Bashar Saad

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• Prof. Dr.
• Professor at Al-Qasemi Academic College of Education

The present in vitro and randomized, double‐blind, placebo‐controlled trial aims to determine the efficacy and safety of nine Mediterranean antiacne medicinal plants. The antimicrobial, antisebum, and anti-inflammatory activities of the plant extracts were evaluated in cells from the immortalized human keratinocytes (HaCaT) and human monocytic cell...

Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce cardiac function, induce arrhythmias, and finally, cause heart failure. The majority of current CVD treatment...

Obesity is a long-term condition resulting from a continuous imbalance between the amount of energy consumed and expended. It is associated with premature mortality and contributes to a large portion of the global chronic disease burden, including diabesity, cardiovascular disease, hypertension, and some cancers. While lifestyle changes and dietary...

This study provides a comprehensive evaluation of Ziziphus jujuba honey, commonly referred to as sidr honey (SH), collected from five distinct botanical origins in Morocco: SHE from Errachidia (Daraa-Tafilalet), SHZ from Zaggota (Rabat-Sale-Kenitra), SHA from Ain Chair (Oriental), SHS from Saka (Oriental), and SHK from Khenifra (Beni Mellal-Khenifr...

Traditional Palestinian medicine uses Thymus capitatus (T. capitatus), a plant recognized for its therapeutic properties due to its high concentration of essential oils such as thymol and carvacrol, to treat skin diseases, gastrointestinal disorders, and respiratory infections. The present study was conducted to evaluate the antioxidant and antican...

Hyphaene thebaica honey, commonly known as doum honey (DH), is widely utilized in the Mediterranean region due to its putative health benefits. However, the precise mechanisms underpinning these benefits remain obscure. This study sought to assess the anti-infective, anti-inflammatory, and anticancer properties of DH, and analyze its polyphenolic c...

The present study evaluates the physicochemical attributes, antibacterial efficacy, and antioxidant capacities of four distinct varieties of honey from the West Bank region of Palestine: Assal Barsem (Medicago sativa) AB, Assal Morar (Centaurea dumulosa Boiss) AM, Assal Horfesh (Silybum) AH, and Assal Sader (Ziziphus spina-christi) AS. The analysis...

The phenolic compounds of four Palestinian honey samples (PH1-PH4) and their antibacterial effects as well as their cytotoxic, cytostatic, and antimigration effects in human breast cancer cell line (MDA) were evaluated here. HPLC analysis of PH2 (Cornflower), PH3 (Milk thistle), and PH4 (Ziziphus) revealed 15 phenolic compounds, namely, caffeic aci...

Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxidant, anti-inflammatory, and antibacterial propert...

Wound healing is a multifaceted process necessitating the collaboration of numerous elements to mend damaged tissue. Plant and animal-derived natural compounds have been utilized for wound treatment over the centuries, with many scientific investigations examining these compounds. Those with antioxidant, anti-inflammatory, and antibacterial propert...

Inflammation is a crucial factor in the development and progression of cardiovascular diseases (CVD). Cardiac remodeling in the presence of persistent inflammation leads to myocardial fibrosis and extracellular matrix changes, which reduce cardiac function, induce arrhythmias, and finally, cause heart failure. Medicinal plants and phytochemicals ca...

Citation: Mansour, B.; Shaheen, N.; Kmail, A.; Haggag, N.; Saad, S.; Sadiq, O.; Zaid, R.; Saad, B. Anti-Inflammatory and Anti-Adipogenesis Effects of Alchemilla vulgaris L., Salvia officinalis L., and Vitis vinifera L. in THP-1-Derived Macrophages and 3T3-L1 Cell Line. Abstract: The production of pro-inflammatory and anti-inflammatory cytokines, as...

Subjects: Plant Sciences Contributor: Bashar Saad Numerous scientific papers published highlight the immunological role of adipocytes and their role in inflammatory responses through the secretion of adipocytokines (adipokines), which regulate the adipocyte phenotype through complex mechanisms of action. Normally, adipose tissue produces anti-infla...

