Bennie Ten Haken

Bennie Ten Haken
University of Twente | UT · Institute for Biomedical Technology and Technical Medicine (MIRA)

Professor

About

227
Publications
19,173
Reads
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4,366
Citations
Citations since 2016
47 Research Items
1770 Citations
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Introduction
Bennie Ten Haken currently works at the Institute for Biomedical Technology and Technical Medicine (MIRA) , University of Twente. After his research on superconducting materials he made a switch to the field of physics for medicine and started a new research groep on Magnetic Detection & Imaging (MD&I)
Additional affiliations
January 2005 - present
University of Twente
Position
  • Ass. Professor

Publications

Publications (227)
Article
Full-text available
Background A procedure for sentinel lymph node biopsy (SLNB) using superparamagnetic iron-oxide (SPIO) nanoparticles and intraoperative sentinel lymph node (SLN) detection was developed to overcome drawbacks associated with the current standard-of-care SLNB. However, residual SPIO nanoparticles can result in void artefacts at follow-up magnetic res...
Conference Paper
A recently developed prototype (Laparoscopic Differential Magnetometer, in short LapDiffMag) identifies magnetic tracer accumulated inside sentinel lymph nodes (SLNs) during clinical laparoscopic procedures. The LapDiffMag relies on excitation of superparamagnetic iron oxide nanoparticles (SPIONs) and subsequent laparoscopic detection based on a no...
Article
En-bloc tumor resection is the standard treatment for locally advanced colorectal cancer (CRC). An extensive histopathological assessment is necessary to evaluate the metastatic spread and adjuvant therapy. Sentinel lymph node biopsy decreases the histopathological burden when only sentinel lymph nodes (SLNs) are examined. This study aims to evalua...
Article
Background: Cerebral venous pathways are subjected to geometrical and patency changes due to body position. The internal jugular veins (IJVs) are the main venous drainage pathway in supine position. Their patency and geometry should be evaluated under different body inclination angles over a three-dimensional (3D) volume in the healthy situation t...
Article
Full-text available
A magnetic sentinel lymph node biopsy ((SLN)B) procedure has recently been shown feasible in oral cancer patients. However, a grading system is absent for proper identification and classification, and thus for clinical reporting. Based on data from eight complete magnetic SLNB procedures, we propose a provisional grading system. This grading system...
Article
Full-text available
The efficient development and utilisation of magnetic nanoparticles (MNPs) for applications in enhanced biosensing relies on the use of magnetisation dynamics, which are primarily governed by the time-dependent motion of the magnetisation due to externally applied magnetic fields. An accurate description of the physics involved is complex and not y...
Article
Background: There is a transition from wire-guided localization (WGL) of non-palpable breast cancer to other localization techniques. Multiple prospective studies have sought to establish superior clinical outcomes for radioactive-seed localization (RSL), but consistent and congruent evidence is missing. Methods: In this study, female patients w...
Article
Full-text available
Objectives To assess the feasibility and merits of a complete magnetic approach for a sentinel lymph node biopsy (SLNB) procedure in oral cancer patients. Materials and methods This study included ten oral cancer patients (stage cT1-T2N0M0) scheduled for elective neck dissection (END). Superparamagnetic iron oxide nanoparticles (SPIO) were adminis...
Article
Full-text available
Recently, there has been a renewed interest in low-field MRI. Contrast agents (CA) in MRI have magnetic behavior dependent on magnetic field strength. Therefore, the optimal contrast agent for low-field MRI might be different from what is used at higher fields. Ultra-small superparamagnetic iron-oxides (USPIOs), commonly used as negative CA, might...
Article
Full-text available
Objective: Sentinel lymph node harvesting is an essential step in the surgical treatment of a growing number of malignancies. Various techniques are available to facilitate this purpose. The present study reports a new laparoscopic technique for lymph node harvesting using magnetic nanoparticles containing a superparamagnetic iron-oxide core and d...
Article
Full-text available
Background Low oesophageal temperatures (OTs) during cryoballoon pulmonary vein isolation (PVI) have been associated with complications. This study assessed the incidence of low OT in clinical practice during cryoballoon PVI and verified possible predictive values for low OT. Methods Consecutive patients who underwent PVI using the second-generati...
Article
Full-text available
Superparamagnetic iron oxide nanoparticles (SPIONs) are promising for clinical applications, because they have a characteristic nonlinear magnetic response when an external magnetic field is applied. This nonlinearity enables the distinct detection of SPIONs and makes measurements less sensitive to the human body and surgical steel instruments. In...
Article
Full-text available
Sentinel lymph node biopsy (SLNB) is a diagnostic staging procedure that aims to identify the first draining lymph node(s) from the primary tumor, the sentinel lymph nodes (SLN), as their histopathological status reflects the histopathological status of the rest of the nodal basin. The routine SLNB procedure consists of peritumoral injections with...
Article
Full-text available
Background: In the 123-study we prospectively assessed, in a randomized fashion, the minimal cryoballoon application time necessary to achieve pulmonary vein (PV) isolation (PVI) in patients with paroxysmal atrial fibrillation (AF) with the aim to reduce complications by shortening the application duration. The first results of this study demonstr...
