Beata Sarecka-Hujar Phd

Beata Sarecka-Hujar Phd
Medical University of Silesia in Katowice | SUM · Department of Basic Biomedical Science

PhD

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91
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Publications

Publications (91)
Article
Introduction The present study aimed to evaluate the prevalence of the arterial ischaemic stroke (AIS) in Polish children, as well as to analyse the parameters related to AIS hospitalization, including age, gender, region, month and season of a year at admission, duration and costs based on data from National Health Fund (NHF) registery in 2011–202...
Article
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The occurrence of arterial ischemic stroke (AIS) is a serious medical problem due to the deleterious neurological consequences that affect the daily functioning of the patient as well as the costs of medical care and rehabilitation [...]
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Background: Standard treatment of epileptic seizures involves the use of antiepileptic drugs (AEDs). Both AEDs themselves and treatment duration may influence the levels of biochemical parameters, e.g., lipids or homocysteine (HCys), that may increase the risk of cardiovascular diseases. The aim of the present study was to compare the levels of li...
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Since the teratogenicity of Thalidomide has been proven, herbal products are more commonly used in pregnancy to not only relieve morning sickness but also to fight infections. These products are frequently considered as natural and therefore harmless. However, herbs contain a number of active substances that, when used during pregnancy, can affect...
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Background: One of the parts of the broadly understood pharmaceutical care is health promotion. Therefore, the study aimed to find out how pharmacy students in Poland assess their own readiness to promote health in pharmacies and their own qualifications, competences, relevance, motivation and effectiveness of health promotion in pharmacies. Meth...
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Background: Cerebral palsy (CP) is not a defined, separate disease classification, but a set of etiologically diverse symptoms that change with the child’s age. According to the up-to-date definition, CP is a group of permanent but not unchanging disorders of movement and/or posture and motor function, which are due to a nonprogressive interference...
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Background: Numerous data show a role for genetic polymorphisms in the development of epilepsy. Previously, the TT genotype of the MTHFR 677C>T polymorphism was found to be associated with a decreased leucocyte DNA methylation status. Polymorphisms in the MTHFR gene could modify the pharmacodynamics of many drugs. This meta-analysis aimed to assess...
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Advances in genotypic technologies enable identification of possible associations between genetic variants of certain genes and increased risk of developing plaque psoriasis or psoriatic arthritis. The aim of the study was to analyze the NOTCH3 (6746T>C) (rs1044009) and PSMA6 (-8C>G) (rs1048990) polymorphisms and their role in genetic susceptibilit...
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(1) Background: The microbiome consists of microorganisms from various kingdoms with numerous physical and chemical properties Lactobacillus species constitute the highest percentage of healthy cervical and vaginal microbiota. Dysbiosis may cause adverse outcomes, e.g., bacterial vaginosis, pelvic inflammatory disease and pregnancy complications. T...
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Background Vitamin D deficiency occurs in as much as 90–95% of the Polish population, although this condition is known to cause negative long-term health implications. The role of medical doctors in advising proper supplementation, monitoring and correcting the levels of 25-hydroxyvitamin D in individuals is of great importance and should be used t...
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Health promotion programmes are complex and need to engage all health care specialists, including pharmacists. Pharmacies are considered as a potentially ideal place for health promotion and education. To evaluate own qualifications, competences, relevance, motivation and effectiveness of Polish pharmacy staff with regard to health-related informat...
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In developed countries, cerebrovascular diseases are among the 10 most common causes of death in both the pediatric and adult population. The prevalence of fatal outcomes following arterial ischemic stroke (AIS) in various groups of pediatric patients ranges from 1% to almost 32%. However, a constant improvement in stroke mortality among children h...
Preprint
Full-text available
Advances in genotypic technologies enable identification of possible associations between genetic variants of certain genes and increased risk of developing plaque psoriasis or psoriatic arthritis. The aim of the study was to analyze the NOTCH3 (6746T>C) (rs1044009) and PSMA6 (8C>G) (rs1048990) polymorphisms and their role in genetic susceptibility...
