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Publications (166)
Background
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome, is a rare type of anti-neutrophil cytoplasm antibody-associated vasculitis, associated with asthma, nasal poliposis and rinosinusitis, in which eosinophils play a key role.Eosinophil targeted therapies alone or associated to conventional treatment with...
Immunoglobulin G4 related disease (IgG4 RD) is a fibroinflammatory disorder that begins in one or more organs as inflammatory tumours that evolve toward fibrosis and is often accompanied by elevated serum IgG4. It was first described in 2003 as a new concept that encompasses a number of diseases, immune allergic in nature, previously considered unr...
Background
Some patients with Systemic Lupus Erythematosus (SLE) have lymphadenopathy (LAP) at diagnosis or at follow-up. The prevalence of LAP in SLE was 59% in the oldest series,¹ 12% in the 1993 EUROLUPUS series² and in the last two decades its prevalence was not mentioned. However, the presence of LAP and their histological type may have clinic...
Objectives:
The low overall prevalence of systemic sclerosis (SSc) and the low proportion of male patients have resulted in a scarcity of studies assessing sex differences in Ssc patients, and contradictory results have often been show among those studies that have been performed.
Methods:
A prospective study was conducted with the Spanish RESCL...
Background
Anti-centromere pattern (ACA) is infrequently seen among antinuclear antibodies (ANA) detected by indirect immunofluorescence (IFI). ACA is associated with systemic autoimmune diseases (SAD), especially systemic sclerosis (SSc). Some studies had recently related ACA with cancer, mostly with breast and lung cancer [1]. However, most publi...
Giant cell arteritis (GCA) and Takayasu’s arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main diseas...
The aim of this study was to describe the clinical characteristics of ANCA-associated vasculitides (AAV) at presentation, in a wide cohort of Spanish patients, and to analyze the impact of the vasculitis type, ANCA specificity, prognostic factors, and treatments administered at diagnosis, in the outcome.A total of 450 patients diagnosed between Jan...
Objective:
To perform a systematic review of all cases of the association between Kikuchi's disease (KD) and systemic lupus erythematosus (SLE), and to ascertain the clinical and laboratory characteristics of this association (KD-SLE).
Methods:
We conducted a systematic search of the scientific literature until 31 January 2016. For study purpose...
Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunologic factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commercial turbidimetric assay in 413 ind...
BACKGROUND:
We hypothesized that the clinical course of venous thromboembolism in patients with active cancer may differ according to the specificities of primary tumor site.
AIM AND METHODS:
We used data from RIETE (international registry of patients with venous thromboembolism) to compare the clinical venous thromboembolism-related outcomes dur...
Patient registries are useful tools for assessing rare diseases. Our objective is to present the Spanish registry of patients with systemic lupus erythematosus (Registro español de pacientes con lupus eritematoso sistémico, RELES).
Introduction: Patient registries are useful tools for assessing rare diseases. Our objective is to present the Spanish registry of patients with systemic lupus erythematosus (Registro español de pacientes con lupus eritematoso sistémico, RELES). Patients and methods: RELES was started in 2008 as an observational, prospective, multicentre cohort reg...
Aim
To study the influence of prednisone dose during the first month after systemic lupus erythematosus (SLE) diagnosis (prednisone-1) on glucocorticoid burden during the subsequent 11 months (prednisone-2–12).
Methods
223 patients from the Registro Español de Lupus Eritematoso Sistémico inception cohort were studied. The cumulative dose of predni...
Background
The Birmingham Vasculitis Activity Score (BVAS), and the Five Factor Score (FFS) at the time of diagnosis have been shown useful to asses prognosis in AAV (1,2), but few studies have been done comparing these tools to predict survival
Objectives
To compare the usefulness of BVAS vs 3, 1996 FFS and 2009 FFS at the time of diagnosis, to p...
Background
AAV are still related to a high morbidity and mortality in spite of new available therapies. To recognize factors associated with a worse prognosis is essential to tailor the treatment
Objectives
To identify survival prognostic factors in a large cohort of patients with AAV from Spain and analyze changes in the new century
Methods
mult...
Background
The diagnosis of not necrotizing granulomatosis (NNG) is very frequent in clinical practice. Physicians often focused their attention on sarcoidosis. However, there are many conditions that can cause this histological diagnosis, including infectous diseases, neoplasms or inflamatory diseases. There ara a few studies into the spectrum of...
Background
The presence of anti-centromere antibodies (ACA) has been associated with limited cutaneous systemic sclerosis (lcSSc), primary biliary cirrhosis (PBC), Sjogren's syndrome and less frequently with other autoimmune diseases (AID). However, given the low prevalence of ACA (<3% of positive ANA), the series published to date have included fe...
