Bergoi Ibarlucea

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Verified

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• PhD in Chemistry
• Project Manager at Tecnalia

The escalating threat of environmental issues to both nature and humanity over the past two decades underscores the urgency of dealing with environmental pollutants. In the study of materials as...

This is an update on the funding acknowledgment of the original publication.

Graphene is extremely sensitive to its surrounding environment. In fact, any modification on its surface, such as an adsorption of a molecule, can change its properties. The conductivity of graphene is a crucial parameter to be examined for potential graphene-based applications, especially biosensors. In this paper, we have investigated the effects...

In recent years, neuromorphic computing has gained attention as a promising approach to enhance computing efficiency. Among existing approaches, neurotransistors have emerged as a particularly promising option as they accurately represent neuron structure, integrating the plasticity of synapses along with that of the neuronal membrane. An ambipolar...

The discrimination and identification of complex mixtures remain a significant challenge to chemical analysis. The conventional technique for complex mixture analysis refers to a complete component-by-component approach, such as gas chromatography/mass spectrometry (GC/MS), which requires sophisticated facilities and professional personnel. In this...

Objectives The oral cavity is an easily accessible unique environment and open system which is influenced by the oral fluids, microbiota, and nutrition. Little is known about the kinetics and dynamics of metabolic processes at the intraoral surfaces. Real-time monitoring of salivary biomarkers, e.g., glucose, lactate, fluoride, calcium, phosphate,...

The SARS-CoV-2 pandemic has increased the demand for low-cost, portable, and rapid biosensors, driving huge research efforts toward new nanomaterial-based approaches with high sensitivity. Many of them employ antibodies as bioreceptors, which have a costly development process that requires animal facilities. Recently, sybodies emerged as a new alte...

The recent Coronavirus Disease 2019 (COVID‐19) outbreak strongly propels advancements in biosensor technology, leading to the emergence of novel methods for virus detection. Among them, those using nanostructured field‐effect transistors (FETs) provide an ultrasensitive approach toward point‐of‐care diagnostics. However, the application of these bi...

Vibrio vulnificus (Vv) is a marine pathogen that can cause rapid death by septicemia (vibriosis) in humans and several fish species. This pathogen is considered a biomarker of climate change, as both its presence and vibriosis incidence in coastal environments are increasing because of global warming. Currently, gold-standard methods for Vv detecti...

Inspired by biological noses, their electronic counterparts i.e. e-noses are designed to imitate them by detecting and identifying surrounding gases and volatile compounds through the use of gas sensor arrays. These arrays are typically composed of metal oxide sensors, which are limited by energy efficiency and sensitivity issues. However, the use...

In recent years, neuromorphic computing has gained attention as a promising approach to enhance computing efficiency. Among existing approaches, neurotransistors have emerged as a particularly promising option as they accurately represent neuron structure, integrating the plasticity of synapses along with that of the neuronal membrane. An ambipolar...

Gas identification plays a critical role in characterizing our (chemical) environment. It allows to warn of hazardous gases and may help to diagnose medical conditions. Miniaturized gas sensors, and especially those based on chemiresistive detection mechanisms, have gained rapid development and commercialization in the past decades due to their num...

Olfaction is an evolutionary old sensory system, which provides sophisticated access to information about our surroundings. In particular, detecting the volatile organic compounds (VOCs) emitted during natural and artificial processes can be used as characteristic fingerprints and help to identify their source. Inspired by the biological example, a...

Pandemics as the one we are currently facing, where fast-spreading viruses present a threat to humanity, call for simple and reliable methods to perform early diagnosis, enabling detection of very low pathogen loads even before symptoms start showing in the host. So far, standard polymerase chain reaction (PCR) is the most reliable method for doing...

The recent COVID-19 outbreak has strongly pushed the field of biosensors, resulting in multiple new approaches for quantitative virus detection. Among them, those using nanostructured field-effect transistors (FETs) as transducers provide an ultrasensitive approach requiring simple setups for their miniaturization toward point-of-care diagnostics o...

