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157
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Introduction
Additional affiliations
June 1976 - June 1978
Position
- Post doc fellow of the Max Planck Society
Description
- studying the biochemical mechanism of the calcium pump of the sarcoplasmatic reticulum of dog skeletal muscle cells
August 1985 - August 1993
August 1984 - July 1985
Publications
Publications (157)
Systematic reviews and meta-analyses of clinical trials are considered to represent the highest level of scientific evidence in clinical medicine provided internationally accepted guidelines and checklists are followed.
In systematic reviews and meta-analyses all clinical studies focussing a specific predefined clinical question are collected and e...
Whereas exercise training, as part of multidisciplinary rehabilitation, is a key component in the management of patients with chronic coronary syndrome (CCS) and/or congestive heart failure (CHF), physicians and exercise professionals disagree among themselves on the type and characteristics of the exercise to be prescribed to these patients, and t...
Systematic reviews and meta-analyses of clinical trials are considered to represent the highest level of scientific evidence in clinical medicine provided internationally accepted guidelines and checklists are followed.
In systematic reviews and meta-analyses all clinical studies focussing a specific predefined clinical question are collected and e...
The Editorial of the European Journal of Preventive Cardiology published the list of reviewers for the year 2022.
Background:
Scientific guidelines have been developed to update and harmonize exercise based cardiac rehabilitation (ebCR) in German speaking countries. Key recommendations for ebCR indications have recently been published in part 1 of this journal. The present part 2 updates the evidence with respect to contents and delivery of ebCR in clinical p...
Background: Although cardiovascular rehabilitation (CR) is well accepted in general, CR-attendance and delivery still considerably vary between the European countries. Moreover, clinical and prognostic effects of CR are not well established for a variety of cardiovascular diseases. Methods: The guidelines address all aspects of CR including indicat...
Risks and benefits of cardiac rehabilitation in patients after acute myocarditis
Viral myocarditis (MC) is a multifaceted disease entity characterized by a broad clinical spectrum ranging from oligosymptomatic abortive forms to fulminant MC including cardiogenic shock.¹ A definite diagnosis may be difficult and a causal therapy is not yet establish...
Was ist neu?
Indikationen zur kardiologischen Rehabilitation Zur Indikation und Durchführung der kardiologischen Rehabilitation (KardReha) ist erstmals eine evidenzbasierte Leitlinie auf S3-Niveau publiziert worden 1. Neben der federführenden DGPR wurde diese Leitlinie von 6 weiteren deutschen Fachgesellschaften (DGK, DGTHG, DGSP, DKPM, DGRW, BNK)...
The guideline "Cardiac rehabilitation in German-speaking countries in Europe Germany, Austria, Switzerland" is available on
https://www.awmf.org/uploads/tx_szleitlinien/133-001l_S3-Kardiologische-Rehabilitation-in-D-A-CH_2020-12.pdf
This Delphi consensus by 28 experts from the European Association of Preventive Cardiology (EAPC) provides initial recommendations on how cardiovascular rehabilitation (CR) facilities should modulate their activities in view of the ongoing coronavirus disease 2019 (COVID-19) pandemic. A total number of 150 statements were selected and graded by Lik...
There is a great deal of information available on why we should perform cardiac rehabilitation (CR) and in which type of patients. It has a permanent place in any book on secondary prevention. There are also many academic textbooks focusing on the pathophysiological aspects of exercise and rehabilitation. However, this handbook provides specific gu...
Management of cardiovascular disease (CVD) has rapidly improved during recent decades and is still changing with the introduction of novel medication and advanced invasive procedures and devices. Notwithstanding these developments, cardiac rehabilitation (CR) is still a cornerstone of secondary prevention. Its effectiveness in improving the physica...
Thoracic aortic aneurysms or dissection are associated with high morbidity and mortality.1–3 In addition, these patients might exhibit significant cardiovascular risk factors beyond hypertension causing concomitant coronary syndromes, heart failure, stroke or peripheral arterial disease.1–3 Exercise-based cardiac rehabilitation (CR) is able to cont...
