Bernhard Kis

Bernhard Kis
Contilia GmbH · Department of Psychiatry Psychotherapy and Psychosomatics

Priv.-Doz. Dr. med.

About

134
Publications
45,733
Reads
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3,002
Citations
Citations since 2017
43 Research Items
1100 Citations
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
2017201820192020202120222023050100150200
Additional affiliations
August 2019 - present
Contilia GmbH
Position
  • Head of Department
Description
  • https://www.contilia.de/ansprechpartner/pd-dr-med-bernhard-kis.html
June 2017 - July 2019
Universitätsmedizin Göttingen
Position
  • Managing Director
March 2014 - May 2017
Universitätsmedizin Göttingen
Position
  • Medical Doctor

Publications

Publications (134)
Article
Full-text available
Attention-deficit hyperactivity disorder (ADHD) is associated with a range of cognitive deficits and social cognition impairments, which might be interpreted in the context of fronto-striatal dysfunction. So far only few studies have addressed the issue of social cognition deficits in ADHD. Medline and Psyclit searches were performed for a 30-year...
Article
Full-text available
The aim of this study was to determine the relationship between serum albumin, affective prosody, and symptoms of attention-deficit hyperactivity disorder (ADHD) found coincidentally in a recently published study. Here, serum albumin levels were assessed as a covariate. Twenty healthy male adults (controls) and 20 adult male patients with ADHD part...
Article
Full-text available
Objective: Adults with attention deficit hyperactivity disorder (ADHD) have difficulties processing affective prosody, and research evidence demonstrates the importance of brain serotonin (5-HT) in the neurobiology of ADHD. This study aimed to investigate whether diminished brain 5-HT synthesis, as achieved by acute tryptophan depletion (ATD), can...
Article
Full-text available
Objective: To date, the impact of the neurotransmitter serotonin (5-HT) on different neuropsychological functions in adults with attention deficit hyperactivity disorder (ADHD) is underinvestigated. We aimed to examine the effects of acute tryptophan depletion (ATD) and the resulting reduction in central nervous 5-HT synthesis on target/non-target...
Article
Full-text available
Objective: The Conners Adult ADHD Rating Scales (CAARS) assess symptoms specific to adults that are frequently used and have been translated into German. The current study tests the factor structure of the CAARS in a large sample of German adults with ADHD and compares the means of the CAARS subscales with those of healthy German controls. Method...
Preprint
Full-text available
There is broad consensus that to improve the treatment of adult Attention-Deficit/Hyperactivity Disorder (ADHD), the various therapy options need to be tailored more precisely to the individual patient's needs and specific symptoms. This post-hoc analysis evaluates the multimodal effects of first-line medication (methylphenidate [MPH] vs placebo [P...
Article
There is broad consensus that to improve the treatment of adult Attention-Deficit/Hyperactivity Disorder (ADHD), the various therapy options need to be tailored more precisely to the individual patient's needs and specific symptoms. This post-hoc analysis evaluates the multimodal effects of first-line medication (methylphenidate [MPH] vs placebo [P...
Article
Background Combining antipsychotics is common in schizophrenia treatment, despite evidence-based guidelines generally not recommending such practice. Otherwise, evidence remains inconclusive, especially regarding specific combinations. The trial aimed to test whether a combination of amisulpride plus olanzapine is more effective than either interve...
Article
ZUSAMMENFASSUNG Hintergrund Verschiedene Studien berichten über das Stresserleben von Krankenhausmitarbeitern während der COVID-19-Pandemie, aber auch vor der Pandemie fühlten sich viele ärztliche Klinikmitarbeiter durch ein hohes Arbeitspensum oder unklare Vorgaben emotional erschöpft. Methoden Kognitive Bewertungen und das Stresserleben von ärztl...
Article
Introduction: Non-invasive brain stimulation techniques such as repetitive transcranial magnetic stimulation (rTMS) offer a promising alternative to psychotherapeutic and pharmacological treatments for depression. This paper aims to present a practical guide for its clinical implementation based on evidence from the literature as well as on the ex...
