Benoit Dervaux

Université de Lille · Faculty of Medicine

Background In young children, respiratory syncytial virus (RSV)-related bronchiolitis is typically more severe than other respiratory tract infections, with a greater need for oxygen therapy and respiratory support. Few studies have compared the cost of hospitalization with regard to virological status. The objective of this study was to compare th...

Background: Respiratory syncytial virus (RSV) causes a considerable disease burden in young children globally, but reliable estimates of RSV-related costs and health-related quality-of-life (HRQoL) are scarce. This study aimed to evaluate the RSV-associated costs and HRQoL effects in infants and their caregivers in four European countries. Method...

Within the life-cycle assessment of health technologies, real-world data (RWD) have until now been of secondary importance to clinical trial data. The availability of massive, better quality RWD, particularly with the emergence of connected devices, the the improvement of methods for characterizing populations, mak it possible to have a better insi...

Résumé Dans le contexte de l’évaluation des technologies de santé tout au long de leur cycle de vie, les données en vie réelle (DVR) occupaient jusqu’à présent une place secondaire par rapport à celles issues des essais cliniques. Avec l’accessibilité à des DVR massives, de meilleure qualité, en particulier avec l’émergence des dispositifs connecté...

Background Since the beginning of the COVID-19 pandemic, many countries, including Canada, have adopted unprecedented physical distancing measures such as closure of schools and non-essential businesses, and restrictions on gatherings and household visits. We described time trends in social contacts for the pre-pandemic and pandemic periods in Queb...

Background Since the beginning of the Covid-19 pandemic, many countries, including Canada, have adopted unprecedented physical distancing measures such as closure of schools and non-essential businesses, and restrictions on gatherings and household visits. We described time trends in social contacts for the pre-pandemic and pandemic periods in Queb...

Objectives For medical devices, a usability assessment is mandatory for market access; the objective is to detect potentially harmful use errors that stem from the device’s design. The manufacturer assesses the final version of the device and determines the risk-benefit ratio for remaining errors. Nevertheless, the decision rule currently used to d...

Background: Usability testing of medical devices are mandatory for market access. The testings' goal is to identify usability problems that could cause harm to the user or limit the device's effectiveness. In practice, human factor engineers study participants under actual conditions of use and list the problems encountered. This results in a bina...

Objective: The aim of this study was to compare the efficacy and safety of 12-month implantation of a duodeno-jejunal bypass liner (DJBL) with conventional medical care in patients with metabolic syndrome (MS). Summary background data: DJBL is an endoscopic device for treating obesity and related disorders. The persistence of favorable results a...

Background Endovascular treatment has become the first-line revascularisation technique for femoropopliteal lesions. This technique lacks of reliable and accurate morphological control of the arterial segment treated. Intraoperative 2-D angiogram consumes iodinated contrast media and increases X-ray exposure; this subsequently provides none 3D info...

Background: Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is related to the high prevalenc...

Introduction La maîtrise des durées de séjour est une composante de la performance hospitalière mesurée par l’IPDMS. Cet indicateur identifie des activités dont la durée est en écart à la moyenne, mais néglige les caractéristiques « patients » et « séjours » et la distribution de durée. L’objectif de l’analyse est de permettre à un établissement de...

Background Usability studies of medical devices are mandatory for market access. The studies’ goal is to identify and eliminate usability problems that could cause harm the user or limit the device’s effectiveness. In practice, human factor engineers study participants under actual conditions of use and list the problems encountered. This results i...

Background . Usability testing of medical devices are mandatory for market access. The testings’ goal is to identify usability problems that could cause harm to the user or limit the device’s effectiveness. In practice, human factor engineers study participants under actual conditions of use and list the problems encountered. This results in a bina...

Background. Usability testing of medical devices are mandatory for market access. The testings’ goal is to identify usability problems that could cause harm to the user or limit the device’s effectiveness. In practice, human factor engineers study participants under actual conditions of use and list the problems encountered. This results in a binar...