Human beings live and work in close proximity to dangerous gases. Chemical accidents often cause considerable damages to human lives as well as properties and their short- and long-term impact on the environment can be high. Hence, diligent monitoring and management of these gases are of profound importance. In industries where chemical accidents p...

Susceptibility point-of-care testing (POCT) and bacterial inactivation are crucial for food safety and clinical diagnosis since bacteria pose a severe hazard to public health and healthcare. To enable photothermal determination and hyperthermal inactivation of bacteria, vancomycin-modified near-infrared (NIR)-responsive copper selenide nanoparticle...

The Internet of Things era has promoted enormous research on sensors, communications, data fusion, and actuators. Among them, sensors are a prerequisite for acquiring the environmental information for delivering to an artificial data center to make decisions. The MXene‐based sensors have aroused tremendous interest because of their extraordinary pe...

Multiphase microfluidics enables the high-throughput manipulation of droplets for multitude of applications, from the confined fabrication of nano- and micro-objects to the parallelization of chemical reactions of biomedical or biological interest. While the standard methods to follow droplets on a chip are represented by a visual observation throu...

Ionic and molecular selectivity is considered unique for the nanoscale and not realizable in microfluidics. This is due to the scale-matching problem -- a difficulty to match the dimensions of ions and electrostatic potential screening lengths with the micron-sized confinements. Here, we demonstrate a microscale realization of the ionic transport p...

Breath analysis is an emerging technique in the field of diagnostics. The presence of thousands of gases and volatile organic compounds (VOCs), many of them at part per billion (ppb) concentration levels, require the development of ultrasensitive and selective detection approaches, which pose challenges still trying to be addressed by the scientifi...

Ionic and molecular selectivity are considered unique for the nanoscale and not realizable in microfluidics. This is due to the scale-matching problem — a difficulty to match the dimensions of ions and electrostatic potential screening lengths with micron-sized confinements. Here, we demonstrate a microscale realization of ionic transport processes...

Many biomarkers including neurotransmitters are found in external body fluids, such as sweat or saliva, but at lower titration levels than they are present in blood. Efficient detection of such biomarkers thus requires, on the one hand, to use techniques offering high sensitivity, and, on the other hand, to use a miniaturized format to carry out di...

Both ammonia (NH3) and phosphine (PH3) play a significant role in an extensive range of industrial processes, while they are harmful to human health even at very low concentration. So far, a variety of gas sensors have been developed to detect them in an industrial environment aimed to protect the health of workers at their work place. Among variou...

The number of patients in intensive care units has increased over the past years. Critically ill patients are treated with a real time support of the instruments that offer monitoring of relevant blood parameters. These parameters include blood gases, lactate, and glucose, as well as pH and temperature. Considering the COVID-19 pandemic, continuous...

Impedance spectroscopy-based biosensors are typically functionalized following two-dimensional immobilization strategies, with bioreceptors attached through crosslinkers. These methodologies may lead to a decreased receptor activity due to wrong orientation, conformational changes or limited interaction kinetics with the liquid sample. Entrapment o...

Gas accidents frequently turn industrial or civil structures into extremely dangerous environments. Disasters like the Ahrtal flood in summer 2021 destroy infrastructures such as the gas grid and the power grid, so that people loose control and suddenly find themselves confronted with explosions, suffocation, and death. This paper presents a case s...

Both ammonia and phosphine are widely used in industrial processes, and yet they are noxious and exhibit detrimental effects on human health. Despite the remarkable progress on sensors development, there are still some limitations, for instance, the requirement of high operating temperatures, and that most sensors are solely dedicated to individual...

Immunotherapy using CAR-T cells is a new technological paradigm for cancer treatment. To avoid severe side effects and tumor escape variants observed for conventional CAR-T cells approach, adaptor CAR technologies are under development, where intermediate target modules redirect immune cells against cancer. In this work, silicon nanowire field-effe...

