Berislav Perić

Ruđer Bošković Institute | RBI · Division of Materials Chemistry

Among ruthenium complexes studied as anticancer metallodrugs, NKP‐1339, NAMI‐A, RM175, and RAPTA‐C have already entered clinical trials due to their potent antitumor activity demonstrated in preclinical studies and reduced toxicity in comparison with platinum drugs. Considering the advantages of ruthenium‐based anticancer drugs and the cytostatic a...

Bis(2‐picolyl)amine (bpa), iminodiacetamide (imda), and bis‐1,2,3‐triazole (bta) ferrocene ligands (L) with and without an aliphatic linker were prepared by multi‐step synthesis. The cis‐fac, trans‐fac, or mer stereochemistry of their ML2 complexes with Ni(II), Cu(II), Cd(II), and Zn(II) was studied in the solid state (infrared [IR] and single‐crys...

This publication describes oxazoline-amino acid bioconjugates 1 capable of supramolecular interactions. The bioconjugates contain three main building blocks: an oxazoline ring, a central aromatic unit and an amino acid substituent....

This publication describes monodentate phosphine and oxazoline ligands attached to an amino acid ester and the application of their supramolecularly assembled rhodium(I) or iridium(I) complexes in asymmetric catalysis. The major...

Bioorganometallic complexes have attracted considerable interest and have shown promise for potential application in the treatment and diagnosis of cancer, as well as bioimaging agents, some acting as theranostic agents....

With the aim of achieving bioorthogonal intracellular catalysis, a library of platinum(II) complexes was synthesized. Their non‐toxicity to living cells was demonstrated and their catalytic activity was evaluated on a cyclization reaction leading to a highly fluorescent coumarin. None of the platinum complexes showed any catalytic activity for coum...

The isomerism of zinc complex [Zn(L)2]2+ with tridentate ligand L having acetamide and pyridine groups on each side of the central amino- nitrogen atom has been investigated by DFT calculations, liquid state NMR and single-crystal X-ray diffraction. DFT was used for obtaining the ensembles of low-energy conformers of L and [Zn(L)2]2+ and for the ca...

Seven bis(2-picolyl)amine (bpa) and five iminodiacetamide (imda) ligands were prepared with different modifications in their side chain structure. The coordination properties of the ligands (L) were influenced by changes in the aliphatic linker length (C1, C2, or C3), amide group isomers and type of chiral terminal group. Complexation with Cu(II) a...

Ferrocene derivatives with mono- (8a–c) and bis-1,2,3-triazolyl (9 and 10a–13c) chelating groups were synthesized by regioselective copper(I)-catalysed 1,3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determine...

Amides are common molecules which are most often prepared using benzotriazole oxide coupling reagents. Such amides can be derivatised with compounds that contain a triple carbon-carbon bond in order to...

The crystal structure of tris­[dimethyl 5-({1-[(pyridin-2-yl-κN)carbamoyl-κO]eth­yl}carbamo­yl)benzene-1,3-di­carboxyl­ate]zinc(II) dinitrate aceto­nitrile tri­solvate, [Zn(C19H19N3O6)3](NO3)2·3CH3CN or [Zn(L)3](NO3)2·3CH3CN, (1), has been determined by single-crystal X-ray diffraction. The neutral ligand L coordinates to the Zn²⁺ cation in a biden...

Heme and nonheme-type flavone synthase enzymes, FS I and FS II are responsible for the synthesis of flavones, which play an important role in various biological processes, and have a wide range of biomedicinal properties including antitumor, antimalarial, and antioxidant activities. To get more insight into the mechanism of this curious enzyme reac...

The Cover Feature shows a supramolecular catalytic system, envisioned as a factory machine. The worker uses a chiral cyclohexane to control the chirality in the remote rhodium machine head which does the selective hydrogenation reaction. The transfer of chirality is achieved by stacked phenyl‐phosphine gears shown in the insides of the machine. The...

This paper describes the synthesis and characterization of 21 chiral monodentate ligands L, assembled of three building blocks utilizing amide bonds: a metal binding triphenylphosphine, a chiral cyclic diamine and an additional substituent for fine‐tuning the steric and/or electronic properties. Cis square‐planar metal complexes of RhI and PtII wit...

