Bernhard Strauss

Bernhard Strauss
University of Cambridge | Cam · Department of Biochemistry

PhD

About

41
Publications
2,628
Reads
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455
Citations
Introduction
Proposing new ways forward in cancer research. "RETHINKING CANCER; A New Paradigm for the Postgenomics Era" AVAILABLE HERE: https://mitpress.mit.edu/books/rethinking-cancer

Publications

Publications (41)
Article
Full-text available
The process of oriented divisions of polarised cells is a recurrent mechanism of cell fate diversification in development. It is commonly assumed that a specialised mechanism of spindle alignment into the axis of polarity is a prerequisite for such systems to generate cell fate diversity. Oriented divisions also take place in the frog blastula, whe...
Article
Full-text available
A key feature of early vertebrate development is the formation of superficial, epithelial cells that overlie non-epithelial deep cells. In Xenopus, deep and superficial cells show a range of differences, including a different competence for primary neurogenesis. We show that the two cell populations are generated during the blastula stages by perpe...
Article
Full-text available
There is remarkable redundancy between the Cyclin–Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is essential for early cell divisions. Cyclin B1 is essential for development, but whether it is required for cell division is contentio...
Book
Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence. Current consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the indi...
Article
Full-text available
Over the past 20 years, the impression has arisen that therapeutic approaches based on DNA sequencing data and mutation analyses of tumor tissue have been advanced through an ever better understanding of their scientific basis. Their success in the clinic was therefore almost inevitably expected. However, this hope to have finally found the long-so...
Article
In the liver, ductal cells rarely proliferate during homeostasis but do so transiently after tissue injury. These cells can be expanded as organoids that recapitulate several of the cell-autonomous mechanisms of regeneration but lack the stromal interactions of the native tissue. Here, using organoid co-cultures that recapitulate the ductal-to-mese...
Article
Full-text available
Epithelial, stem‐cell derived organoids are ideal building blocks for tissue engineering, however, scalable and shape‐controlled bio‐assembly of epithelial organoids into larger and anatomical structures is yet to be achieved. Here, a robust organoid engineering approach, Multi‐Organoid Patterning and Fusion (MOrPF), is presented to assemble indivi...
Article
In article number 2003332 by Joo‐Hyeon Lee, Yan Yan Shery Huang, and co‐workers, a robust organoid engineering method is developed to ‘up‐size’ and ‘shape’ organoids—miniature collections of cells which mimic biological features of an organ. The method, named Multi‐Organoid Patterning and Fusion (MOrPF), is used to assemble scaffold‐free macroscale...
Preprint
Epithelial, stem-cell derived organoids are ideal building blocks for tissue engineering, however, scalable and shape-controlled bioassembly of epithelial organoids into larger and anatomical structures has yet to be achieved. Here, a robust organoid engineering approach, Multi-Organoid Patterning and Fusion (MOrPF), is presented to assemble indivi...
Preprint
Full-text available
In the homeostatic liver, ductal cells intermingle with a microenvironment of endothelial and mesenchymal cells to form the functional unit of the portal tract. Ductal cells proliferate rarely in homeostasis but do so transiently after tissue injury to replenish any lost epithelium. We have shown that liver ductal cells can be expanded as liver org...
Article
Full-text available
The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also present in oocytes, suggesting that it might be critical as a maternally inherited factor. Here we identify SRSF3 as an essential regulator...
Article
The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also present in oocytes, suggesting that it might be critical as a maternally inherited factor. Here, we identify SRSF3 as an essential regulator...
Article
There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery: none of the mammalian A, D or E-type cyclins is required in development until implantation and only Cdk1 is essential for early cell divisions. Cyclin B1 is essential for development but whether it is required for cell division is contentious. He...
Article
Full-text available
The correct temporal regulation of mitosis underpins genomic stability because it ensures the alignment of chromosomes on the mitotic spindle that is required for their proper segregation to the two daughter cells. Crucially, sister chromatid separation must be delayed until all the chromosomes have attached to the spindle; this is achieved by the...
Article
Full-text available
The development of an anterior-posterior (AP) polarity is a crucial process that in the mouse has been very difficult to analyse, because it takes place as the embryo implants within the mother. To overcome this obstacle, we have established an in-vitro culture system that allows us to follow the step-wise development of anterior visceral endoderm...
Data
Full-text available
Supplementary Figures S1-S4, Supplementary Tables S1-S3 and Supplementary References
Data
Live imaging of a representative embryo throughout development in vitro, from the blastocyst to the egg cylinder stage. The movie is a compilation of consecutive movies of the same embryo made through this time period with a 20x objective.
Data
Live imaging of a representative embryo throughout development in vitro, from the blastocyst to the egg cylinder stage. The movie is a compilation of consecutive movies of the same embryo made through this time period with a 20x objective.
Data
Live imaging of a representative embryo throughout development in vitro, from the blastocyst to egg cylinder stage. The movie shown is a compilation of consecutive movies of the same embryo made through this time period starting with a 20x objective and enhancing resolution with a 40x lens after the embryos had attached to the gel.
Data
Time-lapse confocal imaging of development of chimeric embryos, on collagen-coated hydrogels, from the implanting blastocyst stage (late Day 2) to the egg cylinder stage (Day 4). dsRed-ES cells were aggregated with H2B-GFP embryos at the 8-cell stage. The movie is a compilation of consecutive movies of the same embryo made through this time period...
Data
Cerl-GFP embryo developing on a collagen-coated polyacrylamide matrix from the blastocyst to the egg cylinder stage. DIC channel shows a selected focal plane throughout the observations. GFP image is a maximum intensity projection over the z-axis of confocal sections. 10 hours of filming between day 2 and day 3 have been omitted, as they are not in...
Data
Live imaging of a representative Cerl-GFP embryo throughout development in vitro, from the blastocyst to the egg cylinder stage. The movie is a compilation of consecutive movies of the same embryo made throughout development with a 20x objective. GFP is a maximum intensity projection over the z-axis.
Data
Live imaging of Cerl-GFP expressing embryos in which the pioneer cell was ablated at E5.5.
Data
Live imaging of AVE migration in control embryos expressing Cerl- GFP and recovered from mothers at E5.5.
Article
Full-text available
A broad understanding of the relationship between gene activation, pattern formation and morphogenesis will require adequate tools for three-dimensional and, perhaps four-dimensional, representation and analysis of molecular developmental processes. We present a novel, computer-based method for the 3D visualization of embryonic gene expression and...
Article
Ultrastructure and peroxidase cytochemistry of the granulocytes of the lungfish Lepidosiren paradoza were investigated. In peripheral blood and hemopoietic tissue (kidney and spleen) only three granulocytic types were found. After comparison with light microscopic images of Giemsa-stained semithin sections the granulocytes were tentatively designat...

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