Background Usability testing of medical devices are mandatory for market access. The testings’ goal is to identify usability problems that could cause harm to the user or limit the device’s effectiveness. In practice, human factor engineers study participants under actual conditions of use and list the problems encountered. This results in a binary...

Background Catheter-related bacteremia (CRB) is the most frequent nosocomial infection in neonatal intensive care unit (NICU) patients, especially in very low-birth-weight infants. Administration of injectable drugs in premature newborn infants has many particularities and several types of infusion incidents have been reported. The Edelvaiss® Multi...

Objective: The objective of this study was to evaluate the impact of a rapid diagnostic test for influenza (the Sofia® Influenza A+B FIA rapid diagnostic test [RDT]) in a pediatric emergency department (PED). Methods: A retrospective, observational, cross-sectional study was conducted in the PED of the Lille University Hospital between 2013 and 201...

Article 51 of the French social security financing act for 2018 creates a derogatory funding system to support experimentation with new ways of organizing care pathways. The growing interest local leaders have expressed for this very open framework has led to a large number of candidate projects presented to public authorities in charge of the syst...

Résumé L’article 51 de la loi de financement de la Sécurité sociale (LFSS) de 2018 ouvre la voie à des expérimentations de nouvelles organisations des parcours de soins, assises sur des modalités de financement dérogatoires aux règles actuelles. Le cadre très ouvert du dispositif suscite une réelle adhésion des acteurs locaux, en témoigne les multi...

Background and aims: The potential benefit of the centralization of Bariatric surgery (BS) remains debated. The aim of this study was to evaluate the impact on 90-day mortality of an innovative organization aiming at centralizing the care of severe postoperative complications of BS. Study design: The centralization of care for postoperative comp...

Background Large measles and mumps outbreaks recently occurred throughout Europe and the United States. Aim: Our aim was to estimate and map the risk of resurgence for measles, mumps and rubella in France. Methods: We used a multi-cohort model combining seroprevalence information, vaccine coverage and social contact data. Results: The overall outbr...

The question of what monetary value should be assigned to consumed resources, that is to say the choice of the unit cost, is a major consideration in terms of impact on the cost analysis results. To date, no agreement has been reached regarding this methodological question. The choices made by methodologists and the subsequent impact on the results...

This work addresses the analysis of individual cost data in the setting of interventional or observational studies using statistical analysis software once the costs per patient have been estimated. It is in fact necessary to be able to present and describe data in an appropriate manner in each of the studied health strategies and to test whether t...

Résumé Les méthodes de costing hospitalier nécessitent d’avoir recours à des sources de données diverses, que l’on travaille selon une approche micro-costing ou gross-costing, le choix de la méthodologie reposant sur un compromis entre coût de recueil, précision et transférabilité. Ce travail décrit les sources de données disponibles en France, les...

Résumé La mise sur le marché précoce de produits de santé s’accompagne d’une demande accrue d’informations par les autorités de santé. En regard de cette attente, l’enrichissement croissant des bases de données de santé représente une opportunité de réponse aux interrogations des autorités. L’informatisation du système de santé offre de nombreuses...

Early market access of health products is associated with a larger number of requests for information by the health authorities. Compared with these expectations, the growing expansion of health databases represents an opportunity for responding to questions raised by the authorities. The computerised nature of the health system provides numerous s...

Purpose: The aim of this study was to determine the impact of a biomarker-based strategy on early discontinuation of empirical antifungal treatment. Methods: Prospective randomized controlled single-center unblinded study, performed in a mixed ICU. A total of 110 patients were randomly assigned to a strategy in which empirical antifungal treatme...

Introduction Le GHT Lille Metropole Flandre Interieure est compose de dix etablissements, dont huit ayant une activite MCO. Ils sont situes dans le territoire de sante « Metropole Flandre Interieure » (MFI). L’objectif de ce travail est d’estimer la zone de chalandise du GHT et d’analyser ses similitudes en comparaison au territoire de sante. Metho...