Article
Full-text available
This pilot study explored the value of localized index node removal after neoadjuvant immunotherapy in patients with stage III melanoma, for use as a response indicator to guide the extent of completion lymph node dissection. Promising technology
Article
Full-text available
Superparamagnetic iron oxide nanoparticles (SPIONs) are used as a tracer material in sentinel node biopsies. The latter is a procedure to analyze if cancer cells have spread to lymph nodes, helping to personalize patient care. To predict SPION behavior in vivo, it is important to analyze their magnetic properties in biological environments. The sup...
Article
Full-text available
Background The second generation cryoballoon significantly improves outcome of pulmonary vein (PV) isolation (PVI) but may cause more complications than the first generation. Currently no consensus regarding optimal cryoballoon application time exists. The 123‐study aimed to assess the minimal cryoballoon application duration necessary to achieve P...
Poster
Full-text available
The aim of this study is to develop a novel laparoscopic probe for magnetic sentinel node biopsy. The latter is a procedure to determine if a tumor has metastasized via the lymphatic system, enabling personalized patient care.
Article
Full-text available
Background: Roentgen stereophotogrammetric analysis (RSA) is used to measure early prosthetic migration and to predict future implant failure. RSA has several disadvantages, such as the need for perioperatively inserted tantalum markers. Therefore, this study evaluates low-field MRI as an alternative to RSA. The use of traditional MRI with prosthe...
Article
Full-text available
Purpose To compare diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM), and tri-exponential models of the diffusion magnetic resonance imaging (MRI) signal for the characterization of renal lesions in relationship to histopathological findings. Methods Sixteen patients planned to undergo nephrectomy for kidney tumour were scanned b...
Article
A novel probe for laparoscopic in vivo detection of superparamagnetic iron oxide nanoparticles (SPIONs) has been developed. The main application for in vivo detection of SPIONs our research group aims at is sentinel node biopsy. This is a method to determine if a tumor has spread through the body, which helps to improve cancer patient care. The met...
Article
For small, early-stage or otherwise non-palpable breast tumors, surgeons rely on localization technologies to accurately find and remove the tumor tissue during breast conserving surgery. However, current widely accepted localization technologies either use painful and logistically challenging guidewires, or complex radioactive iodine sources. We h...
Article
Background: The rate of retear after rotator cuff surgery is 17%. Magnetic resonance imaging (MRI) scans are used for confirmative diagnosis of retear. However, because of the presence of titanium suture anchors, metal artefacts on the MRI are common. The present study evaluated the diagnostic value of MRI after rotator cuff tendon surgery with re...
Article
Full-text available
Objectives: Accurate tumour localisation is essential for breast-conserving surgery of non-palpable tumours. Current localisation technologies are associated with disadvantages such as logistical challenges and migration issues (wire guided localisation) or legislative complexities and high administrative burden (radioactive localisation). We pres...
Conference Paper
Full-text available
PURPOSE The talking toilet (TT) is a home uroflowmeter designed for children that gives objective scores to flows and produces immediate spoken feedback to the child. Analysis of the TT uroflow curves of children with dysfunctional voiding, showed that, in a tertiary centre setting with patients, refractory to earlier treatment in a secondary setti...
Article
Objectives. To assess the feasibility of a new wearable, wireless ultrasonic device, the URIKA bladder monitor (UBM), in the detection of a full bladder in children with dysfunctional voiding (DV). Methods. This observational study included 14 children with DV who were subjected to an UBM monitoring session of 1.5–2 h. Transabdominal ultrasound (TU...
Article
Full-text available
Carbon nanotubes (CNTs) are increasingly being developed for use in biomedical applications, including drug delivery. One of the most promising applications under evaluation is in treating pulmonary diseases such as tuberculosis. Once inhaled or administered, the nanoparticles are likely to be recognised by innate immune molecules in the lungs such...
Article
Sentinel lymph node biopsy has become a staple tool in the diagnosis of breast cancer. By replacing the morbidity-plagued axillary node clearance with removing only those nodes most likely to contain metastases, it has greatly improved the quality of life of many breast cancer patients. However, due to the use of ionizing radiation emitted by the t...
Article
Full-text available
Purpose: To evaluate if a three-component model correctly describes the diffusion signal in the kidney and whether it can provide complementary anatomical or physiological information about the underlying tissue. Materials and methods: Ten healthy volunteers were examined at 3T, with T2 -weighted imaging, diffusion tensor imaging (DTI), and intr...
Article
Background: The standard for sentinel lymph node biopsy (SLNB), the dual technique (radiolabelled tracer and blue dye), has several drawbacks. A novel magnetic technique without these drawbacks has been evaluated in a number of clinical trials. It uses a magnetic tracer and a handheld magnetometer to identify and excise sentinel lymph nodes. A sys...
Conference Paper
Full-text available