Three-dimensional (3D) graphene with a high specific surface area and excellent electrical conductivity holds extraordinary potential for molecular gas sensing. Gas molecules adsorbed onto graphene serve as electron donors, leading to an increase in conductivity. However, several challenges remain for 3D graphene-based gas sensors, such as slow res...

The ability to monitor molecular targets is crucial in fields ranging from healthcare to industrial processing to environmental protection. Devices employing biomolecules to achieve this goal are called biosensors. Over the last half century researchers have developed dozens of different biosensor approaches. In this chapter we analyze recent advan...

The dream of human beings for long living has stimulated the rapid development of biomedical and healthcare equipment. However, conventional biomedical and healthcare devices have shortcomings such as short service life, large equipment size, and high potential safety hazards. Indeed, the power supply for conventional implantable device remains pre...

Two-dimensional van der Waals heterostructures possess potentials of atomic-layer thick p-n junctions for ultrathin optoelectronics. The tungsten diselenide becomes one of the most important building blocks because of its p-type charge carrier conductivity. To date, strict monolayer tungsten diselenide film is still required. Jinbo Pang, Hong Liu,...

The graphene-based biosensors such as microfluidic system-integrated field-effect transistors have featured a rapid and precise detection of biomarkers, which supports early diagnosis of diseases. The comprehensive review discusses the sensing mechanisms and applications of the main-streaming sensors in the detection of small molecules, viruses, ba...

Tungsten diselenide (WSe2) possesses extraordinary electronic properties for applications in electronics, optoelectronics, and emerging exciton physics. The synthesis of monolayer WSe2 film is of topmost for device arrays and integrated circuits. The monolayer WSe2 film has yet been reported by thermal chemical vapor deposition (CVD) approach, and...

Both NH 3 and PH 3 are widely used in industrial processes, and yet they are noxious and exhibit detrimental effects on human health. 1 A variety of gas sensors have been developed to detect and monitor the NH 3 /PH 3 gas in an industrial environment. 2-4 Despite the remarkable progress of sensors development, there are still some limitations, for...

We demonstrate the selective detection of hydrogen sulfide at breath concentration levels under humid airflow, using a self-validating 64-channel sensor array based on semiconducting single-walled carbon nanotubes (sc-SWCNTs). The reproducible sensor fabrication process is based on a multiplexed and controlled dielectrophoretic deposition of sc-SWC...

Immunotherapy using CAR-T cells is a new paradigm technology for cancer treatment. To avoid severe side effects and tumor escape variants observed for conventional CAR-T cells approach, adaptor CAR technologies are under development, where intermediate target modules redirect immune cells against cancer. In this work, silicon nanowire field effect...

In many species, social communication and mate choice are influenced by olfactory cues associated with the major histocompatibility complex (MHC). It has been reported that humans also respond to olfactory signals related to the human MHC-equivalent, the Human Leucocyte Antigen (HLA)-System, and exhibit an olfactory-mediated preference for potentia...

The rapid development of two-dimensional (2D) transition-metal dichalcogenides has been possible owing to their special structures and remarkable properties. In particular, palladium diselenide (PdSe 2 ) with a novel pentagonal structure and unique physical characteristics have recently attracted extensive research interest. Consequently, tremendou...

The real-time monitoring of physiological parameters is essential for point-of-care testing. While nowadays routine tests are done through ex vivo analysis on frequently extracted blood, placing implantable sensors monitoring key blood parameters such as lactate, glucose, ions, and oxygen would mean a giant step forward in the care of critically il...

Although showing impressive therapeutic potential, treatments of leukemias with T-cells expressing chimeric antigen receptors (CARs) is limited by their risk of several severe side effects. To overcome these problems, a switchable CAR platform has been developed termed UniCAR. Unlike conventional CAR, which is directed against tumor-associated anti...

The first isolation of graphene opens the avenue for new platforms for physics, electronic engineering, and materials sciences. Among several kinds of synthesis approaches, chemical vapor deposition is most promising for the growth at wafer‐scale, which is compatible with the Si‐based electronic device integration protocols. In this review, the typ...

