Benoit DUGUE

Université de Poitiers | UP · UFR Sciences du sport

To study the effects of physical stimulation based on walking exercises, equilibrium and endurance on cognitive function and walking efficiency in patients with dementia. Randomized controlled trial including 31 subjects suffering from dementia (age: 81.8 +/- 5.3 years). The intervention group (n = 16) benefited from a 15-week physical activity pro...

A commentary on Could whole-body cryotherapy (below −100 • C) improve muscle recovery from muscle damage? Recently, an interesting model trying to explain the anti-inflammatory action of whole body cryotherapy (WBC) after exercise induced muscular damage (EIMD) was published by Ferreira Junior et al. in Frontiers in Physiology (Ferreira-Junior et a...

Objectives: To study the effects of whole body cryostimulation (WBC) on fatigue and functional status in multiple sclerosis (MS) patients with different levels of fatigue. Subjects and Methods: Two groups of MS patients with fatigue were studied. At the beginning of the study, the first group presented a Fatigue Severity Scale (FSS) score between 3...

Rehabilitation using cryotherapy has widely been used in inflammatory diseases to relieve pain and decrease the disease activity. The aim of this study was to explore the metabolite changes in inflammatory knee-joint synovial fluids following local cryotherapy treatment (ice or cold CO 2). We used proton nuclear magnetic resonance (1 H NMR) spectro...

Background Endothelial function (EndFx) is a core component of cardiovascular (CV) health and cardioprotection following acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (PCI). Hypothesis AMI patients experience endothelial dysfunction (EndDys), associated with traditional CV risk factors and sleep patterns...

Background: Whole-body cryostimulation (WBC) involves exposure to extremely low temperatures to reduce inflammation and pain and to enhance recovery. Despite its growing popularity and the importance of the magnitude of WBC-induced skin cooling in triggering the cascade of effects, limited research has focused on skin temperature changes in individ...

The objectives of the study were (i) to evaluate the effects of whole‐body cryostimulation (WBC) after training as an effective tool to improve sleep and recovery and (ii) to determine which exposure schedule for WBC (immediately after training vs. 1h before bedtime) is the most appropriate to improve sleep and recovery. Twenty‐two well‐trained mal...

Background: The efficacy of whole-body cryostimulation (WBC) may be influenced by individual characteristics. The aim of this study is to determine the optimal exposure time required to reach the analgesic threshold of 13.6 °C, which has been proposed to be a target temperature to be reached at skin level. Our objective is also to follow the skin t...

Background: The GHG combines several treatment factors, such as low-level radon exposure, high humidity, and mild hyperthermia, at a moderate altitude above sea level. Every year, well over 8,000 patients with different diseases resulting in functional disabilities due to muscle loss/weakness, e.g., caused by sarcopenia, seek treatment in this heal...

The aim of this study was to evaluate the effects of daily whole-body cryostimulation (WBC) sessions during 5 consecutive days on wellness and sleep parameters in healthy young men and women. Twenty healthy subjects (9 women; 11 men) aged 23.1 ± 2.6 years old participated in this randomized protocol, with 5 consecutive days with (CRYO) or without W...

Background Each year, over 2500 patients with ankylosing spondylitis (AS) take a series of treatment sessions in the Gastein Healing Gallery (GHG). This setting combines several treatment factors, such as exposure to high humidity (75% to 100% depending on the treatment area), heat (37° to 41° C, resulting in mild hyperthermia), and a low level of...

Background Cryostimulation and cold-water immersion (CWI) have recently gained widespread attention due to their association with changes in cardiovascular and cardiac autonomic control responses. Therefore, the aim of the present systematic review and meta-analysis was to identify the global impact of such cold exposures on cardiovascular and card...

Acceptable definitions of thermal sensation for cold and hot water immersion do not exist. The use of subjective thermal sensation scales remains unsolved with broad psycho-physiological, and semantic implications. We hypothesize that perception of thermal sensation could be a valid and reliable indicator for thermal strain during exposure in water...

Prolonged or repeated cold exposure in humans causes physiological changes that occur in endocrine, circulatory, neuromuscular and immunological systems. Our body maintains core temperature during acute cold exposure through (1) vasomotor responses including cutaneous vasoconstriction to reduce heat loss to the environment and (2) thermogenesis whi...

