Benjamin Davido

Verified

Benjamin verified their affiliation via an institutional email.

Learn more

Verified

Benjamin verified their affiliation via an institutional email.

Learn more

• MD, PhD
• Physician at Hôpital Raymond-Poincaré – Hôpitaux universitaires Paris Ile-de-France Ouest

Objectives: Influenza significantly contributes to seasonal morbidity and strains healthcare resources, yet data directly comparing types A and B remain limited. This study assesses potential differences in clinical severity and outcomes between these two influenza types. Methods: We conducted a multicenter retrospective study of adult patients dia...

The rise of antimicrobial resistance presents a challenge to public health, undermines the efficacy of antibiotics, and compromises the management of infectious diseases. Gut colonisation by multidrug-resistant organisms, such as multidrug-resistant Enterobacterales and vancomycin-resistant enterococci, is associated with increased morbidity and mo...

An evaluation was conducted to predict the economic and clinical burden of vaccinating all immunocompromised (IC) individuals aged ≥30 years with mRNA-1273 variant-adapted COVID-19 vaccines versus BNT162b2 variant-adapted vaccines in Fall 2023 and Spring 2024 in France. The number of symptomatic SARS-CoV-2 infections, hospitalizations or deaths due...

Background Detailed comparative assessment of procedure‐related factors associated with faecal microbiota transplantation (FMT) efficacy in Clostridioides difficile infection (CDI) is limited. Aims We took advantage of the differences in procedures at the various French FMT centres to determine clinical and procedure‐related factors associated wit...

Background Understanding COVID-19 outcomes remains a challenge. While numerous biomarkers have been proposed for severity at admission, limited exploration exists for markers during the infection course, especially for the requirement of oxygen therapy. This study investigates the potential of eosinophil count normalization as a predictor for oxyge...

This narrative review aims to discuss the main interest in and cautions associated with the use of expired antibiotics in the context of repeated shortages, notably in Europe. Articles concerning the topic of expiry dates related to antibiotic use were reviewed using keywords in the PubMed®/MEDLINE and Google Scholar databases to identify the most...

An economic evaluation was conducted to predict the economic and clinical burden of vaccinating immunocompromised (IC) individuals aged ≥30 years with mRNA-1273 variant-adapted COVID-19 vaccines in Fall 2023 and Spring 2024 versus BNT162b2 variant-adapted vaccines in France. The number of symptomatic COVID-19 infections, hospitalizations, deaths, a...

Background The initial need for oxygen during Covid-19 has been correlated with the severity of lung involvement observed on CT-scan caused by the cytokine storm. A recent study showed that the normalization of eosinophil count (≥100/mm3) after 48 hours of appropriate regimen was related to a favorable outcome in sepsis. Our work intends to assess...

Background Fecal microbiota transplantation (FMT) can effectively decolonize multidrug-resistant organisms but its efficacy is variable. We evaluated the impact of FMT treatment at eliminating carbapenemase-producing Enterobacterales (CPE) carriage compared to spontaneous decolonization and identified microbial signatures of successful decolonizati...

Introduction: There now exist preventive and curative treatments available for both early and advanced stages of COVID-19 management. Current knowledge: Antibiotics have no place in the initial therapeutic management of Sars-Cov-2 pneumonia. On the other hand, corticosteroids are recommended for patients requiring oxygen therapy≥2L/min. Accordin...

Background: Natural history and treatment of bone infections caused by carbapenemase-producing Enterobacterales (CPE) are poorly defined. We evaluated the impact of treatment on the progression of subacute osteomyelitis in a rabbit model. Methods: Two isolates were used: a KPC-producing K. pneumoniae and an E. coli harbouring blaOXA-48 and blaCTX-...

Introduction: Prior to the emergence of COVID-19, when influenza was the predominant cause of viral respiratory tract infections (VRTIs), this study aimed to analyze the distinct biological abnormalities associated with influenza in outpatient settings. Methods: A multicenter retrospective study was conducted among outpatients, with the majority se...