Objectives:
This is the first Spanish multicentric inception lupus cohort, formed by SLE patients attending Spanish Internal Medicine Services since January 2009. We aimed to analyse drug therapy during the first year of follow-up according to disease severity.
Methods:
223 patients who had at least one year of follow-up were enrolled upon diagn...
Background and Aim
Serum IgG4 concentrations are commonly measured in clinical practice. The aim of this study was to investigate serum IgG4 concentrations in adults and their potential relationship with demographic, lifestyle, metabolic, and allergy-related factors.
Methods
Serum IgG4 concentrations were measured with a commercial assay in 413 in...
Individual data.
(XLS)
There are few data regarding the existence of clinical differences between patients with systemic sclerosis (scleroderma) exposed to silica (SSc-si) and "idiopathic" cases (SSc-id). Our goal is to describe the clinical characteristics of patients with SSc-si and see if they differ from the SSc-id cases.
We performed a systematic review of the liter...
Background AAV are still related to a high morbidity and mortality in spite of therapeutic advances.To identify factors present at diagnosis that are associated with a worse prognosis, it is essential to tailoring the treatment
Objectives To describe the long-term survival rate and possible prognostic factors at presentation in a large cohort of pa...
Background Some patients with LV-GCA does not have cranial symptoms of giant cell arteritis (C-GCA) and the temporal artery biopsy (TAB) is negative for arteritis. This subset of patients usually has diagnostic delay and inappropriate treatment [1]. Furthermore, patients with biopsy-proven C-GCA and isolated ESR increase could be erroneously consid...
Background
Antiphospholipid syndrome (APS) is a multisystem disease, and the heart may be affected from 10 to 50% in some series [1,2]. Heart valve lesions are the most frequent manifestations. Coronary arteries and myocardium may be also affected. Other findings include chronic thromboembolic pulmonary hypertension and accelerated atherosclerosis....
OBJECTIVE:
Different lines of evidence have highlighted the role of IL-17A in the inflammatory process occurring in giant cell arteritis (GCA). The aim of the present study was to assess whether the IL17A locus influences GCA susceptibility and its clinical subphenotypes.
METHODS:
We carried out a large meta-analysis including a total of 1266 biops...
Objectives To analyze the demographic, clinical, laboratory features and outcome of patients with EGPA in a large cohort of Spanish patients with AAV
Methods multicenter retrospective-longitudinal study that included patients diagnosed with AAV between January 1995 and December 2012 in 19 Hospitals from Spain (REVAS Study). Statistical analysis was...
Background
85-90% of patients with systemic sclerosis (SSc) are women, so there are few series that have evaluated distinguishing clinical features in men (1).
Objectives
To describe clinical features of the male subgroup of a cohort of patients diagnosed with scleroderma in our hospital and evaluate the differences within the female subgroup.
Me...
Background
HLA-B27 uveitis has been defined as a unilateral acute syndrome without associated systemic disease [1]. However, in some patients the ocular disease precedes the occurrence of systemic diseases as ankylosing spondylitis (AS), reactive arthritis (ReA), spondyloarthritis (SpA), undifferentiated spondyloarthritis (UspA), SpA associated wit...
The Xq28 region, containing IRAK and MECP2, represent a common susceptibility locus for a high number of autoimmune diseases. Our aim in the present study was to evaluate the influence of the IRAK1 and MECP2 autoimmunity-associated genetic variants in the giant cell arteritis (GCA) susceptibility and its clinical subphenotypes.
We analysed a total...
This article lists the integral elements of the Sherlock Holmes method, which is based on the intelligent collection of information through detailed observation, careful listening and thorough examination. The information thus obtained is analyzed to develop the main and alternative hypotheses, which are shaped during the deductive process until th...
Objective:
To evaluate systemic involvement in primary SS in a large cohort of Spanish patients using the EULAR-SS disease activity index (ESSDAI) definitions.
Methods:
Systemic involvement was characterized using ESSDAI definitions for the 10 clinical domains (constitutional, lymphadenopathy, glandular, articular, cutaneous, pulmonary, renal, p...
Background
The mixed connective tissue disease (MCTD) is an infrequent and possibly underdiagnosed connective tissue disease, which is characterized by the presence of high titres of anti-U1 ribonucleoprotein antibodies (anti-RNP). Although, the anti-RNP antibodies are always present in patients with MCTD because its positivity is part of the defin...
Background CD226 genetic variants have been associated with a number of autoimmune diseases.
