Belen Pastor VillaescusaInstituto Maimónides de Investigación Biomédica de Córdoba | IMIBIC · Metabolism in childhood
Belen Pastor Villaescusa
PhD Nutrition and Food Technology
About
28
Publications
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523
Citations
Citations since 2017
Publications
Publications (28)
Background:
Monitoring of the macrocirculation during surgery provides limited information on the quality of organ perfusion.
Objective:
We investigated the feasibility of perioperative microcirculatory measurements in children.
Methods:
Sublingual microvessels were visualized by handheld videomicroscopy in 11 children (19 mo - 10 yrs) undergo...
Obesity plays an important role in the development and progression of breast cancer via various oncogenic pathways. However, the biological mechanisms underlying this relationship are not fully understood. Moreover, it is unclear whether obesity-related and further associated biomarkers could be suitable targets for lifestyle interventions. This sy...
Introduction: The high prevalence of childhood obesity in Spain requires the implementation of preventive strategies.
Objectives: The aim was to evaluate an intervention based on Mediterranean lifestyle and the regular practice of physical activity to reduce the incidence of pediatric obesity and improve the physical fitness in children aged 3 to 6...
Objective
To assess the associations between eating speed, adiposity, cardiometabolic risk factors and diet quality in a cohort of Spanish preschool-children.
Study design
A cross-sectional study in 1271 preschool children (49% girls; mean age: 4.8 ± 1.0 years) from the CORALS cohort was conducted. After exclusions, 956 participants were included...
Background: Kawasaki Disease (KD) is a generalized vasculitis in childhood with possible
long-term impact on cardiovascular health besides the presence of coronary artery lesions. Standard vascular parameters such as carotid intima–media thickness (cIMT) have not been established as reliable markers of vascular anomalies after KD. The carotid intim...
Aims
Kawasaki disease (KD) is an acute systemic vasculitis with possible long-term impact of general cardio-vascular health. An endothelial glycocalyx disorder during the disease's acute phase might predispose to long-term vascular anomalies leading to endothelial dysfunction and atherosclerosis. To investigate any association between increased car...
Reducing the incidence of gastrointestinal infections (GIs) that occur at early stages to mitigate hospitalizations and treatments with adverse effects is a promising strategy for providing well-being to infants and their families. This systematic review and meta-analysis explores whether the early administration of Limosilactobacillus fermentum CE...
Background
Metformin, a first-line oral antidiabetic agent that has shown promising results in terms of treating childhood and adolescent obesity, might influence the composition of the gut microbiota. We aimed to evaluate whether the gut microbiota of non-diabetic children with obesity changes after a metformin intervention.
Methods
The study was...
Background
Conduit dilatation above 110% and TPVI in conduits <16 mm is not recommended. However, if we want to reach normal values for RVOT diameters and diminish reintervention rates, pushing these boundaries is essential.
Methods
Analysis of subsequent patients who underwent TPVI with Edwards Sapien valves in conduits ≤16 mm between 2010 and 20...
Polygenetic risk scores (pGRSs) consisting of adult body mass index (BMI) genetic variants have been widely associated with obesity in children populations. The implication of such obesity pGRSs in the development of cardio-metabolic alterations during childhood as well as their utility for the clinical prediction of pubertal obesity outcomes has b...
Sweeteners that are a hundred thousand times sweeter than sucrose are being consumed as sugar substitutes. The effects of sweeteners on gut microbiota composition have not still been completely elucidated and numerous gaps related to the effects of nonnutritive sweeteners (NNS) in health are still in discussion. The NNS, aspartame and acesulfame-K...
The breast milk microbiota has been described as a source of bacteria for infant gut colonisation. We studied the effect of Lactobacillus fermentum CECT5716 (Lc40) on growth and infection incidence of the infants, when the probiotic is administrated to the mothers. Moreover, whether such effects might depend on the interaction between the mother or...
