Bernard Veyret

• Thèse Etat 1983
• Retired at Université Bordeaux-I

Aim: The Pasche research group has reported that tumor-specific electromagnetic field frequencies have physiological and potential anti-tumor effects in cells, animals, and humans. Our aim was to investigate whether these fields have similar effects on physiological parameters in murine tumor models. Methods: Human HuH7 or HEPG2 cells were implante...

So far, the only identified biological effects of radiofrequency fields (RF) are known to be caused by heating but the issue of potential nonthermal biological effects, especially on the central nervous system (CNS), remains open. We previously reported a decrease in the firing and bursting rates of neuronal cultures exposed to a Global System for...

Blood-brain barrier (BBB) permeation and neuron degeneration were assessed in the rat brain following exposure to mobile communication radiofrequency (RF) signals (GSM-1800 and UMTS-1950). Two protocols were used: (i) single 2 h exposure, with rats sacrificed immediately, and 1 h, 1, 7, or 50 days later, and (ii) repeated exposures (2 h/day, 5 days...

The existence of effects of radiofrequency field exposure at environmental levels on living tissues and organisms remains controversial, in particular regarding potential "nonthermal" effects produced in the absence of temperature elevation. Therefore, we investigated whether TRPV1, one of the most studied thermosensitive channels, can be activated...

Multiplexed bioluminescence resonance energy transfer (BRET) assays were developed to monitor the activation of several functional transient receptor potential (TRP) channels in live cells and in real time. We probed both TRPV1 intramolecular rearrangements and its interaction with Calmodulin (CaM) under activation by chemical agonists and temperat...

The International Commission on Non-Ionizing Radiation Protection issued guidelines in 1998 for limiting public and occupational exposure to radiofrequency electromagnetic fields (100 kHz to 300 GHz). As part of the process of updating this advice, a 2‐d workshop titled “A closer look at the thresholds of thermal damage” was held from 26–28 May 201...

In this paper, the dosimetric characterization of an EMF exposure setup compatible with real-time impedance measurements of adherent biological cells is proposed. The EMF are directly delivered to the 16-well format plate used by the commercial xCELLigence apparatus. Experiments and numerical simulations were carried out for the dosimetric analysis...

The present study focused on gap junctional intercellular communication (GJIC) as a target for biological effects of extremely low-frequency (ELF) magnetic field (MF) exposure. Fluorescence recovery after photobleaching microscopy (FRAP) was used to visualize diffusion of a fluorescent dye between NIH3T3 fibroblasts through gap junctions. The direc...

In this paper, we propose, setup and characterize a delivery system to expose biological cells to nanosecond pulsed electric fields (nsPEF). The delivery system, based on the commercially available xCELLigence device, was characterized through numerical simulations and experimental time-domain measurements. The ability of the delivery system to del...

Disease tolerance is the ability of the host to reduce the effect of infection on host fitness. Analysis of disease tolerance pathways could provide new approaches for treating infections and other inflammatory diseases. Typically, an initial exposure to bacterial lipopolysaccharide (LPS) induces a state of refractoriness to further LPS challenge (...

The central nervous system is the most likely target of mobile telephony radiofrequency (RF) field exposure in terms of biological effects. Several electroencephalography (EEG) studies have reported variations in the alpha-band power spectrum during and/or after RF exposure, in resting EEG and during sleep. In this context, the observation of the s...

The bioeffects of exposure to Wireless High-Fidelity (WiFi) signals on the developing nervous systems of young rodents was investigated by assessing the in vivo and in situ expression levels of three stress markers: 3-Nitrotyrosine (3-NT), an oxidative stress marker and two heat-shock proteins (Hsp25 and Hsp70). These biomarkers were measured in th...

An experimental approach was used to assess immunological biomarkers in the sera of young rats exposed in utero and postnatal to non-ionizing radiofrequency fields. Pregnant rats were exposed free-running, 2 h/day and 5 days/week to a 2.45 GHz Wi-Fi signal in a reverberation chamber at whole-body specific absorption rates (SAR) of 0, 0.08, 0.4, and...

The increase in exposure to the Wireless Fidelity (Wi-Fi) wireless communication signal has raised public health concerns especially for young people. Animal studies looking at the effects of early life and prenatal exposure to this source of electromagnetic fields, in the radiofrequency (RF) range, on development and behavior have been considered...