Background: While the treatment of ESBL-producing Enterobacterales osteomyelitis relies on carbapenems, the optimal regimen for OXA48 types remains unclear. We evaluated the efficacy of ceftazidime/avibactam in different combinations in an experimental model of OXA-48-/ESBL-producing Escherichia coli osteomyelitis. Methods: E. coli pACYC184 is a...

We present the case of an 81-year-old man, who was immunocompetent, who was admitted to the hospital with symptoms of fever and dyspnea, suspected to be caused by Covid-19. Further examination revealed a triple coinfection, as determined by multiplex PCR testing, caused by RSV, hCoV-OC43, and rhinovirus. Upon auscultation, diffuse wheezing without...

Background Optimal treatment of carbapenemase-producing Enterobacterales (CPE) bone infections is poorly defined. We evaluated the efficacy of the novel beta-lactam -beta-lactamase inhibitor, ceftazidime-avibactam (CAZ-AVI) with different antibiotic combinations in an experimental model of CPE osteomyelitis. Methods KPC-99YC is a clinical strain o...

Highlights Descriptions of monkeypox 2022 outbreak have been increasingly reported with unusual presentations and therefore a risk of misdiagnosis. Diagnosis is primarily based on risk factors, including men having sex with men and high-risk contact, with the presence of cutaneous lesions and/or rashes including the genitals in a context of fever.

Background Since monkeypox virus has been firstly described in 1970s in Africa, virus has been repeatedly introduced to non-endemic regions in the last 20 years (USA, UK, Israel and Singapore).¹ As of 2 June, >550 laboratory confirmed cases have been reported by at least 30 countries outside Africa, according to the World Health Organization (WHO),...

Background: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. Methods: We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants...

The COVID-19 pandemic is a unique crisis challenging healthcare institutions as it rapidly overwhelmed hospitals due to a large influx of patients. This major event forced all the components of the healthcare systems to adapt and invent new workflows. Thus, our tertiary care hospital was reorganized entirely. During the cruising phase, additional s...

We report the case of a 58-year old immunocompetent man from Algeria who presented to the hospital with fever and hepatic cytolysis. Abdominal CT-scan showed a homogeneous splenomegaly and a hypodense 12-mm mass of posterior wall of the esophagus. After ruling out tuberculosis, patient was diagnosed with brucellosis. Patient was cured after receivi...

Background To ensure the success of COVID-19 vaccination, public authorities need to have the support of the entire population and build vaccine confidence. Identifying and understanding the determinants of vaccine acceptance is essential for conducting vaccine strategy. The aim was to estimate vaccine hesitancy among healthcare students in France...

Introduction We aimed to describe the management and treatment of hip joint infections caused by multidrug-resistant Enterobacterales among patients with spinal cord injury (SCI). Methods We included all hip joint infections associated with grade IV decubitus ulcers caused by Extended-Spectrum Beta-Lactamase producing Enterobacterales (ESBL-PE) an...

Background Following the study of the predictors of superinfection in viral respiratory tract infections (VRTIs), this study analyses the predictors of the outcome. Methods Multicenter retrospective study conducted among adults who tested positive for VRTIs with RT-PCR. We compared characteristics between Influenzavirus, Paramyxoviridae and Pneumo...

We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and didesethylchloroquine, didesCQ) in COVID-19 patients in order to determine whether a pharmacokinetic (PK)/pharmacodynamic (PD) relationship was present. The population PK of HC...

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advan...

Highlights The Omicron SARS-CoV-2 variant of concern is driving the COVID pandemic at a pace never seen before. When the threat of overwhelming healthcare systems balances the hope of achieving herd immunity, providing booster shots and vaccinating fragile individuals can still be attempted in France to prevent death and hospitalizations.

Résumé Au décours d'un épisode aigu de COVID-19 symptomatique, plus de 30 % des patients adultes ont encore des symptômes à 1-2 mois et 10 à 15 % à 6-8 mois. Il peut s'agir de symptômes persistants ou de nouveaux symptômes. Si les plus fréquents sont une fatigue sévère, une dyspnée et des signes neurocognitifs, de nombreux autres organes peuvent êt...