Introduction Dans le modele de performance des poles hospitalo-universitaires du PREPS-PERFHU se pose la question de la couverture des besoins. Pour juger de l’adequation des moyens deployes aux besoins, la connaissance du perimetre de responsabilite des poles est necessaire. Pour le pole de geriatrie, la fragilite de la personne âgee constitue un...

Background Clostridium difficile infection (CDI) is characterized by high rates of recurrence, resulting in substantial health care costs. The aim of this study was to analyze the cost-effectiveness of treatments for the management of second recurrence of community-onset CDI in France. Methods We developed a decision-analytic simulation model to c...

Supplementary Table and Figure. (DOCX)

L’accès au marché des médicaments innovants en France comporte une évaluation médico-économique (amélioration du service médical rendu/amélioration du service attendu [ASMR/ASA] I, II, III avec impact significatifs sur les dépenses d’assurance maladie). En sus d’une analyse coût-résultat (ACR), des analyses d’impact budgétaire (AIB) peuvent être pr...

In France, market access for innovative drugs (level I, II & III improvement of medical service rendered having significant impact on health insurance expenditure) involves medico-economic evaluation. In addition to cost-effectiveness analysis (CEA), budget impact analysis (BIA) can be performed, especially since the sustainability of the health in...

Background Urinary tract infections (UTIs) are among the most common bacterial infections. Despite this burden, there are few studies of the costs of UTIs. The objective of this study was to determine the costs of UTIs in women over 18 years of age who visit general practitioners in France. Methods The direct and indirect costs of clinical UTIs wer...

Vaccine-preventable diseases still occur although measured coverage rates at 2 y of age are high. The occurrence of these diseases may be explained in part by untimely, that is, late vaccination. Our objective was to identify potentially dangerous vaccination delays for each dose of each vaccine in children younger than 2 y. A 3-round Delphi proces...

Introduction: Despite its low incidence in France, invasive serogroup B meningococcal disease remains a public health concern. A new vaccine against the disease, Bexsero(®), has been licensed in the EU. We studied the epidemiological impact and cost-effectiveness of routine vaccination using Bexsero(®) in order to inform the decision-making proces...

La grande majorité des hommes et des femmes sont infectés par les papillomavirus humains (HPV) au cours de leur vie. Concernant les hommes, l’infection anale par les HPV et ses manifestations cliniques (lésions pré-cancéreuses, cancers, condylomes anaux) sont plus fréquentes chez ceux ayant des relations sexuelles avec des hommes (HSH) et en partic...

‘Public Health surveillance is the ongoing systematic collection, analysis and interpretation of health data, closely integrated with the timely dissemination of these data both to those providing the data and to those who can apply the data to control and prevention programs’.1 Public health surveillance is therefore, closely linked to action as i...

Background: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion...

Giving the human papillomavirus (HPV) vaccination to females has been shown to be cost-effective in most countries. The epidemiological evidence and economic burden of HPV-related diseases have gradually been shown to be gender neutral. Randomized clinical trials report high efficacy, immunogenicity and safety of the HPV vaccine in males aged 16-26...

Background: Empirical social contact patterns are essential to understand the spread of infectious diseases. To date, no such data existed for France. Although infectious diseases are frequently seasonal, the temporal variation of contact patterns has not been documented hitherto. Methods: COMES-F is the first French large-scale population surve...

Medical devices (MDs) cover a wide variety of products. They accompany changes in medical practice in step with technology innovations. Innovations in the field of MDs can improve the conditions of use of health technology and/or modify the organisation of care beyond the strict diagnostic or therapeutic benefit for the patients. However, these non...

Résumé Les dispositifs médicaux (DM) couvrent une large variété de produits. Ils accompagnent, au gré des innovations technologiques, l’évolution des pratiques médicales. Les innovations dans le champ du DM peuvent améliorer les conditions d’utilisation de la technologie de santé et/ou modifier l’organisation des soins au-delà du strict bénéfice th...

Since 3rd October 2013 in France, drug companies applying for reimbursement of an innovative and expensive drug or medical device are required to provide the French National Authority for Health (HAS) with a cost-effectiveness assessment of their product. After a methodological audit of the economic evaluation submitted by the drug company, the Hea...

