Benjamin Rolland

Benjamin Rolland
Claude Bernard University Lyon 1 | UCBL · Addiction Medicine

M.D. / Ph.D. / Prof. of Addiction Medicine
Head of the Academic Department of Addiction Medicine of Lyon (Hospices Civils de Lyon & CH Le Vinatier)

About

290
Publications
81,009
Reads
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3,240
Citations
Introduction
Academic Department of Addiction Medicine for Lyon Urban Area, Hospices Civils de Lyon / CH Le Vinatier, Bron, France. Lyon Neuroscience Research Center (CRNL), Inserm U1028 / CNRS UMR5292, CH Le Vinatier, Univ Lyon, UCBL, Lyon, France.
Additional affiliations
September 2017 - February 2018
Centre Hospitalier Le Vinatier
Position
  • Head of Department
March 2017 - August 2017
Université Catholique de Louvain - UCLouvain
Position
  • PostDoc Position
September 2016 - February 2017
Université de Picardie Jules Verne
Position
  • PostDoc Position

Publications

Publications (290)
Preprint
Background Opioid Agonist Treatments (OAT), i.e., methadone and buprenorphine, are key elements in the treatment of opioid addiction. Moreover, they help foster healthcare behaviors and reduce medical harm in people who use opioid drugs (PWUD). Here, aimed to explore whether the percentage of time on OAT (pOAT) among PWUD with hepatitis C virus (HC...
Article
Introduction La prévention de la transmission du virus de l'hépatite C (VHC) chez les usagers de drogues par injection (UDI) est essentielle pour éliminer l'hépatite C en France. Le succès des traitements antiviraux à action directe (AAD) offre la possibilité d'éliminer le VHC dans cette population. Dans le contexte des AAD, une approche par modéli...
Article
Full-text available
Excessive alcohol consumption is the leading cause of liver diseases in Western countries, especially in France. Alcohol-related liver disease (ARLD) is an extremely broad context and there remains much to accomplish in terms of identifying patients, improving prognosis and treatment, and standardising practices. The French Association for the Stud...
Article
Full-text available
Over the last decade, one-month alcohol abstinence campaigns (OMACs) have been implemented within the general population in an increasing number of countries. We identified the published studies reporting data on OMACs to explore the following aspects: profile of participants, rates and factors associated with the completion of the abstinence chall...
Article
Background: Early liver transplantation for severe alcohol-related hepatitis is an emerging treatment option. We aimed to assess the risk of alcohol relapse 2 years after early liver transplantation for alcohol-related hepatitis compared with liver transplantation for alcohol-related cirrhosis after at least 6 months of abstinence. Methods: We c...
Article
Background: Alcohol and benzodiazepines are psychoactive substances frequently associated in voluntary drug intoxications that share common mechanisms of action, including facilitation of GABAergic transmission. Objective: To assess the separate and combined effects of ethanol and diazepam acute exposure on hippocampal metabolite levels, as well...
Article
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D epuis quelques années, le concept de réta-blissement (recovery chez les Anglo-Saxons) pénètre de plus en plus les unités de soins psychiatriques. Ce concept peut s'appliquer à des domaines cliniques aussi variés que la schizophrénie, la bipolarité, les troubles du comportement alimen-taire et, plus récemment, l'addictologie. Il est vrai que ce co...
Article
Background: Take-home naloxone (THN) helps to revert the medical consequences of an opioid overdose among people who use drugs (PWUD). In France, an intranasal THN was available from July 2016 to Dec 2020, which was directly dispensed in addiction centers, after a specific education program. However, this intranasal THN was subsequently removed fr...
Article
Full-text available
We aimed to examine the association between religious beliefs and observance and the prevalence of psychiatric disorders, psychotic symptoms and history of suicide attempts in the French general population. The cross-sectional survey interviewed 38,694 subjects between 1999 and 2003, using the MINI. Current religious beliefs and observance were ide...
Article
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In October 2018, France became the first country to officially approve baclofen for alcohol use disorder (AUD), even if the French Drug Agency (ANSM) officially stated that the efficacy of baclofen in AUD could be not established at this stage, in the light of the available evidence. The decision of the ANSM comprised obvious political aspects, as...
