Berkcan Doğan

Uludag University · Department of Medical Genetics

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher...

Artificial intelligence provides modelling on machines by simulating the human brain using learning and decision-making abilities. Early diagnosis is highly effective in reducing mortality in cancer. This study aimed to combine cancer-associated risk factors including genetic variations and design an artificial intelligence system for risk assessme...

Introduction: The roles of dysregulated microRNAs (miRNAs) have been known in cancer and affect nearly all pathways of carcinogenesis via functioning as either oncomiRs or tumor suppressor miRNAs. Since the mechanisms by which miRNAs impact ovarian cancer (OC) and their signalling pathways remain unknown, we aimed to reliably predict the validated...

Growing evidence has revealed several associations between alterations in human microbial composition and colorectal cancer (CRC). However, utilizing the results of human microbiome research into the translational applications is still challenging due to the inter-individual variation in the human genome, which also shapes and affects the microbial...

MikroRNA’lar (miRNA) ~21-23 nükleotid uzunluğunda küçük kodlanmayan RNA çeşididir. Hücre proliferasyonu, hücre döngüsü, apoptoz, tümörogenez, stres yanıtı ve yağ metabolizması gibi çeşitli biyolojik süreçlerde önemli rol oynarlar. MiRNA’lar transkripsiyon aşamasında protein kodlayan genlerin translasyonunu kendi nükleotid dizilerine tamamlayıcı hed...

Coronary artery disease (CAD) is still the preliminary cause of mortality and morbidity in the developed world. Identification of novel predictive and therapeutic biomarkers is crucial for accurate diagnosis, prognosis and treatment of the CAD. The aim of this study was to detect novel candidate miRNA biomarker that may be used in the management of...

Melanoma has the highest mortality rate in skin cancers and highly aggressive and metastatic phenotype. Latest studies have shed new perspectives into melanoma development whereas the interference of regulatory non-coding RNAs remains unclear. Long non-coding RNAs (lncRNAs) can modulate essential pathways including cell cycle, cell proliferation, t...

Aim of the study: The purpose of this study was to identify specific circulating microRNAs (miRNAs) and investigate expression level of their target genes for evaluation of pathogenesis of epithelial ovarian cancer (EOC). Materials and methods: In this study, we have studied on EOC patients' serum and whole blood, healthy control (HC) serum, and...

Aim: Dietary miRNAs in foods were recently suggested to be absorbed into the human circulation and engage in human gene regulation. This started a debate on their possible impacts on human diseases which need further investigation. In this study, we aimed to identify the putative functions and possible implications of selected Xeno-miRs in human di...

Scope: Recent studies have found a close connection between obesity and the development of colorectal neoplasia. It is known that central obesity is associated with an increased risk of colorectal cancer and that these diseases have common genes associated with pathogenesis. Hsa-miR-335-5p, targeting the highest number of identified mutual genes, r...

Multiple changes in the cancer-causing genes convert the normal cells into cancer phenotypes characterized by prolonged proliferative signalling, resistance to cell death, stimulation of vascular growth for oxygen and nutrient supply (angiogenesis), active invasion, and metastasis. Some of these phenotypic changes are metabolic adaptations such as...

Purpose Ovarian cancer (OC) is first gynaecologic cancer that causes women death and epithelial ovarian cancer (EOC) is the most lethal ovarian cancer type. While treatment is commonly successful, some cases (10–20%) show resistance to chemotherapy which is followed by recurrence. MicroRNA (miRNA) based diagnosis methods are slightly important for...