Article
Full-text available
Arterial ischemic stroke (AIS) in children is a rare condition; its frequency is estimated at 0.58 to 7.9 new onsets in 100,000 children per year. The knowledge on risk factors, clinical outcomes and consequences of pediatric AIS is increasing. However, there are still many unknowns in the field. The aim of the study was to analyze the clinical pre...
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Background: Abnormalities in levels of lipid parameters are one of the main causes of cardiovascular and cerebrovascular disease in adults. There are limited data on the role of disturbances of lipid metabolism in the etiopathogenesis of arterial ischemic stroke (AIS) in children and the results provided are ambiguous. The aim of the study was to c...
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In recent years, polyphenols have been extensively studied due to their antioxidant, anticancer, and anti-inflammatory properties. It has been shown that anthocyanins, flavonols, and flavan-3-ols play an important role in the prevention of bacterial infections, as well as vascular or skin diseases. Particularly, resveratrol, as a multi-potent agent...
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The male sex has been suggested to predominate in paediatric patients with arterial ischemic stroke (AIS), especially in newborns. The explanation for this phenomenon remains unsatisfactory since it focuses on the analysis of the potential relationship with trauma and arterial dissection. In turn, in some populations of young adults, men suffer fro...
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The objective of this study was to determine whether the severity of depressive symptoms was linked to healthy behaviors in Polish postmenopausal women and whether the strength of the link differed between women living in urban versus rural settings. The study was conducted in 2018 in the Lublin region of Poland and included 396 postmenopausal wome...
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Psoriasis (Ps) is an immune-mediated inflammatory skin disease that is widely associated with the clinical features of metabolic syndrome (MetS), including hypertension, abdominal obesity, insulin resistance, type 2 diabetes and dyslipidemia. Osteopontin (OPN), a multifunctional protein involved in the modulation of inflammatory processes, may cont...
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(1) Background: Caesarean sections in obese patients are associated with an increased risk of surgical wound complications, including hematomas, seromas, abscesses, dehiscence, and surgical site infections. The aim of the present study is to perform a meta-analysis and systematic review of the current literature focusing on the strategies available...
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Arterial ischemic stroke (AIS) in childhood is reported to occur more frequently in boys, which may lead to the assumption that the prevalence of post-stroke deficits is sex related. The present study aimed to evaluate sex-related differences in functional outcomes (hemiparesis, seizures, aphasia, and motor disturbances other than hemiparesis) in p...
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Background: Cesarean section is a surgical procedure, which is the most frequently performed in gynecology and obstetrics. It is commonly believed that an operative delivery is a less painful and safer mode of delivery, which translates into an increasing number of the procedures performed without medical indications. The maternal sequelae of cesa...
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Headaches are common complaints in children. The International Classification of Headache Disorders, 3rd edition (beta version), defines more than 280 types of headaches. Primary headaches refer to independent conditions that cause pain and include migraine, tension-type headaches (TTH), and trigeminal autonomic cephalalgias (TACs). Several agents...
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Background and objectives: Depression is a serious problem affecting people worldwide, however it more commonly concerns women. Depression reduces the quality of life and, in many cases, leads to suicide. Numerous new biological factors have been demonstrated to have an impact on the pathogenesis of depression, including vitamin D, thyroid hormones...
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Background Nowadays, pharmacists are expected to focus not only on dispensing medicines but also on the wellness of the patient. In some developed countries a pharmacist is clearly defined as a health care professional that can make a contribution to improving the general health of the population. Objective To assess the readiness of Polish pharmac...
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Cerebral palsy (CP) is a set of etiologically diverse symptoms that change with the child’s age. It is one of the most frequent causes of motor disability in children. CP occurs at a frequency of 1.5 to 3.0 per 1000 live-born children. CP often coexists with epilepsy, which is drug-resistant in a high number of cases. The aim of the present study w...