Introduction L’objectif de ce travail est de mener une revue de la littérature traitant de l’analyse coût-efficacité de l’extension aux hommes de la vaccination contre les papillomavirus humains (HPV). Méthode Une recherche bibliographique est réalisée dans Pubmed. Sont considérées les études coût-efficacité de la vaccination des hommes contre les...

Introduction L’analyse des opinions spontanément exprimées sur Internet permet d’apprécier l’acceptabilité des politiques préventives, en complément de l’approche classique par questionnaire. L’objectif de ce travail est d’analyser les opinions concernant la vaccination contre les papillomavirus humains (HPV), exprimées par les internautes sur le...

La vaccination contre les infections à papillomavirus humains fait actuellement l’objet de polémiques médiatisées. La Direction générale de la santé a demandé au HCSP de faire une revue des dernières données scientifiques et de préciser les conditions dans lesquelles la vaccination HPV pourrait aussi apporter une protection collective par immunité...

Decree No. 2012-1116 of 2 October 2012 on medico-economic assignments of the French National Authority for Health (Haute autorité de santé, HAS) significantly alters the conditions for accessing the health products market in France. This paper presents a theoretical framework for interpreting the results of the economic evaluation of health technol...

Résumé Le décret n° 2012-1116 du 2 octobre 2012 relatif aux missions médico-économiques de la Haute autorité de santé modifie significativement les conditions d’accès au marché des biens de santé en France. Cet article présente le cadre théorique d’interprétation des résultats de l’évaluation économique des technologies de santé et synthétise les é...

This paper investigates the reliability of self-assessed measures of health using panel data collected in Albania by the World Bank from 2002 to 2004 through the Living Standard Measurement Study project. As the survey includes questions on the usual self-assessed measure of health and on more objective health problems, we combine both types of inf...

Background Economic costs related to treatment of multiple sclerosis (MS) must be justified by health state, quality of life (QOL) and social participation improvement. This study aims to describe correlations between social participation, economic costs, utility and MS-specific QOL in a sample of patients with MS (pwMS). Methods We interviewed 42...

Innovative medical devices offer solutions to medical problems and greatly improve patients' outcomes. Like National Health Technology Assessment (HTA) agencies, hospitals face numerous requests for innovative and costly medical devices. To help local decision-makers, different approaches of hospital-based HTA (HB-HTA) have been adopted worldwide....

Objectif.– La compréhension de la dynamique de transmission de l’infection génitale par les papillomavirus humains passe par la modélisation de l’histoire naturelle de la vie sexuelle, décomposée dans notre modèle individus-centré en trois étapes : l’initiation sexuelle, l’appariement et le renouvellement de partenaire. Ce travail propose une métho...

The participants in round table 6 of the Giens Workshops 2012 drafted recommendations based on the collective interpretation of important elements of the decree concerning the medico-economic evaluation of health products published a few days earlier (02 October 2012). The medico-economic evaluation (MEE), becomes an additional determinant for fixi...

Résumé Les participants de la table ronde N° 6 des Ateliers de Giens 2012 ont élaboré des recommandations sur la base de l’interprétation collective des éléments importants du décret relatif à l’évaluation médico-économique des produits de santé paru quelques jours auparavant (le 2 octobre 2012). L’évaluation médico-économique (EME), en hiérarchisa...

In infected incisional ventral hernias (IVHs), the use of a synthetic non-absorbable mesh is not recommended and biological meshes hold promise. However, the level of evidence for their safety and efficacy remains low. The SIMBIOSE trial is a multicenter, phase III, randomized, controlled trial comparing the use of a biological mesh versus traditio...

This article analyses the heterogeneous character of compensation amounts awarded by insurance companies and the courts. The information source – the Association for Insurance Risk Information (AGIRA) database – covers all surviving victims of injuries resulting from road accidents in France over the period 2002 to 2008. Three results emerge: first...

