Benjamin Thomas Schleenvoigt

Friedrich Schiller University Jena | FSU · Center of Infectious Diseases and Hospital Epidemiology

Streptobacillus moniliformis is the main cause of human streptobacillosis, also known as rat-bite or Haverhill fever. A correct diagnosis might be delayed due to scarcity, non-specific symptoms, and difficulties in cultivating this fastidious organism. We report on an 85-year-old man with periprosthetic streptobacillosis, which manifested itself in...

There are few data on mortality after discharge with community-acquired pneumonia (CAP). Therefore, we evaluated risk factors for 30-day post-discharge mortality after CAP. We included all patients of the prospective multi-national CAPNETZ study between 2002 and 2018 with (1) hospitalized CAP, (2) survival until discharge, and (3) complete follow-u...

Background Streptobacillus moniliformis is the main cause of human streptobacillosis, also known as rat-bite or Haverhill fever. Generally transferred by bites or scratches of rats and other rodents or by rat-excrement polluted water, symptoms commonly start to appear after < 10 days and are highly variable. Due to scarcity, non-specific symptoms,...

Zusammenfassung Hintergrund Über die qualitative Bedeutung der testenden Zentren im Gesundheitswesen ist wenig bekannt, gleichzeitig stellen die Late-Presenter eine immer noch große Gruppe bei den HIV-Erstdiagnosen. Ziel der Arbeit Analyse des Einflusses von Testzentren und -grund auf die Prävalenz von HIV-Erstdiagnosen und Late-Presentation, exemp...

Background: Infections, as well as adverse birth outcomes, may be more frequent in migrant women. Schistosomiasis, echinococcosis, and hepatitis E virus (HEV) seropositivity are associated with the adverse pregnancy outcomes of fetal growth restriction and premature delivery. Methods: A cohort study of 82 pregnant women with a history of migrati...

Purpose: Thorough knowledge of the nature and frequency of co-infections is essential to optimize treatment strategies and risk assessment in cases of coronavirus disease 2019 (COVID-19). This study aimed to evaluate the multiplex polymerase chain reaction (PCR) screening approach for community-acquired bacterial pathogens (CABPs) at hospital admi...

Leptospirosis is an infectious disease with an increasing incidence worldwide. The clinical presentation is unspecific and ranges from an asymptomatic clinical course to an acute fulminant disease. The current case report describes a 32-year-old male patient who presented with ST segment elevation in the electrocardiogram about 14 days after cross-...

Background Migrant women may have an increased risk of adverse birth outcomes. This study analyses the occurrence of low birth weight, preterm birth and intrauterine growth restriction / fetal growth restriction (IUGR/FGR) in pregnant migrants. Method Cross-sectional study of 82 mother-child pairs of pregnant migrants attending medical care in Ger...

Around 88,000 people in Germany live with an HIV (human immunodeficiency virus) infection. The proportion of those over 50 is around 30% and it has now become more likely that an older HIV-positive patient with other pre-existing illnesses will have to be treated in an intensive care unit (ICU) for a reason not directly associated with HIV than a p...

Introduction: HIV-PrEP (HIV-Pre-Exposure Prophylaxis) has been available through German pharmacies in various package sizes since 2017. It can be used for daily dosing or as an intermittent product used as required. Aim: The aim of this survey was to record socio-demographic basic characteristics, the respondents' medical history regarding STI (...

[This corrects the article DOI: 10.1371/journal.pntd.0008183.].

Background: Migrant women may have an increased risk of adverse birth outcomes. This study analyses the occurrence of low birth weight, preterm birth and intrauterine growth restriction (IUGR) in pregnant migrants. Method: Cross-sectional study of 82 mother-child pairs of pregnant migrants attending medical care in Germany. Results: Median age was...

Shiga toxin–producing Escherichia coli (STEC) and Shigella spp./enteroinvasive E. coli (EIEC) are common diarrheagenic bacteria that cause sporadic diseases and outbreaks. Clinical manifestations vary from mild symptoms to severe complications. For microbiological diagnosis, culture confirmation of a positive stool screening PCR test is challenging...

Die HIV-Infektion ist besonders für Frauen bis heute mit Stigmatisierung verbunden. Schwangerschaft und Mutterschaft HIV-infizierter Frauen gehen daher mit Tabuisierung und Ängsten einher. Dank heutiger antiretroviraler Therapie (ART) konnte die Mutter-Kind-Transmissionsrate auf < 1% gesenkt werden [1], [2]. Dieses Ziel ist nur zu erreichen, wenn G...

According to the Robert Koch Institute, the estimated HIV prevalence in Germany is 86 100. On-third of the affected persons is over 50 years old. Overall, the prognosis of patients with HIV infection depends crucially on the time of diagnosis. The unfounded stigmatization of affected patients stands in the way of today's treatment options as it did...

Impfen ist insbesondere bei immundefizienten Patienten eine wichtige Schutzmaßnahme. Welche Impfungen sind unproblematisch, welche müssen gut abgewogen werden? Welches Vorgehen ist vor geplanter Immunsuppression empfehlenswert?

1966 verstirbt ein 39-jähriger Akademiker. Die Genese seiner Erkrankung bleibt ungeklärt. Dabei könnte es sich um einen der ersten AIDS-Fälle in Deutschland gehandelt haben. Die wegweisenden Indizien fasst dieser Artikel zusammen.

