Benjamin Sandler

• Reproductive Medicine Associates of New York

Study question: Do infertile couples who recently utilized clomiphene citrate (CC) for ovulation induction or ovarian stimulation (<90 days previously) followed by a single euploid embryo transfer (SEET) have lower implantation potential compared with patients who were not exposed to CC within 90 days before embryo transfer (ET)? Summary answer:...

Study question Can implantation failure (IF) and pregnancy loss be predicted in serum prior to in vitro fertilization (IVF)? Summary answer Tumor necrosis factor (TNFα) and milk fat globule-epidermal growth factor 8 (MFG-E8) levels may serve as serum markers to predict IF and pregnancy loss. What is known already In a normal pregnancy, mediators...

Study question Do progesterone (P) levels the day after trigger for oocyte maturation impact the oocyte recovery rate? Summary answer A progesterone cutoff value of ≤ 5.0 ng/ml the day after trigger for oocyte maturation is associated with a lower oocyte recovery rate. What is known already Oocyte maturation and embryo development are controlled...

Objective To analyze the correlation between TE grading and initial β-hCG serum level after single euploid embryo transfer. Secondarily, to explore the association between TE grading with subsequent IVF outcomes. Design Retrospective cohort analysis. Setting Single, academic, private infertility and assisted reproductive care institute. Patients...

Study question Does the use of double dose of GnRH antagonists during COH in women with risk of premature LH surge alter luteinization after final oocyte maturation induction? Summary answer The use of double dose of GnRH antagonist in women with risk of premature luteinizing hormone surge dosent affect luteinization after final oocyte maturation...

Objective: Although chromosomal heteromorphisms are commonly found in the general population, some researchers have suggested a correlation with higher rates of embryo aneuploidy. This study aimed to assess the rates of embryo aneuploidy in couples who carry a chromosome heteromorphism. Methods: The study included couples who had G-banding karyo...

Objective The coronavirus (COVID-19) pandemic has forever reshaped the United States health care system. However, assisted reproductive technology (ART) treatment remains an essential form of medicine. Reproductive practices have since incorporated vigilant practices regarding social distancing, ample use of Personal Protective Equipment (PPE), and...

Objective Elevation of progesterone (P) during day 3 of a menstrual cycle is an uncommon phenomenon during ovarian stimulation cycles. Incomplete luteolysis, endogenous P production by the adrenals and ovarian aging have been described as potential causes of baseline progesterone elevation (BPE). Some authors have postulated that BPE predicts decre...

Objective PGT-A with NGS is broadly utilized by reproductive specialists at modern ART treatment centers to improve embryo transfer selection. However, there are technical limitations to PGT which might prevent formal designation of the embryo as euploid or aneuploid. While re-biopsy of the embryo is possible, some studies suggesting that the selec...

OBJECTIVE: To compare obstetrical and neonatal outcomes following single embryo transfer (SET) versus (vs.) multiple embryo transfer (MET) from frozen-thawed embryo transfer cycles (FET) of autologous pre-implan-tation genetic tested for aneuploidy (PGT-A) embryos. DESIGN: Retrospective cohort study from the SART CORS national database. MATERIALS A...

(Abstracted from Hum Reprod 2020;35:1889–1899) Although the physiologic mechanism remains unclear, late follicular phase progesterone elevation (LFPE) commonly occurs during controlled ovarian hyperstimulation (COH) for assisted-reproductive technology (ART) such as in vitro fertilization (IVF). Late follicular phase progesterone elevation has been...

Los índices elevados de fragmentación del ADN espermático no se asocian con escasa blastulación o aumento de aneuploidía embrionaria en tratamientos de fertilización in vitro Resumen OBJETIVO: Analizar la relación entre el índice de fragmentación del ADN espermático y el desarrollo embrionario; además, las tasas de euploidía embrionaria en una pobl...

Study question: What is the impact of a late follicular phase progesterone elevation (LFPE) during controlled ovarian hyperstimulation (COH) on embryonic competence and reproductive potential in thaw cycles of preimplantation genetic testing for aneuploidy (PGT-A) screened embryos? Summary answer: Our study findings suggest that LFPE, utilizing...

Study question: Does hysteroscopic endometrial peeling improve reproductive outcomes in women with implantation failure? Summary answer: Women with implantation failure may benefit from intraoperative endometrial peeling prior to a frozen embryo transfer (FET). What is known already: Trials on endometrial scratching with pipelle and diagnostic h...