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Introduction Schizencephaly is one of the rare congenital defects of the central nervous system (CNS), known as neuronal migration disorders. The etiology of schizencecephaly is unequivocal. Established etiologies include in-utero infections (cytomegalovirus and herpes simplex virus, HSV type I), toxic abuse (cocaine, alcohol), as well as drug use...
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Małgorzata Sadowska,1 Beata Sarecka-Hujar,2 Ilona Kopyta3 1Department of Paediatrics and Developmental Age Neurology, Upper Silesian Child Health Centre, Katowice, Poland; 2Department of Basic Biomedical Science, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia in Katowice, Sosnowiec, Poland; 3Department of...
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Antiphospholipid syndrome (APS) or Hughes syndrome is an acquired thromboinflammatory disorder. Clinical criteria of APS diagnosis are large- and small-vessel thrombosis as well as obstetric problems; laboratory criteria are the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein-1). The...
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Currently, over 80% of all deaths result from the incidence of chronic diseases. The challenge of modern medicine is to develop innovative and effective methods of diagnosis and therapy of these disorders. Different types of particles can be obtained with the use of nanotechnology, including nanoliposomes, solid lipid nanoparticles (SLN), nanospher...
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Arterial ischemic stroke (AIS) experienced at a young age is undoubtedly a serious medical problem. AIS very rarely occurs at a developmental age, whereas in young adults, it occurs with a higher frequency. The etiologic mechanisms of AIS occurring in childhood and adulthood differ. However, for both age populations, neurological consequences of AI...
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The role of genetic risk factors for ischemic stroke seems to be in particular significance in pediatric patients. Numerous polymorphic variants of genes encoding proteins, that is, plasminogen activator inhibitor as well as coagulation factors, involved in the coagulation cascade may be related to arterial ischemic stroke (AIS) both in adults and...
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Epilepsy is a disease arising from morphological and metabolic changes in the brain. Approximately 60% of patients with seizures can be controlled with 1 antiepileptic drug (AED), while in others, polytherapy is required. The AED treatment affects a number of biochemical processes in the body, including increasing the risk of cardiovascular disease...
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Wprowadzenie Układy wielokompartmentowe, w których dawka substancji leczniczej jest rozdzielona między nośniki (liposomy, mikrosfery, mikrokapsułki, nanokapsułki), otwierają nowe możliwości w uzyskaniu przedłużonego lub kontrolowanego uwalniania substancji leczniczej. Mikrosfery to monolityczne, porowate lub gładkie cząstki sferyczne o wielkości 1–...
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The article presents current literature on interstitial pneumonia in children and infants in clinical and forensic medical aspect. Particular attention has been paid to the clinical course and etiological factors of the disease, as well as to the results of autopsy and histopathology. The article also discusses the possibility of extending the post...
Article
Microspheres are one of the multicompartment drug delivery systems. The active substance is incorporated into a polymeric matrix. The aim of the study was to determine physicochemical properties of furosemide microspheres prepared with Eudragit L30 D-55 matrix and to analyze their stability and drug release. A test formulation at the drug-polymer r...
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Introduction During menopause the level of estrogens is decreased, which may lead to cognitive impairment or dementia. Some forms of genetic polymorphism were found to be related to cognitive functions, including APOE and ESR1 (PvuII and XbaI) polymorphisms. In the present study we aimed to analyze the impact of interactions between APOE and ESR1 p...
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Beata Sarecka-Hujar,1 Ilona Kopyta2 1Department of Pharmaceutical Technology, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland; 2Department of Paediatric Neurology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland Abstrac...
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An elevated level of homocysteine is a risk factor for vascular diseases, brain atrophy and several other disorders. The 1298A>C polymorphism (rs1801131) leads to mildly decreased MTHFR activity. Previously, it was observed that the MTHFR 1298A>C polymorphism in combined analysis with the MTHFR 677C>T polymorphism increases homocysteine levels. How...
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ABSTRAKTWstęp: Prewencja wtórna pozwala zmniejszyć odsetek umieralności z powodu chorób układu krążenia (ChUK). Kluczową rolę w tym zakresie odgrywa promocja zdrowia i kampanie profilaktyczne. Farmaceuci w myśl założeń „Dobrej Praktyki Farmaceutycznej” powinni być w nie czynnie zaangażowani. Zweryfikowano wiedzę studentów kierunku farmacja na temat...