Article
Attention Deficit Hyperactivity Disorder (ADHD) negatively impacts Quality of Life (QoL) in adults. Earlier studies on pharmacological treatment have shown short-term beneficial effects on QoL. No data are available on long-term effects on multimodal psychosocial and/or pharmacological interventions. The Comparison of Methylphenidate and Psychother...
Article
Ein Erratum zu dieser Publikation wurde veröffentlicht: https://doi.org/10.1007/s00115-021-01076-2
Article
Attention deficit hyperactivity disorder (ADHD) symptomatology, comorbid diseases, and pharmacological treatment with antidepressants can have a negative impact on sexual function, which in turn increases the likelihood of sexual dysfunction in people with ADHD. The objective of this pilot study was to differentiate and delineate possible sexual dy...
Article
Full-text available
The purpose of the study was to evaluate the current clinical practice of Electroconvulsive Therapy and Repetitive Transcranial Magnetic Stimulation in German psychiatry. Case-based data (> 1.000.000 cases) were collected according to §21 of the German hospital remuneration law from January 2015 to December 2017. The study cohort comprises approxim...
Article
Introduction The Comparison of Methylphenidate and Psychotherapy in adult ADHD Study (COMPAS) was a prospective, randomized multicenter clinical trial, comparing methylphenidate (MPH) with placebo (PLAC) in combination with cognitive behavioral group psychotherapy (GPT) or individual clinical management (CM) over the period of 1 year. Here, we repo...
Article
Full-text available
The Star Trek franchise currently includes five spin-off series and 13 motion pictures. Star Trek’s central theme is the utopian future of mankind, but the series does not disregard issues that were socially relevant for its time of production. Therefore, Star Trek has functioned as a representation of history throughout its 50-year lifespan. This...
Article
Full-text available
Background Current guidelines support the use of nuclear medical imaging (NMI) techniques for differential diagnostics of certain cases of dementia. Aims We aimed at studying the association between using NMI and the accuracy of dementia diagnoses. Additionally, we evaluated the effect of conducting NMI on the duration of hospital treatment. Meth...
Article
Full-text available
Objective: The cognitive capacity to change perspective is referred to as theory of mind (ToM). ToM deficits are detectable in a variety of psychiatric and neurological disorders. Since executive abilities are closely associated with ToM skills, we suspected that due to a common neuropsychological basis, ToM deficits exist in treatment-naïve adult...
Article
Zusammenfassung Der Übergang vom Kindesalter ins Erwachsenenalter stellt die Behandlung persistierender Erkrankungen wie die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) vor große Herausforderungen. Während noch 43 % aller Jugendlichen mit ADHS eine medikamentöse Behandlung erhalten, fällt dieser Anteil bei den Anfang zwanzigjährigen Patie...
Article
ZUSAMMENFASSUNG Der Übergang vom Kindesalter ins Erwachsenenalter stellt die Behandlung persistierender Erkrankungen wie die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) vor große Herausforderungen. Während noch 43 % aller Jugendlichen mit ADHS eine medikamentöse Behandlung erhalten, fällt dieser Anteil bei den Anfang zwanzigjährigen Patie...
Article
Full-text available
Objective: A restrictive use of tricyclic antidepressants (TCA) in patients with dementia (PwD) is recommended due to the hazard of anticholinergic side effects. We evaluated the frequency of TCA dispensing in PwD over a period of 1 year and the use of TCA before and after the incident diagnosis of dementia. Methods: This analysis was based on admi...
Article
Background Hyperkinetic disorders (HKD, ICD-10 F90.‑) have increasingly been the focus of research literature in recent years. Empirical studies analyzing the care situation in psychiatric clinics are so far primarily available for a few health insurances. This study analyzed a German sample from 2015 consisting of inpatient as well as day care psy...
Preprint
Background Proximal femoral fractures are frequent injuries of elderly people and are often associated with declines in physical function and high rates of morbidity and mortality. A severe and frequent complication after hip surgery is postoperative delirium (POD), potentially associated with poorer clinical outcomes. We hypothesized that elderly...