Article
Background: Gabapentinoids (i.e., gabapentin and pregabalin) are medications approved for epilepsy, chronic pain, or generalized anxiety disorder. Recently, there have been regular reports of misuse of pregabalin, and to a lesser extent, gabapentin, in particular among opioid and polydrug users. Objectives: To longitudinally explore the amounts of...
Article
Even though tobacco-induced sleep disturbances (TISDs) have been reported in previous studies, the present article is the first meta-analysis quantitatively assessing the impact of tobacco on sleep parameters. We conducted a systematic review and meta-analysis of the studies comparing objective (i.e. polysomnography and actigraphy) and/or subjectiv...
Article
Résumé En soixante ans, les benzodiazépines ont pris le relais des barbituriques et se sont imposées dans le monde entier. La France est l’un des plus gros consommateurs au monde avec plus de 13 % de sa population exposée à cette classe pharmacologique. Dans ce contexte de surconsommation, l’objectif de cet article est de rappeler, de façon synthét...
Article
Full-text available
Background: There is considerable unexplained variability in alcohol abstinence rates (AR) in the placebo groups of randomized controlled trials (RCTs) for alcohol dependence (AD). This is of particular interest because placebo responses correlate negatively with treatment effect size. Recent evidence suggests that the placebo response is lower in...
Article
Full-text available
Background and Aims: This work aims to assess the impact of the COVID-19 pandemic on hospital workers' psychological parameters and attitudes toward substance use, before and during the French COVID-19 lockdown. Methods: An online survey was proposed to the staff of the University Hospital of Nice and Sainte-Marie psychiatric hospital in France fro...
Article
Full-text available
Introduction: Smoking prevalence in the overall population in France was 27% in 2017. There are few data about smoking prevalence in hospital workers. The aim of this study was to assess prevalence of current smoking in student and staff populations at Lyon University Hospital. Secondary objectives were to identify main variables associated with c...
Conference Paper
Introduction: Alcohol dependence is the most severe stage of alcohol misuse. In France, the GABA-B receptor agonist baclofen has been used since 2008 to treat alcohol dependence. However, both efficacy and safety aspects of baclofen remain unclear in this indication [1]. Material and methods: BACLOPHONE (NCT02596763) is a multicentric phone-based...
Article
Background: Impulsivity is an important transdiagnostic feature of many psychiatric disorders, as well as a marker of poorer outcome. Topiramate is broadly used for reducing impulsivity in various neuropsychiatric disorders, but no systematic review or meta-analysis has ever explored whether evidence supports this clinical use. Methods: We condu...
Article
Full-text available
Purpose: Extended-release buprenorphine (XR-BUP) covers a range of formulations of buprenorphine-based treatments for opioid use disorder (OUD) that release the medication over a period of one week, one month, or six months. OUD is particularly prevalent among incarcerated populations, and previous findings have shown that incarcerated subjects we...
Article
Full-text available
Background Patients with psychiatric disorders are exposed to high risk of COVID-19 and increased mortality. In this study, we set out to assess the clinical features and outcomes of patients with current psychiatric disorders exposed to COVID-19. Methods This multi-center prospective study was conducted in 22 psychiatric wards dedicated to COVID-...
Article
L'impact sur la santé mentale de l'infection par le coronavirus SARS-CoV-2 et des restrictions de diverses natures mises en oeuvre pour lutter contre l'épidémie de Covid-19 à l'oeuvre en 2020 et en 2021, dont les périodes de confinement représentent l'acmé, a été mis en évidence par de nombreuses études en population générale. Une dégradation du bi...
Article
Opioid analgesic (OA) addiction occurs frequently among the elderly, and results in high morbidity and mortality due to geriatric pathologies associated with pharmacokinetic modifications. However, patients with this type of addiction are under-identified and specific screening tools should be more widely used to detect the risk factors for OA addi...
Article
Introduction and aims: Several questionnaires have been developed for screening cannabis use disorder (CUD) in clinical populations, but very few studies have compared the screening abilities of the different instruments. Here, we aimed to confirm the psychometric properties of a French version of the Cannabis Use Disorder Identification Test – Rev...
Article
Methylphenidate hydrochloride is an approved medication for attention deficit hyperactivity disorder (ADHD), and one the most‐used drugs in this indication [1]. Methylphenidate is an amphetamine derivative which modulates, among others, the dopaminergic neurotransmission pathways [2]. This pharmacological effect has been associated with specific sa...