Fears concerning possible effects on health were first expressed in 1993 on account of the rapid development of wireless communications and following a highly mediatised lawsuit in the United States against a mobile phone manufacturer accused of being responsible for the death of a woman from cancer. Since then, widespread research has been carried...

The dominant effect of human exposures to microwaves is caused by temperature elevation ('thermal effect'). In the safety guidelines/standards, the specific absorption rate averaged over a specific volume is used as a metric for human protection from localized exposure. Further investigation on the use of this metric is required, especially in term...

Animal studies can contribute to addressing the issue of possible greater health risk for children exposed to 50-60 Hz extremely low frequency (ELF) magnetic fields (MFs), mostly in terms of teratological effects and cancer. Teratology has been extensively studied in animals exposed to ELF MFs but experiments have not established adverse developmen...

In this paper, the authors present a comprehensive review of animal studies on carcinogenicity of radiofrequency (RF) electromagnetic fields. The rapid increase in mobile telephony has resulted in concerns regarding possible heath effects from the low-level but increasingly ubiquitous exposure to RF fields. The possible carcinogenicity of RF fields...

This paper describes the design of a zero-current crossing detection circuit for a high-power (650 V, 6000 A) magnetic generator (1). The magnetic pulses are produced by discharging a capacitor Cd into a coil in resonant mode via thyristors and are used to stimulate living tissues. The generator delivers short (340 �s), high-inten sity 2 Tesla magn...

This paper describes the design and construction of a zero-current crossing detection circuit for a high-power (6000 A, 650 V) magnetic generator delivering short (340 mu s), high-intensity (2 Tesla) pulses, used to stimulate living tissues. The magnetic pulses are produced by discharging a capacitor C-d into a coil in resonant mode. Half-sine or f...

Real-time investigations on the effects of mobile-phone exposure on neuronal activity are considered the highest priority in the health risk assessment of RF fields. Therefore, this paper describes a new real-time exposure setup for electrophysiology recordings, combining an open transverse electro-magnetic cell with a multiple electrode array. The...

The impact of Wi-Fi exposure was investigated on the developing immune system of C57BL/6 mice, whole-body exposed 2-hour/day for 7 weeks at 2.45 GHz. The pups were exposed for 2 weeks in utero and then for 5 weeks post-natal. The free-running animal exposure system was a reverberation chamber with SAR levels of 0, 0.8, 0.4, and 4 W/kg. There was no...

The present study aimed, for the first time, at evaluating the consequences of in utero exposure to a Wi-Fi signal on pregnant rats and their pups. SAR levels of 0.08, 0.4, and 4 W/kg were used. Prenatal study of foetuses delivered by caesarean was carried out on 5 females/group. Maternal observations after delivery and offspring follow-up were don...

The effects of RF radiation were investigated on the rat reproductive system in compliance with the OECD protocole-421. Free moving male and female rats (before and during pregnancy) were whole-body sham exposed or exposed to a Wi-Fi signal (2450 MHz) using a reverberation chamber at WB SAR of 0.1 or 4 W/kg. Preliminary results show that body-weigh...

In this study we investigated the effect of the Enhanced Data rate for GSM Evolution (EDGE) signal on cells of three human brain cell lines, SH-SY5Y, U87 and CHME5, used as models of neurons, astrocytes and microglia, respectively, as well as on primary cortical neuron cultures. SXC-1800 waveguides (IT'IS-Foundation, Zürich, Switzerland) were modif...

Pregnant rats were daily whole-body exposed or sham-exposed to a Wi-Fi signal in a free-running reverberation chamber at 0, 0.08, 0.4, and 4 W/kg for 2 h during the last 2 weeks of gestation (5 days/week). Following this in utero exposure, the pups were divided into two groups and 1 group continued exposure for 5 weeks after birth. Several brain ar...

There has been growing concern about the possibility of adverse health effects resulting from exposure to radiofrequency radiations (RFR), such as those emitted by wireless communication devices. Since the introduction of mobile phones many studies have been conducted regarding alleged health effects but there is still some uncertainty and no defin...

Few studies have shown that local exposure to radiofrequency electromagnetic fields (RF) induces intensity-dependent physiological changes, especially in the brain. The aim of the present study was to detect reproducible responses to local RF exposure in the parietal cortex of anesthetized rats and to determine their dependence on RF intensity. The...

