Bèatrice Fervers

• Centre Léon Bérard

Background Usual walking pace represents a practical indicator of overall health. However, its association with cancer development remains unexplored. We investigated the relation between self-reported walking pace and cancer risk. Methods Using baseline UK Biobank data from 2006 to 2010, excluding the first two years of follow-up to reduce revers...

Background: Several studies have highlighted the role of environmental exposures in malignant hemopathies etiology. Some patients with malignant hemopathies can be compensated as occupational diseases. The Prolymphome research aimed to assess a systematic screening of occupational exposures in patients with lymphoma or myeloma treated in three hosp...

Background: Cancer, cardiovascular diseases (CVD), and type 2 diabetes (T2D) may co-occur, a condition referred to as multimorbidity. Physical activity is inversely associated with each of these diseases; however, the biologic pathways underlying these relationships remain incompletely understood. Methods: In 33,806 UK Biobank participants, we deri...

Complications are often poorly identified and managed in cancer survivors after treatment and restoring their initial quality of life remains a challenge, particularly in a context of unequal access to care nationwide. The PASCA “Parcours de Santé au cours du Cancer [in English: healthcare pathways with cancer]” feasibility study was conducted in t...

Objective Low body fat and high physical activity levels are key lifestyle factors in cancer prevention, but the interplay of abdominal obesity and physical activity on cancer risk remains unknown. We explored individual and joint associations of waist circumference and physical activity with cancer risk. Methods Using UK Biobank data (n=315 457),...

Mycotoxins have been hypothesized to contribute to a diversity of adverse health effects in humans, even at low concentrations. Certain mycotoxins are established human carcinogens, whereas for others research suggests potential carcinogenic effects. The aim of this study was to determine the association between dietary exposure to mycotoxins and h...

Background Growing epidemiological evidence suggests an association between exposure to air pollutants and breast cancer. Yet, the underlying mechanisms remain poorly understood. This study explored the mediating role of thirteen metabolic health biomarkers in the relationship between exposure to three air pollutants, i.e. nitrogen dioxide (NO2), p...

Background Individual traditional anthropometric measures like body mass index (BMI) and waist circumference may not fully capture the relation of adiposity to mortality. Investigating multi-trait body shapes could overcome this limitation, deepening insights into adiposity and mortality. Methods Using UK Biobank data from 462,301 adults (40-69 ye...

Background: Current evidence on associations between circulating bilirubin and colorectal cancer (CRC) risk is inconsistent. Methods: In this prospective study, we investigated associations of pre-diagnostic circulating levels of total and indirect bilirubin with CRC risk in 78,467 Korean adults aged 40-78 years at recruitment, considering poten...

Introduction Adolescents and young adults (AYA) with cancer undergo physical transformations due to disease and treatments occurring alongside puberty and adolescence. Although physical activity is recommended for its benefits, its practice among AYA with cancer remains insufficient. The aim of the Éducation Thérapeutique et Activité Physique: Enga...

Background Physical activity reduces colorectal cancer risk, yet the diurnal timing of physical activity in colorectal cancer etiology remains unclear. Methods This study used 24-h accelerometry time series from UK Biobank participants aged 42 to 79 years to derive circadian physical activity patterns using functional principal component analysis....

Background While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP) are of particular concern due to endocrine-disrupting properties and their carcinogenetic effect. Obje...

Background Women with breast cancer face many barriers to return to work (RTW) after their cancer. The main objective of the FASTRACS-RCT is to evaluate the impact of the FASTRACS (Facilitate and Sustain Return to Work after Breast Cancer) intervention on the sustainable RTW of breast cancer patients, 12 months after the end of active treatment. M...

Background Growing epidemiological evidence suggests an association between exposure to air pollutants and breast cancer. Yet, the underlying mechanisms remain poorly understood. This study explored the mediating role of thirteen metabolic health biomarkers in the relationship between exposure to three air pollutants, i.e. nitrogen dioxide (NO2), p...

Introduction With an incidence of 2769 cases in 2018 in France, testicular cancer is a “rare” cancer, however an increase in the incidence of TGT has been observed in recent decades. Recently, the link with pesticide exposure has begun to be suspected, but the data are currently discordant. The aim of the TESTISPRO study is to estimate the effects...

Outdoor exposure to particulate matter (PM2.5 and PM10) in urban areas can vary considerably depending on the mode of transport. This study aims to quantify this difference in exposure during daily travel, by carrying out a micro-sensor measurement campaign. The pollutant exposure was assessed simultaneously over predefined routes in order to allow...

