Bartira Pinheiro Da Costa

Bartira Pinheiro Da Costa
Pontifícia Universidade Católica do Rio Grande do Sul | PUCRS · Instituto de Pesquisas Biomédicas

BSc, PhD

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117
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Publications

Publications (117)
Article
Full-text available
Background Pressure injuries (PIs), especially in the sacral region are frequent, costly, and increase morbidity and mortality of patients in an intensive care unit (ICU). These injuries can occur as a result of prolonged pressure and/or shear forces. Neuromuscular electrical stimulation (NMES) can increase muscle mass and improve local circulation...
Article
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Background In spontaneous pregnancies, maternal weight and gestational diabetes are independent risk factors for macrosomia and large-for-gestational-age newborns. Furthermore, maternal body mass index (BMI) of ≥25 kg/m ² is associated with worse neonatal vitality, classified as an Apgar score of < 7 at the fifth minute of life. However, few studie...
Article
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Preeclampsia, a human pregnancy syndrome, is characterized by elevated blood pressure and proteinuria after the 20th week of gestation. Its etiology remains unknown, and its pathophysiological mechanisms are related to placental hypoperfusion, endothelial dysfunction, inflammation, and coagulation cascade activation. Recently, the role of the compl...
Article
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Aims: To report an unusual case of herpes zoster meningoencephalitis in an immunocompetent patient exposed to HIV/AIDS. Presentation of Case: The present report deals with an immunocompetent patient who was diagnosed with meningoencephalitis caused by Herpes Zoster, an opportunistic infection that presented complications. Discussion: Varicella-zost...
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Objective: Outcome data for oocyte vitrification for fertility preservation are still scarce despite the scientific and technological advances. Studies suggest that patients with cancer have worse outcomes regarding mature vitrified oocytes when compared to healthy patients. Thus, the objective of this study was to evaluate and compare the oocyte...
Article
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Patients with severe COVID-19 may have endothelial dysfunction and a hypercoagulable state that can cause skin damage. In the presence of external pressure on the tissues, the local inflammatory process regulated by inflammatory cytokines can increase and prolong itself, contributing to the formation of pressure injury (PI). PI is defined as locali...
Preprint
Background In spontaneous pregnancies, evidence shows that maternal weight and gestational diabetes are independent risk factors for macrosomia and large for gestational age newborns. Maternal body mass index (BMI) ≥ 25 kg/m ² is also associated with worse neonatal vitality, classified as Apgar score less than 7 at 5th minute of life. However, litt...
Article
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Background: Hypertension is the most common medical condition during pregnancy. Hypertensive disorders are associated with an increased risk of adverse outcomes for both mother and fetus. This study examined the role played by personality and coping strategies in relation to blood pressure levels during pregnancy. The specific goal was to study wh...
Article
In January 2020, the World Health Organization (WHO) classified the outbreak of Covid-19 as an International Public Health Emergency. After a year of pandemic, health systems needed to absorb not only new cases, but also the sequels resulting from the disease. Data on sequels correlated to endothelial disorders are still limited. Thus, this study p...
Article
To evaluate total Th1/Th2 cytokines in CD3⁺ cells (immunocompetent T-lymphocytes) and peripheral blood lymphocytes, mostly CD4+ (T helper cells) and CD8+ (T-cytotoxic cells) subpopulations in preeclampsia. Total blood leukocytes and lymphocytes counts, percent cells: CD3⁺, INF-g⁺/CD3⁺, IL-4⁺/CD3⁺, and IL-10⁺/CD3⁺, CD4⁺/CD8⁺ were determined by flow-...
Article
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Introduction: Pressure injury is 1 of the most common pressure related injuries in patients admitted to the intensive care unit. In individuals with darker skin tones, skin assessment protocols appear to be less effective, resulting in early damage from pressure. Bedside assessment measures using ultrasound and infrared thermography (IRT) have been...
Article
Background: Hypertensive disorders are important causes of maternal and perinatal morbidity and death. Considering the role of both physical and psychological factors in pregnancies complicated by hypertension, the aim of this study is to examine psychological factors and coping strategies in pregnancies complicated by hypertension. Methods: Cro...
Article
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Cytomegalovirus (CMV) and Pneumocystis jirovecii fungus are the main op-portunistic microorganisms that affect transplanted individuals. Immunosup-pressive drugs administered to prevent organ rejection leave the immune system vulnerable to these infections. The present report is about a kidney transplanted patient using immunosuppressants who was d...
