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Publications (139)
Coral reefs are severely threatened by global and local environmental changes. However, susceptibility to perturbations and subsequent mortality varies among coral species. In this study, we tested the contribution of genetic and environmental conditions to coral’s phenotypic response in Pocillopora spp. and Porites spp. sampled together at a large...
Coral reefs are considered one of the most emblematic ecosystems in our oceans, but their existence is increasingly threatened by climate change. In this study, natural populations of two reef-building coral genera, Pocillopora spp. and Porites spp., and one hydrocoral Millepora cf. platyphylla from two different marine provinces in the Pacific Oce...
With climate projections questioning the future survival of stony corals and their dominance as tropical reef builders, it is critical to understand the adaptive capacity of corals to ongoing climate change. Biological mediation of the carbonate chemistry of the coral calcifying fluid is a fundamental component for assessing the response of corals...
Tropical coral reefs are among the most affected ecosystems by climate change and face increasing loss in the coming decades. Effective conservation strategies that maximize ecosystem resilience must be informed by the accurate characterization of extant genetic diversity and population structure together with an understanding of the adaptive poten...
Background
Over the last decade, several coral genomes have been sequenced allowing a better understanding of these symbiotic organisms threatened by climate change. Scleractinian corals are reef builders and are central to coral reef ecosystems, providing habitat to a great diversity of species.
Results
In the frame of the Tara Pacific expedition...
Telomeres are environment-sensitive regulators of health and aging. Here,we present telomere DNA length analysis of two reef-building coral genera revealing that the long- and short-term water thermal regime is a key driver of between-colony variation across the Pacific Ocean. Notably, there are differences between the two studied genera. The telom...
Heat waves are causing declines in coral reefs globally. Coral thermal responses depend on multiple, interacting drivers, such as past thermal exposure, endosymbiont community composition, and host genotype. This makes the understanding of their relative roles in adaptive and/or plastic responses crucial for anticipating impacts of future warming....
Coral reefs are among the most diverse ecosystems on Earth. They support high biodiversity of multicellular organisms that strongly rely on associated microorganisms for health and nutrition. However, the extent of the coral reef microbiome diversity and its distribution at the oceanic basin-scale remains to be explored. Here, we systematically sam...
Health and resilience of the coral holobiont depend on diverse bacterial communities often dominated by key marine symbionts of the Endozoicomonadaceae family. The factors controlling their distribution and their functional diversity remain, however, poorly known. Here, we study the ecology of Endozoicomonadaceae at an ocean basin-scale by sampling...
The Tara Pacific expedition (2016–2018) sampled coral ecosystems around 32 islands in the Pacific Ocean and the ocean surface waters at 249 locations, resulting in the collection of nearly 58 000 samples. The expedition was designed to systematically study warm-water coral reefs and included the collection of corals, fish, plankton, and seawater sa...
Coral reef science is a fast-growing field propelled by the need to better understand coral health and resilience to devise strategies to slow reef loss resulting from environmental stresses. Key to coral resilience are the symbiotic interactions established within a complex holobiont, i.e. the multipartite assemblages comprising the coral host org...
Fish mucus is the main surface of exchange between fish and the environment and plays numerous biological and ecological roles such as protection and chemical mediation. In this study, we investigated the influence of phylogeny, reef habitat, diet, and gill parasitism levels on the gill mucus metabolome of butterflyfishes in Moorea (French Polynesi...
Lipopeptides are a class of compounds generally produced by microorganisms through hybrid biosynthetic pathways involving non-ribosomal peptide synthase and a polyketyl synthase. Cyanobacterial-produced laxaphycins are examples of this family of compounds that have expanded over the past three decades. These compounds benefit from technological adv...
The resilience of coral reefs is dependent on the ability of corals to settle after disturbances. While crustose coralline algae (CCA) are considered important substrates for coral settlement, it remains unclear whether coral larvae respond to CCA metabolites and microbial cues when selecting sites for attachment and metamorphosis. This study teste...
