Bernd Jastorff

Bernd Jastorff
Universität Bremen | Uni Bremen · Center for Environmental Research and Sustainable Technology (UFT), Department of Sustainable Chemistry

Prof. Dr. Dr. hc mult

About

267
Publications
21,701
Reads
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11,231
Citations
Additional affiliations
July 1994 - July 2000
Center of Environmental Research and Technonogy (UFT), at University of Bremen
Position
  • Managing Director
Description
  • www.uft.uni-bremen.de
July 1994 - September 2007
Center of Environmental Research and Technology (UFT), University of Bremen
Position
  • Department Leader
April 1973 - September 2007
University of Bremen
Position
  • Professor (Full)
Description
  • Interdisciplinary Research on - SAR of Cyclic Nucleotide Analogs, - Chromatographic Separation (HPLC) - SAR of Ionic Liquids - Hazard and Risk Assessment of Ionic Liquids - Thinking in Terms of SAR (T-SAR) as a Tool for Working Hypothesis -
Education
October 1968 - April 1970
Max Planck Institute for Experimental Medicine
Field of study
  • Dissertation
October 1962 - September 1967

Publications

Publications (267)
Article
Full-text available
Methyltrioxorhenium (MTO) is one of the best examined catalysts for the activation of H2O2 in oxidation reactions, particularly for olefin epoxidation reactions. The broad applicability and high activity of MTO and MTO Lewis base adducts combined with their selectivity for a variety of processes has also generated industrial interest. In compliance...
Article
Full-text available
Die theoretische Betrachtung des Zusammenhangs zwischen molekularer Struktur und physiologischer Wirkung im Menschen gehört zu den zentralen Elementen moderner Wirkstoffforschung. Vorgestellt wird, wie sich zentrale Elemente dieser Strategie durch G. Elion seit den 1940er Jahren entlang der Forschung zu Antimetaboliten entwickelt hat. Anwendung erf...
Article
Full-text available
A frontier to be conquered in the field of membrane technology is related to the very limited scientific base for the rational and task-specific design of membranes. This is especially true for nanofiltration membranes with properties that are based on several solute-membrane interaction mechanisms. “Thinking in terms of Structure-Activity-Relation...
Article
To demonstrate how baseline toxicity can be separated from other more specific modes of toxic action and to address possible pitfals when dealing with hydrophobic substances, the four isothiazol-3-one biocides N-methylisothiazol-3-one (MIT), 5-chloro-N-methylisothiazol-3-one (CIT), N-octylisothiazol-3-one (OIT), and 4,5-dichloro-N-octylisothiazol-3...
Article
We report the esterification of the carboxyl groups of the cyclic peptide toxins nodularin-R and microcystin-LA to produce stable diacetoxymethyl and dipropionyloxymethyl ester derivatives. The derivatives had no activity but were reactivated upon esterase treatment. When injected into cells, the acyloxymethyl moieties were cleaved off and apoptosi...
Article
Full-text available
The biopolymer chitosan has shown great potential for a tremendous number of applications despite the fact that typical chitosan preparations are always mixtures of different chemical entities, natural impurities and process-induced impurities. However, chitosan preparations described in the literature or offered on the market are analytically high...
Article
Bioregenerative closed ecological life support systems (CELSS) will be necessary in the exploration context revitalizing atmosphere, waste water and producing food for the human CELSS mates. During these long-term space travels and stays far away from Earth in an hostile environment as well as far for example from any hospital and surgery potential...
Article
In the last decade, ionic liquids have shown great promise in a plethora of applications. However, little attention has been paid to the characterisation of the purity of these fluids, which has ultimately led to non-reproducible data in the literature. In order to facilitate specification of ionic liquids, a number of analytical protocols with the...
Article
To investigate the toxic mode of action of isothiazol-3-one biocides the four compounds N-methylisothiazol-3-one (MIT), 5-chloro-N-methylisothiazol-3-one (CIT), N-octylisothiazol-3-one (OIT) and 4,5-dichloro-N-octylisothiazol-3-one (DCOIT) were purified and tested as single chemical entities for their effects on the human hepatoblastoma cell line H...
Chapter
Background Description of Selected SubstancesFirst Results from Biological TestingPreliminary (Eco-)Toxicological Risk ProfilesOutlook
Article
Full-text available
We investigated the primary biodegradation of different N-imidazoles, imidazolium, pyridinium and 4-(dimethylamino)pyridinium compounds substituted with various alkyl side chains and their analogues containing functional groups principally based on OECD guideline 301 D. For the experiments we used two different types of inocula, a freeze-dried mix...