Control over micromotors’ motion is of high relevance for lab-on-a-chip and biomedical engineering, wherein such particles encounter complex microenvironments. Here, we introduce an efficient way to influence Janus micromotors’ direction of motion and speed by modifying their surface properties and those of their immediate surroundings. We fabricat...

A flexible sensor is presented for electrochemical detection of ascorbic acid in sweat based on single-step modified gold microelectrodes. The modification consists of electrodeposition of alginate membrane with trapped CuO nanoparticles. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can withstand mec...

Despite the recent progress in the synthesis of crystalline boronate ester covalent organic frameworks (BECOFs) in powder and thin‐film through solvothermal method and on‐solid‐surface synthesis, respectively, their applications in electronics, remain less explored due to the challenges in thin‐film processability and device integration associated...

Despite the recent progress in the synthesis of crystalline boronate ester covalent organic frameworks (BECOFs) in powder and thin‐film through solvothermal method and on‐solid‐surface synthesis, respectively, their applications in electronics, remain less explored due to the challenges in thin‐film processability and device integration associated...

Here, we present a miniaturized lab-on-a-chip detecting system for an all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires-based field-effect transistors (FETs). We specifically focus on the analysis of β-galactosidase e.g.activity, which is an important enzyme of the glycolysis metabolic path...

With the advances of nanotechnology, the introduction of nanomaterials as sensing elements into the existing sensor technologies that have been developed for decades have contributed to an impressive increase in the sensitivity. With various electrical and optical properties and geometries, low-dimensional structures, such as wires, tubes, flakes,...

We demonstrate a flexible sensor for ascorbic acid detection in sweat based on single-step modified gold microelectrodes. The modification consists on the electrodeposition of alginate membrane with trapped CuO nanoparticles on top of the electrodes. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can w...

We demonstrate a flexible sensor for ascorbic acid detection in sweat based on single-step modified gold microelectrodes. The modification consists on the electrodeposition of alginate membrane with trapped CuO nanoparticles on top of the electrodes. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can w...

We propose a hybrid device substituting the software synapse in artificial neural networks with an individual hardware transistor unit. The unit merges a silicon nanowire semiconductor channel with a metal-ion doped solgel film as hybrid gate of the transistor. The film, amorphous and transparent, shows a memristive property due to ion redistributi...

Here we present a miniaturized lab-on-a-chip detecting system for all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires based field-effect transistors for real-time monitoring of the enzymatic reaction of β-galactosidase and ortho-nitrophenol-galactose (ONPG).

In the pool of nanostructured materials, silicon nanostructures are known as conventionally used building blocks of commercially available electronic devices. Their application areas span from miniaturized elements of devices and circuits to ultrasensitive biosensors for diagnostics. In this Review, the current trends in the developments of silicon...

2D molybdenum disulfide (MoS2) gives a new inspiration for the field of nanoelectronics, photovoltaics, and sensorics. However, the most common processing technology, e.g., liquid‐phase based scalable exfoliation used for device fabrication, leads to the number of shortcomings that impede their large area production and integration. Major challenge...

We present a biosensor chip with integrated large area silicon nanowire-based field effect transistors (FET) for human α-thrombin detection and propose to implement the hysteresis width of the FET transfer curve as a reliable parameter to quantify the concentration of biomolecules in the solution. We further compare our results to conventional surf...

Miniaturized and cost-efficient methods aiming at high throughput analysis of microbes is of

The intriguing properties of self-assembled microtubular architectures open new possibilities to develop three-dimensional functional devices for molecule and cell analysis. [...]

Miniaturized and cost-efficient methods aiming at high throughput analysis of microbes is of great importance for the surveillance and control of infectious diseases and the related issue of antimicrobial resistance. Here we demonstrate a miniature nanosensor chip based on a honeycomb-patterned silicon nanowire field effect transistor (FET) capable...

We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the current-minima voltage gap VGAP by involving the third g...