Obesity, defined by excessive fat mass and its associated low-grade chronic inflammation, leads to insulin resistance, diabetes, and metabolic dysfunctions. The immunomodulatory properties of natural agents have gained much interest in recent decades. Some of the plant-derived agents are known to be immunomodulators that can affect both innate and...

Despite the great achievements of evidence-based modern medicine and pharmacology, traditional Greco-Arab and Islamic medicine-based herbal remedies are currently becoming more popular in the Arab and Islamic world. Historical circumstances and the belief that these remedies are prepared according to the principles of Greco-Arab and Islamic medicin...

This study aims to in vitro evaluate the impact of three traditionally used anti-obesity medicinal plant extracts on inflammatory mediators in the THP-1 cell line and adipocyte differentiation and fat accumulation in the 3T3-L1 cell line. After extract preparation, an in vitro evaluation of cell viability using MTT on THP-1 and 3T3-L1, NO productio...

Special Issue Information Dear Colleagues, The therapeutic and health-promoting use of natural products—compounds that are derived from natural origin such as plants, animals, or microorganisms—precedes recorded history, most likely by thousands of years. They are the source of many medicines used in modern medicine. Due to the growing demand for...

Background: Ficus sycomorus is one of the recommended antipsoriatic medicinal plants in the traditional Greco-Arab herbal medicine. However, the knowledge on its action mechanisms is limited. Original Research Article Kmail et al.; EJMP, 33(9): 1-14, 2022; Article no.EJMP.90697 2 Aims: Cytotoxic, cytostatic, and anti-inflammatory effects of water/e...

Over the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignancies. Therapeutic usage of medicinal plants and natu...

Introduction : The significance of the crosstalk between pro-inflammatory mediators and carcinogenesis is widely discussed. These mediators play decisive roles at different stages of tumor development, including initiation, promotion, and metastasis. Arum palaestinum Boiss., Ocimum basilicum L., and Trigonella foenum-graecum L. and their crude extr...

Abstract: Nigella sativa, Conyza bonariensis, and Alchemilla vulgaris are highly recommended in Greco-Arab traditional medicine as anti-hemorrhoid medicinal plants. The efficacy and safety of a topical cream (HPC) consisting of water–ethanol extracts of these three plants were evaluated here in vitro and in a randomized, double-blind, placebo-contr...

Ever-growing research efforts are demonstrating the potential of medicinal plants and their phytochemicals to prevent and manage obesity, either individually or synergistically. Multiple combinations of phytochemicals can result in a synergistic activity that increases their beneficial effects at molecular, cellular, metabolic, and temporal levels,...

From the beginning of time, history shows man’s reliance on natural products, varying from healthcare and basic needs to flavours and fragrances to name a few. This required the culmination of hundreds of wild plants, domestic animals and their respective by-products (e.g., bones, feathers, hooves, skins, and tusks) form important ingredients for t...

Arab-Islamic Medicinal Plants: From Traditional Use to Scientific Establishment

Propolis is a resin that honeybees produce by mixing saliva and beeswax with exudate gathered from botanical sources. .e present in vitro study investigated the potential use of propolis as a multitarget therapeutic product and the physicochemical properties, chemical composition, and immunomodulatory, antioxidant, antibacterial, and anticancer pro...

Naturally derived drugs and plant-based products are attractive commodities that are being explored for cancer treatment. This in vitro study aimed to investigate the role of Hypericum triquetrifolium (50% ethanol: 50% water) extract (HTE) treatment on apoptosis, cell cycle modulation, and cell cycle arrest in human colon cancer cell line (HCT-116)...