Innovative medical devices offer solutions to medical problems and greatly improve patients’ outcomes. Like National Health Technology Assessment (HTA) agencies, hospitals face numerous requests for innovative and costly medical devices. To help local decision-makers, different approaches of hospital-based HTA (HB-HTA) have been adopted worldwide....

Introduction: As for other vaccines that only target a subset of circulating pathogen types, human papillomavirus (HPV) immunization raises the concern of a potential risk of genotype replacement. Potential interactions between HPV types may affect infection acquisition and clearance. However, the existence and the nature of these interactions are...

Introduction.– L’infection par les papillomavirus humains à haut risque oncogène provoque des lésions néoplasiques de l’épithélium génital dont la persistance mène au cancer du col utérin. Plusieurs facteurs de risques individuels de cette infection sont déjà documentés, mais la compréhension globale de la dynamique de transmission requiert l’étude...

To assess the levels of primary care physicians' adherence to the 2010 French vaccination schedule against pertussis, measles-mumps-rubella (MMR), and pneumococcal infections in northern France. Two hundred forty-nine primary care physicians were questioned over the phone from February 15th to May 27th 2010. The total response rate was 61% (n=152)...

Objective To assess the levels of primary care physicians’ adherence to the 2010 French vaccination schedule against pertussis, measles-mumps-rubella (MMR), and pneumococcal infections in northern France. Methods Two hundred forty-nine primary care physicians were questioned over the phone from February 15th to May 27th 2010. Results The total re...

Sacral nerve modulation (SNM) is an established treatment for urinary and fecal incontinence in patients for whom conservative management has failed. This study assessed the outcome and cost analysis of SNM compared to alternative medical and surgical treatments. Clinical outcome and cost-effectiveness analyses were performed in parallel with a pro...

The deterrence of murders Econometric evidence using French panel data Ehrlich’s seminal work led to several econometric analyses on the deterrent effect of punishment. Our paper extends this literature by using original cross-section time-series covering the 30 French appeal court areas from 1988 to 1993. Because of a restricted access to the crim...

Ehrlich's seminal work led to several econometric analyses on the deterrent effect of punishment. Our paper extends this literature by using original crosssection time-series covering the 30 French appeal court areas from 1988 to 1993. Because of a restricted access to the crime data, we focus our attention on murders. Estimation results validate t...

Objectives The study's objective was to evaluate the adequacy of treatment to recommendations, for the management of pediatric malaria.MethodsA descriptive, retrospective, multicentre cohort study was conducted over a 7-year period (2000–2006) in 18 pediatric and infectious diseases units in northern France. All children, under 18 years of age, hav...

Dengue vaccines are currently in development and policymakers need appropriate economic studies to determine their potential financial and public health impact. We searched five databases (PubMed, EMBASE, LILAC, EconLit, and WHOLIS) to identify health economics studies of dengue. Forty-three manuscripts were identified that provided primary data: 3...

This contribution proposes an analysis of heterogeneity for damages awarded by insurance companies and judges. Data concerning non fatal injuries related to road accidents occurred in France over the 2002-08 period are used. The model shows three important outcomes. First the awards for incapacities, Pretium doloris, aesthetic damage and loss of am...

The study's objective was to evaluate the adequacy of treatment to recommendations, for the management of pediatric malaria. A descriptive, retrospective, multicentre cohort study was conducted over a 7-year period (2000-2006) in 18 pediatric and infectious diseases units in northern France. All children, under 18 years of age, having consulted in...

Prostate cancer (CaP) has become the most frequent cancer in France and represents the 4th cause of mortality by cancer. Main risk factors include age, family history, black ethnic origin and carcinogenesis results from interaction between environmental and endogen factors. This work aimed to review main data and strategic trends about evolution of...

Capitalizing on available data, we used a decision model to estimate the clinical and economic outcomes associated with early initiation of treatment with neuraminidase inhibitors in all patients with influenza-like illnesses ( ILI ) (systematic strategy) vs. only those at high risk of complications (targeted strategy). Systematic treatment of ILI...