As a result of an acute symptomatic COVID-19 episode, more than 30% of adult patients still have symptoms at 1-2 months and 10-15% at 6-8 months. These may be persistent symptoms or new symptoms. If the most common are severe fatigue, dyspnea and neurocognitive signs, many other organs may be affected. These symptoms generally evolve in a fluctuati...

Introduction: Native osteomyelitis caused by Extended-Spectrum Beta-Lactamase producing Enterobacterales (ESBL-PE) is a matter of expert in antibiotics. Very limited epidemiologic and outcome data are available, warranting a study of these cases. Methods: We included osteomyelitis patients infected with ESBL-PE treated in a reference center for bo...

Covid booster shots should be proposed and recommended to all fully vaccinated individuals, considering antibody levels are waning over time and that the risk of being infected typically reappears after 6 months.

Background Clostridioides difficile infection (CDI) is rising and increases patient healthcare costs due to extended hospitalisation, tests and medications. Management of CDI in French primary care is poorly reported. Objectives To characterise patients suffering from CDI, managed in primary care and describe their clinical outcomes. Methods Retr...

Importance Failure of treatment is the most serious complication in community-acquired pneumonia (CAP). Objective To assess the potential risk factors for treatment failure in clinically stable patients with CAP. Design, Setting, and Participants This secondary analysis assesses data from a randomized clinical trial on CAP (Pneumonia Short Treatm...

Introduction Infection is one of the major causes of mortality and morbidity in older adults. Available biomarkers are not associated with prognosis in older patients. This study aimed to analyze the value of eosinopenia (eosinophil count< 100/mm ³ ) as a prognosis marker among older patients with suspected or confirmed bacterial infection. Method...

Background: Viral respiratory tract infections (VRTIs) are one of the most common diseases, but the risk of superinfection has never been compared depending on virus species. Methods: Multicenter retrospective study conducted amongst adults tested positive to VRTIs by RT-PCR. We compared characteristics between influenza (A-B) and paramyxoviruses...

Obesity is a significant public health concern associated with high morbidity. Obese patients are at risk of severe COVID-19 infection, and obesity is a high-risk factor for admission to the intensive care unit. We aimed to write a narrative review of cardiac and pulmonary pathophysiological aspects of obese patients in the context of COVID-19 infe...

Introduction Durant la première vague de l’épidémie de COVID-19, notre hôpital a dédié un pavillon à la prise en charge des patients COVID: la consultation de dépistage, le service de maladies infectieuses (SMIT) (38 lits), la réanimation (32 lits) et la post-réanimation (47 lits). Nous nous sommes intéressés aux consommations d’antibiotiques de ce...

Que s’est-il passé lors de la débâcle d’AstraZeneca ? Le médecin Benjamin Davido raconte comment, en quelques jours, les agences françaises et européennes, les politiciens et les professionnels de la santé ont proposé des évaluations différentes sur l’efficacité du vaccin AstraZeneca. Le résultat inévitable de ce message contradictoire des autorité...

What happened in the AstraZeneca debacle? Physician Benjamin Davido recounts how, within a matter of days, French and European agencies, politicians, and medical professionals offered differing assessments on the efficacy and potential limitations of the AstraZeneca vaccine. The inevitable result of this mixed messaging from the authorities was con...

Objectives : We aim to compare the efficacy of temocillin to carbapenems for ESBL-E UTI. Methods : We conducted a multicenter retrospective case-control study of adults with ESBL-E UTI between January-2015 and October-2019. Cases received temocillin ≥50% of the effective antibiotic therapy duration. Control exclusively received carbapenem. They we...

After one year, among 236 hospital staff members (HSMs) tested positive for SARS-CoV-2, we observed 5 cases of suspected reinfection in our teaching hospital in France. No probable reinfection was retained considering PCR Cycle Threshold and clinical context. Focus should concern COVID-free HSMs still not vaccinated rather than the ones previously...