Abstract: Obesity causes serious chronic diseases and affects quality of life of all age groups. It is associated with vascular and metabolic alterations and chronic inflammation leading to the development of the metabolic syndrome. Adipose tissue expansion occurs mainly through hypertrophy (increasing the volume of preexisting adipocytes) and/or h...

The aim of this in vitro study is to characterize the phenolic compounds of twelve honey samples collected from different locations in Palestine (H1-6) and Morocco (H7-12) and to evaluate their cytotoxic and cytostatic effects in cells from the human colorectal carcinoma cell line HCT-116 and breast cancer cell line MCF-7. Quantitative HPLC analysi...

Diabetes is a predominant metabolic disease nowadays due to the off-beam lifestyle of diet and reduced physical activity. Complications of the illness include the gene-environment interactions and the downstream genetic and epigenetic consequences, e.g., cardiovascular diseases, tumor progression, retinopathy, nephropathy, neuropathy, polydipsia, p...

ABSTRACT Despite the enormous achievements in the development of conventional drugs, herbal-based medicines are still a common practice for the prevention/treatment of diabetes and its related complications. Asparagus aphyllus L. (AA), Abelmoschus esculentus L. (AE) and Crataegus azarolus L. (CA) are recommended in the Greco-Arab traditional medic...

Based on knowledge from traditional Arab medicine, this in vitro study aims to evaluate cytotoxic and cytostatic effects of traditionally used as anti-cancer propolis from four different regions in Morocco. Propolis samples were collected from different locations in Morocco, which are characterized by different plant predominant vegetations. The re...

In the present in vitro study, we tested the chemical composition, cytotoxicity and antidiabetic activity of two distinct extracts of wild Artichoke-like vegetable, Gundelia tournefortii : methanol and hexane. GC/MS phytochemical analysis of G. tournefortii methanol and hexane extracts revealed 39 compounds reported here for the first time in G. to...

Background: High expectations about acupuncture might contribute to larger treatment effects (Prady et al., 2015). However, problems in the assessment are well known: 1) floor or ceiling effects lower variance; 2) expectation measures include general beliefs about complementary medicine; 3) construct validity of expectation measures remains unclear...

Implications for practice: European oncologists face a communication gap with refugee patients who have recently immigrated from Middle Eastern and northern African countries, with their different health belief models and affinity for traditional and herbal medicine. A culturally-sensitive approach to care will foster doctor-refugee communication,...

Obesity is a global health problem affecting all age groups, leading to many complications such as type 2 diabetes, systemic hypertension, cardiovascular diseases, dyslipidemia, atherosclerosis, and stroke. Physiologically, obesity which arises from metabolic changes at tissue and organ levels results in an imbalance between energy intake and energ...

Diabetes has been recognized by ancient physicians and its main symptoms were known by the increased thirst, frequent urination, and tiredness. Medicinal plants were commonly used for treating these combined symptoms. In addition to several instructions for specific food consumption, a mild exercise was recommended. Currently, traditional medicine...

Recent researches demonstrated the potential of phytochemicals to prevent and to counteract obesity. Multiple combinations of phytochemicals can result in a synergistic activity that increases their bioavailability and action on multiple molecular targets, offering advantages over chemical treatments. Herbal-derived compounds have potential for con...

Diabetes is one of the prominent metabolic disorders nowadays. It is associated with many complications, including polyuria, weight loss, polydipsia, polyphagia, blurred vision, retinopathy, neuropathy, and nephropathy. Ongoing research has advanced on the mechanisms accompanying the prevention and treatment of diabetes, and the vast majority of re...

The utilization of herb-based products to prevent/treat diseases is a therapeutic modality that has stood the test of long history of use and has played important roles in the development of conventional medicine. Indeed, many of the currently utilized pharmacological classes of drugs include a phytochemical prototype. Aspirin, atropine, codeine, e...

Because of their natural origin and reduced side effects, we are watching worldwide an extensive growth and increased popularity in the field of herbal mixtures. In contrast to synthetic pharmaceuticals based upon single compounds, many medicinal plants exert their beneficial pharmacological effects through synergistic or additive mechanisms of mul...