Triphenyphosphine amino acid bioconjugates Ph2P-pC6H4-Aaa-OR, Aa = glycine (1G), alanine (2A), valine (3V), isoleucine (4I), proline (5P) or phenylalanine (6F), have been synthesized and used as monodentate ligands for the preparation of twelve metal complexes, [MCl2(Lig)2], M = Pd(II) or Pt(II). All prepared compounds were characterized by spectro...

Non-covalent self-assembled chiral alanyl aminopyridine ligand exhibits supramolecular chirality in solution, independent of the organic solvent used. The supramolecular chirality of the assemblies is completely inverted by complexation to zinc ions. Up to now, such supramolecular metal-ligand system has not been reported in the literature.

This paper describes the synthesis of an amide based conjugate of ferrocene (Fc), ethylenediamine (eda) and iminodiacetamide (imda), Fc-eda-imda (2). The compound (2) is characterized by various spectroscopic, crystallographic and thermoanalytical techniques in solid state and in solution. By crystallization of the title compound 2 from methanol or...

Two hexanuclear niobium halide cluster compounds with a [Nb6×12]2+ (X=Cl, Br) diamagnetic cluster core, have been studied by a combination of experimental solid-state NMR/NQR techniques and PAW/GIPAW calculations. For niobium sites the NMR parameters were determined by using variable Bo field static broadband NMR measurements and additional NQR mea...

https://bib.irb.hr/prikazi-rad?&rad=689955

Pseudo-peptide Me2N-pC6H4C(O)-Phe-OEt (1) exhibits two polymorphic forms which crystallizes in non-centrosymmetric space groups, monoclinic 1m (P21) and orthorhombic 1o (P212121). Both forms occur concomitantly or as a pure phase depending on the solvent of crystallization. Single crystal X-ray diffraction revealed equivalent two-dimensional layers...

The influences of an oxygen ligand on the structural, magnetic and electronic properties of octahedral niobium cluster-based oxides and oxychlorides are reported. The Nb6 metal cluster is edge-bridged by twelve inner ligands and additionally bonded to six apical ligands to form Nb6Li 2La6 units (L = Cl, O) wherein oxygen and chlorine are perfectly...

Magnetic interactions in solid-state tantalum cluster compounds have been evidenced by using magnetic susceptibility measurements and corroborated by broken-symmetry DFT calculations. The three selected compounds are based on [Ta(6)X(12)(H(2)O)(6)](3+) (X=Cl or/and Br) units with edge-bridged Ta(6) octahedral clusters. Although two of them crystall...

For Abstract see ChemInform Abstract in Full Text.

The novel title compound, [(CH3)(4)N](2)[Ta6Br12(H2O)(6)]Br-4.-2H(2)O, with a [Ta6Br12](2+) cluster unit, has been prepared and structurally characterized. The compound crystallizes in space group C2/c, with a twofold axis passing through the cluster and the centre of symmetry located between the clusters. The nearest neighbouring cluster units are...

The compound [Ni(RPOEt)2(C2H5OH)2](ClO4)2 (1) [RPOEt = bis{(diphenylphosphinyl)methyl}ethyl phosphinate] has been prepared in the form of single crystals and characterized by elemental and thermal analyses, IR spectroscopy and by a single crystal X-ray diffraction study. The complex crystallizes in the triclinic $ P\bar{1} $ space group with a =...

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The compound [NH4][(CH3)2NH2]2[Ta(C2O4)4]·2H2O has been synthesized and characterized by elemental and TG/DTA analyses, IR spectroscopy and by the single-crystal X-ray diffraction study. The structure comprises the [Ta(C2O4)4]3− anion, NH4+ and [(CH3)2NH2]+ cations and crystallization water molecules. The Ta atom is octacoordinated by oxygen atoms...

A new hexanuclear cluster compound, [Et4N][Ta6Br12(H2O)6]Br4·4H2O (Et=ethyl) (1), with the paramagnetic [Ta6Br12]3+ cluster entity, was synthesized and characterized by elemental and TG/DTA analyses, IR and UV/Vis spectroscopy and by a single-crystal X-ray diffraction study. The presence of the paramagnetic [Ta6Br12]3+ unit was confirmed also by th...

