to elucidate the protective/therapeutic effects of regular exercise on experimental renovascular hypertension (RVH)-induced oxidative stress and cardiac dysfunction. Wistar albino ra...
Article
Hyperglycemia is one of the major causes of suppressed angiogenesis and impaired wound healing leading to chronic wounds. Nesfatin-1 a novel peptide was reported to have antioxidant and anti-apoptotic properties. This study is aimed to investigate the potential healing-promoting effects of nesfatin-1 in non-diabetic or diabetic rats with surgical w...
Conference Paper
Kernicterus is a disabling chronic neurological disorder presenting with bilirubininduced neuronal injury. Erythropoietin (Epo), via its receptor activation, was suggested to trigger neuroprotective mechanisms in hypoxia, epilepsy and neurodegeneration. The neuroprotective effect of exogenous Epo administration in hemolysis-induced hyperbilirubinem...
Conference Paper
Aim: Melatonin was shown to exert protection in several inflammatory and neurodegenerative disorders. Current study was conducted to investigate the possible neuroprotective effect of melatonin in an experimental hemolysis-induced hyperbilirubinemia in newborn rats. Material and Method: To induce hyperbilirubinemia secondary to hemolysis, newborn S...
Article
Full-text available
Recently, integrated and contextual learning models such as problem-based learning (PBL) and brain/mind learning (BML) have become prominent. The present study aimed to develop and evaluate a PBL program enriched with BML principles. In this study, participants were 295 first-year medical students. The study used both quantitative and qualitative m...
Article
Melatonin exerts protection in several inflammatory and neurodegenerative disorders. To investigate the neuroprotective effects of melatonin in an experimental hemolysis-induced hyperbilirubinemia, newborn Sprague Dawley rats (25-40 g, n=72) were injected with phenylhydrazine hydrochloride (PHZ; 75 mg/kg) and the injections were repeated at the 24(...
Conference Paper
Full-text available
Giriş Diyabet, baskılanmış anjiyojeneze ve yara iyileşmesinde gecikmeye neden olarak kronik yara oluşumuna yol açan nedenler arasında başta gelir. Nesfatin-1, daha önce yapılmış çalışmalarda antioksidan ve anti-apoptotik özellikleri gösterilmiş olan yeni bir peptittir. Amaç Bu çalışmada amacımız, diyabetik-olan ve diyabetik-olmayan sıçanlarda nesf...
Conference Paper
Full-text available
Introduction: Diabetes mellitus (DM) is one of the major causes of suppressed angiogenesis and impaired wound healing leading to chronic wounds. Nesfatin-1, a novel peptide, was reported to have antioxidant and anti-apoptotic properties. Objectives: This study is aimed to investigate the potential healing-promoting effects of nesfatin-1 in non-dia...
Conference Paper
https://www.youtube.com/watch?v=zv2VtSV4lZA&list=UUy4D1nNOzIYe685NEtIvDZg&index=2
Conference Paper
PC079 Treatment with Milk Thistle Extract (Silybum Marianum), Ursodeoxycholic Acid or their Combination Attenuates Liver Injury and Stem Cells in Bile Duct-Ligation Induced-Cholestasis in Rats Nuray Alaca1,2 , Dilek Ozbeyli1, Serap Uslu3, Hasan Hüseyin Şahin4, Gürkan Yigitturk5, Hızır Kurtel1, Gülperi Oktem5, Berrak C. Yeğen1 1Department of Physiol...
Article
To investigate the effect of intravesical hyaluronic acid on Escherichia coli-induced cystitis and cystitis-induced hypercontractility in rats. Bacterial cystitis was induced in Wistar female rats by intravesical inoculation of E. coli. Isotonic saline was instilled in the control group (n = 6). The rats were either non-treated, treated with gentam...
Article
Full-text available
Purpose: The present study was conducted to characterize the possible therapeutic effects of glucagon-like peptide (GLP)-1 and GLP-2 against oxidative damage in the ileum and colon of irradiated rats. Methods and materials: Sprague-Dawley rats of both sexes received either a single dose of GLP-1 (0.1 nmol/kg, intraperitoneally, ip; n = 6) 10 min be...