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ABSTRAKTWstęp: Do profilaktyki pierwotnej chorób układu krążenia należy promowanie zdrowego trybu życia, przez m.in. stosowanie zdrowej diety, zaprzestanie palenia czy regularne ćwiczenia fizyczne. Choroby układu krążenia (ChUK) są główną przyczyną wysokiej umieralności, przede wszystkim mężczyzn. Są to przewlekłe, wieloczynnikowe choroby, których...
Article
Introduction Elevated lipid concentrations were observed in adults with headaches. However, studies in children are scarce. Recent data suggest new potential risk factors for atherosclerosis, which may be associated with headaches. The aim of the study was to analyse the blood levels of lipids and new markers of atherosclerosis in children with idi...
Article
Melatonin is a hormone synthesized mainly by the pineal gland. Its precursor is the exogenous amino acid L-tryptophan. The basic function of this hormone is the regulation of circadian and seasonal rhythms. As an amphiphilic molecule, melatonin can easily cross biological barriers, which is why its effects can be exerted through a variety of mechan...
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The purpose of the study was to assess impact of four disintegrants (starch, microcrystalline cellulose, crospovidone and croscarmellose sodium) on release of trimetazidine hydrochloride from orally disintegrating tablets (ODTs). Tablets weighting 100 mg and containing 20 mg of trimetazidine were prepared with direct compression method using Erweka...
Article
In pharmaceutical technology, the analysis of physicochemical properties of raw materials, intermediates and products is part of quality control testing at each stage of designing formulations and in the routine evaluation of the final product. The aim of the study was to analyse the physical state of drug and the morphology of microspheres obtaine...
Chapter
Drug form technology enables a dosage form formulation that provides a drug directly to the site of action, with safe release for the patient, in controlled or extended ways. Biodegradable and biocompatible nanocarriers, in which the drug substance may be incorporated, closed, dissolved or adsorbed, were developed. Nanoparticles are spherical forms...
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The quality of the drug, its purity and identification of degradation products provide the highest quality of pharmaceutical products. The energy dispersive spectroscopy (EDS) method analyses the percentage of each element form as well as their distribution, and morphological characteristics of the drug form. We analysed the usefulness of EDS metho...
Article
The aim of the study was to evaluate the risk factors for spinal pain in Polish, postmenopausal women, working in agriculture. The study included 1751 randomly selected postmenopausal women aged 45−65. The women were exposed to hazardous work conditions, in particular the use of force, heavy lifting, often more than 10 kg and with frequency of at l...
Article
Objectives: To asses a possible relationship between serum cortisol concentration and cognitive function in peri- and postmenopausal women engaging in non-manual work. Methods: The Montreal Cognitive Assessment (MoCA) was used to screen women for the study and the Computerized Neurocognitive-assessment Software (CNS) Vital Signs to diagnose cogn...
Article
Introduction and objective. Postmenopausal women working in agriculture suffer from spinal pain for two overlapping reasons, the first is related to the menopause and the second to the specificity of rural work, which includes lifting heavy objects and changing weather conditions. Spinal pain affects the daily life of women as well as their ability...
Article
Introduction and objective. Since the role of vitamin D is essential in numerous biological processes its deficiency was suggested to be a risk factor for e.g. osteoporosis, musculoskeletal pain and spine pain. The purpose of the study was to analyse whether serum vitamin D concentration is related to pain involving the motor system in Polish postm...
Article
Background: Previous data have shown that the 20210G>A polymorphism of the Factor II gene is related to an increased prothrombin level, which may in turn lead to a procoagulant state. The heterogeneous and multifactorial character of arterial ischemic stroke often results in contradictory reports describing the association between the 20210G>A pol...