Study question: Does endometrial receptivity analysis (ERA) test offer clinical utility in patients with recurrent pregnancy loss (RPL)? Summary answer: Women with RPL may benefit from a personalized adjustment in timing of frozen embryo transfer. What is known already: Successful embryo implantation requires an appropriate embryonic development...

Objective: Genetic carrier screening has the potential to identify couples at risk of having a child affected with an autosomal recessive or X-linked disorder. However, the current prevalence of carrier status for these conditions in developing countries is not well defined. This study assesses the prevalence of carrier status of selected genetic...

OBJETIVO: Revisar la bibliografía de la prevalencia, factores de riesgo, síntomas, diagnósticos y tratamiento de las pacientes con istmocele. MÉTODO: Búsqueda electrónica en las bases de datos: PubMed, EMBASE y Google Scholar. Se utilizaron los siguientes términos, palabras y sus combinaciones: “Cesarean section defect, uterine niche, isthmocele,...

Objective To analyze outcomes of IVF treatment among women diagnosed with an ovarian dermoid cyst (DC). Methods Retrospective analysis of women with an ovarian DC who underwent IVF with fresh blastocyst transfer at a single center in New York from January 2010 to March 2018. Outcomes were compared between women with conservative treatment and thos...

To assess clinical outcomes of females diagnosed with Inflammatory Bowel Disease (IBD) and infertility, which underwent in vitro fertilization (IVF) with preimplantation genetic testing for aneuploidy. (PGT-A). Retrospective cohort study comparing clinical outcomes of patients with Inflammatory bowel disease who underwent IVF with PGT-A with a subs...

Study question: What is the rate of euploidy and the reproductive potential of embryos biopsied after 6 days of development? Summary answer: Embryos biopsied after 6 days of development have higher rates of aneuploidy; however, day 7 euploid embryos selected at transfer can achieve acceptable pregnancy rates and live birth (LB) outcomes. What i...

Efecto del tabaquismo en la fertilidad femenina y masculina Resumen El tabaquismo tiene un efecto nocivo en la salud causando daño multisistémico y aumentando el riesgo de distintas enfermedades. La fertilidad es una de las funciones biológicas que puede verse afectada; sin embargo, los mecanismos subyacentes de este problema siguen sin estar claro...

Study question:Do women with baseline hyperandrogenemia have differential ovarian response, oocyte maturation, and/or embryo quality as compared to normoandrogenemic women? Summary answer: Despite greater ovarian reserve, hyperandrogenemic patients had similar oocyte yield, blastulation, and aneuploidy compared to normoandrogenemic women. Hyperandr...

Study question: Does endometrial biopsy (EMB) and chronic endometritis (CE) screening offer clinical utility in patients following euploid embryo implantation failure? Summary answer: Patients, regardless of endometrial biopsy findings, have similar IVF outcomes on a subsequent treatment cycle as compared with patients who do not undergo endometria...

INTRODUCTION Patients who undergo surgical excision of a dermoid-cyst prior to in vitro fertilization may be at risk of resection of healthy ovarian tissue. Our objective was to analyze ovarian reserve, response to stimulation, and IVF success rates in patients with a dermoid-cyst versus those who underwent a cyst removal prior to undergoing IVF....

Objective: To investigate whether the duration of estrogen administration before euploid embryo transfer affects clinical outcome. Design: Retrospective cohort study. Setting: Private, academic fertility center. Patient(s): Patients (n = 1,439) undergoing autologous freeze-only in vitro fertilization with preimplantation genetic testing (PGT...

Title: THE PRESENCE OF MTHFR GENE POLYMORPHISMS IT’S NOT ASSOCIATED WITH IMPAIRED CLINICAL IVF OUTCOMES AFTER A EUPLOID EMBRYO TRANSFER. Authors: Carlos Hernandez-Nieto, MD1, Tamar Alkon, MD1; Jeffrey Klein MD1; Enrique Cervantes, MD1; Martha Luna-Rojas MD1; Alan B. Copperman, MD1; Benjamin Sandler, MD1,2 Affiliations: 1. Reproductive Medicine As...