In the marine environment, sessile cyanobacteria have developed chemical strategies for protection against grazers. In turn, herbivores have to circumvent these defenses and in certain cases even take advantage of them as shelter from their own predators. This is the case of Stylocheilus striatus, a sea hare that feeds on Anabaena torulosa, a cyano...
The settlement and growth of fouling organisms on man-made surfaces can be prevented by the application of antifouling paints containing active compounds (biocides, heavy metals), most of which are toxic to non-target organisms. As part of our research program in chemical ecology and blue biotechnology, we are conducting studies to investigate the...
Laxaphycins are a family of non-ribosomal lipopeptides that have been isolated from several cyanobacteria. Some of these compounds have presented cytotoxic activities, but their mechanism of action is poorly understood. In this work, the already described laxaphycins B and B3, and acyclolaxaphycins B and B3 were isolated from the marine cyanobacter...
In the last decades, an apparent increase in the frequency of benthic cyanobacterial blooms has occurred in coral reefs and tropical lagoons, possibly in part because of global change and anthropogenic activities. In the frame of the survey of marine benthic cyanobacteria proliferating in the lagoon of Moorea Island (French Polynesia), 15 blooms we...
Understanding natural defense mechanisms against parasites can be a valuable tool for the development of innovative therapies. We have previously identified a butterflyfish species (Chaetodon lunulatus) that avoids gill monogenean parasites while living amongst closely related parasitized species. The metabolome and microbiome of several sympatric...
The growing interest in marine natural substances as potential new drugs has made total synthesis a real asset for structure confirmation. Trichormamide C (1), a cyclic lipopeptide isolated from the cyanobacteria Oscillatoria sp., is characterized by the presence of nonproteinogenic amino acids in the sequence. Trichormamide C structural confirmati...
Five new laxaphycins were isolated and fully characterised from the bloom forming cyanobacteria Anabaena torulosa sampled from Moorea, French Polynesia: three acyclic laxaphycin A-type peptides, acyclolaxaphycin A (1), [des-Gly ¹¹ ]acyclolaxaphycin A (2) and [des-(Leu ¹⁰ -Gly ¹¹ )]acyclolaxaphycin A (3), as well as two cyclic ones, [L-Val ⁸ ]laxaph...
Fish mucus layers are the main surface of exchange between fish and the environment, and they possess important biological and ecological functions. Fish mucus research is increasing rapidly, along with the development of high-throughput techniques, which allow the simultaneous study of numerous genes and molecules, enabling a deeper understanding...
The structures of three new cyclic depsipeptides, tiahuramides A (1), B (2), and C (3), from a French Polynesian collection of the marine cyanobacterium Lyngbya majuscula are described. The planar structures of these compounds were established by a combination of mass spectrometry and 1D and 2D NMR experiments. Absolute configurations of natural an...
Fish mucus has important biological and ecological roles such as defense against fish pathogens and chemical mediation among several species. A non-targeted liquid chromatography–mass spectrometry metabolomic approach was developed to study gill mucus of eight butterflyfish species in Moorea (French Polynesia), and the influence of several fish tra...
Covering: up to 2017
Chemical mediation regulates behavioral interactions between species and thus affects population structure, community organization and ecosystem function. Among marine taxa that have developed chemical mediation strategies, gastropods belong to a diverse group of molluscs found worldwide, including species with a coiled, reduce...
The replenishment and persistence of marine species is contingent on dispersing larvae locating suitable habitat and surviving to a reproductive stage. Pelagic larvae rely on environmental cues to make behavioural decisions with chemical information being important for habitat selection at settlement. We explored the sensory world of crustaceans an...
The progress realized in chemical ecology during recent decades has led to awareness growing from the interest, from an economic point of view, to better decrypt chemical communication. This chapter shows concrete applications of directed studies in chemical ecology, practical applications as well as fundamental applications. In chemical ecology, t...
In the lagoon of Moorea, Lyngbya majuscula blooms ephemerally scudding across wide area. It is an occasionally toxic filamentous cyanobacterium, present in worldwide tropical and subtropical warm waters. L. majuscula is responsible of severe human injuries like dermatoses. This cyanobacterium is a rich source of bioactive compounds like tiahuramide...
