Ben Sessa

Imperial College London | Imperial · Division of Brain Sciences

Background In the context of the need to increase treatment options for substance use disorders, recent research has evaluated the therapeutic potential of psychedelics. However, there is an incomplete understanding of psychedelics’ effects on craving, a core symptom of addictive disorders and a predictor of substance use and relapse. Aims To dete...

There is substantial contemporary interest in psychedelic agents as medicines for maladies of the mind. This follows research in the 1950s and 1960s exploring the use of LSD and other psychedelics to treat a range of psychiatric illnesses as well as addictions. This research was shut down after prohibition of these drugs; however, the last decade h...

Objective: Reports have indicated possible uses of ayahuasca for the treatment of conditions including depression, addictions, post-traumatic stress disorder, anxiety and specific psychoneuroendocrine immune system pathologies. The article assesses potential ayahuasca and N,N-dimethyltryptamine (DMT) integration with contemporary healthcare. The re...

Psychedelics were used in the treatment of psychiatric conditions prior to their prohibition in the late 1960s. In the past three decades, there is a revived research interest in the therapeutic potential of psychedelic drugs with expected FDA approvals for treatment of various conditions. Given the exponential scientific growth of this field, we s...

Background Incorporating 3,4-methylenedioxymethamphetamine (MDMA) as an adjunct to psychotherapy has shown promise in recent years for treating various mental health conditions, particularly those involving trauma. However, concerns about declines in mood and cognition during the days following dosing, also known as ‘Blue Mondays’, have been raised...

Background: Despite rescheduling of cannabis to Schedule 2 and amendments to the law permitting legal availability of cannabis for the treatment of medical conditions, access to cannabis for medical use remains challenging for patients in the United Kingdom (UK). Recreational use is widespread despite laws stating users can be sentenced to prison f...

Background: 3,4-methylenedioxymethamphetamine (MDMA) therapy has qualities that make it potentially well suited for patients with addictions, but this has never been explored in a research study. We present data from the Bristol Imperial MDMA in Alcoholism (BIMA) study. This is the first MDMA addiction study, an open-label safety and tolerability...

Objective Research into psychedelic therapy models has shown promise for the treatment of specific psychiatric conditions. Mystical‐type experiences occasioned by psilocybin have been correlated with therapeutic benefits and long‐term improvements in positive mental outlook and attitudes. This article aims to provide an overview of the topic, highl...

There is growing recognition of the potential utility of medical cannabis as a harm reduction intervention. Although used for this indication in other countries, there is an absence of UK clinical guidelines that supports such an approach. We administered a short survey to gain a better understanding of the potential role of medical cannabis by 39...

The Trials of Psychedelic Therapy: LSD Psychotherapy in America By Matthew Oram Johns Hopkins University Press. 2018. 288 pp. £33.30 (hb). ISBN 9781421426204 - Volume 215 Issue 2 - Ben Sessa

We present the preliminary data in an ongoing open-label safety and tolerability proof of concept study exploring the potential role for 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in treating patients with alcohol use disorder. At this stage, seven participants have completed the full 8-week MDMA-assisted psychotherapy course,...

This paper provides a brief review of the history, proposed pharmacological mechanisms, safety issues, and clinical applications of the medicine 3,4-methylenedioxymethamphetamine (MDMA). Most clinical MDMA research in patients to date has focused on MDMA-assisted psychotherapy to treat posttraumatic stress disorder (PTSD). In this review paper othe...

Seit hunderten, wenn nicht sogar seit tausenden von Jahren werden Psychedelika von Menschen verwendet. Die ernsthafte medizinische Erforschung dieser Substanzen begann im Westen erst im späten 19. Jahrhundert mit der Entdeckung von Meskalin.

Alcohol use disorder represents a serious clinical, social and personal burden on its sufferers and a significant financial strain on society. Current treatments, both psychological and pharmacological are poor, with high rates of relapse after medical detoxification and dedicated treatment programs. The earliest historical roots of psychedelic dru...

Given the plethora of new studies and published papers in the scientific press and the increasingly emerging presence of articles about positive psychedelic experiences appearing in the popular media, there is little doubt that we are in the midst of a Psychedelic Renaissance. The classical psychedelic drugs LSD and psilocybin and the entactogen MD...

An interdisciplinary selection of twenty-five essays first delivered at Breaking Convention 2015, the third conference on psychedelic consciousness, culture, and clinical research, held at the University of Greenwich, London. Breaking Convention is the largest symposium of its kind, featuring more than 120 academic presentations biennially. Widely...

Since the late 1980s the psychoactive drug 3,4-methylenedioxymethamphetamine (MDMA) has had a well-known history as the recreationally used drug ecstasy. What is less well known by the public is that MDMA started its life as a therapeutic agent and that in recent years an increasing amount of clinical research has been undertaken to revisit the dru...

