Beatrice Kern

• medical doctor at Claraspital Basel

Background Teratomas are germ cell tumors composed of somatic tissues from up to three germ layers. Primary retroperitoneal teratomas usually develop during childhood and are uncommon in adults and in the retroperitoneal space. While there are only a few cases of retroperitoneal thyroid tissue, we report a unique case of a retroperitoneal papillary...

Background The most frequent complication of total thyroidectomy remains hypocalcemia due to low postoperative levels of serum intact parathyroid hormone (iPTH). The purpose of this study was to investigate the role of decreased iPTH at the end of surgery in predicting hypocalcemia. In addition, we examined the percentage decrease of iPTH as potent...

Background Teratomas are germ cell tumors composed of somatic tissues from up to three germ layers. Primary retroperitoneal teratomas usually develop during childhood and are uncommon in adults and in the retroperitoneal space. While there are only a few cases of retroperitoneal thyroid tissue, we report a unique case of a retroperitoneal papillary...

Background Robotic-assisted colorectal surgery has gained more and more popularity over the last years. It seems to be advantageous to laparoscopic surgery in selected situations, especially in confined regions like a narrow male pelvis in rectal surgery. Whether robotic-assisted, left-sided colectomies can serve as safe training operations for les...

The use of 18F-2-Fluoro-2-Desoxy-D-Glucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT) has become an integral part of patient management in many lymphoid malignancies. However, the diagnostic accuracy of FDG-PET/CT in some indolent lymphoid malignancies with commonly low FDG-avidity, including Chronic Lymphocytic Leukaemia (CLL) c...

Neoadjuvant chemo-radiotherapy (nCRT) of locally advanced rectal cancer is associated with challenging surgical treatment and increased postoperative morbidity. Robotic technology overcomes laparoscopy limitations by enlarged 3D view, improved anatomical transection accuracy, and physiologic tremor reduction. Patients with UICC stage II–III rectal...

Objective Total thyroidectomy represents the gold standard surgical procedure for patients with malignant thyroid disease. Over the past decades, the total thyroidectomy gradually replaced the subtotal thyroidectomy for benign thyroid disorders as well. Postoperative hypocalcemia remains the most frequent complication. The close proximity of parath...

Background: Since 2015 operations performed in the field of endocrine surgery have been entered into the European registry EUROCRINE®. The aim of this analysis was a description of the current healthcare situation for adrenal surgery in a homogeneous healthcare environment corresponding to the German-speaking countries-or to the presence of the wo...

Die Hypokalzämie bedingt durch eine Dysfunktion der Nebenschilddrüsen ist eine mögliche Komplikation nach totaler Thyreoidektomie. Die Inzidenz des passageren Hypoparathyreoidismus liegt bei 8 %, die des permanenten Hypoparathyreoidismus bei 1,5 %. Ursachen sind hauptsächlich die Devaskularisation oder die akzidentielle Entfernung der Nebenschilddr...

Comparison of robotic­-assisted vs laparoscopic resection of rectal cancer after neoadjuvant chemoradiotherapy

Objective: In the course of laparoscopic Roux-en-Y gastric bypass (LRYGB), a tight gastroenterostomy (GE) may lead to higher weight loss but possibly to an increase of local complications such as strictures and ulcers. Different operative techniques for Roux-en-Y reconstruction may also influence the rate of internal hernias, a typical late compli...

Obesity is associated with impaired mitochondrial function. This study compares mitochondrial protein expression in omental fat in obese and non-obese humans. Omental adipose tissue was obtained by surgical biopsy, adipocytes were purified and mitochondria isolated. Using anion-exchange chromatography, SDS-PAGE and mass-spectrometry, 128 proteins w...

Supplementary data

Impaired mitochondrial function is important in obesity and the development of insulin resistance and diabetes. The aim of this study was to identify human adipocyte-derived mitochondrial proteins associated with obesity. Mitochondrial proteins from 20 abdominal omental adipose tissue biopsies (13 obese and 7 control subjects) were separated by ani...

Laparoscopic sleeve gastrectomy (LSG) has been proposed as an effective alternative to the current standard procedure, laparoscopic Roux-en-Y gastric bypass (LRYGB). Prospective data comparing both procedures are rare. Therefore, we performed a randomized clinical trial assessing the effectiveness and safety of these 2 operative techniques. Two hun...

The activities of some key enzymes in mitochondria from 135 human omental adipose tissue samples of obese and nonobese patients were analyzed for potential association with the patients' state of obesity. The activities of respiratory complexes I and II as well as citrate synthase in isolated mitochondria were measured using spectrophotometric enzy...

