Bengu Nisa Akay

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• Professor
• Professor at Ankara University

Infantile hemangiomas (IH) are the most common benign vascular tumors in infants, often requiring treatment in 10–15% of cases due to complications. While systemic propranolol is the first-line treatment, its potential for systemic side effects raises interest in topical therapies. This study investigates the efficacy of topical 2% carteolol in tre...

Multiple aggregated yellow-white (MAY) globules are high-specificity dermatoscopic structures associated with high-risk basal cell carcinoma (BCC). They appear as clusters of white-to-yellowish clods and are visible with both polarized and non-polarized light. Other entities displaying MAY globules include trichoblastic tumors, microcystic adnexal...

Dermatoscopic examination of eccrine chromhidrosis reveals pigmentation around the eccrine pores on the ridge, which may reflect the presence of colored compounds secreted by the eccrine glands. The absence of pigmentation in the furrows, where eccrine pores are not present, supports this observation. We believe that defining the dermatoscopic find...

Porokeratosis is a group of clinical conditions characterized by abnormal epidermal keratinization and cornoid lamellae histologically.1 While porokeratosis presents with various clinical forms, a rare subtype localized to the genitogluteal region often leads to delayed diagnosis. This form can be classified into three distinct types: classical por...

The “costal fringe” refers to a linear arrangement of venous telangiectasias distributed along the anterolateral costal margins. The costal fringe is typically observed in older adults, although it has also been reported in younger patients. On the other hand, linear telangiectasias, arranged in a broad, crescent-shaped distribution across the ches...

Melanomas on the dorsum of the hand are exceedingly rare, with limited documentation in medical literature. This report presents seven cases of dorsal hand and finger melanomas, encompassing patients from Australia, New Zealand and Turkey, predominantly women with a mean age of 53 years. The majority were invasive, with a mean Breslow thickness of...

Background and Design: Primary cutaneous B-cell lymphomas (PCBCLs) have not been well characterized due to their relatively low incidence and heterogeneous clinical features. Materials and Methods: Data of 29 patients with primary cutaneous marginal zone lymphoma (PCMZL) (n=18), primary cutaneous follicle center B-cell lymphoma (PCFCL) (n=7), and...

Background Skin cancer incidence increases globally, requiring effective preventive measures and evidence‐based treatment strategies. Current guidelines advocate for surgical excision as a first‐line treatment for most early skin cancers. The study investigated practices regarding changing scalpel blades when excising multiple skin lesions in the s...

Background: As the majority of T-cell lymphomas lack CD20 expression, cases of mycosis fungoides (MF) exhibiting aberrant CD20 expression are exceedingly uncommon. Objectives: We aim to comprehensively evaluate the clinical, histopathological, and prognostic features of 7 patients diagnosed with CD20-positive MF. Methods: This retrospective study...

Idiopathic facial aseptic granuloma (IFAG) is a benign condition presenting as one or more asymptomatic, red/purple, soft/elastic nodules involving the face of young children, especially the cheeks and eyelids. It is included in the spectrum of childhood rosacea. However, a possible association with a late inflammation of an embryonic remnant or a...

Background/purpose: Interferon (IFN)-a is often used in combination with psoralen plus ultraviolet A (PUVA) in patients with mycosis fungoides (MF) refractory to skin-targeted therapies in early or advanced stages. The main objective is to evaluate the effectiveness of combined PUVA and low-dose IFN-α-2a therapy in patients with early- and advanced...

Mycosis fungoides (MF) is a diverse and clinically heterogeneous disease, making its diagnosis challenging, especially when it presents with atypical manifestations. Facial lesions in MF patients can resemble benign skin conditions, such as pigmented actinic keratosis (PAK) and lichen planus pigmentosus (LPP), further complicating the diagnostic...

Introduction: Classic Kaposi's sarcoma (CKS) is a chronic and indolent skin tumor. Because CKS has a low mortality rate but can have a significant impact on quality of life, it is important to choose safe, long-term treatments with minimal side effects. Objectives: The aim was to assess the efficacy of long-pulsed Nd:YAG laser therapy in treating...