Background
Despite numerous studies and meta-analyses the prognostic effect of cardiac rehabilitation is still under debate. This update of the Cardiac Rehabilitation Outcome Study (CROS II) provides a contemporary and practice focused approach including only cardiac rehabilitation interventions based on published standards and core components to e...
The guideline "Cardiac rehabilitation in German-speaking countries in Europe Germany, Austria, Switzerland" is available on https://www.awmf.org/uploads/tx_szleitlinien/133-001l_S3-Kardiologische-Rehabilitation-in-D-A-CH_2020-01.pdf
The guideline "Cardiac rehabilitation in German-speaking countries in Europe Germany, Austria, Switzerland" is available on https://www.awmf.org/uploads/tx_szleitlinien/133-001l_S3-Kardiologische-Rehabilitation-in-D-A-CH_2020-01.pdf
The guideline "Cardiac rehabilitation in German-speaking countries in Europe Germany, Austria, Switzerland" is available on https://www.awmf.org/uploads/tx_szleitlinien/133-001l_S3-Kardiologische-Rehabilitation-in-D-A-CH_2020-01.pdf
Background:
In heart failure with reduced left ventricular ejection fraction (HFrEF) patients the effects of exercise-based cardiac rehabilitation on top of state-of-the-art pharmacological and device therapy on mortality, hospitalization, exercise capacity and quality-of-life are not well established.
Design:
The design of this study involved a...
Background:
Exercise-based cardiac rehabilitation (ebCR) often includes various psychological interventions for lifestyle change or distress management. However, the additional benefit of specific psychological interventions on depression, anxiety, quality of life, cardiac morbidity and cardiovascular or total mortality is not well investigated....
Whereas exercise training is key in the management of patients with cardiovascular disease (CVD) risk (obesity, diabetes, dyslipidaemia, hypertension), clinicians experience difficulties in how to optimally prescribe exercise in patients with different CVD risk factors. Therefore, a consensus statement for state-of-the-art exercise prescription in...
Exercise rehabilitation is highly recommended by current guidelines on prevention of cardiovascular disease, but its implementation is still poor. Many clinicians experience difficulties in prescribing exercise in the presence of different concomitant cardiovascular diseases and risk factors within the same patient. It was aimed to develop a digita...
Aim:
Results from EuroCaReD study should serve as a benchmark to improve guideline adherence and treatment quality of cardiac rehabilitation (CR) in Europe.
Methods and results:
Data from 2.054 CR patients in 12 European countries were derived from 69 centres. 76% were male. Indication for CR differed between countries being predominantly ACS in...
Background:
The prognostic effect of multi-component cardiac rehabilitation (CR) in the modern era of statins and acute revascularisation remains controversial. Focusing on actual clinical practice, the aim was to evaluate the effect of CR on total mortality and other clinical endpoints after an acute coronary event.
Design:
Structured review an...
Las declaraciones de conflictos de intereses de los expertos participantes en el desarrollo de esta guía están disponibles en la página web de la ESC: www.escardio.org/guidelines
With the changing demography of populations and increasing prevalence of co-morbidity, frail patients and more complex cardiac conditions, the modern medicine is facing novel challenges leading to rapid innovation where evidence and experiences are lacking. This scenario is also evident in cardiovascular disease prevention, which continuously needs...
In clinical trials, the primary efficacy endpoint often corresponds to a so-called " composite endpoint " . Composite endpoints combine several events of interest within a single outcome variable. Thereby it is intended to enlarge the expected effect size and thereby increase the power of the study. However, composite endpoints also come along with...
Despite major improvements in diagnostics and interventional therapies, cardiovascular diseases remain a major health care and socio-economic burden both in western and developing countries, in which this burden is increasing in close correlation to economic growth. Health authorities and the general population have started to recognize that the fi...
Abstract
Background: Cardiovascular rehabilitation in Germany traditionally is offered as in-patient service
often located far from patient’s residence, and ambulatory rehabilitation still represents a
minority. The German Registry of Ambulatory Cardiac Rehabilitation (KARREE) was designed to
contribute to rehabilitation quality assurance and to ev...