Study question: What clinical factors are associated with optimal cryopreserved oocyte survival, fertilization, embryo culture, and transfer outcomes? Summary answer: The outcome of autologous oocyte vitrification-warming cycles is optimized in younger patients who undergo transfer of blastocyst-stage embryos.

Study question: Is reproductive outcome compromised in patients with IBD who undergo IVF with transfer of single euploid blastocyst? Study design, size, duration: This was a retrospective cohort study of patients who underwent IVF with preimplantation genetic testing and subsequent euploid single embryo transfer (SET) of a vitrified-warmed blastocy...

Objective: To study whether maternal exposure to selective serotonin reuptake inhibitors (SSRIs) has any influence on rates of blastocyst aneuploidy and/or in vitro fertilization (IVF) cycle outcomes. Design: Retrospective cohort analysis. Setting: Private and academic IVF center. Patient(s): Patients who underwent IVF with preimplantation g...

OBJECTIVE: To analyze the implantation and pregnancy rates in cycles of in vitro fertilization with elective transfer of a single blastocyst, with control of the embryonic factor by transfer of euploid embryos. MATERIALS AND METHODS: Retrospective analysis who included patients that underwent IVF and had at least one euploid embryo available for tr...

Pre-implantation genetic treatment (PGT) in good-prognosis patients increases clinical pregnancy rates and improves embryo selection. Unfortunately, some patients with diminished ovarian reserve do not produce enough biological material to realize the advantages of PGT. The aim of this study is to analyze clinical factors associated with impaired a...

Fertility and Sterility , Volume 107 , Issue 3 , e37 - e38

Background: This retrospective study evaluated the effect of profound pituitary suppression with oral contraceptive pill (OCP) pretreatment in gonadotropin-releasing hormone (GnRH) antagonist cycles stimulated with recombinant follicle stimulating hormone plus highly purified human menopausal gonadotropin. Methods: The analysis included women aged...

Objective: To evaluate outcomes of patients with unexplained infertility who underwent letrozole (LET)- stimulated controlled ovarian stimulation (COS) with timed sexual intercourse (IC) as compared to patients treated with clomiphene citrate (CC) and intrauterine insemination (IUI). Study design: A non- randomized, retrospective study where une...

STUDY QUESTION Do the reproductive outcomes from the transfer of fully hatched (FH) blastocysts differ from those of not fully hatched (NFH) blastocysts? SUMMARY ANSWER Biochemical pregnancy rate (BPR), implantation rate (IR), live birth rate (LBR) and early pregnancy loss (EPL) rate are similar in FH and NFH single euploid blastocyst embryo trans...

Introduction: The upper limit of normal TSH has been revised from 5 mIU/L to 2.5 mIU/L. We sought to evaluate IVF patients and the association between abnormal TSH and early pregnancy loss. Methods: A retrospective study of patients who had TSH levels measured within the 2 weeks prior to their fresh autologous IVF cycles (2002-2014). Cohorts wer...

Introduction: Analysis of ectopic pregnancies using traditional cytogenetic techniques has demonstrated a higher than expected increase in aneuploidy of these extrauterine implantation sites. Newer molecular techniques have greater diagnostic accuracy. We sought to evaluate the likeliness of a ectopic implantation of embryos that have undergone pr...

Purpose The aim of this study is to compare implantation and live birth rates (LBR) between fresh euploid embryo transfers versus cryo-all cycles with a subsequent embryo transfer into a prepared endometrium. Material and Methods This is a retrospective cohort study. Patients who underwent an IVF cycle with PGS with trophectoderm biopsy from Januar...

Background: Endometriosis is one of the most challenging clinical conditions for gynecologists. Associated pain and infertility are often difficult to manage, and current treatment strategies remain limited. Objective: This review reviews the current scientific evidence for general gynecologist and provides an overview of current information regard...

Elevated follicle stimulating hormone (FSH) is associated with poor vaginal oocyte retrieval (VOR) outcomes and cycle cancellations but intercycle variability in basal FSH reportedly does not predict ovarian response. We conducted a retrospective cohort study of basal FSH (n = 15573 cycles) in couples (n = 9132) who initiated IVF cycle(s) with basa...

Objective: To compare the incidence of numerical chromosomal abnormalities (NCAs) reported after preimplantation genetic screening (PGS) analysis compared with that reported after cytogenetic analysis of products of conception after spontaneous abortion. Design: Retrospective study. Setting: Private academic in vitro fertilization center. Pat...