Metformin is a first-line oral antidiabetic agent that has shown additional effects in treating obesity and metabolic syndrome. Inter-individual variability in metformin response could be partially explained by the genetic component. Here, we aimed to test whether common genetic variants can predict the response to metformin intervention in obese c...
Introduction
Obesity is a disorder characterized by a disproportionate increase in body weight in relation to height, mainly due to the accumulation of fat, and is considered a pandemic of the present century by many international health institutions. It is associated with several non-communicable chronic diseases, namely, metabolic syndrome, type...
Purpose:
This study aimed to examine the associations of sedentary time, physical activity (PA) and step-related behaviors with neurotrophic growth factors.
Methods:
A total of 97 children with overweight/obesity age 8 to 11 yr participated in this study. Sedentary time, PA, and steps were measured by GT3X+ accelerometers in hip and nondominant...
Objectives:
Metformin has shown its effectiveness in treating obesity in adults. However, little research has been conducted in children, with a lack of attention on pubertal status. The objectives were to determine whether oral metformin treatment reduces BMI z score, cardiovascular risk, and inflammation biomarkers in children who are obese depe...
Introducción: La metformina es un fármaco indicado para tratar la diabetes mellitus tipo-II debido a su efecto anti-hiperglucemiante, pudiendo ser eficaz para el tratamiento de la obesidad. Sin embargo, existe poca evidencia de su efecto en niños, y su diferente respuesta según pubertad.
Objetivo: Evaluar el efecto de metformina en la sensibilidad...
Background:
Overweight and obesity are considered to be serious public health problems. In pediatric populations, insulin resistance, dyslipidemia, and hypertension associated with obesity occur with increased frequencies. Metformin is an oral anti-hyperglycemic agent that has been demonstrated to be efficacious in the treatment of diabetic and no...
Introducción: La obesidad y el sobrepeso son importantes problemas de salud pública que están aumentando en las últimas décadas, especialmente en la población infantil. La metformina es un fármaco indicado para el tratamiento de la Diabetes Mellitus Tipo II debido a su efecto anti-hiperglucemiante, que podría ser eficaz para el tratamiento de la ob...
The new and recent advances in neuroelectric and neuroimaging technologies provide a new era for further exploring and understanding how brain and cognition function can be stimulated by environmental factors, such as exercise, and particularly to study whether physical exercise influences brain development in early ages. The present study, namely...
The prevalence of cardiovascular diseases (CVD) is rising and is the prime cause of death in all developed countries. Bioactive compounds (BAC) can have a role in CVD prevention and treatment. The aim of this work was to examine the scientific evidence supporting phenolic BAC efficacy in CVD prevention and treatment by a systematic review. Database...
The prevalence of cardiovascular diseases (CVD) is rising and it is the prime cause of death in all developed countries. Bioactive compounds (BACs) can play a role in CVD prevention and treatment. To examine the scientific evidence supporting BACs groups' efficacy in CVD prevention and treatment, we conducted a systematized review.
All available in...
Questions
Question (1)
When you have two measurements for each patient, and you want to assess if these two values are statistically similar or not, which statistical method is more suitable?
Thank you very much in advance!!
Projects
Projects (6)
This is a clinical trial performed to study the efficacy of Lactobacillus fermentum CECT5716 to reduce the mastitis incidence in nursing women. Moreover, we also evaluate the effect of this probiotic on the infants growth and health when is administrated to the mothers.
CORALS es el primer estudio de cohortes prospectivo multi-céntrico, que incluye niños de 3 a 6 años con recogida de información anual en los que se pretende realizar un seguimiento durante una media de 10 años.
El objetivo principal del presente estudio es identificar los factores de riesgo de obesidad infantil
La obesidad infantil ha sido reconocida por la OMS como una prioridad en el Plan de acción mundial 2013-2020 para la prevención y el control de las enfermedades crónicas no transmisibles. España tiene una de las frecuencias más elevadas de sobrepeso de Europa.