Magnetic properties of single crystals of the heterometallic complex [Cu(bpy)3]2[Cr(C2O4)3]NO3·9H2O (bpy = 2,2′-bipyridine) have been investigated. From the recorded EPR spectra, the spin-Hamiltonian parameters have been determined. The magnetization measurements have shown magnetic anisotropy at low temperatures, which has been analysed as a resul...

Solvatomorphism has been found between two series of complexes of the composition [M(bpy)3]2[NbO(C2O4)3]Cl.nH2O [M = Fe2+ (1, 2), Co2+ (3, 4), Ni2+ (5, 6), Cu2+ (7) and Zn2+ (8, 9); bpy = 2,2'-bipyridine)], crystallizing in the monoclinic space group P2 1/c [3, 5, 8 (n = 11)] or in the orthorhombic space group P21 21 21 [2, 4, 6, 7 (n = 12)]. All t...

Two novel compounds of the formulae [{Cu(phen)2}2(μ-C2O4)][Cu(phen)2(μ-C2O4)NbO(C2O4)2]2 · 8H2O (1) and [{Cu(bpy)2}2(μ-C2O4)][Cu(bpy)2(μ-C2O4)NbO(C2O4)2]2 · 0.5bpy · 7H2O (2) (phen = 1,10-phenanthroline, bpy = 2,2′-bipyridine) have been prepared and characterized by single crystal X-ray diffraction, IR spectroscopy and magnetic susceptibility measu...

The compound Rb3[NbO(C2O4)3]⋅2H2O (1) has been synthesized by two different methods and its exact chemical composition established. The niobium atom is heptacoordinated by oxygen atoms forming a distorted pentagonal bipyramid. Inspite of some similarities, the structure of 1 is not isotypic with the structure of (NH4)3[NbO(C2O4)3]⋅H2O.

By partial oxidation of a solution of (Ta6Cl12)Cl2·6 EtOH in n-butyl cyanide (n-BuCN) reddish crystals of the title compound were formed. The compound crystallizes in the monoclinic C2/m space group. The double salt components [(Ta6Cl12)Cl3(n-BuCN)3] and [(Ta6Cl12)Cl4(n-BuCN)2] are of Cs and C2h symmetry, respectively. The structure consists of lay...

The synthesis and crystal structure of the mononuclear title compound, [Co(C2O4)(C10H8N2)2]·5H2O, is reported. The Co atom is six-coordinated by two O atoms of a bidentate oxalate group and by four N atoms of two bi­pyridine ligands. The neutral [Co(C2O4)(C10H8N2)2] entities are connected by π–π stacking interactions of the aromatic systems into a...

To compare the structural properties of oxalamide and thiooxalamide groups in the formation of hydrogen bonds suitable for supramolecular assemblies a series of retropeptides was studied. Some of them, having oxalamide bridges, are gelators of organic solvents and water. However, retropeptides with oxygen replaced by the sp² sulfur have not exhibit...

Comparative studies based on x-ray crystallography and NMR spectroscopy were used for structural characterization of the novel minor, imidazolidinone moiety containing, product 2b of the Maillard reaction obtained in vitro by using the galactose-modified endogenous opioid pentapeptide leucine-enkephalin (Tyr-Gly-Gly-Phe-Leu) 1. The x-ray analysis u...

The title compound, [Ta6Br12(H2O)6](Br0.4Cl1.6)·8H2O, crystallizes in space group P. The structure contains two crystallographically independent [Ta6Br12(H2O)6]²⁺ cluster cations forming distinct layers parallel to the ab plane. The compound is isoconfigurational with the double salts [Ta6Br12(H2O)6]X2·trans-[Ta6Br12(OH)4(H2O)2]·18H2O (X = Cl, Br).

The novel title compound, [(CH3)4N]2[Ta6Br12(H2O)6]Br4·2H2O, with a [Ta6Br12]²⁺ cluster unit, has been prepared and structurally characterized. The compound crystallizes in space group C2/c, with a twofold axis passing through the cluster and the centre of symmetry located between the clusters. The nearest neighbouring cluster units are aligned alo...