Despite a huge number of whole-body cryotherapy (WBC) sessions performed worldwide, adverse events appear to be rare in relation to the extent to which WBC has grown worldwide. Part of the reason for this is, on one side, the precautionary measures taken over the last two decades for safety and, on the other side, the fact that not all studies have...

Metabolomics is a powerful tool that encompasses the complete set of metabolites involved in various metabolic pathways, providing valuable insights into an organism’s physiological status. The external environment plays a crucial role in shaping the metabolome of living organisms. Metabolomics is particularly useful for investigating how external...

This chapter aims to provide a summary, though not exhaustive, of some topics that have been only marginally, if not at all, covered in published whole-body cryostimulation (WBC) studies, but hold some rationale for its application. Local cold application has been shown to induce prolonged inhibitory effects on spasticity in patients with upper mot...

Cryotherapy has garnered significant attention in several medical and high-level sport performance domains. Although it is necessary to evaluate this technique’s efficacy in recovery processes, numerous studies have shown its usefulness in improving physical performance. Multiple physiological and psychological mechanisms have been identified. The...

As the Chairman of the Working Group of the International Institute of Refrigeration (IIR) on “Whole-Body Cryotherapy/cryostimulation,” it is my great pleasure to introduce the book entitled Whole-body Cryostimulation. Clinical Applications, organized by Professor Paolo Capodaglio from the University of Torino and the IRCCS Istituto Auxologico, Ita...

Objective Common features in chronic inflammatory disease patients (CIDP) are inflammation, mental stress (MS), and autonomic nervous system imbalance. Whole‐body cryotherapy (WBC) exposure and regular physical exercise are known to regulate these features. In this study, we assessed the impact of regular physical exercise and the use of WBC exposu...

The benefits of cold have long been recognized in sport and medicine. However, it also brings costs, which have more rarely been investigated, notably in terms of sensorimotor control. We hypothesized that in addition to peripheral effects, cold slows down the processing of proprioceptive cues, which has an impact on both feedback and feedforward c...

Over the two last decades, whole-body cryotherapy/cryostimulation (WBC) has emerged as an exciting non-pharmacological treatment influencing inflammatory events at a cellular and physiological level, which can result in improved sleep quality, faster neuromuscular recovery after high-intensity exercise, and chronic pain relief for patients sufferin...

The aim of this study is to measure the difference in skin temperature variation between males and females during a 4-min whole-body cryotherapy (WBC) exposure. Nine males (31 ± 13 years, 175 ± 5 cm, 76 ± 9 kg, and 17 ± 13 % BF) and nine females (31 ± 14 years, 167 ± 1 cm, 59 ± 10 kg, and 24 ± 4 % BF) volunteered to participate at this study. Their...

Common features in chronic inflammatory disease patients (CIDP) are inflammation, mental stress (MS), and autonomic nervous system imbalance. Whole-body cryotherapy (WBC) and regular physical exercise are known to regulate these features. In this study, we assessed the impact of regular physical exercise and WBC in CIDP on the level of skin resista...

This study aimed to investigate the effect of partial-body cryostimulation (PBC) on microvascular responsiveness and muscular metabolic O2 consumption rate (m V˙ O2). Twenty healthy young adults (ten males and ten females) underwent post-occlusive reactive hyperaemia (PORH) test at the flexor digitorum superficialis area before and after a 3-min PB...

Introduction: So far there is not a widely acceptable definition of cold and hot water. This problem is multidimensional, since it arises from the difficulty in understanding the meaning of sensation, the variety of thermal scales and the difficulty in finding objective criteria that could separate physiological responses from deep internal interpr...

Over the two last decades, whole-body cryotherapy/cryostimulation (WBC) has emerged as an exciting non-pharmacological treatment in uencing in ammatory events at a cellular and physiological level, which can result in improved sleep quality, faster neuromuscular recovery after high-intensity exercise, and chronic pain relief for patients suffering...