10551 Background: Li-Fraumeni syndrome (LFS) and more generally g TP53m situations increase the risk of many malignancies. A modifier role of several attributable factors has been recently suggested on LFS-carcinogenesis, including reproductive and lifestyle factors, obesity, physical activity (PA) and diet. However, among g TP53m carriers, prevent...

10572 Background: Human exposure to air pollution involves complex mixtures of multiple correlated air pollutants. To date, very few studies have assessed the combined effect of exposure to multiple air pollutants on breast cancer risk. We assessed the joint effects of multiple air pollutants and breast cancer risk. Methods: The study was based on...

Background While overall head and neck cancer incidence decreases due to reduced tobacco and alcohol consumption, the incidence of HPV negative oral cavity squamous cell carcinoma (SCC) is raising in several industrialized countries, especially in non-smoking and non-drinking patients. Case presentation We document a case of gingiva SCC in a 56 ye...

It remains unknown whether adiposity subtypes are differentially associated with colorectal cancer (CRC). To move beyond single-trait anthropometric indicators, we derived four multi-trait body shape phenotypes reflecting adiposity subtypes from principal components analysis on body mass index, height, weight, waist-to-hip ratio, and waist and hip...

Outdoor exposure to particulate matter (PM 2.5 and PM 10) in urban areas can vary considerably depending on the mode of transport. This study aims to quantify this difference in exposure during daily travel, by carrying out a micro-sensor measurement campaign. The pollutant exposure was assessed simultaneously over predefined routes in order to all...

Objectives: Etiological factors of testicular germ cell tumors (TGCT) remain largely unknown, but a causal role of occupational exposures to solvents has been suggested. Previous studies analyzing these exposures reported discordant results, potentially related to exposure assessment methods. The aim of this study was to investigate the role of oc...

Body shape phenotypes combining multiple anthropometric traits have been linked to postmenopausal breast cancer (BC). However, underlying biological pathways remain poorly understood. This study investigated to what extent the associations of body shapes with postmenopausal BC risk is mediated by biochemical markers. The study included 176,686 post...

This article describes some of the key prevention services in the Leon Berard Comprehensive Cancer Center (CLB) Lyon, France, which are based on clinical prevention services, outreach activities, and collaboration with professional and territorial health communities. In addition, research is embedded at all stages of the prevention continuum, from...

Background: While genetic, hormonal, and lifestyle factors partially elucidate the incidence of breast cancer, emerging research has underscored the potential contribution of air pollution. Polychlorinated biphenyls (PCBs) and benzo[a]pyrene (BaP), are of particular concern due to endocrine-disrupting properties, and accumulation in various environ...

Acute exercise induces transient modifications in the tumor microenvironment and has been linked to reduced tumor growth along with increased infiltration of immune cells within the tumor in mouse models. In this study, we aimed to evaluate the impact of acute exercise before treatment administration on tumor growth in a mice model of MC38 colorect...

Introduction Residential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. This...

Background Testicular germ cell tumors (TGCT) are the most frequent cancer in young men in developed countries. Parental occupational exposures during early-life periods are suspected to increase TGCT risk. The objective was to estimate the association between parental occupations at birth and adult TGCT. Methods A case–control study was conducted...

Background Testicular germ cell tumours (TGCTs) are the most common malignancy in men aged 15–40 years, with increasing incidence worldwide. About 33 ~ 50% of the patients present with metastatic disease at diagnosis. TGCT survivors experience short- and long-term sequelae, including cancer-related fatigue (CRF). Physical activity (PA) has establis...

Body shape phenotypes combining multiple anthropometric traits have been linked to postmenopausal breast cancer (BC). However, underlying biological pathways remain poorly understood. This study investigated to what extent the associations of body shapes with postmenopausal BC risk is mediated by biochemical markers. The study included 176,686 post...

The incidence of the mobile tongue cancer in young patients has been rising. This oral cancer (OC) type has no identified risk factors (NIRF), no established molecular markers and is not yet recognized as a distinct clinical entity. To understand this emerging malignancy, we innovatively analyzed the public head and neck cancer multi-omics data. We...

Background: The benefit of physical activity (PA) for increasing longevity is well-established, however, the impact of diurnal timing of PA on mortality remains poorly understood. We aimed to derive circadian PA patterns and investigate their associations with all-cause mortality. Methods: We used 24 h PA time series from 96,351 UK Biobank parti...

The chronic distress faced by healthcare professionals (HCPs) in oncology was exacerbated by the COVID-19 pandemic, heightening the need to improve their resilience. The Entretiens Jacques Cartier symposium provided an opportunity for participants from France and Quebec to share perspectives on resilience at work and discuss interventions at indivi...