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Este é um artigo publicado em acesso aberto sob uma licença Creative Commons ABSTRACT The study aimed to explain the opinion of school principals regarding the influence of COVID-19 on the socio-emotional-affective aspect of students, teachers, coordinators and the school community in order to contribute to public policies in the field of health an...
Article
Objective: to investigate the role of personality in pregnancies complicated by hypertension, thru analysis of structure and associations between negative affect and coping strategies, and their role towards psychological distress. Method: a cross-sectional study with 343 women, where 192 pregnancies complicated by hypertension, was carried out...
Article
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Patients with decompensated hepatic cirrhosis may present systemic alterations and dysfunction of multiple organs. Ascites, portal hypertension, esophageal varices, and hepatic encephalopathy are common complications arising from cirrhosis. The aim of this paper is to report a case of a patient with liver cirrhosis and the complications of a transj...
Article
Objective: Ectopic pregnancy is a well-known complication following in vitro fertilization with embryo transfer; studies have questioned, however, whether there are risk factors that could be identified before the procedure. The objective of this study was to investigate the possible risk factors involved in ectopic pregnancy following in vitro fe...
Article
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Introdução: A lesão por pressão é uma área localizada de morte celular que se desenvolve quando um tecido mole é comprimido entre uma proeminência óssea e uma superfície dura por um prolongado período. Objetivo: O objetivo deste estudo foi investigar o conhecimento dos profissionais de saúde sobre o estadiamento, a avaliação e a prevenção da lesão...
Article
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O Exame Nacional de Desempenho de Estudantes (ENADE) tem por objetivo aferir o desempenho de estudantes em relação ao conteúdo programático previsto nas Diretrizes Curriculares. Neste estudo, analisaram-se os domínios cognitivos requeridos nas provas do ENADE de graduandos em Farmácia, sob a perspectiva da Taxonomia de Bloom Revisada (TBR). Os resu...
Preprint
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Background: Hypertension is a disorder that affects many people and its complications can cause serious damage to health. In pregnancy, it is even more serious with risks both to pregnant women and their fetuses. This study investigated the role played by personality and coping strategies in blood pressure levels during pregnancy. Its specific goal...
Chapter
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Introduction: Childbirth is a highly painful experience that generates both physical and psychological consequences for patients. Multiple analgesic therapies have been developed for its management, with neuraxial blockade being the gold standard, however the availability of many of these is limited, making the search for easily accessible alternat...
Article
Objetivo: revisar as publicações científicas atuais sobre os impactos da COVID-19 na saúde mental da população chinesa no início da epidemia. Método: Trata-se de uma revisão integrativa com levantamento de estudos em bases de dados online: PubMed, SciELO e LILACS. Os descritores utilizados na busca foram: “COVID 19 AND social isolation” “COVID 19 A...
Article
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Esta cartilha objetiva divulgar orientações relacionadas a educação e saúde acerca da COVID-19 no contexto de uma possível retomada de aulas presenciais em período de pandemia. No atual momento o retorno gradativo às aulas presenciais necessita de um adequado plano político-educacional para minimizar as perdas educacionais. A questão é relevante po...
Article
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Background: The increasing global use of smartphones has contributed to the growing use of apps for various health conditions, showing promising results. Through mobile apps, it is possible to perform chronological and iconographic follow-up of wounds, such as pressure ulcers, using a simple and practical tool. However, numerous surveys have pointe...
Article
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O objetivo deste estudo foi revisar as principais evidências científicas sobre a lesão por pressão e o estado nutricional em pacientes adultos internados em hospital. Trata-se de uma revisão de literatura. Foi realizada uma busca em bases de dados científicas online como: SciELO, PubMed e LILACS. Os descritores utilizados foram “pressure ulcer” AND...
Article
Introduction: Posterior reversible encephalopathy syndrome is a clinicoradiologic entity with typical MR imaging showing a white matter vasogenic edema predominantly affecting the occipital and parietal lobes of the brain. The aim of this article is evaluated the importance of DWI as a prognosis factor in patients with PRES. Materials and methods...
Article
O Exame Nacional de Desempenho de Estudantes (ENADE) integra o Sistema Nacional de Avaliação da Educação Superior (SINAES) aferindo o rendimento dos alunos quanto às Diretrizes Curriculares Nacionais. O objetivo deste trabalho foi analisar a opinião de professores dos Cursos de Farmácia de Instituições públicas e privadas do Estado do Rio Grande do...