L’utilisation de bains froids après un exercice physique intense a pour but de limiter les douleurs liées à des courbatures et à récupérer de la fatigue plus rapidement. Un certain nombre d’études ont été conduites sur ce sujet et les premières méta-analyses effectuées il y a une dizaine d’années (2012) concluaient que les bains froids permettaient...

Background Severe thermal discomfort may increase risk of drowning due to hypothermia or hyperthermia from prolonged exposure to noxious water temperatures. The importance of using a behavioral thermoregulation model with thermal sensation may predict the thermal load that the human body receives when exposed to various immersive water conditions....

In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the forecasting of patient outcomes. Overnight urine specime...

The aim of the study was to investigate the efficiency, the feasibility, and the safety of a hybrid cardiovascular rehabilitation program in low-risk acute coronary syndrome (ACS) patients. Sixty low-risk patients with stable clinical status who experienced an ACS in the previous 3 months were included in a 3-week rehabilitation program. The patien...

The Greek historian Lycus of Rheghium recorded an extraordinary thermal paradox in the Sicilian ritual Palici lake, where bathers expressed a warm sensation after immersion in cold sulfurous – carbonated waters. It is well established that CO2 rich water bath has a strong physiological effect on cardiovascular and thermoregulatory systems. However,...

Currently available treatments for the management of obesity struggle to provide clinically significant weight loss and reduction of the chronic low-grade inflammatory state in order to reduce obesity-related complications. This scoping review aims to provide an up-to-date picture of the therapeutic effects of Whole-Body Cryostimulation (WBC) in pa...

The sleep apnea syndrome (SAS) is a sleep related-breathing disorder with several features such a systemic inflammation, oxidative stress, a cognitive impairment and a poor sleep quality. Patients with SAS present an increased incidence of cardiovascular diseases. There is no real effective treatment that prevents and treats all of these illness sy...

Recovery after exercise is a crucial key in preventing muscle injures and in speeding up processes to return at the homeostasis level. There are several ways of developing a recovery strategy with the use of different kinds of traditional and up-to date techniques. The use of cold has traditionally been used after physical exercise for recovery pur...

Severe discomfort or even drowning incident may lurk due to potential hypothermia or hyperthermia during prolonged exposure to noxious water temperatures. Therefore, particular emphasis should be given to thermal perception, as it can predict the thermal load that the human body receives when exposed to various climatic conditions. However, there i...

La thérapie par le froid ou cryothérapie a longtemps été utilisée pour soulager les douleurs et les symptômes inflammatoires. De nos jours, ce que nous appelons cryothérapie ou cryostimulation à corps entier (CCE) indique une exposition (ou une série d’expositions) administrée dans une chambre froide dans laquelle la température de l'air peut attei...

The importance of thermoregulation lies in the fact that temperature as a physical parameter is crucial both for cellular function and humans' survival. The thermoregulatory system correlates not only with the cardiovascular and musculoskeletal system but also with neural activity and pain sensation. Whole-body water immersion can alter both the co...

We assessed the effects of a 3-min partial-body cryostimulation (PBC) exposure-where the whole body is exposed to extreme cold, except the head-on cognitive inhibition performance and the possible implications of parasympathetic cardiac control and cerebral oxygenation. In a randomized controlled counterbalanced cross-over design, eighteen healthy...

The aim of this study was to evaluate the impact of using a cooling vest during physical exercise (per-cooling) in humid and temperate conditions (≈22°C, ≈80% relative humidity) on perceptual and physiological responses (tissue oxygenation and heart rate). 20 physically active men performed twice a 30-min cycling exercise at 70% of their theoretica...

Complementary data concerning the work Douzi Wafa, Guillot Xavier, Bon Delphine, Seguin François, Boildieu Nadège, Wendling Daniel, Tordi Nicolas, Dupuy Olivier, Dugué Benoît: 1H-NMR-based analysis for exploring knee synovial fluid metabolite changes after local cryotherapy in knee arthritis patients. Metabolites 2020, 10(11), 460; https://doi.org...

Whole-Body Cryotherapy (WBC) and Partial-Body Cryotherapy (PBC) – grouped under the term Cryostimulation – are new techniques consisting in exposing the whole body (head excluded for PBC) to extreme cold for a short period of time (typically 3 minutes at -110 °C). After exposure, patients experienced decreased soreness, oedema and inflammation, as...