Article
Full-text available
Introduction Les signaux d’addictovigilance portant sur la prégabaline se sont accentués depuis 2018, avec une hausse des notifications des mésusages de ce médicament [1]. Afin d’estimer la prévalence et d’évaluer les modalités d’usage de prégabaline au sein de leurs files actives respectives, 2 Centres de soins, d’accompagnement et de prévention e...
Article
Importance Growing evidence supports an association between attention-deficit/hyperactivity disorder (ADHD) in childhood and subsequent psychotic disorders. Both disorders share physiopathological features such as attention deficits, dopaminergic imbalance, and genetic susceptibility. However, the results of epidemiologic studies have been conflict...
Article
Chronic pain is a major public health issue that frequently leads to analgesic opioid prescriptions. These prescriptions could cause addiction issues in high-risk patients with associated comorbidities, especially those of a psychiatric, addictive, and social nature. Pain management in dependent patients is complex and is yet to be established. By...
Article
Full-text available
Background. This study evaluated factors linked with perceived stress related to the COVID-19 pandemic and lockdown and addictive behaviours prior to and during lockdown in a sample of students who indicated engaging in alcohol consumption behaviours before lockdown. Methods. Cross-sectional study. French students from four universities participate...
Article
Résumé La substitution propose de remplacer une substance dont le patient est dépendant par un analogue pharmacologique moins nocif afin de faciliter l’arrêt ou la réduction des prises, et réduire les dommages induits du produit initialement consommé. Devenue classique pour les opioïdes ou le tabac, il n’existe à ce jour aucun traitement de substit...
Article
Full-text available
Aim: To explore the factors determining the interest in extended-release buprenorphine (XR-BUP) injections among patients receiving opioid agonist treatment (OAT) in France. Methods: 366 patients receiving OAT for opioid use disorder, recruited in 66 French centers, were interviewed from 12/2018 to 05/2019. A structured questionnaire assessed thei...
Chapter
While severe alcohol use disorder (SAUD) is classically characterized as a compulsion to seek and consume alcohol and a reduced ability to control these behaviors, a growing number of studies shows social cognition difficulties among recently detoxified patients. The present chapter proposes an overview of this literature by presenting the main fin...
Article
Background and objective: Topiramate has been approved by the US Food and Drug Administration for the treatment of epilepsy since the 1990s, and it has also been used off-label in the treatment of many types of addictive disorders. To date, no systematic review has embraced the entire field of addiction, both substance use and behavioral addiction...
Article
Full-text available
In the field of substance use disorders (SUDs), medications are frequently labeled according to their main symptomatic effect (e.g., ‘‘anticraving drugs’’) or according to imprecise and sometimes old concepts related to treatment strategies (e.g., ‘‘replacement therapies’’, ‘‘antabuse drugs’’, or ‘‘substitution treatments’’). By contrast, the neuro...
Article
Full-text available
Introduction: Improving the knowledge and attitudes of people facing an opioid overdose is one of the key prevention measures for reducing overdose occurrence and severity. In this respect, the Opioid Overdose Knowledge (OOKS) and Attitudes (OOAS) Scales have been developed and validated in English to assess and improve knowledge and attitudes of o...
Presentation
Full-text available
Bulletin de liaison des CSAPA et CAARUD, médecins et pharmaciens d'officine impliqués dans l'accompagnement des usagers de drogues et autres conduites addictives, services d'addictologie, équipes de liaison et services de soins en milieu pénitentiaire Septembre 2020
Article
Psychiatric comorbidities are frequent in adolescents with internet gaming disorder (IGD). In contrast, the proportion of IGD among adolescents hospitalized for a psychiatric disorder has not been documented yet. In addition, parental ratings of IGD could be useful for diagnosis, but very few data exist on this issue. The objectives of this study w...
Article
Full-text available
Analgesic opioids addiction (AOA) is very frequent in the elderly, and results in a high morbi-mortality due to geriatric associated pathologies with pharmacokinetics modifications. However, it is poorly detected in these subjects and specific screening tools should be widely used to detect the risk factors for AOA prevention. Before initiating opi...