We developed chemiresistor-type biosensors based on carbon nanotubes for highly efficient and fast detection of avian influenza virus (AIV) subtype H5N1 DNA sequences. Semiconducting single-walled carbon nanotube (sc-SWCNTs) or nitrogen-doped multi-walled carbon nanotubes (N-MWCNTs) were used as two alternative active sensing elements, and their se...

Conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route towards sensitive, optics-less analysis of biochemical processes with high throughput, where single device can be employed for probing of thousands independent reactors. Here we combine droplet microfluidics with the compact silicon nanowire b...

Carbon nanotubes (CNTs) show great potential for biosensing, because of their quasi-one-dimensional structure offering high sensitivity, high electron mobility and their effective and facile integration into electrode network. In this study, we fabricated two types of chemiresistor arrays: based on nitrogen doped multi-walled CNTs (N-MWCNTs) and se...

We report an ultrasensitive label-free DNA biosensor with fully on-chip integrated rolled-up nanomembrane electrodes in which the hybridization of complementary DNA strands (Avian Influenza Virus subtype H1N1) is selectively detected down to attomolar concentrations - an unprecedented level for miniaturized sensors without amplification. Impedimetr...

This paper reports on a miniaturized and highly integrated lab-on-a-chip (LoC) combining both optical and electrochemical transduction modes for self-validating determination of biological analytes that undergo enzyme-catalyzed-reactions. This LoC monolithically integrates a biofunctionalized microfluidic mixer, also working as bioreactor, together...

A flexible light weight diagnostic platform is realized on cost-efficient large-area flexible foils enabling its cost-efficient high-volume delivery to medical institutions worldwide. The devices presented by L. Baraban, D. Makarov, and team on page 1517 allow the timely diagnosis of viral or infectious diseases, for example, the here demonstrated...

A phaseguide-based optofluidic router (PHASOR) is presented. By using phaseguides, DI-water can be pinned in the required angle so that light incident undergoes total internal reflection and can be reflected towards one of the six output channels without movable parts. In addition, the PHASOR is coupled to two enzymatically-functionalized photonic...

A flexible diagnostic platform is realized and its performance is demonstrated for early detection of avian influenza virus (AIV) subtype H1N1 DNA sequences. The key component of the platform is high-performance biosensors based on high output currents and low power dissipation Si nanowire field effect transistors (SiNW-FETs) fabricated on flexible...

A photonic lab on a chip (PhLOC), comprising a solid-state light emitter (SSLE) aligned with a biofunctionalized optofluidic multiple internal reflection (MIR) system, is presented. The SSLE is obtained by filling a microfluidic structure with a phenyltrimethoxysilane (PhTMOS) aqueous sol solution containing a fluorophore organic dye. After curing,...

A dual (electrochemical and optical) Lab-on-a-Chip is presented, which monolithically combines a Multiple Internal Reflection and a biofunctionalized mixer that also plays the role of reactor. Here, there is no need to include an enzyme reservoir, resulting in a reduction of dead volumes. This approach was validated by functionalizing the mixer/rea...

The selective absorbance detection of mercury(ii) (Hg(2+)) and lead(ii) (Pb(2+)) ions using ferrocene-based colorimetric ligands and miniaturized multiple internal reflection (MIR) systems implemented in a low-cost photonic lab on a chip (PhLoC) is reported. The detection principle is based on the formation of selective stable complexes between the...

This work presents the monolithic integration of a fluorophore-doped hybrid xerogel polymeric light emitter and a multiple internal reflection configuration (MIR) optofluidic system in a photonic lab on a chip (PhLoC). Two different air mirrors at both sides of the emitter were implemented that improves light coupling into the MIR system. The MIR i...

Here we present a protocol for analyzing cell cultures using a photonic lab-on-a-chip (PhLoC). By using a broadband light source and a spectrometer, the spectrum of a given cell culture with an arbitrary population is acquired. The PhLoC can work in three different regimes: light scattering (using label-free cells), light scattering plus absorption...