Peripheral eosinophilia is reported in 50%–60% of BP patients in various studies, with findings suggesting that both peripheral and lesional eosinophil counts correlate with the disease's severity. This retrospective study evaluated the eosinophil count, D-dimer level and venous thromboembolism (VTE) frequency and their relationship with clinical f...

Background The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. Objectives Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours. Methods Retrospective, multicentre, descriptive, cross‐sectional study of biopsy‐proven CMs. Result...

Porokeratosis encompasses a group of relatively uncommon skin disorders, either hereditary or acquired, with an unknown aetiology, characterized by abnormal keratinization. Regardless of the clinical subtype of porokeratosis, they all exhibit a common histopathological hallmark known as the ‘cornoid lamella’. This feature consists of a parakeratoti...

Background Inverted follicular keratosis (IFK) is a rare benign tumour of the follicular infundibulum. Owing to its similarity to other benign and malignant cutaneous lesions, it poses a diagnostic challenge. There is limited information on the dermatoscopic characteristics of IFK and the majority of cases have been reported in patients with lighte...

Linear basal cell carcinoma (BCC) is a distinct clinical morphological variant of BCC. Although it has been speculated that trauma and the Koebner phenomenon may be linked to linear BCC, the pathophysiology has not yet been shown. Herein, 5 cases of BCC were presented that developed in the postauricular region as a result of trauma caused by the co...

A systematic review on the dermoscopic features of cutaneous neoplasms in dark skin phototypes

air and scalp disorders are of significant interest for physicians dealing with dark phototypes due to their prevalence and potential aesthetic impact resulting from a higher tendency for scarring. In order to facilitate their non-invasive diagnosis, several dermoscopic studies have been published, yet data are sparse and no systematic analysis of...

Dermoscopy has been showed to facilitate the non-invasive recognition of several infectious disorders (infectiouscopy) thanks to the detection of peculiar clues. Although most of the knowledge on this topic comes from studies involving light-skinned patients, there is growing evidence about its use also in dark phototypes. This systematic literatur...

Dermoscopic patterns of inflammatory dermatoses (inflammoscopy) have been extensively studied in the recent years, though data on patients with darker phototypes (IV-VI) are sparse. The aims of this systematic review were to summarize the current state of knowledge on inflammoscopy applied to skin of color and provide a standardized nomenclature of...

Over the last few decades, dermoscopy has been showed to facilitate the non-invasive diagnosis of both benign and malignant skin tumors, yet literature data mainly comes from studies on light phototypes. However, there is growing evidence that skin neoplasms may benefit from dermoscopic assessment even for skin of color. This systematic literature...

This chapter is about of non-pigmented lesion in gluteal area such as eccrine porome and Spitz nevus and Squamous Cell Carcinoma in situ focusing in their dermatoscopic features.KeywordsEccrine poromeSpitz nevusSquamous Cell Carcinoma in situ

We investigated whether human preferences hold the potential to improve diagnostic artificial intelligence (AI)-based decision support using skin cancer diagnosis as a use case. We utilized nonuniform rewards and penalties based on expert-generated tables, balancing the benefits and harms of various diagnostic errors, which were applied using reinf...

Combined tumours are uncommon and therefore these tumours may pose a diagnostic challenge. In the current case report, it is aimed to present the clinicopathological features of a combined tumour including melanoma with aberrant cytokeratin expression and poroma.

Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. Skin-directed therapies, including phototherapy, are the first-line treatment modalities. Psoralen plus ultraviolet A light photochemotherapy (PUVA) is quite effective in controlling the disease; however, long-term adverse effects, particularly carcinogenesis, are the...

Mikozis fungoides derinin T hücreli lenfomaları içerisinde en sık görülen alttiptir ve klasik ve atipik formları ile çok farklı klinik görünümlerde karşımıza çıkabilmektedir. Klasik formda eritemli yüzeyel yamalar şeklinde görülmekle birlikte, ilerleyen evrelerde daha geniş vücut alanlarını etkileyebilen ekzema veya psoriasis benzeri plaklar ve tüm...

