Bernard Jean Louis Sudan

• Retired
• Ex-Laboratory Head in Pharmacology and Toxicology at Independent Researcher

Consistent evidence from the included studies published between 2014-2024 suggests nicotine possesses the potential to act as a cutaneous hapten, capable of eliciting hypersensitivity reactions in susceptible individuals. Findings include positive diagnostic tests (prick/patch), clinical correlations (e-cigarette dermatitis), and plausible biologic...

To determine hypersentivity to the hapten nicotine by pricktests in patients afflicted by seborrheic dermatitis and the antiallergic properties of magnesium chloride of dead Sea salts on tissue mast cells and circulating basophils. Further research for atopic dermatitis and psoriasis with the same influence of passive smoking as for seborrheic derm...

Seborrheic dermatitis is a dermatological syndrome which was first described in 1887 at about the time that tobacco smoking was becoming widespread in public places. Since 1978 the study of a familial seborrheic dermatitis revealed an immune reaction to the hapten nicotine of tobacco smoke. At that time, the efficacy of a sodium cromoglycate ointme...

Seborrheic dermatitis is a dermatological syndrome first described in 1887 at about the time that tobacco smoking was becoming widespread in public places. While current treatments have still not resolved this skin reaction, a new approach with Dead Sea salts allows us to better understand the probable mechanism of the cells involved in this dermat...

Following the interesting publication "Analysis of the epidemiology, coexisting skin diseases, and variables affecting seborrheic dermatitis severity", the author concluded that "disease severity was higher in smokers". I observed the same correlation while studying my familial dermatitis which resembles seborrheic dermatitis since 1978. In all pat...

There is nothing more pleasant, in medicine as in science, than to see different clinical results come together perfectly to ultimately support the development of a theory that we initially thought was shaky. Take for example the cytophylaxis imagined by Delbet in the 1910s, which attempted to explain the therapeutic capacities of magnesium chlorid...

Observational medicine has solved the etiology of a familial seborrheic dermatitis, an allergy to hapten nicotine and allergen tobacco. Also a targeted treatment with sodium cromoglycate and then with Dead Sea salts shows well the involvement of tissue mast cells at the base of the sebaceous glands. Recently, epidemiological studies show a link of...

Background: Seborrheic and atopic dermatitis are common and chronic inflammatory skin diseases. Conventional treatments are often ineffective and can have significant side effects. Magnesium dead sea salt has a high concentration of magnesium, and previous research shows its potential to help improve skin conditions. Case presentation: Patients...

Since my first publication in 1978 describing my familial atopic dermatitis to the tobacco allergen and the nicotine hapten, several international observations have confirmed my original work. First of all, my familial dermatitis resembles facial seborrheic dermatitis , the first description of which dates back to 1887. Since 2010, a soap and cream...

This case study demonstrates that the normal human body frequency, which can be disturbed by electromagnetic influences of the environment, can be modulated by 0.9% sodium chloride solutions (physiological saline) and that occurrence of allergic reactions have subsequently been suppressed as a result of this modulation. The use of distilled water a...

Extremely low frequencies, from 1 to 1.1 Hz, imprinted in water (imprinting was done by succussing a glass containing the water) led to a total abrogation of a facial seborrhoeic dermatitis, previously proposed as a visible model for the theory of 'memory of water'. This technique provides a new perspective on the enigma of homoeopathy and the trea...

Following the recent publication of Levin and associates on "Nicotine Skin Patch Treatment" and their comment on adverse effects, especially the most prominent adverse effect ascribed as "skin irritation", I wish to add some information concerning the irritation and sensitization capacity of nicotine....... Thus, there is now evidence that, in some...

As a follow-up to the letter by Rockwell entitled "Potential interaction between niacin and transdermal nicotine", I wish to add some information regarding the haptenic role of nicotine; the possible interaction between nicotine and niacin; and the occurence of flushing after passive inhalation of tobacco smoke, chewing nicotine gums, transdermally...

The author describes the activity of homoeopathic high dilutions of tobacco to treat his familial facial seborrhoeic dermatitis induced by the hapten nicotine. A double-blind experiment against placebo and several treatments with continuous and single intakes of tobacco high dilutions led after a break to a late abrogation of dermatitis simulating...

This important publication provides up-to-date reviews using data from human patients and animal models. The goal is to understand the relationship between immunological modification by drugs of abuse and disease resistance. Examined are the major drugs of abuse and their effects on lymphoid cell function, numbers, development, and interactions. Al...

Several members of my family have seborrheic facial dermatitis, an allergy to the hapten nicotine of tobacco smoke. This facial reaction can be used as a visible model for observing the symptoms after oral administration of homeopathic high dilutions. The first results showed on one side marked side effects with dermatitis and asthma and on the oth...

Transdermal patch tests were used for smoking cessation in different dosages (7,7 mg, 13,8 mg and 21,2 mg). Unfortunately the placebo used to compare dermally side-effects contained 1 mg nicotine. Thus, the results of 25% skin reactions in the active groups could not be valuable and compared to 13% in the placebo group. Nicotine free patches are...

The localization of the rash described by Goodman and Douglas corresponded exactly to that of seborrheic dermatitis on the face; the location is frequently perioral in this reaction. In addition, the reappearance of the rash shortly after the patient chewed another piece of nicotine gum supports the existence of an immediate hypersensitivity reacti...

There is evidence in some individuals that seborrhoeic dermatitis is an immuno-allergic reaction induced by nicotine as hapten. Nicotine is present in passive smoking, botanic areas, some foods at very low levels, smokeless tobacco and chewing gums. The successful use of topical ketoconazole as an anti-fungal treatment has been recently explained b...

Seborrheic dermatitis induced by nicotine as a hapten in passive smoking

One of these patients was regularly in contact with horsetails in the proximity of his house in April 1985. In the hour after exposure, he developed dermatitis of the right hand and of the face which resembles "seborrheic dermatitis" after passive inhalation of tobacco smoke. A fresh exposure to this plant induced a more rapid reaction which necess...

A high-performance liquid chromatographic (HPLC) system has been developed for the determination of nicotine and cotinine in allergenic extracts of tobacco leaf. This analysis showed eight allergenic extracts of tobacco (leaf and Mix) to have markedly different nicotine patterns. Cotinine, a photodegradation product of nicotine, was not detected.

1984-1985 DIRECTORY On-Going Research in Smoking and Health Determination of Nicotine in Allergenic Extracts of Tobacco Leaf by High Performance Liquid Chromatography Project No. 0217 page 68 : to determine nicotine content of allergenic extracts of tobacco leaf, detect cotinine, control standardization of allergenic extracts, better results in des...

1984-1985 DIRECTORY On-Going Research in Smoking and Health page 77 Project no. 0247 Project title: Nicotine as a hapten in seborrheic dermatitis. To detect a reaction of hypersensitivity to nicotine as a hapten in patients afflicted with seborrheic dermatitis.

In the Review Article "Tobacco dermatitis" by R.J.G. Rycroft in the British Journal of Dermatology (1980) 103, 225, the author writes that "nicotine itself is not the sensitizer (Silvette et al., 1957). The letter to the Editor describes a familial dermatitis which resembles seborrheic dermatitis. All patients have reacted to the allergen tobacco a...

A sodium cromoglycate cream has been successfully used for the treatment of seborrheic dermatitis of the face confirming a stabilization of tissue mast cells at the base of the sebaceous glands. It is therefore a new allergenic approach to seborrheic dermatitis (allergen tobacco and hapten nicotine) first described in 1887 at about the time when t...