Article
Full-text available
Background: The increasing global use of smartphones has contributed to the growing use of applications for various health conditions, showing promising results. Through mobile applications it is possible to perform the chronological and iconographic follow-up of wounds such as pressure ulcers using a simple and practical tool. However, numerous s...
Preprint
BACKGROUND The increasing global use of smartphones has contributed to the growing use of apps for various health conditions, showing promising results. Through mobile apps, it is possible to perform chronological and iconographic follow-up of wounds, such as pressure ulcers, using a simple and practical tool. However, numerous surveys have pointed...
Article
Full-text available
O objetivo do estudo foi realizar uma revisão da literatura sobre a pessoa surda e as dificuldades enfrentadas na consulta com profissionais da saúde, principalmente o nutricionista no Brasil. Trata-se de uma revisão de literatura. Foi realizada busca em bases de dados do SciELO e Google Acadêmico. Os descritores utilizados foram “Libras”, “surdos”...
Article
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Objectives: Eclampsia results in high morbidity and mortality, so it is important to identify clinical and laboratorial aspects that may be useful as potential markers to differentiate women at higher risk. Thus, we aim to identify, among women with preeclampsia, aspects that may increase the risk to develop eclampsia. Study design: Retrospective c...
Article
Introduction Singling out high-risk patients from the diverse hypertensive disorders of pregnancy (HDP), and not only preeclampsia, is a challenge for clinicians. Objectives The aim of the study is to evaluate the performance of the fullPIERS model and the placental growth factor (PlGF) to predict adverse outcomes in women with HDP. Methods A pro...
Article
Introduction Monocyte chemotactic protein-1 (MCP1) main function is to recruit monocytes and other leukocytes into sites of inflammation. Inflammatory mediators, such as TNFα, regulate its expression. Objectives/hypothesis To analyze MCP1 levels in maternal, fetal plasma and placental in women with pre-eclampsia (PE) and correlate with TNFα. We hy...
Article
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Objective To analyze endocan-1, a biomarker of vascular endothelial related pathologies, and the placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with preeclampsia (PE). Methods Case-control study conducted at Hospital São Lucas, in the city of Porto Alegre, Brazil. Endocan-1 and PlGF levels were q...
Article
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Purpose of review: The present study intends to review the possibility of using phosphodiesterase inhibitors as a treatment option for preeclampsia, addressing potential risks and benefits. Recent findings: Preeclampsia is the most common hypertensive disorder of pregnancy, often responsible for severe maternal and fetal complications, which can...
Article
Objective: To analyse Endocan-1, a biomarker of vascular endothelial related pathologies, and Placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with pre-eclampsia (PE). Methods: Case-control study conducted at São Lucas Hospital. Endocan-1 and PlGF levels were quantified in maternal plasma using Mag...
Article
***Using the Reduced Uterine Perfusion Pressure model of preeclampsia to study the blood brain barrier permeability***AIMS: To use the Reduced Uterine Perfusion Pressure (RUPP) model for preeclampsia to describe and evaluate the blood brain barrier permeability in pregnant rats.METHODS: Forty-one pregnant Wistar rats were divided into different int...
Article
The National Student Performance Examination (ENADE) is part of the National System of Higher Education Assessment (SINAES) as a mandatory curricular component in Brazilian undergraduate courses. The objective of this study was to analyse, in a critical-reflexive way, the ENADE questions, applied to the academics of Pharmacy. Four questionnaires we...
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Resumo Objetivo: Caracterizar o perfil de enfrentamento e qualidade de vida dos pacientes em lista de espera de transplante renal. Métodos: Estudo transversal, com abordagem quantitativa, foram entrevistados pacientes maiores de 18 anos, alfabetizados e em lista de espera de transplante renal. Foram excluídos os pacientes em espera de mais de um ór...
Article
Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction. We hypothesize that the phosphodiesterases in maternal plasma, phosphodiesterase-5 in p...
Article
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Purpose: to determine the usefulness of serum TF as a potential marker for patients with clear cell RCC. Materials and methods: prospective study of 30 patients with clear cell RCC submitted to nephrectomy and 16 controls without clear cell RCC treated surgically for other conditions. TF is a endothelium marker that was correlated with worse pro...