Article
Full-text available
Importance: Knowledge about the long-term effects of multimodal treatment in adult attention-deficit/hyperactivity disorder (ADHD) is much needed. Objective: To evaluate the long-term efficacy of multimodal treatment for adult ADHD. Design, Setting, and Participants: This observer-masked, 1.5-year follow-up of the Comparison of Methylphenidate an...
Article
Background Clinical outcomes of patients with proximal femoral fracture within 1 year after hospitalization are presented. In particular, associations between the patients' clinical status and their pre‐fracture residence were evaluated (community‐dwelling vs nursing home). Methods Patients aged ≥60 years with proximal femoral fractures were inclu...
Article
Full-text available
The prevalence of infections is supposed to be higher in older patients and to extend the length of hospital stays. This study aimed, first, to test this supposition within a large psychiatric population which we divided into four clusters of psychiatric ICD-10 diagnoses: F00-F03 (dementias), F10 (substance disorders), F20-29 (schizophrenia, schizo...
Data
Dataset of the study. The minimal dataset of the study is provided as SAV-file (SPSS). (SAV)
Article
Background Hearing-impairment can lead to a reduced quality of life and thus represents a vulnerability factor for mental disorders. Objective This study represents the first psychiatric analysis of subjective quality of life and depression in people with hearing-impairment in Germany. Materials and methods The patient group included 30 hearing-i...
Article
Background Multimorbidity in dementia is associated with an increased risk of complications and a higher need for care. Having knowledge of cardiovascular and metabolic comorbidities is crucial when making decisions about diagnostic procedures and therapies. We compared the prevalence of comorbidities in hospitalized patients with Alzheimer's disea...
Article
Background: Up to now, there are only few studies on the influence of the sociodemographic factors on the diagnosis of ADHD in Germany, although the knowledge of these characteristics can be important for the design of prevention programs. Therefore, the aim of this study is to broaden the evidence on the factors influencing the diagnosis of ADHD...
Article
Full-text available
Long-term treatment with benzodiazepines (BZD) should be avoided in dementia patients because of an increased risk of adverse events. We evaluated how continuously dementia patients were prescribed BZD over 12 months. For this observational study, we used claims data from a large German public sickness fund for 2014 and 2015, including patients wit...
Article
Introduction Benzodiazepines and related drugs (BZDR) should be avoided in patients with cognitive impairment. We evaluated the relationship between a BZDR treatment and the health status of patients with Alzheimer’s disease (AD). Methods Cross-sectional study in 395 AD patients using bivariate and multiple logistic analyses to assess correlations...
Article
Objective: The use of antidepressant drugs in dementia patients is associated with the risk of adverse events, and the evidence for relevant effects is scarce. We aimed to determine the associations between the prescription of antidepressants and patients' sociodemographic (e.g., age, gender, living situation) and clinical characteristics (e.g., d...
Article
Full-text available
Zusammenfassung: In den letzten Jahren wurden die kardiovagale Kontrolle und die damit assoziierten Indizes der vagal-mediierten Herzratenvariabilität als Biomarker der physiologischen und emotionalen Aktiviertheit sowie der Emotionsregulation herausgestellt. Gerade Patienten mit einer Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) weisen in...
Article
Full-text available
Objective: A restrictive use of antipsychotic drugs in patients with Alzheimer’s disease (AD) is recommended due to an increased risk of cerebrovascular events and mortality. We hypothesise that the prescription of antipsychotics is associated with the patients’ socio-demographic and clinical status (e.g., dementia severity). Methods: The prescript...
Article
The objective of this study was to evaluate the use of antidementia drugs (ADDs) in patients with Alzheimer's disease (AD) regarding German guideline recommendations and to assess correlations between the use of ADDs and the patients' characteristics. A total of 395 community-dwelling and institutionalized patients with AD across all severity stage...
Book
Full-text available
Inhalt Das AMDP-System ist seit mehr als 50 Jahren neben der Forschung auch in der klinischen Anwendung ein wichtiges Verfahren, insbesondere zur Erfassung und Dokumentation des psychopathologischen Befundes. Im praktischen Einsatz ergeben sich immer wieder Fragen im Hinblick auf Vorgehensweisen der Erhebung, auf Möglichkeiten der Anwendung, auf d...