Abstract
Secondary metabolites play a crucial role in marine invertebrate chemical ecology. Thus, it is of great importance to understand factors regulating their production and sources of variability. This work aimed to study the variability of the bromotyrosine derivatives in the Mediterranean sponge Aplysina cavernicola, and also to better under...
Three new compounds, named tiahuramides A, B and C, were isolated from the marine cyanobacteria Lyngbya majuscula. This filamentous eubacteria has been a source of several secondary metabolites with different biological activities. Lyngbya majuscula compounds have shown cytotoxicity against cancer cell lines, anti-inflammatory activity, blockage of...
When fish larvae recruit back to a reef, chemical cues are often used to find suitable habitat or to find juvenile or adult conspecifics. We tested if the chemical information used by larvae was intentionally produced by juvenile and adult conspecifics already on the reef (communication process) or whether the cues used result from normal biochemic...
As it is unlikely that successful settlement is solely a matter of chance (i.e. to find a suitable habitat), one of the greatest challenges facing the fish larvae is how to locate the relatively rare patches of coral reef habitat on which they settle and ultimately reside as adults. The answer must lie partly in the sensory modalities of fishes at...
The potential role of microbial consortia on sponge chemistry is well known. However, how environmental factors affect microbial and chemical profiles and how these shifts affect the sponge holobiont are far from being understood. This study experimentally investigated the effect of light on both the concentration of secondary metabolites and the b...
The present study (Ishigaki Island, Japan) explored the distance of transmission of chemical cues
emitted by live versus dead coral reefs (Exp. 1: High performance liquid chromatography (HPLC) analyses with water sampling station at 0, 1, and 2 km away from the reef) and the potential attraction of these chemical cues by larval fish, crustaceans, a...
A large proportion of the marine natural products actually under clinical investigation are peptide secondary metabolites with unusual amino acids residues. This growing family of compounds can be produced via two major pathways, ribosomal and nonribosomal. In this chapter are presented and illustrated, with a few famous examples, ribosomal-and non...
The extraction and purification of the bioactive extract of Cystodytes violatinctus (Solomon Islands) led to the isolation and identification of six pyridoacridine alkaloids. The structures of four new members of this family, shermilamine F (1), dehydrokuanoniamine F (2), and arnoamines C (3) and D (4), were elucidated on the basis of NMR and MS da...
The first total synthesis of laxaphycin B was accomplished through stepwise automated Solid Phase Peptide Synthesis (SPPS), leading to the structural revision of its stereochemistry especially with regard to the configuration of one of the two 3-hydroxyleucines of this cyclic dodecapeptide of marine origin. The analogous Lyngbyacyclamide A was obta...
Geographical variations in the diterpene composition of the diethyl ether extract from the brown alga Bifurcaria bifurcata are described in algae collected on the French Atlantic coasts. They are then compared with those in same algae from the coasts of Morocco. Several types of extracts have been found, and they vary according to where they are co...
Many marine reef fishes have pelagic larval stages that develop in offshore waters. These larvae face the great challenge of relocating to patchily distributed reef environments in a vast oceanic matrix. We explored how chemical cues emitted from coral versus algal reefs attract fish larvae at Rangiroa Atoll (French Polynesia). Experiments with 2-c...
Several studies report temporal, geographical, and intra-individual variation in sponge metabolite yields. However, the internal and/or external factors that regulate the metabolite production remain poorly understood. Dysidea avara is a demosponge that produces sesquiterpenoids (avarol and derivatives) with interesting medical properties, which ha...
The present study was conducted to assess the structures of the main unknown oxygenated metabolites of EAPB0203. The first step was to assign all the 1H and 13C nuclear magnetic resonances (NMR) of both EAPB0203 and its demethylated metabolite (EAPB0202) to the corresponding atoms in their molecular structures and to elucidate the fragmentation pat...
