Benani Bennani Abdelouaheb

Benani Bennani Abdelouaheb
Institut Pasteur International Network · Medical Biology

PhD Molecular Genetics

About

100
Publications
4,243
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Citations
Introduction
The aim of our current project is the Molecular Epidemiology of HBV/HDV & HCV in Moroccan patients, and the monitoring of imported new genotypes found and their treatment response. In other hand, we use new molecular tools in order to study molecular HBV resistance to antiviral drugs. Evaluation of commercial RT-qPCR kits is also in our expertise. Hepatitis E is also in our research pipeline.
Additional affiliations
October 1993 - present
Pasteur Institute of Morocco
Position
  • Head of Molecular Biology Laboratory
January 1993 - present
Institut Pasteur du Maroc
Description
  • Molecular Epidemiology of Hepatitis B & C on Morocco
Education
January 1991 - October 1993
Université Libre de Bruxelles
Field of study
  • Biologie Moléculaire et Biotechnologie

Publications

Publications (100)
Article
Full-text available
Viral outbreaks can result from the consumption of contaminated bivalve mollusks. However, despite the regulation related to enteric bacteria in food products, the consumption of raw and undercooked mollusks remains linked to viral epidemics in human populations. Real-time RT-PCR is a highly sensitive approach for detecting and quantifying enteric...
Article
Full-text available
Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a betacoronavirus, and is associated with cytokine storm inflammation and lung injury, leading to respiratory distress. The transmission of the virus is mediated by human contact. To control and prevent the spread of this virus, the ma...
Article
Full-text available
Viral hepatitis B is a global public health problem affecting nearly two billion subjects; 3.3% of whom are from the WHO (World Health Organization) Eastern Mediterranean Region (EMRO). It induces both acute and chronic hepatic disorders with subsequent liver cirrhosis and hepatocellular carcinoma (HCC) in a considerable percentage of patients base...
Article
Full-text available
Background: Over 240 million people are chronically infected with hepatitis B virus (HBV), the leading cause of liver cancer worldwide. The quantification of the HBV DNA level is critical for monitoring the efficacy of antiviral treatment of chronic HBV patients. Methods: In our study, we compared the performance of the artus HBV QS-RGQ assay to...
Article
Noroviruses belonging to the genogroups I and II (GI and GII) are the leading cause of human gastroenteritis worldwide. Faecal oral transmission is the main route of their spread among people, whereas environmental contamination occurs by transport of contaminated water. Studies on environmental contamination by noroviruses are routinely done using...
Article
A one‐step reverse transcription quantitative PCR (RT‐qPCR) assay in combination with rapid RNA extraction was evaluated for routine testing of HCV RNA. Specific primers and probes were designed for the detection of a 150 bp sequence located in the 5’‐UTR of HCV RNA. The target sequence was selected as the most conserved region between the six know...
Article
Importance: The outcome of this work describes the HCV genetic heterogeneity in high-risk intravenous drug users, and it gives clues to the global migratory flow of genotypes as they cross geographical boundaries between various IDU populations and identifies 'signature' amino acid mutations traceable to HCV genotype 3a. Identification of key amin...
Article
Full-text available
Viral hepatitis C is not only a major public health problem by its significant morbidity and mortality worldwide, but also a medical and economical burden. Over the last 5 years, numerous research laboratories have enabled the development of several direct acting anti-HCV molecules whose effectiveness is well established. Great progress has been ma...
Conference Paper
Full-text available
H epatitis B (HBV) and C (HCV) viruses are major public health problems worldwide and serious cause of liver disease that may silently progress toward cirrhosis and hepatocellular carcinoma. The HCV epidemic in North Africa falls into an 'intermediate' range, characterized by a decreasing East-West gradient, with the average seroprevalence estimate...
Article
Full-text available
The purpose of this study was to determine the prevalence of viral RNA and HCV genotypic profile 6 hemodialysis centers in Casablanca. A total of 630 patients were included in this survey, 194 patients of them have antibodies antiHCV + ; then the prevalence is 30.79% , indeed search for viral RNA by PCR in this population was detected in 105 patien...
Article
Full-text available
The epidemiological transition has reduced infectious diseases mortality in most European countries, yet increased migrant influx risks importing diseases. All reported prevalence rates must be considered on a case-by-case basis depending on the disease in question, respective European Union (EU) country and migratory patterns at work. Tuberculosis...
Article
Full-text available
Hepatitis C virus is a persistent epidemiological problem, with an estimated 170 million individuals infected worldwide, and the leading cause of asymptomatic chronic infection, liver cirrhosis and hepatocellular carcinoma. Injection drug users (IDUs) have the highest seroprevalence as compared to chronic hemodialysis and transfusion patients, and...
Article
Full-text available
Background Viral hepatitis is a serious public health problem affecting billions of people globally. Limited information is available on this issue in Morocco. This cross-sectional study was undertaken with the aim of determining the seroprevalence and risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV) among the general population...
Article
The study of hepatitis B virus (HBV) genomic heterogeneity has become a major issue in investigations aimed at understanding the relationship between HBV mutants and the wide spectrum of clinical and pathological conditions associated with HBV infection. The objective of the current study was to find out the pattern of HBV genotypes circulating in...
Article
Full-text available
Hepatitis B (HBV) and C (HCV) viruses are major public health problems worldwide and are a serious cause of liver disease that may silently progress toward cirrhosis and hepatocellular carcinoma. The epidemiology of HBV and HCV infection in Morocco was studied. A large screening of HBsAg and HCVab was performed by third generation ELISA. Hepatitis...
Article
The aim of this study was to determine the prevalence of hepatitis B and the risk factors in Morocco. A total number of 16,634 individuals were screened for HBsAg using the Murex HBsAg Version 3 assay and were interviewed using a structured standard questionnaire to collect information about risk factor. Two hundred seventy-six subjects were positi...
Conference Paper
Home - 10.05.2011 - Viral hepatitis 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 27th International Congress of Chemotherapy (ICC) 07.05.2011 - 10.05.2011 Viral hepatitis Tuesday, May 10, 2011, 12:30 - 13:30 Molecular epidemiology of HCV in Morocco A. Benani*, W. Baha, N. Dersi, M. Ennaji, F. Lazaar, A. El Malk...