Im Alter wird der Mensch anfälliger für Infektionen, weshalb ein Impfschutz immer wichtiger wird. Allerdings ist die Impfantwort bei alten Menschen oft reduziert. Wie man dieser Tatsache begegnen kann und welche Impfungen sinnvoll sind, erfahren Sie hier.

Background: Here, we report the case of an HIV positive patient under a dual antiretroviral drug regimen with tenofovir disoproxil and darunavir/ritonavir with stable clinical, virological, and immunological response over 126 weeks. Dual antiretroviral therapy has the advantage of reduced toxicity and lower health care costs, treatment failure and...

Eosinophilia can be caused by a variety of diseases including allergies, autoimmune diseases, vasculitides, dermatoses, malignancies and drug-induced side effects as well as parasitic and non-parasitic infections. In patients returning from the tropics parasitic infections are the most frequent cause of eosinophilia. The extent of eosinophilia can...

Purpose Refugees often live in confined housing conditions with shared kitchen and sanitary facilities, rendering susceptible to communicable diseases. We here describe the outbreak, spread and self-limiting nature of a norovirus outbreak in a German refugee camp in the winter of 2015. Methods During a norovirus outbreak, data on clinical symptoms,...

Zusammenfassung Im Jahr 2016 wurden in Deutschland mehr als 700 000 Asylerstanträge gestellt. Das häufigste Herkunftsland war Syrien. Der Anteil weiblicher Migranten lag in verschiedenen Betrachtungen zwischen 20 und 35 %. Mit schwangeren Migrantinnen muss in 3,5 % gerechnet werden. In dieser vulnerablen Patientengruppe sollte gezielt nach Risikofa...

Schistosomiasis in pregnancy may cause low birth weight, prematurity and stillbirth of the offspring. The placenta of pregnant women might be involved when schistosome ova are trapped in placental tissue. Standard histopathological methods only allow the examination of a limited amount of placental tissue and are therefore not sufficiently sensitiv...

Study purpose According to the Robert Koch Institute, 84,700 people in Germany suffer from HIV infection. One-third of the affected persons is over 50 years old. In Germany, community-acquired pneumonia (CAP) is a widespread disease with more than 250,000 cases per year. Incidence and mortality increase with the age of the affected individuals. For...

Purpose The current extent of migration poses emerging socio–economic and humanitarian challenges. Little is known on vaccination rates in migrants entering Europe, and the implementation of guidelines for serological testing and vaccination of refugees are pending. Methods We conducted seroprevalence analyses for measles, mumps, rubella and varice...

The objective of this study was to review the management of patients with influenza during the influenza season 2014/2015 (n = 197). Our study revealed a high rate of healthcare-associated influenza infection (35.5 %) and a correlation between the total number of patients with HA influenza and the number of nurses on sick leave. The results of the...

We report the case of a 59-year-old patient who accidentally underwent live vaccination against yellow fever during continuous treatment with the TNF-α-antibody (AB) infliximab for ulcerative colitis. The clinical course showed fever of short duration and elevation of liver enzymes without further clinical complications. Yellow fever viremia was no...

Background Only estimations are available with respect to the seroprevalence of hepatitis C in refugees arriving in Germany during the current refugee exodus. It is unknown if refugees have a higher prevalence than the German population and if routine testing is necessary. Objectives The prevalence of viral hepatitis C infection in refugees arrivin...

We report on a case of a 48 year old man who presented with acute Q fever infection after having buried two fawn cadavers (Capreolus capreolus). Recent outbreaks of Q fever in Europe have been traced back to intensive goat breeding units, sheep flocks in the proximity of highly populated urban areas or to farmed deer. To the best of our knowledge t...

Here, we report on a case of VL in an HIV-infected patient from the Republic of Georgia who had moved to Germany 14 years before and who had travelled several times to southern Europe in between. After presenting with typical Pneumocystis jiroveci pneumonia, which was treated appropriately, the patient was started on antiretroviral therapy. Shortly...

Ross River virus (RRV) is an arbovirus transmitted by Aedes and Culex mosquitos. It is endemic in Australia, New Zealand and south-east Asia. Clinical manifestation rates in adults range about 20-40 %. Symptoms involve arthralgia, myalgia, lymphadenopathy, fever and rash. Here we report a case of RRV in a Thuringian traveller who visited the urban...

Schistosomiasis is a widespread helminthic infection which sometimes may affect travelers to endemic areas. We report on a case of urogenital and placental schistosomiasis in a 28-year-old German woman who had been exposed to schistosomiasis in Lake Malawi one year earlier. She experienced painless macrohaematuria in her 21st week of pregnancy. Cys...

Long and short term side effects of antiretroviral drugs are not fully understood yet. Here a case of reversible blood count changes following post exposure prophylaxis with tenofovir/emtricitabin and lopinavir/ritonavir is reported. We propose that antiretroviral drugs used in post exposure prophylaxis may have a significant impact on hematopoiesi...

History and clinical findings: After a trivial injury, a male patient from India presented with a non-healing minor injury. A necrotic lesion at the right medial ankle was evident. Examinations: Mycobacterium tuberculosis complex was detected from tissue material both in cultures and by molecular markers. Sonography of the abdomen indicated a re...

A 61-year-old female patient presented with multiple tick bites. Some of them turned into skin ulcera. The patient acquired the tick bites during a stay in South Africa for several weeks. EXAMINATIONS AND DIAGNOSIS: According to the history and typical skin manifestations, a tick borne infection (rickettsiosis) was diagnosed and serologically confi...

Nephrotoxicity is observed in 1.6 % of patients treated with tenofovir disoproxil fumarat (Fux 2007).