Objective To compare the impact of a care bundle including medication reconciliation at discharge by a pharmacist versus standard of care, on continuity of therapeutic changes between hospital and primary care and outcome of patients, within one month after discharge. Methods Randomized controlled trial in 120 adult patients with at least one chro...

Background: . Ceftazidime/Avibactam (C/A) and Ceftolozane/Tazobactam (C/T) are two novel antibacterial agents with a known efficacy on Gram-negative bacteria (GNB). Objectives: . We aimed to describe the efficacy and safety of surgical management combined with C/A or C/T treatment for bone and joint infections (BJI). Patients and methods: . We...

Objective To develop a population pharmacokinetic model for lopinavir boosted by ritonavir in coronavirus disease 2019 (Covid-19) patients. Methods Concentrations of lopinavir/ritonavir were assayed by an accredited LC-MS/MS method. The population pharmacokinetics of lopinavir was described using non-linear mixed-effects modeling (NONMEM version 7...

Background Shortening the duration of antibiotic therapy for patients admitted to hospital with community-acquired pneumonia should help reduce antibiotic consumption and thus bacterial resistance, adverse events, and related costs. We aimed to assess the need for an additional 5-day course of β-lactam therapy among patients with community-acquired...

Highlights: COVID toes can be encountered in young individuals during acute COVID-19 infection while it results from the direct action of Spike protein on vessels. We report the case of COVID toes during the French campaign of vaccination that occurred 4 days after the vaccination with the Pfizer-BioNTech mRNA vaccine against COVID-19.

Introduction Better understanding how hospital staff members (HSMs), including HCWs, were contaminated by SARS-CoV-2 during the first wave can help refining the control measures, in the context of the current second wave in Europe. Methods From March 5th to May 10th 2020, the infectious diseases unit at Raymond-Poincaré teaching Hospital opened a...

The coronavirus disease 2019 (COVID-19) outbreak has become a worldwide public health concern. Cardiovascular complications are relatively frequent, reaching 20% of COVID-19 patients and 43% of COVID-19 patients admitted in Intensive Care Unit. Cardiac injury mechanisms are multiple, including hyper inflammation, pro-coagulant and pro-thrombotic st...

Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients. Methods We performe...

Obesity is a significant public health concern with higher morbidity. Obesity patients are at risk of severe COVID-19 infection and obesity is a higher risk factor for intensive Care Unit admission in COVID-19 infection. Obesity status affects lung volumes, cardiac structure and hemodynamics. Obesity is associated with a low inflammation state, end...

Introduction Comme les autres bactéries multirésistantes (BMR), les bactéries hautement résistantes émergentes (BHRe) sont un problème majeur de santé publique. Leur présence augmente la difficulté de prise en charge des patients, en raison de la complexité logistique nécessaire. Mais la méconnaissance, la méfiance potentielle du personnel soignant...

Introduction La résistance bactérienne est un enjeu majeur de santé publique, directement liée à la prescription antibiotique. Parmi les grands consommateurs, les infections urinaires sont au second rang en France. La littérature des dix dernières années relate des difficultés dans l’application des recommandations en médecine de ville, et une pres...

Introduction Limited data are reported regarding osteomyelitis due to Carbapenemase-producing Enterobacteriaceae (CPE), including co-infections with Extended-Spectrum Beta-Lactamase (ESBL) microorganisms. Methods We conducted a retrospective study in a reference center for bone and joint infection (BJI) from 2011 to 2019 among patients infected by...

We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative me...

Introduction Interest of anti-infective agents in COVD-19 showed discrepant results. However, there is no evaluation about the impact in changes of practices on the prognosis over time. Methods Single center, retrospective study, conducted from March 5th to April 25th 2020, in adults hospitalized in a medicine ward for a COVID-19. Patient characte...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging infectious disease with currently a pandemic state. Cardiac function can be involved, affecting prognosis, in addition with lung feature severity, particularly in patients with comorbidities. Since the renin angiotensin aldosterone (RAA) system may interact with SARS-Co...