Background: A subset of melanocytic proliferations is difficult to classify by dermatopathology alone and their management is challenging. Objective: To explore the value of correlation with dermatoscopy and to evaluate the utility of second opinions by additional pathologists. Methods: For this single center retrospective study we collected 1...

Introduction: A structured set of eight basic dermoscopic parameters (lines, clods, dots, circles, pseu- dopods, structureless, else, and vessels) including a total of 77 variables with corresponding descrip- tive and metaphoric vocabulary has been released for evaluation of skin tumors by the International Dermoscopy Society (IDS). Objectives: To...

Introduction: Skin cancer is the third most common type of cancer worldwide that has increased in incidence. Quality of life (QoL) instruments have been developed to measure the efficacy of treatments of cancers. Objectives: The only validated tool that can be used in both nonmetastatic skin cancer types is the SCQOLIT. This study aimed to validate...

Dermatoscopic white circles, seen with both non‐polarized and polarized dermatoscopy, are a known clue to actinic keratosis in a flat lesion and invasive squamous cell carcinoma in a raised lesion. We have not discovered a previous published example of this clue in a melanoma. We present a case report of a 70‐year‐old Australian male with a pigment...

Background: It is important to evaluate the agreement between clinical diagnosis and histopathological diagnosis. The aim of this study was to review studies and to calculate the degree of agreement between clinical and histopathological diagnosis. Objective: The aim of this review was to find out the concordance level between clinical and histo...

Lichen sclerosus et atrophicus (LSEA) is an inflammatory skin disease that most frequently affects pre-pubertal and post-menopausal females. It commonly affects anogenital skin; however, extragenital lesions are not uncommon and occur in isolation or concomitantly with genital lesions. Autoimmunity, genetic factors, and hormonal influences are the...

Background: There is sparse data regarding total body nevus count (TBNC), nevus count in specific locations, phenotypic factors, anthropometric indices, sunburn, and the relation to multiple primary cutaneous melanomas (MPCM) development. We aim to compare these variables in a cohort of patients diagnosed with single primary melanoma (SPM) and MPCM...

Spitzoid melanocytic lesions characterized by spindle and/or epithelioid tumour cells can occur anywhere on the skin but the acral presentation of Spitz naevus is very rare and comprises about <4% of all Spitz naevi. However, data regarding their dermatoscopic features on the acral volar skin are scarce. Herein, 11 cases of acral Spitz naevus invol...

The pathogenesis of mycosis fungoides (MF) is poorly understood, and an immunogenetic mechanism has been suggested to play a role. Human leukocyte antigen (HLA) class II alleles DRB1*11 and DQB1*03 were found to be significantly increased for patients with sporadic and/or familial MF. The juvenile-onset familial MF is extremely rare. Herein, we rep...

Mantle cell lymphoma (MCL) is a rare aggressive B-cell lym-phoma and represents 6% of all non-Hodgkin lymphomas.Cutaneous involvement (CI) of systemic MCL is rarely reported and is related to poor prognosis. Skin involvementin systemic lymphomas (SLs) can be challenging. Dermatoscopy may serve as a useful tool to diagnose and amelioratethe prognosi...

Background: Clinical differentiation between different cheilitis variants may be difficult. Application of mucoscopy, in addition to clinical background, could provide additional diagnostic clues facilitating initial patient management. Objectives: To determine mucoscopic clues differentiating actinic cheilitis from the main forms of inflammator...

Allogeneic hematopoietic stem cell transplantation (AHSCT) is a promising strategy for treatment of heavily pretreated mycosis fungoides/Sezary syndrome (MF/SS). Herein, we aimed to evaluate the outcomes of AHSCT for heavily pretreated patients with MF/SS retrospectively. This analysis included consecutive 19 patients with MF/SS who received 20 AHS...

