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Ben Hartwig

Ben Hartwig
Dr. rer. nat.
CEO at Neuroblitz

About

Publications

1,028

Reads

117

Citations

Skills and Expertise

Epigenetics

Chromatin Biology

Gene Regulation

Regulation of Gene Expression

Next Generation Sequencing

Histone Modification

Neuroblitz

Current position

Publications

ALP2 acts in the same pathway as ALP1
A. Rosette phenotypes of 9 week...

Expression of PcG targets and ALP genes
A. Real time RT PCR analysis of...

ALP2 has similarity with Harbinger transposase DNA binding...

Volcano plot analysis of IP-MS data
The relative abundance of proteins...

Interaction of ALP proteins in yeast two hybrid assays
A. ALP1 and ALP2...

The domesticated transposase ALP2 mediates formation of a novel Polycomb protein complex by direct interaction with MSI1, a core subunit of Polycomb Repressive Complex 2 (PRC2)

Article

Full-text available

May 2020

A large fraction of plant genomes is composed of transposable elements (TE), which provide a potential source of novel genes through “domestication”–the process whereby the proteins encoded by TE diverge in sequence, lose their ability to catalyse transposition and instead acquire novel functions for their hosts. In Arabidopsis, ANTAGONIST OF LIKE...

Correction: Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2

Article

Full-text available

Feb 2016

Table 1. ALP1 co-purifies with Pc-G proteins.
The table summarises the...

Fig 1. Genetic interaction of ALP1 with PcG.
(A) alp1-4 suppresses the...

Fig 2. Phylogenetic analysis of ALP1 sequences from land plants and...

Fig 3. ALP1 is required to activate PcG target gene expression.
(A) T1...

Fig 4. ALP1 is widely expressed and its protein product is...

Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2

Article

Full-text available

Dec 2015

The Polycomb group (PcG) and trithorax group (trxG) genes play crucial roles in development by regulating expression of homeotic and other genes controlling cell fate. Both groups catalyse modifications of chromatin, particularly histone methylation, leading to epigenetic changes that affect gene activity. The trxG antagonizes the function of PcG g...