Bernardo F Sánchez-Dalmau

Bernardo F Sánchez-Dalmau
Hospital Clínic de Barcelona · Institut Clínic de Oftalmología, ICOF

Doctor of Medicine

About

99
Publications
48,235
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1,451
Citations
Additional affiliations
April 2005 - present
Hospital Clínic de Barcelona
Position
  • Neur-Ophthalmology Unit

Publications

Publications (99)
Article
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by expansion of a polyglutamine (polyQ)-encoding CAG repeat in the ATXN3 gene. Because the ATXN3 protein regulates photoreceptor ciliogenesis and phagocytosis, we aimed to explore whether expanded polyQ ATXN3 impacts retinal function and integrity in SCA...
Preprint
Full-text available
Spinocerebellar ataxia type 3 is an autosomal dominant neurodegenerative disorder caused by expansion of a polyglutamine (polyQ)-encoding CAG repeat in the ATXN3 gene. Because the ATXN3 protein regulates photoreceptor ciliogenesis and phagocytosis, we aimed to explore whether expanded polyQ ATXN3 impacts retinal function and integrity in SCA3 patie...
Article
Full-text available
Artificial intelligence (AI)-based diagnostic algorithms have achieved ambitious aims through automated image pattern recognition. For neurological disorders, this includes neurodegeneration and inflammation. Scalable imaging technology for big data in neurology is optical coherence tomography (OCT). We highlight that OCT changes observed in the re...
Article
Full-text available
Purpose: Raman spectroscopy allows molecular changes to be quantified in vivo from the tissues like the retina. Here we aimed to assess the metabolic changes in the retina of patients with multiple sclerosis (MS). Methods: We built a Raman spectroscopy prototype by connecting a scanning laser ophthalmoscope to a spectrophotometer. We defined the...
Article
Full-text available
Objective To update the consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results, thus revising the previously published Advised Protocol for OCT Study Terminology and Elements (APOSTEL) recommendations. Methods To identify studies reporting quantitative OCT results, we performed a PubMed search for...
Article
The case of a 68-year-old patient with visual loss secondary to prosthetic cobaltism is reported. The degeneration of the metallic hip prosthesis can produce a systemic absorption of cobalt with cardiac, neurological, endocrine, auditory, and visual manifestations. The diagnostic suspicion is confirmed by serum cobalt measurements. Treatment with e...
Article
Resumen Se presenta el caso de un paciente de 68 años con pérdida visual secundaria a cobaltismo protésico. La degeneración de la prótesis metálica de cadera produce una absorción sistémica de cobalto con manifestaciones cardíacas, neurológicas, endocrinas, auditivas y visuales. La sospecha diagnóstica es confirmada mediante determinaciones séricas...
Article
Macular oedema is a rare complication of fingolimod treatment. It usually presents within 3–4 months, but occasionally presents later. It can resolve without treatment despite continuation of fingolimod treatment. Herein we report a case of very late onset macular oedema in a 49-year-old woman with multiple sclerosis treated with fingolimod for 7 y...
Article
Full-text available
Understanding of the role of focal inflammation, a treatable feature, on neuro-axonal injury, is paramount to optimize neuroprotective strategy in MS. To quantify the impact of focal inflammatory activity on the rate of neuro-axonal injury over the MS course. We quantified the annualized rates of change in peripapillary retinal nerve fiber layer, g...
Article
Resumen El conocimiento sobre las neuropatías ópticas desmielinizantes y autoinmunes ha experimentado una revolución en la útima década tras el descubrimiento de los anticuerpos antiacuaporina 4 (AQP4). Las mejoras en las técnicas diagnósticas, el descubrimiento de nuevas dianas y el avance de la neuroinmunología han permitido la detección de antic...
Article
The knowledge on demyelinating and autoimmune optic neuropathies has experienced a revolution the last decade since the discovery of anti-aquaporin 4 antibody. Improvements in diagnostic techniques, and the finding of new targets, along with advances in neuroimmunology have led to the detection of antibodies related to demyelinating diseases. A rev...