Toscana virus (TOSV) is a common cause of meningitis in Mediterranean area. However, rare publications reported extra-meningeal signs. We report the third case of testicular pain associated with TOSV meningitis despite there is no evidence of semen involvement in other well-known arboviruses, excepted in Zika virus.

Mycetoma is a chronic infection that is slow to develop and heal. It can be caused by fungi (eumycetoma) or bacteria (actinomycetoma). We describe a case of actinomycetoma caused by Actinomadura mexicana in the Caribbean region.

Background: Recurrent urinary tract infections (R-UTIs) are the main cause of morbidity and hospitalisations in subjects with neurogenic bladder (NB) due to spinal cord injury (SCI). We evaluated the efficacy of weekly oral cyclic antibiotic (WOCA) prophylaxis, i.e. the alternate weekly administration of two antibiotics, in preventing R-UTI. Meth...

We report the case of an 18-year old immunocompetent man who presented to the hospital with fever, headaches, and arthromyalgia that progressed to an erythematous rash, with a history of a tick bite 72 hours earlier. The diagnosis of rickettsial infection was suspected and a course of doxycycline was initiated for a total of 5 days. Evolution was r...

Ceftazidime is a third‐generation cephalosporin used for the treatment of Gram‐negative bacteria only approved for parenteral use by intravenous and intramuscular route. In some clinical situations, off‐label subcutaneous injection could be a salvage route for the administration of antibiotics, especially in geriatrics, despite the paucity of evide...

Introduction Cotrimoxazole (Sulfamethoxazole-Trimethoprim, SXT) has interesting characteristics for the treatment of bone and joint infection (BJI): a broad spectrum of activity with adequate bone diffusion and oral and intravenous formulations. However, its efficacy and safety in BJIs are poorly documented and its use remains limited. Methods We...

Procalcitonin (PCT) has proven its efficacy to distinguish bacterial from aseptic meningitis in children. Nevertheless, its use in routine is limited by its cost and availability, especially in low- and middle-income countries. It is now acknowledged that eosinopenia is a marker of infection and/or severity of the systemic inflammatory response. Al...

Dalbavancin is a glycopeptide antibiotic with a long half-life, recently marketed in Europe for skin and soft-tissue infections (SSTIs), but its real-life use is not well known. The aim of this study was to describe all first prescriptions in France over an 16-month period. A retrospective study on all adult patients receiving at least one dose of...

Résumé Introduction L’infection urinaire (IU) constitue la deuxième cause d’infection bactérienne communautaire chez le sujet âgé. Ce diagnostic est difficile car les symptômes sont souvent atypiques. Nous présentons les caractéristiques des patients ayant une IU parmi une population gériatrique (signes fonctionnels urinaires et/ou syndrome infect...

Introduction La rifampicine est l’antibiotique de choix dans le traitement des infections ostéo-articulaires (IOA) à bactéries sensibles. Elle doit être prescrite en association avec un autre antibiotique. Cependant la posologie optimale n’est pas connue. Nous nous sommes intéressés à l’efficacité et la tolérance de ce médicament en fonction de la...

This work intend to warn about the armful effect of NSAIDs in sepsis, especially in BSI

Background: Isolation precautions used against multidrug-resistant (MDR) organisms are responsible for many emotional side effects. We evaluated patient's feeling after a hospitalization for an MDR infection. Methods: We conducted a qualitative study that included 11 interviews from August 2017 to June 2018. We used phenomenology and verbatim tr...

Background Spontaneous decolonization of antibiotic-resistant bacteria (ARB) takes time: about 25% after 30 days for Carbapenem-producing Enterobacteriaceae (CPE) or ESBL. Currently, fecal microbiota transplantation (FMT) has been proposed as a new strategy to promote decolonization, in order to reduce the risk of superinfection due to these ARB. W...