Obesity increases the risk for many pathological processes including type 2 diabetes, hypertension, hyperlipidemia, cardiovascular diseases, and certain types of cancer. Thus, obesity mitigation strategies should take into account these secondary pathologies in addition to promoting weight loss. Progress in biological and particularly in biochemica...

Diabetes and obesity have reached epidemic proportions globally, and they are a major contributor to the development of many pathological processes including hypertension, hyperlipidemia, cardiovascular diseases, and certain types of cancer. Increased consumption of more energy-dense, nutrient-poor diets with high levels of carbohydrates and satura...

This work presents a systematic review of traditional herbal medicine and their active compounds, as well as their mechanism of action in the prevention and treatment of diabetes and obesity. The side effects and safety of herbal-derived anti-diabetic and anti-obesity phytochemicals are detailed in depth, and the text has a strong focus on current...

Introduction: Herbal-based medicines are widely used for the prevention and treatments of diverse diseases especially in growing countries as well as many developed countries. Although some of herbal-based medicines have promising therapeutic properties, many of them remain untested and their safety and efficacy were not scientifically assessed. Ba...

Diabetes mellitus is a common chronic global disease affecting children and adolescents in developed as well as developing countries. Diabetes type I and type II are the major types of diabetes mellitus. The former is an autoimmune disorder, leading to pancreatic β-cell dysfunction and thus inadequate production of insulin. The latter arises from r...

The aim of the present in vitro study was carried out to evaluate the anti-inflammatory activity of Hypericum triquetrifolium extracts (HT-extract) on lipopolyssacharide -stimulated human monocytic (THP-1) cells and human peripheral blood mononuclear cells (PBMNCs). The expression and production of pro-inflammatory cytokines tumor necrosis factor-α...

The popularity in utilization of the plant-based remedies has increased worldwide over the last 30 years. One of the main reasons for this increased popularity is probably the belief that natural product-based diet and herbal-based preparations have been used for centuries and that natural products are safe. In parallel with the revival of interest...

Anthocyanins are secondary plant metabolites and are chemically di- or tri-hydroxy B-ring-substituted flavonoids containing a flavylium cation. These are focus of much attention these days due to their vibrant colors and immunity-boosting and health-promoting effects mainly in ameloriating various cholesterol-related and oxidation-induced diseases....

Anthocyanins are the largest group of water-soluble pigments of plant kingdom, are odorless and flavorless and occur in various parts of plants, nuts, vegetables, fruits, legumes and cereals where they perform various specific functions. All anthocyanins are made up of a common single aromatic structure, i.e. cyanidin with different modifications a...

All anthocyanins are made up of a single aromatic structure, i.e. cyanidin. The biochemistry, kinetics and pharmacological as well as physiological actions of anthocyanins have been studied in detail during last 15 years. Although discovered in 1835, kinetic studies of anthocyanins in humans have been reported only recently. Kinetic studies provide...

Diabetes and obesity are part and parcel of the metabolic disorders. It is well-known now that anthocyanins encompass antidiabetic and anti-obesity potential as has been demonstrated by many in vivo and in vitro studies. It is well-known now that hyperglycemia leads to production of ROS, thus generating oxidative stress and anthocyanins being poten...

Anthocyanins, a proanthocyanidin type of flavonoids occur in various berries, flowers and fruits, vegetables and give them very attractive red, blue, purple, violet and orange colors. Their hydro-soluble nature allows their incorporation into aqueous food systems. Plant-based colors are focus of global research by nutrition scientists, chemists, in...

Anthocyanins are substituted glycosides and acyl-glycosides of 2-phenylbenzo-pyrilium salts. This unique structure imparts them specific biological activities. Cancer, immunity-related, age-related and CNS-disorders are key-reasons of death of a large part of population in both developing and developed countries. Integration of research findings fr...