Objectives: The etiology of testicular germ cell tumors (TGCT) is suspected to be related to prenatal environmental risk factors. Some solvents have potential endocrine disrupting or carcinogenic properties and may disrupt male genital development in utero. The aim of this study was to examine the association between parental occupational exposure...

Objective Testicular germ cell tumours (TGCT) are the most common cancer in men of working age and its incidence has increased notably over the past 40 years. Several occupations have been identified as potentially associated with TGCT risk. The aim of this study was to further explore the relationship between occupations, industries and TGCT risk...

Head and neck (HN) squamous cell carcinomas (SCCs) originate from the epithelial cells of the mucosal linings of the upper aerodigestive tract, which includes the oral cavity, the pharynx, the larynx, and the sinonasal cavities. There are many associated risk factors, including alcohol drinking coupled with tobacco use, which accounts for 70% to 80...

Comme pour les patients, les besoins des proches aidants évoluent tout au long de la maladie, nécessitant de ce fait des propositions d’aide tout au long du parcours de soins du patient. En plus des dispositifs de soutien déjà présents, trois dispositifs spécifiques ont été créés : un accueil téléphonique, une consultation proche aidant et une cons...

Introduction Testicular cancer is the most common cancer in young men. The causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated associations between paternal occupational exposure to heavy metals and welding fumes at birth and the risk of testicular germ cell tumors (TGCT) in th...

Occupational lung cancer cases remain largely under-reported and under-compensated worldwide. In order to improve the detection and compensation of work-related lung cancers, we implemented a systematic screening of occupational exposures, combining a validated self-administered questionnaire to assess occupational exposures and a specialized occup...

Objective: This study investigated the association between occupational asbestos exposure (OAE) and survival in patients with histologically confirmed lung cancer (LC). Methods: This monocentric study was conducted in the Comprehensive Cancer Centre Léon Bérard, Lyon, France. A systematic screening has been in place since 2014 for occupational e...

Simple Summary Investigating body shapes may offer novel insights into the role of adiposity and body size in breast cancer development. We derived three distinct body shapes from combinations of height, weight, body mass index (BMI), waist and hip circumference, and waist-to-hip ratio (WHR) by a principal component analysis. We then used genetic v...

Aim: To evaluate the evolution of addictions (tobacco and alcohol) and social precarity in head and neck squamous cell carcinoma survivors when these factors are addressed from the time of diagnosis. Methods: Addictions and social precarity in patients with a new diagnosis of HNSCC were assessed through the EPICES score, the Fagerström score, an...

Simple Summary We reviewed 21 epidemiological studies on breast cancer risk and exposure to traffic-related air pollution. The exposure assessment methodologies were heterogeneous. There was variability across studies on temporal concordance between the exposure periods relevant to breast cancer and the time period of the exposure assessment. There...

Importance The benefit of physical activity (PA) for increasing longevity is well–established, however, the impact of diurnal timing of PA on mortality remains poorly understood. Objective To derive PA patterns and investigate their associations with all–cause mortality. Design, Setting, and Participants This population-based prospective cohort stu...

Background Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers. Methods We derived four distinct body shape phenotypes from principal component (PC) analysis on hei...

Objectifs En épidémiologie des risques professionnels, l’évaluation des expositions est une étape cruciale qui conditionne la capacité d’une étude à mettre en évidence des associations entre une exposition et une maladie. Afin d’évaluer si l’exposition professionnelle aux solvants des parents pendant la grossesse et au cours de l’année de naissance...

Nitrogen dioxide (NO2) is an important air pollutant due to its adverse effects on human health. Yet, current evidence on the association between NO2 and the risk of breast cancer lacks consistency. In this study, we investigated the association between long-term exposure to NO2 and breast cancer risk in the French E3N cohort study. Association of...

Testicular cancer is the most common cancer in young men. Its causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated paternal occupational exposure to heavy metals and welding fumes and the risk of testicular germ cell tumors (TGCT) in their offspring. A total of 454 cases and 670...

Background and Aim Daily travel can represent a significant part of personal exposure to air pollution, up to 30% of the daily inhaled dose, despite very short exposure times (3-6% of circadian time). This exposure varies considerably depending on the mode of transport. This study aims to quantify the difference in exposure during daily mobility by...

Background: Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associatio...

Background/Objectives About 1,000,000 new cases of cancer in Adolescent and Young Adults (AYAs) are diagnosed annually worldwide. . While their long term survival is about 80%, they are six times more likely to develop a second primary cancer (SPC) compared to their peers. This risk is multifactorial and depends on the type of first cancer, treatme...