Laparoscopic sleeve gastrectomy (LSG) is gaining popularity, but studies reporting long-term results are still rare. The objective of this study was to present the 5-year outcome concerning weight loss, modification of co-morbidities, and late complications. This is a retrospective analysis of a prospective cohort with a minimal follow-up of 5 year...

The mechanisms of amelioration of glycemic control early after laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG) are not fully understood. In this prospective, randomized 1-year trial, outcomes of LRYGB and LSG patients were compared, focusing on possibly responsible mechanisms. Twelve patients were randomized t...

La place des prothèses non résorbables dans la chirurgie du prolapsus vaginal a pris beaucoup d’ampleur ces dernières années. Les complications tardives commencent à apparaître.

Die Kenntnis sowohl des regelhaften Verlaufes und der Gefäßversorgung der Gallenwege als auch deren Gang- und Gefäßvariationen ist für eine sichere, komplikationsarme hepatobiliäre Chirurgie essenziell.

Contexte : La place des prothèses non résorbables dans la chirurgie du prolapsus vaginal a pris beaucoup d'ampleur ces dernières années. Les complications tardives commencent à apparaître. Cas : Nous vous présentons le cas d'une érosion tardive dans le bas rectum. Pour autant que nous sachions, il s'agit de la première mention de cette complication...

Deficiencies in micronutrients after bariatric operations are frequent, despite routine supplementation. Main outcome measures were pre- and postoperative frequency of nutrient deficiencies and success rate of their treatment. Between 5/2004 and 12/2006, 136 patients (m:f = 0:4) with an average body mass index of 45 (35-58) kg/m(2) and age of 53 (2...

Hypocalcemia due to a dysfunction of the parathyroid glands is a frequent complication after total thyroidectomy. The incidence has been reported at 8 % for transient hypoparathyroidism and at 1.5 % for permanent hypoparathyroidism. Devascularisation or accidental removal of the parathyroid gland is the most common reason for postoperative hypocalc...

Impairment of mitochondrial function plays an important role in obesity and the development of insulin resistance. The aim of this project was to investigate the mitochondrial DNA copy number in human omental adipose tissue with respect to obesity. The mitochondrial DNA (mtDNA) content per single adipocyte derived from abdominal omental adipose tis...

The exclusion of the proximal small intestine is thought to play a major role in the rapid improvement in the metabolic control of diabetes after gastric bypass. In this randomized, prospective, parallel group study, we sought to evaluate and compare the effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) with those of laparoscopic sleeve gast...

We investigated early and midterm results of laparoscopic sleeve gastrectomy (LSG) as an isolated primary and secondary operation after failed gastric banding. Between May 2004 and October 2007, a total of 70 patients (female 77%, mean age 43 (21-65) years, mean initial body mass index (BMI) 46 (35-61) kg/m(2)) were prospectively evaluated and oper...

Background: The exclusion of the proximal small intestine is thought to play a major role in the rapid improvement in the metabolic control of diabetes after gastric bypass. Objective: In this randomized, prospective, parallel group study, we sought to evaluate and compare the effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) with those of l...

We investigated the outcome predictors of laparoscopic gastric banding (LAGB) for morbidly obese patients. From December 1996 to November 2004, a total of 380 consecutive unselected patients (78% female; median age 40 yr, range 17-66; body mass index 44.3 kg/m(2), range 35-75) were prospectively evaluated and underwent LAGB. The follow-up rate afte...

We report a 68-year-old man with sigmoid colon carcinoma who previously underwent an anterior resection. Five years later, he developed a severe diverticular bleeding which required multiple blood transfusions. He underwent an emergent low anterior colectomy with a right colostomy to protect the anastomosis. Nine days after the operation, he had an...

We investigated the success rate of a two-stage operative concept for treatment of morbid obesity: primary laparoscopic adjustable gastric banding (LAGB, Lap-Band) for all morbidly obese patients, followed by sleeve gastrectomy with biliopancreatic diversion (duodenal switch or DS) in case of failure. From Dec 1996 to May 2004, 366 consecutive pati...

Stapled hemorrhoidopexy has been demonstrated to be advantageous in the short term compared with the traditional techniques. We aimed to evaluate long-term results after stapled hemorrhoidopexy and to assess patient satisfaction in association with postoperative hemorrhoidal symptoms. This prospective study included 216 patients with Grade 2 or 3 h...

b Histopathologie/Zytologie Viollier AG, Basel Summary Solitary thyroid metastasis of renal cell carcinoma eleven years after nephrectomy A 74-year-old patient presented with nodular goitre. A cold nodule in the right upper thyroid lobe, which had been known for several years, had increased in size over the previous few months. The patient had a hi...