Seit hunderten, wenn nicht sogar seit tausenden von Jahren werden Psychedelika von Menschen verwendet. Die ernsthafte medizinische Erforschung dieser Substanzen begann im Westen erst im späten 19. Jahrhundert mit der Entdeckung von Meskalin. Von da an war in den 1940er-Jahren die Synthetisierung der Substanz LSD zu beobachten und darauf folgend die...

Treating people with alcohol use disorder has been an important target area for psychedelic research – both in the first studies of the 1950s and during the Psychedelic Renaissance of the last 10 years. To date, most studies have looked at the classical psychedelic drugs as adjuncts to psychotherapy; with attention paid to the psychospiritual aspec...

Psychedelics have been used for hundreds if not thousands of years by humans. Medical research began in earnest in the West in the late nineteenth century with the discovery of mescaline. From there we saw the development of LSD in the 1940s and an increasingly important role played by psychedelics in the 1950s in the subsequent development of biol...

I am saddened to see the wholly negative review of my novel, To Fathom Hell or Soar Angelic , in the June 2016 edition of the British Journal of Psychiatry .[1][1] Obviously, I open myself up to opinions and critique when publishing anything – and especially on such a controversial subject as this

There is a range of therapies to treat Post Traumatic Stress Disorder (PTSD) but treatment resistance remains high, with many sufferers experiencing the chronic condition. Engagement in trauma-focused psychotherapy is difficult for some patients with PTSD, especially those with extreme affect dysregulation associated with recall of traumatic memori...

Significance Lysergic acid diethylamide (LSD), the prototypical “psychedelic,” may be unique among psychoactive substances. In the decades that followed its discovery, the magnitude of its effect on science, the arts, and society was unprecedented. LSD produces profound, sometimes life-changing experiences in microgram doses, making it a particular...

Underground psychedelic-assisted psychotherapy has persisted in Europe despite the banning of the substances LSD and MDMA in the 1960s and 1980s, respectively. This article describes the work of a Zurich-based psychotherapist providing individual and group psycholytic psychotherapy, whose practice persisted for several years before she was arrested...

Hallucinogen persisting perception disorder is a disorder of uncertain aetiology occurring mainly after ‘classical’ hallucinogen use (ie mescaline, psilocybin, dimethyltryptamine and LSD) use. Here, the authors describe the case of a boy with similar symptoms developing after he reported using cannabis seven times.

After a 40-year hiatus there is now a revisiting of psychedelic drug therapy throughout psychiatry, with studies examining the drugs psilocybin, ketamine, ibogaine and ayahuasca in the treatment of drug dependence. Limitations to these therapies are both clinical and legal, but the possibility of improving outcomes for patients with substance depen...

From its first use 3,4,-methylenedioxymethamphetamine (MDMA) has been recognised as a drug with therapeutic potential. Research on its clinical utility stopped when it entered the recreational drug scene but has slowly resurrected in the past decade. Currently there is enough evidence for MDMA to be removed from its Schedule 1 status of 'no medical...

The UK's largest conference on psychedelic consciousness, Breaking Convention, debuted at the University of Kent in 2011 to an audience of 500 delegates. The three-day event hosted eighty talks, in addition to workshops, music and psychedelic cinema. Breaking Convention returned two years later at the University of Greenwich with twice the number o...

Reviews the book, Drugged: The Science and Culture Behind Psychotropic Drugs by Richard J. Miller (see record 2013-24737-000 ). Miller uses a number of styles and approaches to tackle the multifarious social, cultural, biochemical, political, and clinical angles associated with psychotropic drugs. This book will appeal as much to scholars of histor...

Without researching psychedelic drugs for medical therapy, psychiatry is turning its back on a group of compounds that could have great potential. Without the validation of the medical profession, the psychedelic drugs, and those who take them off-license, remain archaic sentiments of the past, with the users maligned as recreational drug abusers a...

Rates of developmental delay, autism and mental illness in deaf children are higher than in hearing children. Early language acquisition (signed or spoken) is a protective factor against mental disorder. Deaf children and their families are often given conflicting messages and advice about their upbringing and many are unable to access generic chil...

In recent studies, 3,4-methylenedioxymethylamphetamine (MDMA) has shown promise in the treatment of post-traumatic stress disorder (PTSD) as an adjunct to post-trauma psychological therapy. However, because of historical associations with its use as the recreational drug ecstasy, MDMA research remains a controversial subject. Dr Sessa discusses the...

The Pharmacology of LSD: A Critical Review By Annelie Hintzen, Torsten Passie Oxford University Press/Beckley Foundation Press. 2010. £29.95 (pb). 240pp. ISBN: 9780199589821 Many psychiatrists today are not aware of the role lysergic acid diethylamide (LSD) played in the profession in the mid

Ben Sessa believes it is a good thing that, after a 40-year hiatus, international trials are revisiting the role of psychedelic drugs in assisting patients with terminal cancer to explore - and resolve - anxiety-inducing existential issues surrounding their illness.