The identification of sponges that lack a mineral skeleton is always highly challenging, especially for Hexadella species, which are also fibreless. Recently, the yellow species Hexadella pruvoti Topsent was identified as a cryptic species complex while the pink coloured Hexadella racovitzai Topsent showed two highly divergent lineages. We performe...
We describe the diastereoselective synthesis of the marine meroterpenes methoxyconidiol and conitriol in their trans form from the readily available 1-bromo-2,5-dimethoxybenzene in only three steps. The choice of the protective group strategy influenced not only the overall reaction yields but also the diastereoisomeric ratio. In addition, we descr...
Sponges of the family Dysideidae (Dictyoceratida) are renowned for their diversity of secondary metabolites, and its genus Lamellodysidea, particularly Lamellodysidea herbacea, is the most studied taxon biochemically. Despite its importance, the taxonomic status of L. herbacea—whether it is a distinct species or a species complex—has never been ass...
Temporal changes in the production of secondary metabolites are far from being fully understood. Our study quantified, over a two-year period, the concentrations of brominated alkaloids in the ectosome and the choanosome of Aplysina aerophoba, and examined the temporal patterns of these natural products. Based on standard curves, we quantified the...
L'ouvrage "Ecologie chimique : le langage de la nature" rédigé par des chercheurs issus de laboratoires CNRS ou associés, paraît le 25 octobre 2012 en librairie. Publié par le cherche midi, en partenariat avec le CNRS, ce livre grand public dévoile les secrets d'une science encore récente : l'écologie chimique ou l'art de décrypter le langage chimi...
Les odeurs appartiennent à notre vie quotidienne… La majorité des espèces vivantes, y compris l'homme, communique entre elles grâce à des molécules et des signaux chimiques. Reproduction, alimentation, défense… dans toutes ces fonctions, la communication chimique est de très loin le mode de communication le plus utilisé dans le monde vivant ! Ce li...
Understanding the scale at which natural products vary the most is critical because it sheds light on the type of factors that regulate their production. The sponge Aplysina aerophoba is a common Mediterranean sponge inhabiting shallow waters in the Mediterranean and its area of influence in Atlantic Ocean. This species contains large concentration...
Animals use sensory stimuli either to assess and select habitats, mates or food, as well as for communication. The present
study aimed to understand the behavioural processes enabling several Chaetodon species (butterflyfishes) to locate one of their food sources (epibionts present on pearl oyster shells) at Rangiroa atoll
(French Polynesia). Among...
The marine β-carboline alkaloid eudistomin X has been synthesised stereospecifically, using d-phenylalanine as the chiral pool starting material, establishing the absolute configuration of the natural product as (10R). A stereospecific synthesis of both enantiomers of the marine alkaloid eudistomin X using the amino acid chiral pool is achieved. Co...
The sponge Aplysina aerophoba produces a large diversity of brominated alkaloids (BAs) and hosts a complex microbial assemblage. Although BAs are located
within sponge cells, the enzymes that bind halogen elements to organic compounds have been exclusively described in algae,
fungi, and bacteria. Bacterial communities within A. aerophoba could ther...
a b s t r a c t Two new pyridoacridine alkaloids, 13-didemethylaminocycloshermilamine D (1) and demethyldeoxyam-phimedine (2), were isolated from the purple chromotype of the Western Mediterranean ascidian Cystodytes dellechiajei. This morph also contained the known shermilamine B (3), kuanoniamine D (4), N-deacetylshermilamine B (5), N-deacetylkua...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Three new pentacyclic alkaloids were isolated from different chromotypes of the western Mediterranean ascidian Cystodytes dellechiajei. The purple color morph collected in Catalonia contained the known compounds kuanoniamine D (1), shermilamine B (2), N-deacetylkuanoniamine D (3), and styelsamine C (4) and a new alkaloid named N-deacetylshermilamin...
Animals use sensory stimuli to assess and select habitats, mates, and food as well as to communicate with other individuals.
One of the great mysteries of crustacean ecology is how postlarvae locate the relatively rare patches of coral reef habitat
on which they settle. The present study aimed to estimate, by experiments in aquaria and biochemical...
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their...