Anthocyanin profiles of plants are influenced by expression of genes involved in bio-synthetic pathway and are characteristic of specific plant species and families. Although, structure, content and function of various anthocyanins differ significantly, all of them share the same biosynthetic pathway in plants from same precursor. They are products...

It was believed since last three decades that anthocyanins have healthy effects on human organs and organs systems. There are now many evidenced-based nutrition studies including epidemiological surveys, animal studies and randomized controlled trials that have elucidated the mechanism behind the positive influence of anthocyanins on various tissue...

Recent advances in genomics, proteomics, cell biology and biochemistry of tumors have revealed new pathways that are aberrantly activated in numerous cancer types. However, the enormous amount of data available in this field may mislead scientists in focused research. As cancer cell growth and progression is often dependent upon the phosphoinositid...

Background: The authors assessed the use of herbal medicine by Middle Eastern patients with cancer, as reported by their oncology health care professionals (HCPs). Herbal products identified by the study HCPs were evaluated for potential negative effects. Methods: Oncology HCPs from 16 Middle Eastern countries received a 17-item questionnaire as...

We are thankful to all contributors of this special issue for their valuable research papers. We are grateful to the reviewers for their constructive criticisms and timely response that made this special issue possible. Our sincere thanks and gratitude go to the Editorial Board of this journal for inviting us to edit this special issue.

The aim of this study was to evaluate the role of glucose transporter-4 (GLUT4) in the antidiabetic effects of methanol, hexane and dichloromethane extracts of the aerial parts of Ocimum basilicum (OB) and to analyze their phytochemical composition. Phytochemical analysis of the three extracts by GC/MS using the silylation derivatization technique...

www.phcogcommn.org Original Article © Copyright 2015 EManuscript Services, India Pharmacognosy Communications Volume 5 | Issue 3 | Jul-Sep 2015 ABSTRACT Introduction: Herbal-based medicines are widely used for the prevention and treatments of diverse diseases especially in growing countries as well as many developed countries. Although some of herb...

Abstract: Diet therapy is one of the oldest methods of prevention and healing of all types of known diseases and built a substantial part of Greco-Arab medical system in maintaining healthy body, soul, and spirit. According to a statement by Al-Razi (Rhazes, 864-930) "As long as you can heal with food, do not heal with medication". Therefore, in th...

Grape leaves ( Vitis vinifera L. ) are widely consumed in Palestine, and other Mediterranean countries. Positive health effects of grape products are reported by various studies and pharmaceutical preparations from grape leaves are patented and commercialized as drugs. The aim of this in vitro study is to assess the therapeutic potential of leaf ex...

Early Muslims utilized many plants and animal products mentioned in the Holy Quran and in the Hadith of the Prophet for health promotion, for example, dates, black seeds, olive leaf and olive oil, honey, and camel milk. Arab-Islamic medicine laid down the principles for the development of Greco- Arab and Islamic medicine that was developed in the g...

In the last decade, a number of integrative oncology programs have been established within leading oncology departments in Israel aiming to provide consultations that address patients' concerns and improve their quality of life (QOL). To identify Arab cancer patients' attitudes, needs and expectations concerning integration of complementary and tra...

Aim: Based on knowledge from traditional Greco-Arab herbal medicine, this in vitro study aims to evaluate the cytotoxicity and the anti-inflammatory mechanism of Peganum harmala (P. harmala) seeds by measuring the expression and release of both anti-inflammatory (IL10) and proinflammatory (IL-1, IL-2, IL-6 and TNF-a) cytokines in human THP-1-derive...

Aim: Based on knowledge from traditional Greco-Arab herbal medicine, this in vitro study aims to evaluate the cytotoxicity and the anti-inflammatory mechanism of Peganum harmala (P. harmala) seeds by measuring the expression and release of both anti-inflammatory (IL-10) and proinflammatory (IL-1, IL-2, IL-6 and TNF-a) cytokines in human THP-1-deriv...