Article
Full-text available
To contribute to a deeper insight into the hazard potential of ionic liquids to humans and the environment, an acetylcholinesterase (AchE) inhibition screening assay was used to identify toxicophore substructures and interaction potentials mediating enzyme inhibition.The positively charged nitrogen atom, a widely delocalised aromatic system, and th...
Article
Full-text available
P450 monooxygenases oxidize a broad range of substrates including fatty acids, alcohols, aliphatic and aromatic hydrocarbons which are often poorly soluble in water and have Km values in the millimolar range. Cosolvent and host–guest chemistry have thus been supplemented to increase catalytic efficiencies. Ionic liquids are alternative solvents and...
Article
Full-text available
To enlarge the restricted knowledge about the hazard potentials of ionic liquids to men and the environment we have concentrated on systematically analysing the effects of 7 head groups, 10 side chains ( mainly containing functional groups) and 4 anions on cytotoxicity. For our investigations, we used the promyelotic leukemia rat cell line IPC-81 a...
Article
Thinking in structure-activity relationships (T-SAR) is presented as an approach to a systematic collection and networking of knowledge and hypotheses regarding chemical structures. T-SAR can be accompanied by quantitative correlation studies commonly referred to as quantitative structure-activity relationships (QSAR) or linear free energy relation...
Article
Full-text available
To enlarge the restricted knowledge about the hazard potentials of ionic liquids to man and the environment we have concentrated on analysing systematically the anion effect of six different anion moieties (Cl−, BF4−, (CF3SO2)2N−, (CF3)2N−, octylsulfate and bis(1,2-benzenediolato)borate) and the influence of the side chain length at the cation on (...
Article
Full-text available
In this study, the influence of different head groups, functionalised side chains and anions of ionic liquids on the marine bacteria Vibrio fischeri, the limnic green algae Scenedesmus vacuolatus and the fresh water plant Lemna minor was investigated. The aim of these experiments is to improve the knowledge base for the molecular design of ionic li...
Article
Full-text available
Regarding the great structural variability of the currently expanding group of ionic liquids, it is highly desirable to understand the basic factors affecting their toxicity in different biological systems. The present study of a set of 74 ionic liquids with imidazolium, pyrrolidinium, pyridinium, quinolinium, quaternary phosphonium and quaternary...
Article
An idealized diagram of a cyclic design process for sustainable chemical products is presented. The sustainability of an ionic liquid is strongly dependent on the purpose of the technical process on which it is applied. It is important to test the application specific performance of a substance, its potential impact on human health and environment....
Article
Full-text available
The acute biological activity of a homologous series of perfluorinated carboxylic acids - perfluorohexanoic acid (PFHxA), perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA) - was studied. To analyze the potential risk of the perfluorinated acids to humans and the environme...
Article
Full-text available
To enlarge the restricted knowledge about the hazard potentials of ionic liquids to men and the environment we have concentrated on systematically analysing the effects of 7 head groups, 10 side chains (mainly containing functional groups) and 4 anions on cytotoxicity. For our investigations, we used the promyelotic leukemia rat cell line IPC-81 as...
Article
In investigations of the proteins which are responsible for the surface adhesion of the blue mussel Mytilus edulis, an unusually frequent appearance of the otherwise rare amino acid 3-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA) has been observed. This amino acid is thought to play a major role in the mechanism of mussel adhesion. Here we report a deta...
Article
Full-text available
Most recent investigations concerning the toxicological and ecotoxicological risk potentials of ionic liquids are predominantly focusing on the cation moieties. In this study we elucidate, whether the anion species commonly used in ionic liquids are exhibiting intrinsic cytotoxic effects and if these effects can be rationalised by thinking in terms...
Article
Full-text available
Motivated by the prevailing need for a sustainable development and taking the principles of Green Chemistry as a starting point, the present paper describes new and updated findings regarding a sustainable product design for ionic liquids. The focus is on environmental risk. Nevertheless, cytotoxicity testing and first indicative results from a gen...
Article
Full-text available
Cyclic AMP has been generally recognised as activator of cAMP-dependent protein kinases. However, there is little evidence about role of cAMP-dependent protein kinase (PKA), in particular izoenzymes PKA-I and PKA-II, in glomeruli contractility. We measured changes of glomerular inulin space (GIS) as a marker of its contractility in the presence of...
Article
Full-text available
Ecotoxicology and Environmental Safety 60 (2005) 350 Corrigendum Corrigendum to ''Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays'' [Ecotoxicol. Environ. Safety 58 (2004) 396–404] The second sentence in the abstract should read ''Effective concentrations in these te...