Aims: The FREEZE-cohort study (NCT 01360008) is a prospective observational, multicenter and multinational study to evaluate safety and effectiveness of cryoballoon ablation for pulmonary vein isolation as compared to radiofrequency ablation in patients with paroxysmal or persistent atrial fibrillation (lasting <one year) under the conditions of cl...
During the stepwise solubilization of sarcoplasmic reticulum vesicles with detergents, the following changes in the structural and enzymatic properties of the preparation are observed:
1. The viscosity of the vesicular suspension initially rises. This change is accompanied by the formation of elongated tubules. Subsequently the membranes are comple...
The calcium transport protein of the sarcoplasmic reticulum accepts inorganic phosphate rapidly when phosphorylation is initiated either by the addition of phosphate or magnesium ions to the calcium free protein. Phosphorylation proceeds much more slowly when it is initiated by the addition of the calcium chelatro ethyleneglycol-bis (beta-aminoethy...
Despite major improvements in diagnostics and interventional therapies, cardiovascular diseases remain a major health care and socio-economic burden both in western and developing countries, in which this burden is increasing in close correlation to economic growth. Health authorities and the general population have started to recognize that the fi...
Chronic heart failure (CHF) patients suffer from multiple and agonizing symptoms like shortness of breath and reduced functional status, the latter of which is usually assessed using New York Heart Association (NYHA) functional class.
In order to identify potentially modifiable factors of reduced functional status in patients with CHF, we investiga...
The effects of supplementation of the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on prevalence and severity of depression were evaluated in patients after a myocardial infarction.
A cross-sectional evaluation (posttest-only design) within the prospective, randomized, controlled, multicenter OMEGA trial was perfor...
Background:
Predictors of long-term mortality after discharge after acute myocardial infarction (AMI) are well characterized. However, these established risk factors are based on data almost exclusively derived from older studies without consistent use of revascularization therapy and adjunctive therapy with statins, platelet inhibitors, beta-bloc...
Background:
The prognostic effect of early, comprehensive short-term cardiac rehabilitation on top of current, guideline-adjusted treatment of acute myocardial infarction has not sufficiently been evaluated.
Design:
Prospective cohort study.
Methods:
Within the OMEGA study population, the clinical course of 3560 patients still alive 3 months a...
In the setting of acute myocardial infarction and sinus rhythm, the heart rate (HR) has been demonstrated to correlate closely with mortality. In patients presenting with acute myocardial infarction and atrial fibrillation (AF) on admission, however, the prognostic relevance of the HR has not yet been systematically addressed. A post hoc subgroup a...
Background:
Clinical trials in cardiology commonly consider time-to-event endpoints that are often influenced by competing risks. In the presence of competing risks, standard survival analysis techniques, such as the Kaplan-Meier estimator, can yield seriously biased results. Although methods to account for competing risks are well known in the st...
Despite major improvements in diagnostics and interventional therapies, cardiovascular diseases remain a major health care and socio-economic burden both in western and developing countries, in which this burden is increasing in close correlation to economic growth. Health authorities and the general population have started to recognize that the fi...
The beneficial effect of exercise training and exercise-based cardiac rehabilitation on symptom-free exercise capacity, cardiovascular and skeletal muscle function, quality of life, general healthy lifestyle, and reduction of depressive symptoms and psychosocial stress is nowadays well recognized. However, it remains largely obscure, which characte...
Background: In Europe cardiac rehabilitation (CR) outcomes are systematically collected only at national level. The purpose for introducing the European Cardiac Rehabilitation Database (EuroCaReD) was to get a simultaneous overview of CR outcomes across Europe Methods: In the EuroCaReD project, patients undergoing CR, independent of age, gender, an...
Background: Substantial numbers of patients participating in cardiac rehabilitation (CR) do not complete their programs prescribed because of early discontinuation. The purpose of this study was to assess reasons and predictors of drop-out from different CR programs focused on European countries. Methods: European Cardiac Rehabilitation Database (E...