Two techniques for treatment of Zenker's diverticulum, endoscopic stapler-assisted esophagodiverticulostomy and open cricopharyngeal myotomy by transcervical approach, were compared with regard to patient satisfaction and quality of life. Between January 1994 and December 2004 a total of 47 patients with Zenker's diverticulum underwent surgery in o...

Bei der akuten Cholangitis handelt es sich um eine meist bakterielle Entzündung der Gallengänge, die der Antibiotikatherapie sowie der Dekompression der Gallenwege bedarf. Die Papillenstenose ist eine benigne, organische, nichtneoplastische Verengung der Papille. Sie wird heute zusammen mit der Papillendyskinesie zum Begriff der Papillendysfunktion...

Slippage occurs after 2-18% of gastric bandings performed by the perigastric technique (PGT). We investigated the slippage-rate before and after the introduction of the pars flaccida technique (PFT) and the 11-cm Lap-Band, and the long-term results of the re-operated patients. Between Dec 1996 and Feb 2004, 360 patients with a mean BMI of 44 kg/m2...

Perioperative morbidity and long-term results after hemorrhoidectomy (Ferguson's technique) were evaluated as a basis for comparison with new methods such as stapled hemorrhoidectomy. All records of patients who underwent conventional hemorrhoidectomy between January 1, 1993 and December 31, 1997 (five years) were retrospectively analyzed. The surg...

We studied developments in indication, operation time, conversion rate, morbidity, and mortality from the beginning of laparoscopic cholecystectomy. Between 1990 and 2002 we prospectively evaluated 4498 patients undergoing cholecystectomy (CE), of whom 79% were treated laparoscopically (lap). In 6.6%, the procedure had to be converted from laparosc...

In vorliegender Studie wurden Vernderung der Indikationsstellung, Operationsdauer, Umsteigerate, Morbiditt und Mortalitt seit Einfhrung der laparoskopischen Cholezystektomie nach Abschluss der Lernkurve untersucht. Hierzu wurden von 1990 bis 2002 prospektiv 4498 Patienten erfasst, davon wurden 79% rein laparoskopisch operiert (lap. CE), bei 6,6% mu...

We describe a young female patient suffering from a PEComa (perivascular epithelioid cell tumor) of the cecum, incidentally found at an examination made by her family physician. The perivascular epithelioid cell tumor is a very rare tumor, until today reported in a few cases in falciform ligament, uterus, jejunum, terminal ileum, rectum, liver, kid...

Constipation is an occasional problem after gastric banding and is often caused by insufficient liquid intake. As a result, the use of laxatives is widespread in such patients. Depending on the laxative, improper use can lead to bolus obstruction above the band, as occurred in this case. Case Report: A 59-year-old female with uncomplicated laparosc...

Several inhibitors of angiogenesis have been identified in bovine and shark cartilage. One of them is troponin I, which is the molecule responsible for the inhibition of the actomyosin ATPase during muscle contraction. In this study we sought to investigate if the active site of troponin I (peptide Glu94-Leu123; pTnI) is also the one responsible fo...

Background: Patients with ulcerative colitis are at high risk for cancer and are often treated by total proctocolectomy with ileostomy. Primary adenocarcinoma arising at an ileostomy site is an exceedingly rare complication of long-term ileostomies. Patient and Methods: We add the 30th case to the literature, a patient 47 years after colectomy and...

To analyze the feasibility, safety, complication and death rates, and early functional results of the transverse coloplasty pouch procedure after low anterior rectal resection and total mesorectal excision. The authors previously developed a novel neorectal reservoir, the transverse coloplasty pouch, in an animal model; they report the first clinic...

Objective: To analyze the feasibility, safety, complication and death rates, and early functional results of the transverse coloplasty pouch procedure after low anterior rectal resection and total mesorectal excision. Summary Background Data: The authors previously developed a novel neorectal reservoir, the transverse coloplasty pouch, in an animal...

We report the case of a 66-year-old male with ulcerative colitis diagnosed in 1987, who had been treated with azathioprine (AZA) for the past two years (average dose about 1.6 mg/kg/day). In May 1999 he presented with painless jaundice, fatigue and recent weight loss. Cholestatic enzymes were elevated, alpha-fetoprotein was normal and hepatitis B/C...