Article
Disorders of the visual system are one of the main features of multiple sclerosis (MS), and have a great impact on the quality of life of patients. Although optic neuritis is the most frequent manifestation, there are other ophthalmological processes not related to neuritis, a knowledge of which is very useful in the management of patients with MS....
Article
Resumen Las alteraciones del sistema visual son uno de los principales rasgos de la esclerosis múltiple (EM) y conllevan un gran impacto en la calidad de vida de los pacientes. Aunque la neuritis óptica es la manifestación más frecuente, existen otros procesos oftalmológicos no relacionados con la neuritis, cuyo conocimiento es de gran utilidad en...
Article
Aim To evaluate compliance rate to pterygium postoperative treatment with two different protocols. Methods Review of clinical data of patients submitted to pterygium excision and conjunctival autografting in a single centre (and a single surgeon) in Barcelona between March 2014 and December 2017. Initial postoperative protocol (protocol 1) consist...
Chapter
Retrograde trans-synaptic retinal degeneration may occur in patients with post-geniculate optic radiations lesions and can be showed in congenital/long standing homonymous hemianopia, acquired homonymous hemianopia and neurodegenerative diseases like multiple sclerosis or Alzheimer’s disease. This trans-synaptic retinal degeneration has been report...
Article
Importance Neuroprotective and remyelinating therapies are required for multiple sclerosis (MS), and acute optic neuritis (AON) is a potential condition to evaluate such treatments. Objective To comprehensively assess key biological and methodological aspects of AON trials for testing neuroprotection and remyelination in MS. Design, Setting, and...
Article
Resumen Una mujer de 58 años presentó quemosis intensa y oftalmoparesia en el ojo izquierdo 8 h después de cirugía de catarata no complicada bajo anestesia subtenoniana. Tras tratamiento corticoideo y antihistamínico, se observó recuperación de la motilidad extrínseca pero se apreciaron un edema de papila no hemorrágico y un defecto concéntrico de...
Article
A 58 year-old woman presented with severe chemosis and ophthalmoparesis on her left eye 8 h after uncomplicated cataract surgery under sub-tenon anaesthesia. Recovery of extrinsic motility was observed after corticosteroid and antihistamine treatment, but a non-haemorrhagic papillary oedema and a concentric defect of visual field were found. It pro...
Article
Full-text available
Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood. Objective: The obje...
Article
Full-text available
Purpose Cockayne syndrome is a rare autosomal recessive disease, also known as a progeria disorder, causing dwarfism, senile appearance and multiple systemic affections. Ophthalmic abnormalities are frequent, for example, in the forms of pigmentary retinopathy with low visual acuity. We present two genetic-confirmed cases with a detailed electrophy...
Article
Purpose Controversy exists regarding the safety of agents that systemically inhibit epidermal growth factor receptor (EGFRi) in oncologic patients in terms of toxicity to the ocular surface. We performed a prospective clinical study comparing the ocular surface toxicity of systemic EGFRi between a case and a control group. Methods Patients with lu...
Article
Full-text available
Visual impairment significantly alters the quality of life of people with Multiple Sclerosis (MS). The objective of this study was to identify predictors (independent variables) of visual outcomes, and to define their relationship with neurological disability and retinal atrophy when assessed by optical coherence tomography (OCT). We performed a cr...
Data
Univariate association with vision-related quality of life. (DOCX)
Article
Background: Visual recovery after optic neuritis (ON) used to be defined as good, although patients frequently complain of poor vision. Methods: We carried out a prospective study on 38 consecutive patients with acute ON followed monthly for 6 months and evaluated high- and low-contrast visual acuity (HCVA and LCVA, respectively), quality of vis...
Article
Full-text available
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory central nervous system disease that preferentially affects the optic nerve and spinal cord [Wingerchuk et al. 2015]. Up to 70% of patients with NMOSD have antibodies to aquaporin-4 (AQP4-IgG). AQP4 is expressed in astrocytes of the optic nerve and Muller cells in the eye. A subgroup...
Article
Full-text available
Monitoring disease burden is an unmeet need in multiple sclerosis (MS). Identifying patients at high risk of disability progression will be useful for improving clinical-therapeutic decisions in clinical routine. To evaluate the role of visual field testing in non-optic neuritis eyes (non-ON eyes) as a biomarker of disability progression in MS. In...