Article
The selection of a semisolid base type (hydrophobic, hydrophilic or emulsion) has an essential influence on the skin and transdermal delivery of active substances. The cutaneous and percutaneous absorption may be influenced by interactions occurring between base components and skin on the one hand and interactions between base components and the ac...
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Introduction Various neurological complications may occur as a consequence of arterial ischemic stroke (AIS) and have an impact on daily activity of the patients, costs of their medical care and rehabilitation. The aim of this study was to analyze risk factors, stroke symptoms and post-stroke consequences in Polish pediatric patients depending on s...
Article
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Telemedycyna jest formą świadczenia usług medycznych z wykorzystaniem narzędzi telekomunikacyjnych i technologii teleinformatycznych. Obowiązująca od 2015 roku nowelizacja ustawy o systemie informacji w ochronie zdrowia powinna ułatwić pacjentom dostęp do e-usług medycznych. Celem pracy było omówienie roli rozwiązań teleinformatycznych w różnych dz...
Article
Lysosomal storage diseases (LSDs) are metabolic disorders that result from a situation when enzymes taking part in different processes exist in too small an amount or don't exist whatsoever. They exhibit great clinical diversification. The intensity of the symptoms depends on residual enzyme activity, type of stored material and storage speed. The...
Article
Arterial ischemic stroke (AIS) in children is a relatively rare disease, however, there are serious consequences of the disease. The most common ones are neurological deficits (impaired movement, impaired speech and intellectual delay) observed in 68-73% of children. Post-stroke epilepsy occurs in the Polish population in 26% of children with AIS....
Article
Background/purpose: Data on the role of the -455G > A polymorphism of the gene encoding β fibrinogen subunit (FGB) and the Thr312Ala polymorphism of the gene for the α fibrinogen subunit (FGA) in childhood ischemic stroke are insufficient. Therefore the aim of the study was to evaluate a possible association between these two polymorphisms and art...
Article
Aim: The aim of this study was to characterize a group of children with early and late remote seizures, which occurred after arterial ischaemic stroke (AIS), and to find predictors of post-stroke seizures. Method: The study group, recruited in the Department of Neuropediatrics (Medical University of Silesia, Katowice, Poland), comprised 78 individu...
Article
ABSTRACT Stroke is an abrupt onset of both focal and global neurological deficits secondary to a vascular event lasting more than 24 hoursand with a vascular background as its only cause. It can be triggered by a rupture of a blood vessel, aneurysm (hemorrhagic stroke, HS), thrombosis or embolisms (ischemic stroke, IS). In developed countries it is...
Article
The incidence of arterial ischemic stroke (AIS) in childhood (about 2-13 per 100,000 children a year) is much lower than the incidence in the adult population. Still, adverse outcomes of acute brain ischemia in childhood include death (10 % of AIS children), neurological sequel, epileptic seizures (over 50 %) and recurrence (over 20 %). The knowled...
Article
The aim of this study was to characterize a group of children with early and late remote seizures which occurred after arterial ischaemic stroke (AIS) and to find predictors of post-stroke seizures. The study group, recruited in the Department of Neuropediatrics (Medical University of Silesia, Katowice, Poland), comprised 78 patients who had had a...
Article
Full-text available
Schizencephaly is a rare and severe congenital brain defect. Its etiology is not unequivocal and its clinical course differs with every case. The aim of the study was to analyze correlations between clinical and radiologic features of schizencephaly in Polish patients. The study group consisted of 25 children. Epileptic seizures were observed in 60...
Article
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The 677C>T polymorphism within methylenetetrahydrofolate reductase (MTHFR) gene is related to an elevated level of homocysteine. Thus it may be considered as a genetic risk factor in ischemic stroke. Apparently studies of this type of polymorphism in childhood stroke have shown conflicting results. We performed meta-analysis of all the data that ar...
Article
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The presence of several risk factors (genetic and non-genetic) has greater impact on the risk of premature coronary artery disease (CAD) than single risk factor. The aim of the study was to establish possible relations between genotypes and alleles of 677C>T polymorphism of MTHFR gene and some traditional risk factors e.g. elevated levels of lipid...