Preprint
Full-text available
Background: Extended-release buprenorphine (XR-BUP) are new pharmaceutical products that offer a one-week-, one-month- or six-months-long buprenorphine treatment for subjects with opioid use disorder (OUD). OUD is frequent in incarcerated populations, and XR-BUP has been suggested to be an interesting treatment option in prison. However, some opioi...
Article
Full-text available
Impairments in social cognition have been documented in severe alcohol use disorder (SAUD) over the past two decades. They have been linked with lower social functioning and poor treatment outcomes, illustrating their key role in the disorder. However, studies investigating social cognition in SAUD have largely focused on emotional decoding and the...
Article
Nicotine use, which is mostly done through smoking tobacco, is among the most burdensome comorbidities of schizophrenia. However, the ways in which nicotine affects the cognitive and early sensory alterations found in this illness are still debated. After conducting a systematic literature search, 29 studies were selected. These studies involve ind...
Article
Bipolar spectrum disorders encompass heterogeneous clinical manifestations and comorbidities. A latent class analysis (LCA) was performed in 1846 subjects who experienced an episode of abnormally elevated or irritable mood to identify homogeneous groups of subjects, based on the distribution of 11 manic and 7 psychotic symptoms. LCA identified five...
Article
Objective: To assess the efficacy and safety of topiramate in treating binge eating disorder (BED), using a systematic review and meta-analysis of the available randomized clinical trials (RCTs). Methods: The RCTs assessing topiramate versus placebo with or without adjunctive psychotherapy in BED were reviewed using a systematic search in the PubMed...
Article
Chez les sujets âgés, les antalgiques seraient les médicaments de prescription les plus mésusés. Bien que l’âge apparaisse plutôt comme un facteur protecteur, la grande prévalence des prescriptions d’opioïdes dans cette classe d’âge en fait une population à risque de développer des comportements de mésusage voire une addiction. Les données spécifiq...
Article
Full-text available
Résumé La buprénorphine et la méthadone sont les deux traitements agonistes opioïdes indiqués dans le trouble de l’usage des opiacés et opioïdes. La buprénorphine est un agoniste partiel des récepteurs opioïdes mu, jusqu'à présent disponible exclusivement en administration sublinguale. En pratique, la buprénorphine est plus sûre que la méthadone ca...
Article
Full-text available
Buprenorphine and methadone are the two main opioid agonist treatments approved for opioid use disorder. Buprenorphine is a partial agonist of the mu opioid receptors, which has been merely available through sublingual form until now. In practice, the use of buprenorphine is smoother than that of methadone, and it induces reduced risks of overdose....
Article
Full-text available
Résumé L’infection par le virus de l’hépatite C (VHC) est une maladie transmissible qui évolue vers la chronicité dans environ 70 % des cas. Le VHC chronique touche ainsi 0,5 à 1 % de la population, et entraîne d’importantes complications hépatiques mais aussi extra-hépatiques. Aujourd’hui, de nouveaux traitements antiviraux permettent de guérir pl...
Article
Résumé Objectifs La consommation de cannabis est très répandue en France, notamment parmi les adolescents et jeunes adultes, avec parfois de graves conséquences somatiques, psychiatriques et sociales. Le repérage précoce des troubles de l’usage du cannabis est désormais un enjeu majeur de santé publique. Les questionnaires standardisés reposant su...
Preprint
Full-text available
BACKGROUND The international outbreak of the COVID-19 pandemic has led many countries to enforce drastic containment measures. It has been suggested that this abrupt lockdown of populations would foster addiction-related habits, such as caloric food intake, screen use, and substance use. However, no data has supported this assumption until now. OB...
Article
Full-text available
Background The international outbreak of coronavirus disease (COVID-19) has led many countries to enforce drastic containment measures. It has been suggested that this abrupt lockdown of populations will foster addiction-related habits such as caloric/salty food intake, screen use, and substance use. Objective Our aim was to assess the global chang...
Article
Full-text available
Hepatitis C is a transmissible hepatic and extra-hepatic disease caused by the hepatitis C virus (HCV). HCV develops into a chronic infection among approximately 70% of the contaminated subjects. Chronic HCV infection is estimated to affect between 0.5% and 1% of the general population in France, which causes an important burden of disease, in part...