Article
Objective: In the multicenter study Comparison of Methylphenidate and Psychotherapy in Adult ADHD (COMPAS), the efficacy of treatments has been primarily evaluated by observer-rated symptom change. Here, we additionally analyzed the patients’ subjective evaluation of therapy effects. Method: COMPAS compared ADHD-specific group therapy with unspeci...
Article
Zusammenfassung Substanzbezogene Störungen (SUD) sind nach Angst- und affektiven Störungen die psychischen Störungen mit der höchsten Prävalenz in der erwachsenen Allgemeinbevölkerung. Die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) zählt zu den häufigsten psychischen Störungen bei Kindern und Jugendlichen und persistiert bei einem Teil d...
Article
Objective: Diagnosing Attention-Deficit-Hyperactivity Disorder (ADHD) in adults requires that ADHD has already been present in childhood. However, recall of ADHD-symptoms in childhood is fallible, for example influenced by mood. Furthermore, diagnostics need a procedure to handle oblivion and judgment biases. The Essen-Interview-for-school-days-rel...
Article
Full-text available
Objective: Attention deficit hyperactivity disorder (ADHD) is associated with social conflicts. The purpose of this study was to explore domains of social cognition in adult patients with ADHD. Methods: The assessment of social cognition was based on established neuropsychological tests: the Tübinger Affect Battery (TAB) for prosody and the Camb...
Article
Introduction Only few international studies have focused on mental diseases among the hearing-impaired population. However, Fellinger et al. (2012) underline the high discrepancy between the current and future demand of mental treatment and the simultaneous impeded access to health care. Aims The aim of this multicenter project is to conduct the f...
Article
Importance: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with high prevalence in adulthood. There is a recognized need to assess the efficacy of psychotherapy in adult ADHD. Objective: To evaluate the efficacy of cognitive behavioral group psychotherapy (GPT) compared with individual clinical management (CM) a...
Article
Full-text available
Altered time reproduction is exhibited by patients with adult attention deficit hyperactivity disorder (ADHD). It remains unclear whether memory capacity influences the ability of adults with ADHD to reproduce time intervals. We conducted a behavioral study on 30 ADHD patients who were medicated with methylphenidate, 29 unmedicated adult ADHD patie...
Article
Full-text available
Unemployment is related to a higher risk for psychological distress and mental disorders, which cause individual suffering and socioeconomic costs for society in general. This selective review surveys the relationship between unemployment and psychological well-being and mental disorders. The most important programs for the improvement of the menta...
Conference Paper
Einleitung Das Essener Interview zur schulzeitbezogenen Biographie bei ADHS (EIS-B) ist ein neuer innovativer Ansatz in der Diagnostik von Erwachsenen mit Verdacht auf ADHS. EIS-B wurde entwickelt, da Bedenken hinsichtlich der Validität der Wender Utah-Rating-Scale (WURS) bestehen (Mannuzza et al., 2002, Suhr et al., 2009). Methode Das Essener In...
Book
Full-text available
Einsatzbereich: Screening, Diagnostik und Verlaufsuntersuchungen von Aufmerksamkeitsstörungen bei Erwachsenen ab 18 Jahren; Einzel- und Gruppentestung. Das Verfahren: Die CAARS sind ein klinisches Fragebogenverfahren zur Beurteilung von Aufmerksamkeitsstörungen bei Erwachsenen. Die Inhaltsskalen (Unaufmerksamkeit/Gedächtnisprobleme, Hyperaktivität/...
Article
Intensity-dependent auditory evoked potentials (IDAP) were shown to be increased in highly impulsive individuals. As impulsivity is one of the core symptoms of attention deficit/hyperactivity disorder (ADHD), patients with ADHD were expected to exhibit an enhanced IDAP. Twenty-five ADHD patients taking methylphenidate and 21 healthy control partici...