Objectives The aim of this study was to investigate the potential implication of the CD226 loci in the susceptibility to and main clinical manifestations of giant cell arteritis (GCA).
Methods A Spanish Caucasian cohort of 455 patients diagnosed with biopsy...
Background
Progressive systemic sclerosis (PSS) is a complex multisystem connective tissue disease whith unknown aetiology, but environmental and genetic factors may play a role. Since the first association of silica exposure and PSS by Erasmus in 1957 [1], several case reports documented this co-existence [2], but with conflicting results dependin...
Background Systemic lupus erythematous (SLE) represents a heterogeneous group of patients. Some of them are diagnosed with SLE with mild articular and cutaneous symptoms, while others present with severe organ damage. There are also patients with positive ANA and clinical manifestations of SLE, but who don’t fulfill classification criteria for SLE...
Background
Kikuchi disease (KD) and systemic lupus erythematosus (SLE) share many clinical and histological features. The association of both entities has been reinforced over time with the publication of numerous case reports and small series (1). Some reviews about this topic were also published (2-3). However, no systematic review of the literat...
Background The PTPN22/CSK signalling represents one of the most relevant pathways in the innate immunity, and it has been implicated in the susceptibility to develop a wide number of autoimmune diseases.
Objectives To analyse the possible role of different single-nucleotide polymorphisms of the PTPN22 and CSK genes in the predisposition and clinica...
This article lists the integral elements of the Sherlock Holmes method, which is based on the intelligent collection of information through detailed observation, careful listening and thorough examination. The information thus obtained is analyzed to develop the main and alternative hypotheses, which are shaped during the deductive process until th...
Invasive pneumococcal disease (IPD) shows different epidemiological characteristics depending on age and pneumococcus serotype. The aims of the work were to analyze the clinical manifestations and mortality associated with IPD, the serotype isolated and the antibiotic resistance rates in different age groups.
Retrospectively, 141 patients with IPD...
Objective:
To analyse the role of the PTPN22 and CSK genes, previously associated with autoimmunity, in the predisposition and clinical phenotypes of giant cell arteritis (GCA).
Methods:
Our study population was composed of 911 patients diagnosed with biopsy-proven GCA and 8136 unaffected controls from a Spanish discovery cohort and three additi...
Objectives:
Polymorphisms of the CC chemokine receptor 6 (CCR6) gene have been recently reported to be associated with a number of autoimmune diseases. We aimed to investigate the possible influence of CCR6 rs3093024 gene variant in the susceptibility to and clinical expression of GCA.
Methods:
The CCR6 polymorphism rs3093024 was genotyped in a...
Objective:
Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder causing mucocutaneous telangiectases and visceral arteriovenous malformations (AVMs). Pulmonary hypertension (PH) is considered an uncommon complication of HHT whose impact on the survival of these patients is currently unknown.
Methods:
From January 1995 to December 2...
Objectives:
To establish the frequency and describe the characteristics of a cohort of patients with SF eosinophilia (SFE) and a long clinical follow-up. A systematic review of the literature on this topic was performed.
Methods:
From November 2005 to May 2010, 982 consecutive arthrocentesis procedures performed at a tertiary care hospital were...
Synovial fluid eosinophilia is defined as the presence of eosinophils, irrespective of quantity, in the synovial fluid and is a rare finding that is probably underestimated. The pathogenesis of this entity remains incompletely understood. Secondary and idiopathic forms have been described. Idiopathic forms are those not associated with systemic or...
Mujer de 62 años sin antecedentes de interés que acudió repetidas veces a Urgencias en el último mes por crisis dehipertensión arterial, que se acompañaba de edemas en miembros inferiores. En la analítica únicamente destacaba una hipopotasemia de reciente aparición (2.9 meq/l)
CD226 genetic variants have been associated with a number of autoimmune diseases. The aim of this study was to investigate the potential implication of the CD226 loci in the susceptibility to and main clinical manifestations of giant cell arteritis (GCA).
A Spanish Caucasian cohort of 455 patients diagnosed with biopsy-proven GCA and 1414 healthy c...
Kikuchi's disease (KD) has been associated with the presence of autoantibodies, systemic lupus erythematosus (SLE), and other autoimmune diseases. The aim of this study was to assess the frequency of autoimmune manifestations in a KD cohort with a long follow-up.
Twenty patients with histologically confirmed KD since January 1990 until December 201...
To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA).
A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology.
No association was observed between...