PURPOSE Children with dysfunctional voiding (DV) often experience a reduced or loss of bladder sensation. For this reason, a wearable ultrasonic bladder monitor, the URIKA Bladder Monitor (UBM), is developed. This device detects a full bladder before voiding and alarms the user to prevent urinary leakage. In this study, the aim is to determine the...
Article
Aim: Nodal status is the most important prognostic factor in colorectal cancer (CRC). Small occult metastases may remain undetected on conventional histopathological examination, potentially resulting in undertreatment. Ex vivo sentinel lymph node mapping (SLNM) can be used to improve nodal staging accuracy, but currently used tracers suffer from...
Article
Purpose: The use of a magnetic nanoparticle tracer and handheld magnetometer for sentinel lymph node biopsy (SLNB) was recently introduced to overcome drawbacks associated with the use of radioisotope tracers. Unlike the gamma probe, the used magnetometers are not only sensitive to the tracer, but also the diamagnetic human body. This potentially...
Article
Full-text available
Purpose: To compare the clinical benefit of robust optimized Intensity Modulated Proton Therapy (minimax IMPT) with current photon Intensity Modulated Radiation Therapy (IMRT) and PTV-based IMPT for head and neck cancer (HNC) patients. The clinical benefit is quantified in terms of both Normal Tissue Complication Probability (NTCP) and target cove...
Data
Target volumes and organ at risks objectives. (DOCX)
Data
Average optimization dose objectives used for IMRT and minimax IMPT. (DOCX)
Article
Full-text available
Background and purpose: Both hemodynamics and aneurysm wall thickness are important parameters in aneurysm pathophysiology. Our aim was to develop a method for semi-quantitative wall thickness assessment on in vivo 7T MR images of intracranial aneurysms for studying the relation between apparent aneurysm wall thickness and wall shear stress. Mate...
Article
BACKGROUND AND OBJECTIVES: To determine prognosis and treatment, accurate nodal staging is essential in many tumor types. After injection of clinical grade superparamagnetic iron oxide (SPIO) nanoparticles, it has been shown that metastatic lymph nodes can be distinguished from benign specimens using MR imaging. However, MR does not benefit per-ope...
Article
Full-text available
Spreading depression (SD) is a wave phenomenon in gray matter tissue. Locally, it is characterized by massive re-distribution of ions across cell membranes. As a consequence, there is a sustained mem- brane depolarization and tissue polarization that depresses any normal electrical activity. Despite these dramatic cortical events, SD remains diffic...
Article
Objective: Sentinel Lymph Node Biopsy (SLNB) with a superparamagnetic iron oxide (SPIO) tracer was shown to be non-inferior to the standard combined technique in the SentiMAG Multicentre Trial. The MRI subprotocol of this trial aimed to develop a magnetic alternative for pre-operative lymphoscintigraphy (LS). We evaluated the feasibility of using...
Conference Paper
PURPOSE: In the Netherlands, the prevalence of daytime incontinence affects 6-9% of the children older than four year old. Dysfunctional voiding (DV) refers to children who do not develop or even lose the ability to consciously recognize a full bladder. An ultrasonic bladder monitor which is able to sense the bladder filling and is capable of alarm...
Article
A systematic review was undertaken to assess the clinical efficacy of non-invasive high-intensity focused ultrasound (HIFU) ablation in the treatment of breast cancer. MEDLINE/PubMed library databases were used to identify all studies published up to December 2013 that evaluated the role of HIFU ablation in the treatment of breast cancer. Studies w...
Article
Full-text available
Breast fibroadenomata (FAD) are the most common breast lesions in woman. For palpable lesions, three options are available: reassurance (with or without follow-up), vacuum assisted mammotome (VAM) or surgical excision. High intensity focused ultrasound (HIFU) is a non-invasive ablative technique in which an ultrasound (US) beam propagates through t...
Article
The increasing interest for local detection of magnetic nanoparticles (MNPs) during clinical interventions requires the development of suitable probes that unambiguously detect the MNPs at a depth of several centimeters in the body. The present study quantitatively evaluates the limitations of a conventional magnetometry method using a sinusoidal a...
Article
The magnetic technique for sentinel lymph node biopsy (SLNB) has been evaluated in several clinical trials. An in vivo porcine model was developed to optimise the magnetic technique by evaluating the effect of differing volume, concentration and time of injection of magnetic tracer. A total of 60 sentinel node procedures were undertaken. There was...
Article
Full-text available
Breast cancer staging with sentinel lymph node biopsy relies on the use of radioisotopes, which limits the availability of the procedure worldwide. The use of a magnetic nanoparticle tracer and a handheld magnetometer provides a radiation-free alternative, which was recently evaluated in two clinical trials. The hydrodynamic particle size of the us...
Article
Full-text available
Nanoparticles are attractive drug delivery vehicles for targeted organ-specific as well as systemic therapy. However, their interaction with the immune system offers an intriguing challenge to the success of nanotherapeutics in vivo. Recently, we showed that pristine and derivatised carbon nanotubes (CNT) can activate complement mainly via the clas...
Article
Purpose: To correlate T1-weighted (T1w) magnetic resonance (MR) image contrast around a cryoablation iceball with temperature in a phantom study and to compare this to its in vivo appearance during MR-guided focal cryoablation of prostate cancer. Methods: A MR-compatible cryoneedle was inserted into identical gel phantoms (n = 3) on a 1.5 T MR s...