Article
Pyrithione biocides are currently viewed as a major prospect for the replacement of tributyltin antifoulants in ship paints. The chromatographic behavior of 1-hydroxy-2-pyridinethione (pyrithione, PT), bis(2-pyridinyl)disulfide 1,1'-dioxide (PT2), and the metal complexes zinc [Zn(PT)2], iron [Fe(PT)3] and copper [Cu(PT)2] pyrithione, were investiga...
Article
Full-text available
Detailed biological studies of methyl- and some ethylimidazolium ionic liquids in luminescent bacteria as well as in the IPC-81 (leukemia cells) and C6 (glioma cells) rat cell lines are presented. Effective concentrations in these test systems are generally some orders of magnitude lower than effective concentrations [corrected] of the conventional...
Article
Ionic liquids are discussed as sustainable green solvents, but toxicity and ecotoxicity data are rare. In this paper we present our results for different ionic liquids with the acetylcholinesterase inhibition assay. The results show that the acetylcholinesterase can be inhibited by ionic liquids containing a cation with a positively charged nitroge...
Article
Zinc pyrithione (1-hydroxypyridine-2-thione, zinc complex; ZnPT2) is currently viewed as the top prospect for replacing tributyltin antifoulants in ship paints. Thus, the risk assessment of a high scale release of ZnPT2 to the natural environment is of increasing importance. The knowledge of the molecular mechanisms related to biological effects of...
Article
Much interest has been devoted to new supplies of naturally originating astaxanthin, which is mainly used as a pigmentation source for fish aquaculture. One pathway is isolating pigment itself from the natural sources. In recent studies, we have reported the measured astaxanthin adsorption from wastewater to fish scales and suggested the applicatio...
Article
Full-text available
In recent studies, we have developed an applied methanol recycling technology, designed for academic institutions utilizing chromatographic applications. The waste-free concept of the method includes biodegradation steps intended for further degradation of post-processing residues. During the biodegradation process a natural pigment, a carotenoid,...
Article
The paper presents basic data on astaxanthin adsorption from fisheries wastewater to fish scales. This process has been proposed to be applicable in fisheries and shrimp waste management [Helgason, Recovery of compounds using a natural adsorbent, Patent WO 01/77230, 2001]. The innovative feature of the method is the application of a solid waste (fi...
Book
Full-text available
Wir – eine interdisziplinäre Gruppe von Hochschullehrern – legen ein Memorandum „Hochschule neu denken – Neuorientierung im Horizont der Nachhaltigkeit“ vor. Hiermit wollen wir einen Beitrag zu der schon lange laufenden Diskussion über die Hochschulreform leisten. Allerdings teilen wir nicht die in der öffentlichen Diskussion häufige Fixierung auf...
Article
Increased durations in space travel as well as living in extreme environments are requiring reliable life support systems in general and bioregenerative ones in detail. Waste water management, air revitalization and food production are obviously center goals in this research. However, a potential influence by chemicals, drugs etc. released to the c...
Article
Full-text available
In the present study, the cAMP analogs 8-bromo-cAMP (8-Br-cAMP), N6-2'O-dibutyryl-cAMP (DBcAMP) and 8-para-chlorophenylthio-cAMP (8-CPT-cAMP), as well as the corresponding cAMP-acetoxymethyl (AM)-ester-prodrugs were tested in a HPLC study for their membrane permeability, intracellular accumulation and biotransformation. Antiproliferative activities...
Article
The separation of selected 1-alkyl- and 1-aryl-3-methylimidazolium-based room temperature ionic liquid cations has been performed using reversed-phase high-performance liquid chromatography with electrospray ionization mass detection. The RP-HPLC method development started with the selection of a column taking into account especially the resolution...
Article
For ionic liquids only few toxicological and/or ecotoxicological data are available until now. A strategy is presented which aims at an environmental risk assessment of chemicals, using a combination of structure–activity relationships (SAR), toxicological and ecotoxicological tests and modelling. The parts “test-kit-concept” and “multidimensional...
Article
The C.E.B.A.S.-Minimodule (Closed Equilibrated Biological Aquatic System) is a space qualified aquatic microcosm of 8.6 liters volume of water. Several aquatic species can be reared in parallel. Based on its characteristics (closed system, highly standardized, testruns longer than 4 weeks are possible, organisms of different trophic levels can be i...
Book
Full-text available
Vorwort Je mehr das Leben und die Umwelt molekular beschrieben werden können, desto besser lassen sich auch die Auswirkungen von Chemikalien auf lebende Systeme auf molekularer Ebene verstehen und letztendlich auch vorhersehen und planen. Das Wissen und Denken in den Wirkungswissenschaften (Biologie, Pharmakologie, Toxikologie u. a.) bewegt sich m...