There is some concern that exposure to extremely low-frequency magnetic fields (MF) causes adverse health effects via signal transduction pathways. Two previous studies reported that exposure to 50-Hz MF decreased the binding affinity of the 1B receptor subtype of serotonin (5-HT) in rat brain membranes. The aim of this study was to investigate whe...

INTRODUCTION In recent decades, concern has been growing about decreasing fecundity and fertility in the human population [1]. Several studies indicate that semen quality may have decreased, associated with reduced fertility [2], but few potential factors have been identified. Exposures to non-ionizing electromagnetic fields, especially RF fields u...

INTRODUCTION There has been increasing public concern about the adverse health effects of human exposure to electromagnetic waves. In the radiofrequency and microwave (MW) ranges, elevated temperature (1-2 o C) resulting from energy absorption is known to be a dominant factor inducing adverse health effects such as heat exhaustion and heat stroke....

Pregnant Wistar rats were exposed in a reverberation chamber to Wi-Fi signals (whole-body SAR 0.08, 0.4, 4 W/kg) from gestational day 3 to 20. The presence of stress markers was screened in the blood and brain of pups at day 2, and months 1, 2, and 3 after birth. At day 2, no genotoxic effect was detected in the blood. Whatever SAR and age, there w...

In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol from the latter. Other compounds, such as kynurenic acid, serotonin, and melatonin are produced...

A portable transcranial magnetic stimulation (TMS) prototype was designed and constructed for use in clinical trials to manage the pain associated with migraine with aura. In this system, a half-sinusoid (optionally a full-sine) TMS pulse is delivered into a circular coil. The pulse triggering is controlled by a switch in the coil handle. The pulse...

Des craintes concernant de possibles effets sur la santé ont été exprimées dès 1993 en raison du développement rapide des communications sans fil et à la suite d’un procès très médiatisé aux États-Unis, envers un constructeur de téléphones mobiles accusé d’être responsable du décès d’une femme par cancer. Depuis cette date, des recherches ont été m...

There is some evidence from epidemiological studies of an association between occupational exposure to electromagnetic fields and Amyotrophic Lateral Sclerosis (ALS). Our aim was to perform, for the first time, an animal study in a controlled magnetic environment. We used the SOD-1 mouse model to assess the possible effect of ELF magnetic fields on...

In a series of Russian and Ukrainian papers published from 1974-1986, it was reported that 30-day whole-body exposures to continuous-wave (CW) radiofrequency (RF) radiation at 2375 MHz and 5 W/m(2) disrupted the antigenic structure of rat brain tissue. The authors suggested that this action caused an autoimmune response in exposed animals. Moreover...

Salford et al. reported in 2003 that a single 2-h exposure to GSM-900 mobile telephony signals induced brain damage (increased permeability of the blood-brain barrier and presence of dark neurons) 50 days after exposure. In our study, 16 Fischer 344 rats (14 weeks old) were exposed head-only to the GSM-900 signal for 2 h at various brain-averaged S...

The effects of exposure to radiofrequency electromagnetic fields (EMF), specifically related to the use of mobile telephones, on the nervous system in humans have been the subject of a large number of experimental studies in recent years. There is some evidence of an effect of exposure to a Global System for Mobile Telecommunication (GSM)-type sign...

A temporary increase in ornithine decarboxylase (ODC) activity was reported in lysed L-929 fibroblasts after exposure to the microwaves emitted by Digital Advanced Mobile Phone System (DAMPS-835 MHz, 2.5 W/kg, 8 hours). Confirmation of these data was undertaken, given the suggested potential physiopathological consequences, i.e., tumour promotion....

An increase in Ornithine Decarboxylase (ODC) activity was reported in L929 murine fibroblast cells after exposure to a digital cellular telephone signal. This result was not confirmed by several other studies, including the one reported in a companion paper. As a partner in the Perform-B programme, we extended this study to human neuroblastoma cell...

This paper relates to the design and the realization of a high power (6000 A, 650 V) magnetic generator delivering ultra short (340 µs) high intensity (2 T) pulses. More than ten years of technical collaboration between two important graduate engineering schools of Bordeaux were necessary to carry out this project. This practical realisation was su...