Benjamin Lohrer

Benjamin Lohrer
Friedrich-Alexander-University of Erlangen-Nürnberg | FAU · Department of Biochemistry

Master of Science

About

4
Publications
322
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
36
Citations

Publications

Publications (4)
Conference Paper
Succinic semialdehyde dehydrogenase deficiency (SSADHD) represents a rare monogenetic, autosomal-recessive disorder causing an enzymatic block of the degradation of gamma-aminobutyric acid (GABA) due to variants in ALDH5A1. Succinic semialdehyde cannot be converted to succinate and is consecutively converted to gamma-hydroxybutyrate (GHB). The phen...
Conference Paper
Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an autosomal- recessive disorder caused by variants of the ALDH5A1 gene. Symptoms include developmental delay, behavioral problems, impaired motor coordination and seizures. High concentrations of the neurotransmitter gamma-amino butyric acid (GABA) and its degradation byproduct gamma-hydro...
Article
Full-text available
There is considerable interest in harnessing innate immunity to treat Alzheimer’s disease (AD). Here, we explore whether a decoy receptor strategy using the ectodomain of select TLRs has therapeutic potential in AD. AAV-mediated expression of human TLR5 ectodomain (sTLR5) alone or fused to human IgG4 Fc (sTLR5Fc) results in robust attenuation of am...

Network

Cited By