A 16 year review of 391 splenectomies performed at New England Medical Center was done to evaluate the morbidity and mortality of patients with drained splenic weights greater than 1,000 grams. Thirty-six met the criteria for study. Twenty men and 16 women with an average age of 55.4 years were identified. Myeloproliferative disorders were the most...
Livedoid vasculopathy is a rare condition which predominantly affects young women. It is characterized by intense painful purpuric maculae in the legs, ankles and feet, due to thrombosis of the small and medium-sized dermal vessels, in the absence of vasculitis. Livedoid vasculopathy has been frequently associated with hypercoagulable states and an...
Background
Osteonecrosis (ON) of the hip in human immunodeficiency virus (HIV)-infected patients has been related to corticosteroid use, dyslipidemia, alcoholism, lipodystrophy, antiretroviral drug use, and HIV infection, itself. The aim of this study was to evaluate the prevalence of silent ON of the hip in HIV-infected patients and its associatio...
M.T. Pérez Rodríguez, B. Sopeña, F. Lueiro, C. Martínez-Vázquez. Late infection of an embolized renal graft presented as buttock cellulitis. Transpl Infect Dis 2010: 12: 161–163. All rights reserved
Abstract: Graft intolerance syndrome (GIS) is a common complication developed in failed kidney allografts left in situ when the patients returned to he...
Osteonecrosis (ON) of the hip in human immunodeficiency virus (HIV)-infected patients has been related to corticosteroid use, dyslipidemia, alcoholism, lipodystrophy, antiretroviral drug use, and HIV infection, itself. The aim of this study was to evaluate the prevalence of silent ON of the hip in HIV-infected patients and its association with seve...
Clin Microbiol Infect 2010; 16: 274–280
Fifty-five episodes of bacteraemia arising in patients with a permanent endocardial pacemaker (PEP), from May 1987 to March 2006, were reviewed to determine whether clinical and microbiological data might assist in individual clinical management. Episodes of PEP-related bacteraemia were divided into early-ons...
To determine the prevalence and clinical relevance of isolated antibodies to hepatitis B core antigen as the only marker of infection ("anti-HBc alone") among human immunodeficiency virus (HIV) type-1 infected patients. Occult hepatitis B infection frequency was also evaluated.
Three hundred and forty eight histories from 2388 HIV-positive patients...
Refractory edema is defined as peripheral edema that does not respond to dietary sodium restriction and combined diuretic treatment including a loop diuretic, often caused by an evident underlying cardiac or pulmonary condition. We present a case of refractory edema, which remained unexplained until a hidden intrarenal arteriovenous malformation wa...
Although cocaine abuse is an increasingly important medical problem, many manifestations of its toxicity are not well understood. The aim of this study is to review the most serious clinical manifestations related to cocaine abuse.
We reviewed the medical records of all patients over 16 years of age admitted to the hospital from January 1994 to Dec...
Introduction
Although cocaine abuse is an increasingly important medical problem, many manifestations of its toxicity are not well understood. The aim of this study is to review the most serious clinical manifestations related to cocaine abuse.
Patients and method
We reviewed the medical records of all patients over 16 years of age admitted to the...
Introduction
Removal of graft with intravenous antibiotics is traditionally considered the most effective treatment of vascular graft-associated infections. However, an increasing number of reports suggests that this complication can be effectively treated without graft removal.
Methods
A prospective study to evaluate the outcome of conservative m...
Removal of graft with intravenous antibiotics is traditionally considered the most effective treatment of vascular graft-associated infections. However, an increasing number of reports suggests that this complication can be effectively treated without graft removal.
A prospective study to evaluate the outcome of conservative management of vascular...
Correspondencia: Dr. B. Sopeña. C/ Zamora, 10. Portal 2, 2.° 36203 Vigo. Pontevedra. España.
Hepatotoxicity is one of the most serious adverse effects of anti-tuberculosis drugs (ATD). Although many risk factors have been associated with ATD-induced hepatotoxicity, their influence on hepatitis severity has not been studied systematically.
To evaluate whether the presence of hepatotoxicity risk factors (advanced age, chronic liver disease,...
Aspiration of foreign bodies is a serious complication that may occur during the course of dental treatment. A case report of a 60-year-old man with recurrent pneumonia is presented. One year after the onset of his initial symptoms, a hard substance that made a complete mold of the bronchial tree at the inferior right lobe was extracted with a rigi...
The incidence of and risk factors associated with hepatotoxicity in patients with chronic hepatitis have not been systematically
studied. Therefore, we conducted a prospective study that included former drug users who were treated with isoniazid for latent
tuberculosis infection. Of 415 patients, 20 (4.8%; 95% confidence interval [CI], 3–7.4) had h...