Objective We assessed the association between parental prenatal exposures in wood-related jobs and risk of testicular germ cell tumours (TGCT) in offspring. Methods NORD-TEST, a registry-based case–control study in Sweden, Finland and Norway, included 8112 TGCT cases diagnosed at ages 14–49 years between 1978 and 2012 with no history of prior canc...

Air pollution is a dramatic issue that grips the majority of densely populated cities in the world. It is nowadays quite evident that there is a relationship between air quality and some types of cancers (i.e. lung and bladder cancer), as reported by the International Agency for Research on Cancer (IARC 2012). Although the time spent commuting usua...

The International Agency for Research on Cancer established a causal link between asbestos exposure and ovarian cancer. However, the exposure frequency and histological characteristics of asbestos-associated ovarian cancers remain to be investigated in detail. This multicenter case–case study assessed the asbestos exposure in ovarian carcinoma (OC)...

Résumé Les comportements de vie, comme l’alimentation et l’activité physique, sont des facteurs influençant le risque de certains cancers. Ils sont aussi déterminants au cours et au décours de la maladie cancéreuse pour la bonne marche du traitement oncologique, mais aussi dans le pronostic immédiat et à long terme, et la qualité de vie pendant et...

Introduction Patients with metastatic non-small cell lung cancer (mNSCLC) suffer from numerous symptoms linked to disease and treatment which may further impair the patient’s overall condition. In addition to its benefits on quality of life and fatigue, physical exercise may improve treatment response, notably due to its known effects on the immune...

Introduction Les tumeurs germinales du testicule (TGT) représentent le cancer le plus fréquent chez l'homme jeune et leur incidence a doublé en France durant les trente dernières années. Certaines expositions professionnelles ont été identifiées comme potentiellement associées aux TGT. Cependant, leur évaluation rétrospective reste problématique po...

Introduction Les tumeurs germinales du testicule (TGT), bien que rares sur l'ensemble des tumeurs solides, sont les cancers les plus fréquents chez l'homme jeune (15 à 45 ans). Leur incidence a beaucoup augmenté dans les pays occidentaux ces dernières décennies et une origine environnementale des TGT est suggérée. L'exposition aux pesticides à des...

A mechanistic model from radiobiology has emerged by pointing out that the radiation-induced nucleo-shuttling of the ATM protein (RIANS) initiates the recognition, the repair of DNA double-strand breaks (DSB), and the final response to genotoxic stress. More recently, we provided evidence in this journal that the RIANS model is also relevant for ex...

Objectives: Head and neck squamous cell carcinomas (HNSCCs) mainly affect smokers and drinkers. However, oral cavity squamous cell cancers (OCSCCs) are increasingly affecting patients with no identified risk factors (NIRFs). This study aimed at characterising their experience of the disease. Methods: Qualitative study based on semi-structured in...

In epidemiology, left-truncated data may bias exposure effect estimates. We analyzed the bias induced by left truncation in estimating breast cancer risk associated with exposure to airborne dioxins. Simulations were run with exposure estimates from a Geographic Information System (GIS)-based metric and considered two hypotheses for historical expo...

While head and neck cancer incidence decreased worldwide due to reduced tobacco and alcohol consumption, oral tongue cancer (OTC) incidence has been reported to be increasing in several countries. Our study examines the incidence trends of OTC in France from 1990 to 2018, globally and by age; and compares the incidence trends with the evolution of...

Molecular studies suggest that cadmium due to its estrogenic properties, might play a role in breast cancer (BC) progression. However epidemiological evidence is limited. This study explored the association between long-term exposure to airborne cadmium and risk of BC by stage, grade of differentiation, and histological types at diagnosis. A nested...

Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men in developed countries and their incidence rate has doubled worldwide over the past 40 years. Early life exposures to pesticides are suspected to increase TGCT risk. Our research aimed at estimating adult TGCT risk associated with parental domestic use of pest...

Current evidence suggests that 30–50% of cancers are attributable to established lifestyle risk factors. Cancer-screening has been identified as an opportunity for delivering advice on lifestyle behaviour change for cancer prevention. This study aimed to evaluate the feasibility and acceptance of promoting advice on the latest evidence-based lifest...

Objective: The objective of this study is to assess the physical activity interest and preferences of cancer patients aged over 70 years during oncological treatments and to explore how demographic characteristics may modulate preferences. Methods: From April to May 2018, this cross-sectional study collected data from self-administered questionn...

Introduction: Despite safety and benefits of physical activity during treatment of localised breast cancer, successful exercise strategies remain to be determined. The primary objective of the 'dispositif connecté', that is, connected device in English trial is to evaluate the efficacy of two 6-month exercise interventions, either single or combin...