Supplementation of omega-3 fatty acids (Ω-3) has been associated with a decreased cardiovascular risk, thereby concentrating attention on a potentially preventive effect regarding tachyarrhythmias and sudden cardiac death. However, recent randomized controlled trials challenge the efficacy of the additional application of Ω-3 and its anti-arrhythmi...
Professional skills, education and accreditation, along with clinical outcome assessment, are considered important factors to achieve comprehensive delivery and quality of cardiac rehabilitation (CR). This study assessed professional educational programmes, accreditation and use of databases in CR across the European countries.
Questions on profess...
There is no randomized, double-blind trial testing the prognostic effect of highly purified omega-3 fatty acids in addition to current guideline-adjusted treatment of acute myocardial infarction.
OMEGA is a randomized, placebo-controlled, double-blind, multicenter trial testing the effects of omega-3-acid ethyl esters-90 (1 g/d for 1 year) on the r...
The aim was to evaluate the effect of short-term cardiac rehabilitation (CR) on clinical events during a 1-year follow-up after acute myocardial infarction.
From the observational, prospective Acute COronary Syndromes (ACOS) registry, 4547 consecutive patients after ST-elevation (STEMI: n = 2432) or non-ST-elevation myocardial infarction (NSTEMI: n...
Although chronic heart failure (CHF) is often complicated by comorbid depression and poor self-care, little is known about their specific association in patients with CHF.
To investigate self-care behavior among patients with CHF with different degrees of depression severity.
A total of 287 patients with documented CHF, New York Heart Association f...
To determine the factors, which are associated with suicidal ideation and ideas of self-harm in patients with congestive heart failure (CHF).
We examined 294 patients with documented CHF, New York Heart Association (NYHA) functional class II-IV, in a cross sectional study at three cardiac outpatient departments. Measures included self-reports of su...
To assess awareness of heart failure (HF) management recommendations in Europe among cardiologists (C), internists and geriatricians (I/G), and primary care physicians (PCPs).
The Study group on HF Awareness and Perception in Europe (SHAPE) surveyed randomly selected C (2041), I/G (1881), and PCP (2965) in France, Germany, Italy, the Netherlands, P...
Our objective was to assess the prevalence of panic disorder, its influence on quality of life (QoL), and the presence of further anxiety and depressive comorbid disorders in outpatients with chronic heart failure (CHF).
In a cross-sectional study, anxiety and depressive disorders were diagnosed according to Diagnostic and Statistical Manual of Men...
BACKGROUND: Although chronic heart failure (CHF) is often complicated by comorbid depression and poor self-care, little is known about their specific association in patients with CHF.
OBJECTIVE: To investigate self-care behavior among patients with CHF with different degrees of depression severity.
METHODS: A total of 287 patients with documented...
Heart failure exhibits a significant clinical and health economic problem. The implementation of new therapeutic strategies favourably affecting the course of disease is still insufficient in day to day practice. Although multiple programs demonstrated a significant reduction of hospital admissions and thereby a cost effectiveness, an integrated ca...
Myocardial infarction registries investigate the adherence to guidelines and the transferability of randomized trials (RCTs) into clinical practice. Data of the multicenter registry Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) PLUS documented an increase of therapy of acute myocardial infarction in clinical practice in Germany...
The influence of depression and perceived quality of life (QoL) on symptom perception and prognosis in congestive heart failure is well known. The authors therefore introduced routine questionnaire screening for these parameters in patients attending their outpatient heart failure clinic (N320). The authors found QoL to be significantly reduced, an...
During the last decades a large body of data has been accumulated indicating omega-3 fatty acids to exert beneficial effects on the prognosis of patients with cardiovascular disease. Especially, omega-3 fatty acids are regarded to be effective in reducing the risk of sudden cardiac death after acute myocardial infarction. However, treatment of acut...
Exercise testing has been advocated for risk stratification and determination of therapeutic strategies after acute myocardial infarction. Frequency and therapeutic impact of exercise testing after non-ST-elevation myocardial infarction (NSTEMI) in actual clinical practice, however, is not known.
From the German acute coronary syndrome (ACOS) regis...