Chapter
The anterior visual pathway is composed of the axons from retinal ganglion cells, which form the optic nerve, optic chiasm, and optic tract, and synapse in the lateral geniculate nucleus (LGN). The posterior visual pathway is composed of axons from the LGN that form the optic radiations (OR) and project into the visual cortex. Anterior visual pathw...
Article
Background: Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multi...
Chapter
Technological development of photonic-based devices such as optical coherence tomography (OCT) has provided a new window into the multiple sclerosis (MS) brain. Acute multiple sclerosis associated optic neuritis (MSON) resembles an acute lesion model in MS leading to acute retinal neurodegeneration. Acute MSON is clinically eloquent and technically...
Article
Full-text available
Multiple Sclerosis (MS) results in color vision impairment regardless of optic neuritis (ON). The exact location of injury remains undefined. The objective of this study is to identify the region leading to dyschromatopsia in MS patients' NON-eyes. We evaluated Spearman correlations between color vision and measures of different regions in the affe...
Conference Paper
Full-text available
PURPOSE: Evaluate the role of wide-field retinography to detect periphlebitis in patients with MS, without ocular symptoms. BACKGROUND: Retinal periphlebitis (RP) is characterized by perivascular exudation, haemorrhage, and retinal venous sheathing. The relationship between RP and multiple sclerosis (MS) is known and has a variable incidence among...
Conference Paper
PURPOSE: To describe a case of ocular dysfunction after hip arthroplasty with cobalt–chromium alloy prosthesis. There are few case reports in the literature reporting visual problems including optic atrophy due to cobaltism. METHODS: A 70 year-old man who was referred to the neuro-ophthalmological department due to blurred vision and photopsias in...
Article
Full-text available
Purpose: To characterise the changes of the retinal layers in patients with acute anterior ischaemic optic neuropathy (AION), aiming to identify imaging markers for predicting the residual visual function. Methods: This was a retrospective review of consecutive patients with unilateral AION from January 2010 to December 2013. We analysed affecte...
Conference Paper
Full-text available
Introduction: Retinal periphlebitis (RP) is characterized by perivascular exudation, hemorrhage, and retinal venous sheathing. The relationship between RP and multiple sclerosis (MS) is known and has a variable incidence among series (5-39%). RP has been related to a more active disease (1). Retinal inflammation parallels the inflamatory processes...
Conference Paper
Full-text available
Introduction: Peripheral neuropathy secondary to drugs is a cause of severe disability. Usually Invasive techniques as cutaneous nerve biopsy are employed for diagnosis. Corneal confocal microscopy (CCM) is a noninvasive and rapid technique to assess in vivo all structures of the cornea, including the sub-basal nerve plexus. We designed a prospecti...
Article
Full-text available
Objective We set out to assess the dynamics of retinal injury after acute optic neuritis (ON) and their association with clinical visual outcomes.Methods Thirty-one consecutive patients with acute ON were prospectively analyzed over a 6-month follow-up period. Each month, we used optical coherence tomography (OCT) to assess the thickness of peripap...
Article
Full-text available
Opinion statement: Multiple sclerosis is an autoimmune demyelinating disorder of the nervous system, in which almost all patients develop some degree of visual impairment during the disease. Optic neuritis is the most common and known visual affection and may be the initial clinical disease manifestation, but visual complaints can have a wide vari...
Article
Full-text available
Multiple Sclerosis (MS) is an immune-mediated disease of the Central Nervous System with two major underlying etiopathogenic processes: inflammation and neurodegeneration. The latter determines the prognosis of this disease. MS is the main cause of non-traumatic disability in middle-aged populations. The MS-VisualPath Cohort was set up to study the...
Article
Full-text available
Uncontrolled studies of mesenchymal stem cells (MSCs) in multiple sclerosis suggested some beneficial effect. In this randomized, double-blind, placebo-controlled, crossover phase II study we investigated their safety and efficacy in relapsing-remitting multiple sclerosis patients. Efficacy was evaluated in terms of cumulative number of gadolinium-...