La Cryothérapie Corps Entier (CCE) et la Cryothérapie Corps Partiel (CCP) – regroupées sous le terme de Cryostimulation – sont de nouvelles techniques consistant à exposer le corps entier (tête exclue pour la CCP) à un froid extrême pendant une courte période (typiquement 3 minutes à -110 °C). Après exposition, les patients font état de certains bi...

PurposeA predominance of parasympathetic drive is observed following cold exposure. Such modulation of the autonomic nervous system (ANS) is associated with faster post-exercise recovery. Within this context, whole-body cryotherapy (WBC) has been spreading in sport medicine, though the optimal temperature and frequency are unclear. The aim of this...

There are many important sport events that are organized in environments with a very hot ambient temperature (Summer Olympics, FIFA World Cup, Tour de France, etc.) and in hot locations (e.g., Qatar). Additionally, in the context of global warming and heat wave periods, athletes are often subjected to hot ambient temperatures. It is known that exer...

There are many important sport events that are organized in environments with a very hot ambient temperature (Summer Olympics, FIFA World Cup, Tour de France, etc.) and in hot locations (e.g., Qatar). Additionally, in the context of global warming and heat wave periods, athletes are often subjected to hot ambient temperatures. It is known that exer...

The severity of the hot and humid conditions to which miners are exposed increases as the depth of the work site increases. This can cause heat stress that can greatly affect the health and safety of workers. To resolve this, a cooling garment has been developed that uses an atmospheric discharge of liquid CO 2 to create a cool microclimate with an...

Cold therapy or cryotherapy has long been used to relieve pain and inflammatory symptoms. Nowadays, whole-body cryotherapy-an extreme cold therapy-which lasts 1-3 min, and given in a cold room in which the air temperature maybe-110°C or less is also used. Important series of data have been collected in the context of injury prevention, recovery aft...

Introduction: Hyperthermia during exercise induces central and peripheral fatigue and impairs physical performance. To facilitate heat loss and optimize performance, athletes can hasten body cooling prior (pre-cooling) or during (per-cooling) exercise. However, it is unclear whether per-cooling effect is the same on ‘aerobic’ and ‘anaerobic’ types...

Hormones are secreted in a circadian rhythm, but also follow larger-scale timetables, such as monthly (hormones of the menstrual cycle), seasonal (i.e., winter, summer), and, ultimately, lifespan-related patterns. Several contexts modulate their secretion, such as genetics, lifestyle, environment, diet, and exercise. They play significant roles in...

Objective: The aim of the present investigation was to determine whether using cryostimulation (partial-body cryostimulation) impacts sleep quality in professional soccer players. Different exposure durations at −180°C were tested randomly after standardized training sessions in 9 professional soccer players (no cryostimulation, 180-s exposure, tw...

As soluble intercellular adhesion molecule-1 (sICAM-1) was recently hypothesized to be a key player in the mechanisms involved in exercise-induced muscular damage (EIMD), we investigated its circulating concentration changes in athletes before and after EIMD with and without the use of whole-body cryostimulation (WBC; 3 min at -110°C) at the exerci...

A cooling garment for deep mine activities has been developed. It uses the atmospheric discharge of liquid CO2 to treat a constant airflow and create a cool microclimate with an average temperature of 12.5 (±0.4) ℃ under the garment, thus assisting the evaporating of the sweat and cooling the body. To evaluate its cooling efficiency, 19 male subjec...

Exercise training during evening may disturb sleep patterns and hinder recovery process. The present study aimed to examine the effect of whole body cryotherapy (WBC) exposure after training in the evening on sleep quality and night heart rate variability (HRV). A total of 22 physically active men were randomized to undergo either WBC (3-min at −40...

Partial-body cryostimulation is used to improve recovery after exercise, especially during competitions or heavy training; however, a limited number of studies have been conducted with international-level athletes in situ during competitions. This study was undertaken to assess the thermal sensation ratings during 3 min of cold exposure (at –130°C)...