Background: The dermoscopic features of classic patch stage mycosis fungoides (MF) have been described, but data on plaque and tumoral stage as well as rarer MF subtypes is limited. Objective: To evaluate dermoscopic morphology and dermoscopic-pathological correlations of classic MF stages and investigate dermoscopic features of MF variants. Me...

Abstract Background: Limited data on dermoscopy of nodular/plaque-type T/B-cell primary cutaneous lymphomas (PCLs) is available. Objective: To describe dermoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences accordin...

The desire to look more attractive has always been an undeniable demand in every society. With the effect of social media and the continuous use of filtered selfies, the longing for perfection has reached its climax. Nowadays, increasingly more patients apply to dermatology clinics to eliminate skin imperfections, including nevi. We recommend remo...

Background: Ten-year survival rates in mycosis fungoides (MF) broadly varies, however, there is no standardized prognostic index available. This is presumably due to low prevalence, heterogeneity, and diagnostic challenges in MF. Recent studies have focused on identifying objective prognostic indices by using different parameters for survival dete...

Background Limited data on dermoscopy of nodular/plaque-type T/B-cell primary cutaneous lymphomas (PCLs) is available. Objective To describe dermoscopic features of nodular/plaque-type PCLs, comparing them with those of clinical mimickers (pseudolymphomas, tumors, and inflammatory lesions) and investigating possible differences according to histol...

Superficial acral fibromyxoma is a rare, benign, slow-growing, soft-tissue tumor commonly located in the acral regions, with a predilection for the great toe, developing from the nail unit. Because of its nonspecific features and rarity, clinical diagnosis is difficult. In this article, we present a case of superficial acral fibromyxoma located in...

Background Melanoma is associated with poor prognosis in its advanced stages. Potential influence of estrogen and its metabolites on melanoma growth has been suggested. Aims The objective of this review was to provide an overview on the evidence related to estrogen in malignant melanoma. Materials and Methods Literature search using PubMed, Googl...

A ralık 2019'da Çin'in Wuhan kentinde başlayan ve tüm dünyaya yayılan Koro-navirüs hastalığı-19 (COVID-19) pandemisi hızla artan ölüm ve vaka sayıları nedeni ile tüm hekimlerin ve tabi ki dermatologların rutin pratiğini oldukça et-kilemiştir. Salgının hızını kontrol edebilmek için acil olmayan ayaktan hasta başvurula-rının azaltılması, COVID-19 açı...

Background The International Dermoscopy Society (IDS) recently released a set of five basic dermoscopic parameters (vessels, scales, follicular findings, “other structures,” and specific clues) encompassing a total of 31 subitems to standardize the use of dermoscopy in non-neoplastic dermatoses, yet they have been developed taking into account Cauc...

Background The diagnosis of porokeratosis can be challenging and knowledge about its dermoscopic features is limited. Objectives To describe the dermoscopic features of porokeratosis of Mibelli and disseminated superficial actinic porokeratosis (DSAP) and the frequency of these features in a larger case series. The interobserver concordance was al...

Non‐melanoma skin cancer (NMSC), predominantly squamous cell carcinoma and basal cell carcinoma, is increasing worldwide. Dermatoscopy, which is one of the non‐invasive diagnostic techniques, is important for early diagnosis of NMSC. To determine dermatoscopic features of keratinocyte derived tumors including actinic keratosis (AK), Bowen's disease...

Congenital melanocytic naevi are hamartomas of the neuroectoderm caused by genetic mosaicism. Congenital melanocytic naevi are seen in 1-6% of all live births and commonly classified based on the projected size in adults. Congenital melanocytic naevi appear in different colours, shapes, and sizes, and occasionally present with complications. In thi...

Background: Dermoscopy has been shown to be a useful supportive tool to assist the diagnosis of several non-neoplastic dermatoses (i.e. inflammatory, infiltrative and infectious skin diseases), yet data on skin of colour is still limited. Objectives: To characterize dermoscopic features of non-neoplastic dermatoses in dark-skinned patients in orde...