Article
Full-text available
Patients with multiple sclerosis (MS) almost always experience effects in the visual pathway; and thus, visual dysfunction is not only common but also highly relevant. The visual pathway represents a model of acute focal central nervous system (CNS) damage, through acute optic neuritis and retinal periphlebitis, as well as a model of chronic, diffu...
Article
Retinal tissue is damaged during inflammation in Multiple Sclerosis. We assessed molecular changes in inflamed murine retinal cultures by Raman spectroscopy. Partial Least Squares-Discriminant analysis (PLS-DA) was able to classify retina cultures as inflamed with high accuracy. Using Multivariate Curve Resolution (MCR) analysis, we deconvolved 6 m...
Article
Background: Effective management of multisymptomatic chronic diseases such as multiple sclerosis (MS) requires a multimodal, interdisciplinary approach. At MS clinics, numerous healthcare specialties are coordinated to provide patients with quality clinical care for all aspects of their disease. Settings and resource availability may vary between...
Article
Full-text available
Objective Retrograde trans-synaptic degeneration of retinal ganglion cell layer (GCL) has been proposed as one of the mechanisms contributing to permanent disability after visual pathway damage. We set out to test this mechanism taking advantage of the new methods for imaging the macula with high resolution by optical coherence tomography (OCT) in...
Article
Full-text available
It is currently believed that the incidence rate of optic neuritis (ON) ranges between 0.56 and 5.1 cases per 100,000 person-years. However, since these figures were generated, they have not been updated and there are suggestions that the incidence of ON is on the rise. When designing new therapies and clinical trials for ON, and to improve the man...
Article
Full-text available
Objective: To evaluate the association between the damage to the anterior and posterior visual pathway as evidence of the presence of retrograde and anterograde trans-synaptic degeneration in multiple sclerosis (MS). Methods: We performed a longitudinal evaluation on a cohort of 100 patients with MS, acquiring retinal optical coherence tomograph...
Article
Full-text available
Colour vision assessment correlates with damage of the visual pathway and might be informative of overall brain damage in multiple sclerosis (MS). The objective of this paper is to investigate the association between impaired colour vision and disease severity. We performed neurological and ophthalmic examinations, as well as magnetic resonance ima...
Article
Full-text available
Purpose: To report optical coherence tomography (OCT) findings in order to detect subclinical alterations of the afferent visual pathways in spinocerebellar ataxia 3 (SCA-3). Patients and methods: Nine genetically confirmed patients (18 eyes) were evaluated with a complete ophthalmologic examination including visual acuity, colour vision, visual...
Article
To assess the association of primary retinal inflammation, namely retinal periphlebitis (RP) and microcystic macular edema, with clinical, brain, and retinal imaging biomarkers of multiple sclerosis (MS) severity. One hundred patients with MS underwent a neurologic and ophthalmic examination, MRI, and optical coherence tomography. Disability was as...
Conference Paper
Full-text available
Purpose: To describe the inflammatory ocular manifestations of patients with systemic lupus erythematosus (SLE) at a multidisciplinary uveitis unit Methods: Retrospective chart review of patients with SLE in a tertiary referral center between 2007 and 2012 was performed. All patients have undergone complete rheumatologic and ophthalmic examination...
Article
Background Systemic lupus erythematosus (SLE) can affect all structures of the eye and ocular adnexa. The most common ocular findings include dry eye and retinal vascular changes. Objectives To describe the inflammatory ocular manifestations of patients with systemic lupus erythematosus (SLE) at a multidisciplinary uveitis unit. Methods Retrospecti...
Article
Wernicke encephalopathy-a debilitating acute or subacute neurological disorder-is caused by a deficiency in thiamine (vitamin B(1)). It is characterized by a classical clinical triad of symptoms: ocular impairment, cerebellar dysfunction, and confusion. Although bariatric surgery can certainly improve the overall health of an obese individual, it c...
Article
Full-text available
Bilateral ocular ischemic syndrome and ischemic optic neuropathy have rarely been reported as initial manifestations of Takayasu arteritis (TA). Appearance of ocular symptoms in TA is related to the extent and severity of involvement of the aorta and its major branches. We report a case of bilateral ocular ischemic syndrome with unilateral ischemic...