Posture changes have been known for a long time to influence the concentration of many analytes in blood especially macromolecules. It is very clear that when someone switches from supine to sitting or standing or from sitting to standing a hemoconcentration is induced. Similarly, when someone switches from standing to sitting or lying a hemodiluti...

Introduction: The aim of the present work was to perform a meta-analysis evaluating the impact of recovery techniques on delayed onset muscle soreness (DOMS), perceived fatigue, muscle damage, and inflammatory markers after physical exercise. Method: Three databases including PubMed, Embase, and Web-of-Science were searched using the following term...

An evidence-based approach to choose the recovery you need to reduce muscle damage, soreness, fatigue and inflammation: a systematic review with meta-analyses / Douleurs musculaires après exercice physique : une méta-analyse pour connaître les techniques de récupération les plus efficaces (Frontiers in Physiology 2018, in revision)

Introduction: Rheumatoid arthritis (RA) is an autoimmune, chronic and inflammatory disease, which the affected patients present a higher cardiovascular mortality rate. Physical activities have been identified as the most important strategy to prevent cardiovascular diseases. However, the articular damage and the chronic pain caused by RA challenge...

Whole-body cryotherapy (WBC) and partial-body cryotherapy (PBC) are two methods of cold exposure (from −110°C to −195°C according to the manufacturers). However, temperature measurement in the cold chamber during a PBC exposure revealed temperatures ranging from −25°C to −50°C next to the skin of the subjects (using isolating layer placed between t...

Aims of the study: To evaluate a dual-task named the “Stroop Walking Task,” which is similar to the task of making a decision of whether to cross a street based on a pedestrian traffic light. Patients and methods: Fifty-one subjects (15 young adults, 21 subjectively healthy old subjects and 15 old subjects with mild cognitive impairment) had to res...

This is a field study realized during basketball preparation tournaments for the European championship 2013 with men and women French team. During these competitions, athletes used Whole-Body Cryostimulation (WBC) exposures to enhance their recovery. The aim of this work was to investigate the effects of WBC on the quality of sleep (QS) in athletes...

Subjects with mild cognitive impairment (MCI) have disturbances in their spatial navigation abilities and exhibit early deficits in visuospatial short-term memory. The purpose of the present study was to determine whether a quantitative (span score) and qualitative (evaluating navigation strategies used) analysis of the Corsi test (usual condition...

Background Cryotherapy is used empirically as a symptomatic treatment in rheumatology, with well-known analgesic, vasoconstrictive, anti-inflammatory properties. It can be applied locally or to the whole body. This widespread use contrasts with a lack of standardization in techniques and a poor level of evidence. Objectives The aim of this work is...

The aim of this article was to review current evidence about cryotherapy in inflammatory rheumatic diseases (therapeutic and biological effects). For therapeutic effects, we performed a systematic review (PubMed, EMBASE, Cochrane Library, LILACS databases, unpublished data) and selected studies including non-operated and non-infected arthritic pati...

The objective of this preliminary study was to evaluate the effectiveness, in terms of fall reduction, of an in-home strategy that we have developed for elderly fallers. We also aimed at finding links between the expected changes in the data obtained in static posturography and in clinical balance tests through our program. Twelve elderly patients...

Objectives: Metabolomics is has become as an established strategy in the exploration of various stimuli effects. We have recently shown that intense physical exercise can extensively modify the urinary metabolome in human subjects (Ref 1). We have now investigated whether physical training could induce changes at the resting level and after a physi...

Background: In females, estrogen is a potential modulator of cortisol response to stressors. The aim of this study was to determine the influence of menstrual cycle phase, oral contraception (OC) use and exercise training on hypothalamo-pituitary-adrenal (HPA) axis activity and reactivity after physical stress. Aim: We investigated the effects o...

The objective of this study was to analyze whether a meta-analysis could allow us to draw useful conclusions about the risk factors for falls in the elderly. A systematic review was carried out of various databases and completed manually. To satisfy the inclusion criteria, an article had to examine a population of subjects aged over 60 years to per...

The objective of this study was to analyze whether a meta-analysis could allow us to draw useful conclusions about the risk factors for falls in the elderly. A systematic review was carried out of various databases and completed manually. To satisfy the inclusion criteria, an article had to examine a population of subjects aged over 60 years to per...