Article
Acute tryptophan depletion – converging evidence for decreasing central nervous serotonin synthesis in rodents and humans We read the comment provided by Simon N. Young (1) on the articles (2–5) in the special issue of Acta Psychiatrica Scandi-navica (6) dealing with the acute tryptophan depletion (ATD) methodology with great interest. ATD is a pha...
Article
Full-text available
Objective: Patients with ADHD display a decreased contingent negative variation in Go/NoGo tasks. It is unclear whether the attenuation is due to deficits of executive function or to disorder of motor planning. The readiness potential (RP) recorded during self-initiated movements could cast light on this question. Method: RP was recorded in 25 s...
Article
Full-text available
Adult ADHD is a frequent psychiatric disorder affecting relevant aspects of an individual's life. The aim of our study group was to carry out the first randomized controlled multicenter study to evaluate the effects of psychotherapy compared to clinical management in combination with psychopharmacological treatment with methylphenidate (MPH) or pla...
Article
Full-text available
Increased levels of anxiety, depression and alcohol abuse are associated with unemployment. This study compares both DSM-IV-TR Axis-I and Axis-II mental disorders between a representative and a referred sample of unemployed youths aged 16.0 to 24.9. One hundred subjects were randomly recruited on the premises of the vocational services centre in th...
Article
Full-text available
Objectives: The aim of this study is to implement and examine the feasibility of a cross-institutional mental health intervention to comprehend and advance mental health of elderly long-term unemployed persons. Methods: Report on the procedure and on the observational study utilisation in a 14-month period. Results: The structure and processes...
Article
Introduction: Early after having been diagnosed with relapsing remitting multiple sclerosis (RRMS), young patients coping with the new situation require good social support and interactions. Successful social interaction is critically dependent upon the ability to understand the minds of others and their feelings. Social cognition refers to the ab...
Article
Cognitive dysfunction is well known in patients suffering from multiple sclerosis (MS) and has been described for many years. Cognitive impairment, memory, and attention deficits seem to be features of advanced MS stages, whereas depression and emotional instability already occur in early stages of the disease. However, little is known about proces...
Article
Full-text available
Though an important percentage of patients with chronic hepatitis C virus (HCV) undergoing interferon (IFN) therapy develop depressive symptoms, the role of the IFN system in the pathogenesis of depressive disorders is not well understood. 50 patients with HCV infection were treated with standard combination therapy (pegylated IFN-α2a/ribavirin). I...
Article
Full-text available
Background: The neurotransmitter serotonin (5-HT) has been linked to the underlying neurobiology of aggressive behavior, particularly with evidence from studies in animals and humans. However, the underlying neurobiology of aggression remains unclear in the context of attention-deficit/hyperactivity disorder (ADHD), a disorder known to be associat...
Article
Introduction There are complex associations between work and mental health. Self-efficacy, experience of own abilities and appropriate challenges are important prerequisites of mental health. Availability of these factors is specifically decreased in the elder long term unemployed and results in higher vulnerability for mental impairment. Objectiv...
Article
Introduction Unemployment is associated with various psychosocial strain factors. Previous studies show correlations between unemployment and impaired mental health. Present examinations on this set of problems mainly focused on younger unemployed, while specific psychosocial strains of senior unemployed persons were scarcely presented. Objectives...
Article
Introduction Adult patients with ADHD suffer from marriage problems and increased divorce rates significantly more often. There are, however, only a few studies which analyse romantic attachment to a partner or romantic relationships among patients with ADHD in view of attachment theory. Aims The aim of the present study is to research if ADHD pat...
Article
Introduction Instruments for diagnosing Attention-Deficit/Hyperactivity Disorder (ADHD) in childhood are well validated and reliable, but psychometric assessment of ADHD in adults remains problematic. To date the Conners Adult ADHD Rating Scales (CAARS) are frequently used in the assessment of ADHD. Objectives The CAARS were translated into German...
Conference Paper
Attention Deficit Hyperactivity Disorder (ADHD) is a serious risk factor for co-occurring psychiatric disorders and negative psychosocial consequences in adulthood. Given this background, there is great need for an effective treatment of adult ADHD patients. Therefore, our research group has conducted a first controlled randomized multicenter study...