In this multinational Middle-Eastern study, we assessed health-care providers' (HCPs) perspectives on their patients' use of complementary and traditional medicine (CTM) and identified the leading barriers to CTM integration in supportive cancer care. A 17-item questionnaire was developed and administered to HCPs attending palliative medicine works...

Traditional Greco-Arab and Islamic medicine continues to be practiced within the Mediterranean as well as most Islamic countries. This medicine was developed during the Golden Age of Arab-Islamic civilization, which spanned from the seventh to fifteenth century and extended from Spain to Central Asia and India. During the Islamic Golden Age, there...

Limited research is available on the perspectives of patients with cancer regarding integration of complementary medicine (CM) in conventional supportive cancer care. The purpose of this study was to explore patients' perspectives concerning CM integration within conventional oncology settings. A 27-item questionnaire was constructed and administer...

Despite the great progress in Western medicine, Greco-Arab and Islamic medicine has continued to be often utilized by people in most Arab and Islamic countries. Furthermore, the popularity of preparations based on Greco-Arab and Islamic herbal medicines has increased worldwide in the past three decades, probably because of the sustainability of thi...

Despite the enormous achievements in conventional medicine, herbal-based medicines are still a common practice for the treatment of diabetes. Trigonella foenum-graecum, Atriplex halimus, Olea europaea, Urtica dioica, Allium sativum, Allium cepa, Nigella sativa, and Cinnamomum cassia are strongly recommended in the Greco-Arab and Islamic medicine fo...

Despite the enormous achievements in conventional medicine, herbal-based medicines are still a common practice for the treatment of diabetes. Trigonella foenum-graecum, Atriplex halimus, Olea europaea, Urtica dioica, Allium sativum, Allium cepa, Nigella sativa, and Cinnamomum cassia are strongly recommended in the Greco-Arab and Islamic medicine fo...

We would like to deeply thank and acknowledge the extensive editorial work that was invested by the coeditors and reviewers of this special issue. This unique group of five coeditors active in integrative oncology research and practice in three continents has inspired us to recognize and realize that, despite cultural and political challenges, we s...

Diabetes prevention and treatment with Greco-Arab And Islamic-based natural products Hilal Zaid, Omar Said, Bahaa Hadieh, Abdalsalam Kmail & Bashar Saad1 Abstract Diabetes has been recognized by medieval Greco-Arab physicians and its main symptoms were known by the increased thirst, frequent urination, and tiredness. Arab and Muslim physicians ha...

الملخص: يعود تاريخ الطب العربي الإسلامي هذا إلى العصر الذهبي في الحضارة العربية الإسلامية التي امتدت من اسبانيا في الشرق إلى مراكز أسيا والهند في الغرب كانت هذه الفترة تقارب تسعة قرون من وسط القرن السابع حتى نهاية القرن السابع عشر .كان الطب جزءا أساسيا في الحضارة العربية الإسلامية ودرس العرب المسلمون وطوروا علاجا لكثير من الأمراض مثل مرض السرطان فض...

يعود تاريخ الطب العربي الاسلامي الى العصر الذهبي في الحضارة العربية الاسلامية التي امتدت من اسبانيا في الغرب الى مراكز اسيا والهند في الشرق، وامتدت هذه الفترة ما يقارب تسعة قرون، من منتصف القرن السابع حتى نهاية القرن السابع عشر. وكان الطب جزءا" أساسيا" في الحضارة العربية الاسلامية، حيث درسه العرب المسلمون وطوروا فيه علاجا لكثير من الامراض مثل مرض ا...

The incidence of cancer is increasing in the developed countries and even more so in developing countries parallel to the increase in life expectancy. In recent years, clinicians and researchers advocate the need to include supportive and palliative care since the establishment of the diagnosis and throughout the duration of treatment, with the goa...