Article
Numerous studies have explored the morphological differences of the brain between subjects with alcohol use disorder (AUD) and control subjects, but very few have investigated the impact of the duration of alcohol use disorder (DAD) and current level of alcohol consumption (CAC) within AUD subjects using magnetic resonance imaging (MRI). We compare...
Article
Introduction: Insomnia has been implicated in the development, maintenance, worsening, and relapse of alcohol use disorder (AUD). Areas covered: The authors review the possible pharmacological and non-pharmacological treatment options of insomnia for patients with alcohol-use disorder and provide their expert opinion. Expert opinion: Abstinence, or...
Article
Full-text available
Les troubles de l'usage de substances existent chez des sujets âgés, avec une prévalence qui ne décroît que peu avec l'âge. Ils adoptent différentes présentations peu symptomatiques, rarement typiques, allant de la surconsommation, au mésusage (avec ou sans dépendance), à des conduites addictives. Ces addictions peuvent concerner des substances psy...
Chapter
Full-text available
Deuxième cannabinoïde le plus étudié aprèsle THC,sans effet psychoactif, le cannabidiol dispose de propriétés thérapeutiques intéressantes, notamment en psychiatrie. Le point sur les recherches.
Article
Full-text available
Statement: Peer role-play (PRP) is a simulation-based training method (SBTM) in which medical students alternately play the patient's and clinician's role. This review aimed to assess the effectiveness of PRP for improving the communication skills of medical students. A systematic search was conducted in the MedLine, PsycInfo, and ERIC databases....
Article
Increasing evidence suggest a bidirectional link between disrupted circadian rhythms and alcohol use disorders (AUD). A better understanding of these alcohol-induced changes in circadian rhythms will likely provide important therapeutic solutions. We conducted a systematic review based on the PubMed database examining biological rhythms in all stag...
Presentation
L’ensemble des troubles psychiatriques, et singulièrement les conduites addictives, sont susceptibles d’être associés à des atteintes des fonctions cognitives, préexistantes ou conséquentes aux usages. Ces atteintes, variant, selon le type de trouble addictif, dans leur nature, dans leur fréquence, et dans leur caractère plus ou moins réversible, a...
Article
The poor implementation of alcohol use disorder treatment programs has been well documented in many countries. Among the barriers have been identified in health professionals and patients, lack of awareness about existing medications and perceived lack of efficacy seem to deter physicians from offering pharmacotherapy to their patients. Indeed, exi...
Poster
Full-text available
Introduction La dépression psychotique (DP) est un trouble mental sévère souvent sous-diagnostiqué alors qu’il existe des facteurs de risque, caractéristiques, traitements et prises en charge spécifiques [1], [2], [3], [4]. L’objectif de cette étude est de rechercher des caractéristiques sociodémographiques et cliniques associées aux DP en comparan...
Article
Full-text available
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that typically occurs between 6 and 12 years of age and affects between 2% and 7% of school-age children [1] and between 2% and 3% of the adult population [2]. Although ADHD was initially thought to progressively disappear during adolescence, recent evidence suggests t...
Article
Aims Although people who inject drugs (PWID) are the core at-risk population in the hepatitis C (HCV) epidemic in industrialized countries, few initiate treatment. Alcohol use disorder (AUD), common within this population, has been identified as a barrier to HCV treatment uptake in the general population. We investigated whether the arrival of new...
Article
Full-text available
En raison de ses différents risques sanitaires, le cannabis est interdit en France avec une législation sévère pour les usagers. Malgré cela, les niveaux d'usage de cannabis en France sont les plus élevés d'Europe. En outre, la prohibition empêche la mise en place de mesure de régulation et de prévention. Pour ces raisons, la possibilité de faire é...
Article
Full-text available
Background and aims: Although people who inject drugs (PWID) are the core at-risk population in the hepatitis C (HCV) epidemic in industrialized countries, few initiate treatment. Alcohol use disorder (AUD), common within this population, has been identified as a barrier to HCV treatment uptake in the general population. We investigated whether th...
Article
Aims Psychotic symptoms can occur in the general population, and alcohol use disorder (AUD) is an identified vulnerability factor. However, it remains unclear how AUD is associated with psychotic symptoms, depending on the underlying psychiatric condition. We aimed to compare the prevalence of psychotic symptoms among subjects with different types...