The mol­ecule of benzene-1,4-dicarbox­amidine or benzdi­amidine, C8H10N4, reveals Ci symmetry. Hydro­gen bonds utilize the amino groups as double donors, whereas the imino groups act as double acceptors. The network formed is similar to that observed in the crystal packing of terephthal­amide.

Bis(LeuOH) (1a), bis-(ValOH) (2a) and bis(PhgOH) (5a) (Phg denotes (R)-phenylglycine) oxalyl amides are efficient low molecular weight organic gelators of various organic solvents and their mixtures as well as water, water/DMSO, and water/DMF mixtures. The organisational motifs in aqueous gels are dominated primarily by lipophilic interactions whil...

Aroylhydrazones derived from salicylaldehyde, o-vanillin and nicotinic acid hydrazide have been synthesized and characterized on the basis of NMR, IR and UV/Vis spectral data. The crystal and molecular structure of N′-salicylidene-3-pyridinecarbohydrazide has been determined by X-ray diffraction.

In the title compound, C20H22N4O4·C2H6OS, two distinct hydrogen-bond systems connect oxal­amide groups in one pattern and primary amide groups in the other to form a two-dimensional network perpendicular to the c axis. These hydro­philic layers are joined to the three-dimensional structure through C—H⋯π interactions. The hydrogen-bonded waved layer...

The title compound, 2,2'-(oxalyldiimino)bis(3-methylbutanoic acid), C12H20N2O6, possesses a centre of symmetry. In the crystal, molecules are connected by hydrogen bonds between oxamide and carboxyl groups, similar to the pattern of the monoclinic forms of HO-Gly-CO-CO-Gly-OH and HO-Aib-CO-CO-Aib-OH (Gly is glycine and Aib is 2-aminoisobutyric acid...

The title compound, 2,2′-(oxalyldiimino)bis(3-methylbutanoic acid), C12H20N2O6, possesses a centre of symmetry. In the crystal, mol­ecules are connected by hydrogen bonds between ox­amide and carboxyl groups, similar to the pattern of the monoclinic forms of HO–Gly–CO–CO–Gly–OH and HO–Aib–CO–CO–Aib–OH (Gly is glycine and Aib is 2-amino­isobutyric a...

The structure of 4,40-dibromobenzophenone, C13H8Br2O, was determined at two different temperatures (293 and 103 K). A phase transition was not detected in this temperature range. Its crystal structure was found to be isostructural with that of the diiodo analogue, but not with the structure of the dichloro derivative.

The structure of 4,4′-di­bromo­benzo­phenone, C13H8Br2O, was determined at two different temperatures (293 and 103 K). A phase transition was not detected in this temperature range. Its crystal structure was found to be isostructural with that of the di­iodo analogue, but not with the structure of the di­chloro derivative.

Acid-catalyzed methanolysis of N-hydroxy-a-oxobenzeneethanimidoyl chloride (1), a 2-(hydroxyimino)-1- phenylethan-1-one derivative obtained in one step from acetophenone, leads to a constant ratio of methyl a-oxobenzeneacetate (2) and methyl a-(hydroxyimino)benzeneacetate (3). 13C(a) Labelled [13C]-1 affords 13C(a) labelled [13C]-3, thus discarding...

Acid-catalyzed methanolysis of PhCOCClNOH, obtained in 1 step from PhAc, leads to a const. ratio of PhCOCO2Me and PhC(NOH)CO2Me. Ph13COCClNOH, affords Ph13C(NOH)CO2Me, thus discarding the hypothesis of its formation via 1,2-arene migration. The reported sequence opens a novel approach to phenylglyoxylates and mandelates from PhAc. The mol. structur...

The properties of the vanadium valence band have been studied by normal emission ultraviolet photoelectron spectroscopy from V(100) surface by the use of different photon energies (21.2, 16.8 and 11.8 eV). The bottom of the d-band at the high symmetry point H12 was found to be around 2.5 eV. We did not find conclusive evidence for the existence of...