Leishmania is a vector-induced endemic tropical disease caused by protozoans. The most common cutaneous, mucosal and visceral forms are the cutaneous form. The main drugs in treatment are pentavalent antimony compounds, but their side effects create limitation of use. Local antimony compounds are used primarily in the treatment of cutaneous leishma...

ABS TRACT Dermatoscopy is a simple and non-invasive method that is mainly used in the examination of pigmented skin lesions. It is an important diagnostic tool in the differential diagnosis of lesions characterized by melanocyte proliferation, such as melanocytic nevus and melanoma. In this section dermatoscopic features of melanocytic nevus (Clark...

ÖZET Melanonişi tırnak plağının siyah-kahverengi-gri pigmentasyonudur. Melanin varlığına bağlı mey-dana gelir ve genellikle longitudinal bir bant (longitudinal melanonişi) olarak görünür. Ayırıcı tanısı benign ve malign durumları kapsamaktadır. Tırnak dermatoskopisi (onikoskopi) tırnak pigmentasyonları açısından yararlı bilgiler sağlayan güvenilir...

Background Combined blue nevi may mimic melanoma and are relatively often biopsied for diagnostic reasons. Objective To better characterize combined blue nevi and to compare it with melanoma. Methods We collected clinical and dermatoscopic images of 111 histologically confirmed combined blue nevi and contrasted their dermatoscopic characteristics...

Background/Objective The clinical and dermatoscopic features of lichen planus‐like keratosis have been described but the characteristics of this entity in a West‐Asian population are not known. Methods We retrospectively analysed 82 histopathologically verified cases of lichen planus‐like keratosis from 81 patients from Iran and Turkey. Results T...

Henoch-Schönlein purpura (HSP) is a small vessel vasculitis characterized by the presence of vascular immunoglobulin A deposition that usually presents as non-thrombocytopenic palpable purpura. It primarily affects children and is less common in adults. The incidence of hemorrhagic necrotic skin lesions increases with age, similarly to renal involv...

Zusammenfassung Hintergrund und Ziel Pigmentierte intraepidermale Karzinome sind dermatoskopisch durch Punkte und strukturlose Bereiche sowie durch linear angeordnete Punkte und Knäuelgefäße gekennzeichnet. Es gibt keine Studien zu den dermatoskopischen Merkmalen pigmentierter intraepidermaler Karzinome an Kopf und Hals. Unser Ziel ist die Beschre...

Summary Background and Objective Pigmented intraepidermal carcinoma is characterized by dermatoscopic dots and structureless areas, including dots in linear arrangement and by coiled vessels. There are no studies describing the dermatoscopic features of pigmented intraepidermal carcinoma on the head and neck. We aim to characterize the clinical and...

Eccentric black, structureless areas can be seen in Clark’s nevus and melanoma. The major clue here is angulated lines, an important clue for extrafacial lentiginous melanomas.

The major clue here is branched vessels with rounded endings. Poromas are uncommon, benign sweat gland tumors that are clinically and dermatoscopically challenging to diagnose. Pigmented poromas are very rare and may mimic melanoma and basal cell carcinoma dermatoscopically. Characteristic features of poromas are branched vessels with rounded endin...

Folliculotropic mycosis fungoides (FMF) is characterized by a broad clinical spectrum and worse prognosis compared to classical MF. This study aimed to evaluate the clinical characteristics, treatment modalities and long‐term outcome and risk factors for progression and survival of FMF patients. We conducted a single‐center retrospective study and...

Glomus tumors are relatively rare benign tumors originated from normal glomus bodies. These tumors make up approximately 2% of all hand tumors and are most commonly found in the nail matrix and proximal nail bed of the hands. Histopathologically, they are classified into solid glomus tumor, glomangioma, and the least common type glomangiomyoma. Her...

e20038 Background: Allogeneic hematopoietic stem cell transplantation (AHSCT) is a promising strategy for treatment of advanced-stage mycosis fungoides/Sezary syndrome (MF/SS). In this study, we retrospectively analyzed the outcomes of AHSCT for MF/SS and found that MF/SS appears to be susceptible to graft versus leukemia (GVL) effects. Methods: We...