Article
Detailed biological studies of methyl- and some ethylimidazolium ionic liquids in luminescent bacteria as well as in the IPC-81 (leukemia cells) and C6 (glioma cells) rat cell lines are presented. Effective concentrations in these test systems are generally some orders of magnitude lower than the toxicity of the conventional solvents acetone, aceto...
Article
The present paper reports on the current ecotoxicological risk profiles of the five antifouling biocides, copper, tributyltin, Irgarol 1051, Sea-Nine 211 and pyrithionate. These risk profiles consist of evaluations of the five risk indicators release, spatiotemporal range, bioaccumulation, biological activity and uncertainty for each of the biocide...
Article
In order to rise efficiency of the wastewater treatment in a refinery plant, several oxidation experiments were done, testing their applicability as an additional pretreatment method. The influence of treatment with low concentrations of H2O2 combined with stirring and UV light on degradation of organic compounds present in the refinery wastewater...
Article
A bioassay-directed fractionation and identification (toxicity identification evaluation procedure) was performed on extracts of 10 1 River Elbe water samples. The experimental method included a SDB-1 solid phase extraction followed by RP-HPLC fractionation and subfractionation. Chemical analysis by GC-MS as well as acute toxicity testing using a l...
Article
In this paper, we present our results obtained during implementation of a recycling methodology for chromatographic solvent waste in the University of Bremen, Germany. The procedures are combined out of three principal areas of activity where the first covers logistics of waste collection, the second–proper recycling techniques and the third biodeg...
Article
Zur Erhaltung des Schiffsverkehrs müssen die Häfen von sedimentierten Schwebstoffen befreit werden. Diese Sedimente enthalten oft hohe Konzentrationen an Tributylzinn (TBT), welches als Biozid in Antifouling-Anstrichen verwendet wird. Somit stellt sich das Problem einer angemessenen Entsorgung im Sinne einer Minimierung des Gefährdungspotentials fü...
Article
The paper presents results on the ability of activated sludge to tolerate increases in hydrogen peroxide concentration due to the introduction of H2O2 oxidised wastewater. Effects of hydrogen peroxide in the petroleum refinery effluent directed to further biological treatment is also presented. At low H2O2 concentrations the degradation efficiency...
Article
In this paper, we present our results obtained during implementation of a recycling methodology for chromatographic solvent waste in the University of Bremen, Germany. The procedures are combined out of three principal areas of activity where the first covers logistics of waste collection, the second–proper recycling techniques and the third biodeg...
Article
Full-text available
In this paper, we present appliedmethanol recycling technology utilising chromatographic applications, which has been designed for an academic-size institution. The procedure is combined out of proper recovery technique and the biodegradation method intended for postprocessing residues. Additionally, analytical methods controlling the quality of th...
Article
To allow ships to pass, most harbours have to be liberated from sedimented material. These sediments often contain high concentrations of tributyltin (TBT), which is used as a biocide in antifouling paints. Thus, the problem of a disposal which is acceptable with respect to a minimum risk for humans and the environment arises. The aim of our projec...
Article
Full-text available
The final article of a series of three evaluates the in situ-remediation of TNT(trinitrotoluene)-contaminated soil from ‘Werk Tanne’. The multidisciplinary approach allows a differentiated assessment. Grading with large-scale machinery leads to a depletion of TNT for almost 90% within the first 6 months, while ADNT(amino-dinitrotoluene)-content dec...
Article
Full-text available
Zusammenfassung Die Befunde des in seiner Konzeption in Teil I dargestellten Freilandexperimentes dokumentieren die TNT-Abreicherung und Erholung des Standortes im Laufe der Phytoremediation. Das Monitoring umfasst Erhebungen im Feld (Nitroaromatengehalte in Boden, Sickerwasser und Pflanzen; Erfassung von Bodenorganismen und Streuabbau) und den Ein...
Article
In the present study, the influence of the heavy metal ions Cd2+ and Zn2+ on cGMP metabolism in the neurosecretory rat pheochromocytoma (PC12) cell line has been investigated. Cadmium and zinc ions showed a concentration-dependent increase of intracellular cGMP levels as determined by radioimmunoassay: a 20-fold increase in cGMP concentration was f...
Article
Sediments often contain high concentrations of tributyltin, which is used as a biocide in antifouling paints. The aim of our project was to assess land deposition as an alternative in dealing with TBT-contaminated harbour sediments. Therefore, we followed the biological degradation of TBT under aerobic and anaerobic conditions at different temperat...
Article
Results of a field experiment (please refer to Warrelmann et al. 2000a) document TNT-degradation and regeneration after the establishment of a phytoremediation. Various approaches are included in a complex monitoring system, which are conducted in the field (nitroaromatics in soil, seepage water and plants; soil fauna; soil fungi; decomposition) as...