Article
Patients with chronic kidney disease on peritoneal dialysis (PD) are susceptible to infections, with peritonitis being the primary cause of dropout. Peritoneal fluid culture is one of the essential elements for proper diagnosis and peritonitis treatment. The aim of this study was to compare the time required to obtain a positive culture using diffe...
Article
Background: The characteristics of peritoneal membrane transport differ among patients, affecting the prescription of peritoneal dialysis (PD) modality and glucose exposure in order to achieve an effective dialysis. This study aims to verify the influence of glucose exposure load and peritoneal membrane transport on body composition and nutritiona...
Article
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Objective: to investigate the perception of professionals from the health area regarding training for their teaching practice. Method: it is an exploratory, descriptive, prospective study, with qualitative analysis. The sample was made up of 85 lecturers from 10 undergraduate courses in the area of health, from a private Higher Education Instituti...
Article
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O Exame Nacional de Desempenho de Estudantes (ENADE) integra o Sistema Nacional de Avaliação da Educação Superior (SINAES) como um componente curricular obrigatório nos cursos de graduação brasileiros. O objetivo deste trabalho foi analisar a opinião dos professores sobre as questões do ENADE para o curso de Farmácia em 2010, analisando se eram con...
Article
Introduction Many markers have been studied to improve the understanding of preeclampsia (PE) pathophysiology. PlGF stands out as an important marker to predict PE. We hypothesized that PlGF could be associated with the severity of the disease. Objectives To analyze PlGF levels in maternal plasma in normotensive and preeclamptic women, in the thir...
Article
Introduction The fullPIERS model is an instrument of simple evaluation and low-cost that uses clinical variables to stratify pregnant women with preeclampsia at high risk for adverse outcomes. However, differentiating high-risk patients amongst the variety presentations of hypertension disorders of pregnancy (HDP), not only preeclampsia, represents...
Article
Introduction Endocan-1 is a soluble proteoglican specifically expressed in endothelial cells, a biomarker/predictor of vascular endothelial related pathologies, as pre-eclampsia (PE). PlGF is an angiogenic factor, and a marker of placental dysfunction, which is down regulated in women with PE. We hypothesized that Endocan-1 and PlGF levels would be...
Article
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Objectives: To describe a case of Posterior Reversible Encephalopathy Syndrome diagnosed in pregnant women with late-eclampsia, as well as its clinical management. Case description: A 34 years old patient in her third pregnancy had started with high blood pressure levels during labor; after eleven days postpartum, she presented a decreased right...
Article
Objectives: To compare nitric oxide (NO) serum levels in women with and without preeclampsia. Methods: 106 women were classified into preeclampsia group (n = 40) and normotensive group (n = 66). NO content was measured in the serum. Clinical and laboratorial data were recorded for comparison. Results: Preeclampsia presented a significant incre...
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Objective: To prospectively evaluate depressive symptoms, nutritional status, and quality of life (QoL) and search for possible associations in patients with end-stage renal disease undergoing hemodialysis. Methods: A cohort study of 104 adult patients with end-stage renal disease undergoing hemodialysis was conducted. Anthropometric, clinical,...
Article
Glycemic control is an important factor for individuals with diabetes prevent complications such as vascular and kidney disease. Educational interventions carried out by the health team, have the potential to support the necessary change in lifestyle, adherence to treatment and a restrictive diet. The aim of this review was to investigate the educa...
Article
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Background: Imbalance in hemostatic mechanisms can occur during pregnancy with a tendency for hypercoagulability and increased thrombosis risk. Pregnant women with hypertensive disorder, especially preeclampsia, show alterations in platelet indexes. Immature platelet fraction (IPF) has been suggested as a sensitive index for monitoring changes in...
Article
Introduction Caveolin-1 (cav-1) is one of the major protein components of caveolae required for the coordination of some signalling pathways, including that of angiotensin II (AngII) with its Type 1 receptor (AT1R). We have previously reported decreased cav-1 and increased AT1R protein expression in placentae from women with pre-eclampsia (PE). Wit...
Article
Endocan-1 has been proposed as a possible biomarker and predictor of vascular endothelial related pathologies. Thus, we hypothesised that Endocan-1 levels would be up-regulated in maternal plasma and placentae from women with pre-eclampsia. The aim of our study was to compare Endocan-1 concentrations in maternal/fetal plasma and placentae from norm...